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Sep 2024
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Tumor-associated macrophage-derived itaconic acid contributes to nasopharyngeal carcinoma progression by promoting immune escape via TET2

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  12259
  
  DOI: 10.1186/s12964-024-01799-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11348665/
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Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels

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  pSpCas9(BB)-2A-GFP plasmid (PX458
  
  DOI: 10.1042/BCJ20240016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11346430/
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Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivation

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  48139
  
  DOI: 10.1080/15548627.2024.2355074
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11346535/
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Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis

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  108077
  
  DOI: 10.1038/s41598-024-65787-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350193/
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Interplay of FXN expression and lipolysis in white adipocytes plays a critical role in insulin sensitivity in Friedreich’s ataxia mouse model

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  10878
  
  DOI: 10.1038/s41598-024-71099-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350209/
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FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila

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  50553
  
  DOI: 10.1080/15476286.2024.2392304
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11352701/
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mTORC1 phosphorylates and stabilizes LST2 to negatively regulate EGFR

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  220787
  
  DOI: 10.1073/pnas.2405959121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11348030/
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MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity

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  45905
  
  DOI: 10.1073/pnas.2403392121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11348129/
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Differential impact of quiescent non-coding loci on chromatin entropy

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  Addgene
  
  DOI: 10.1093/nar/gkae535
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11347155/
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Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer/dye pairs

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  pAV-U6 + 27-Tornado-Broccoli
  
  DOI: 10.1093/nar/gkae551
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11347136/
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PCAF promotes R-loop resolution via histone acetylation

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  174448
  
  DOI: 10.1093/nar/gkae558
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11347145/
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PRPF40A induces inclusion of exons in GC-rich regions important for human myeloid cell differentiation

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  85133
  
  DOI: 10.1093/nar/gkae557
  
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  RRID:Addgene_85133 DOI:10.1093/nar/gkae557
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ncbi.nlm.nih.gov/pmc/articles/PMC11347146/
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TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice

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  79050
  
  DOI: 10.1093/nar/gkae520
  
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academic.oup.com/nar/article/52/15/9230/7697529
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Re-engineered guide RNA enables DNA loops and contacts modulating repression in E. coli

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  44 251
  
  DOI: 10.1093/nar/gkae591
  
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  RRID:Addgene_44251 DOI:10.1093/nar/gkae591
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ncbi.nlm.nih.gov/pmc/articles/PMC11347156/
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DdrC, a unique DNA repair factor from D. radiodurans, senses and stabilizes DNA breaks through a novel lesion-recognition mechanism

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  206874
  
  DOI: 10.1093/nar/gkae635
  
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  RRID:Addgene_206874 DOI:10.1093/nar/gkae635
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ncbi.nlm.nih.gov/pmc/articles/PMC11347143/
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Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation

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  42251
  
  DOI: 10.1038/s41467-024-50925-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11349758/
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Ultrasound-mediated spatial and temporal control of engineered cells in vivo

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  85430
  
  DOI: 10.1038/s41467-024-51620-2
  
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  RRID:Addgene_85430 DOI:10.1038/s41467-024-51620-2
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ncbi.nlm.nih.gov/pmc/articles/PMC11349879/
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Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress

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  83467
  
  DOI: 10.1038/s41467-024-51821-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350214/
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Astrocyte-derived dominance winning reverses chronic stress-induced depressive behaviors

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  92284
  
  DOI: 10.1186/s13041-024-01134-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11351830/
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TMEM9B Regulates Endosomal ClC-3 and ClC-4 Transporters

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  175152
  
  DOI: 10.3390/life14081034
  
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  RRID:Addgene_175152 DOI:10.3390/life14081034
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ncbi.nlm.nih.gov/pmc/articles/PMC11355779/
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PAI1 Regulates Cell Morphology and Migration Markers in Trastuzumab-Resistant HER2-Positive Breast Cancer Cells

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  52077
  
  DOI: 10.3390/life14081040
  
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  RRID:Addgene_52077 DOI:10.3390/life14081040
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ncbi.nlm.nih.gov/pmc/articles/PMC11355905/
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In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

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  67977
  
  DOI: 10.1038/s41375-024-02357-w
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11347378/
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HDAC1 and FOXK1 mediate EGFR-TKI resistance of non-small cell lung cancer through miR-33a silencing

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  13820
  
  DOI: 10.1186/s12967-024-05563-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350990/
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Neuronal network dynamics in the posterodorsal amygdala: shaping reproductive hormone pulsatility

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  AAV-Ef1a-fDIO-mCherry
  
  DOI: 10.1098/rsif.2024.0143
  
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  RRID:Addgene_114471 DOI:10.1098/rsif.2024.0143
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ncbi.nlm.nih.gov/pmc/articles/PMC11350435/
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Alleviating Hypertension by Selectively Targeting Angiotensin Receptor–Expressing Vagal Sensory Neurons

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  28306
  
  DOI: 10.1523/JNEUROSCI.1154-23.2023
  
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  DOI:10.1523/JNEUROSCI.1154-23.2023 RRID:Addgene_28306
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ncbi.nlm.nih.gov/pmc/articles/PMC10904025/
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A biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation

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  43803
  
  DOI: 10.1016/j.jbc.2024.107571
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11357806/
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Structural insights into rice KAI2 receptor provide functional implications for perception and signal transduction

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  pCOOL
  
  DOI: 10.1016/j.jbc.2024.107593
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350264/
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The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation

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  98292
  
  DOI: 10.1016/j.jbc.2024.107581
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350265/
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Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro

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  118093
  
  DOI: 10.1007/s12026-024-09461-0
  
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  DOI:10.1007/s12026-024-09461-0 RRID:Addgene_118093
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ncbi.nlm.nih.gov/pmc/articles/PMC11347464/
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Original research: Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease

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  37509
  
  DOI: 10.1136/gutjnl-2024-332043
  
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  DOI:10.1136/gutjnl-2024-332043 RRID:Addgene_37509
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ncbi.nlm.nih.gov/pmc/articles/PMC11347221/
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Sex-dependent, lateralized engagement of anterior insular cortex inputs to the dorsolateral striatum in binge alcohol drinking

1
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  55632
  
  DOI: 10.7554/eLife.96534
  
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  RRID:Addgene_55632 DOI:10.7554/eLife.96534
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ncbi.nlm.nih.gov/pmc/articles/PMC11357341/
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Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response

1
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  pCBASceI
  
  DOI: 10.1186/s13148-024-01719-6
  
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  RRID:Addgene_26477 DOI:10.1186/s13148-024-01719-6
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ncbi.nlm.nih.gov/pmc/articles/PMC11350970/
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CRISPR screen of venetoclax response-associated genes identifies transcription factor ZNF740 as a key functional regulator

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  125593
  
  DOI: 10.1038/s41419-024-06995-x
  
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Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis

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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.1038/s41419-024-07015-8
  
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The HOXC10/NOD1/ERK axis drives osteolytic bone metastasis of pan-KRAS-mutant lung cancer

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  KRAS(G12D)
  
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Generating CRISPR-edited clonal lines of cultured Drosophila S2 cells

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  49330
  
  DOI: 10.1093/biomethods/bpae059
  
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Multiplexed In Vivo Imaging with Fluorescence Lifetime‐Modulating Tags

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  136556
  
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Cellular Energy Cycle Mediates an Advection‐Like Forward Cell Flow to Support Collective Invasion

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  49083
  
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mRNA‐Lipid Nanoparticle‐Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple‐Negative Breast Cancer

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  Addgene
  
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CRISPR/Pepper‐tDeg: A Live Imaging System Enables Non‐Repetitive Genomic Locus Analysis with One Single‐Guide RNA

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  185404
  
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High‐Precision Photoacoustic Neural Modulation Uses a Non‐Thermal Mechanism

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  pAAV‐hSyn‐mCherry
  
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PICALM Regulating the Generation of Amyloid β‐Peptide to Promote Anthracycline‐Induced Cardiotoxicity

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  27 691
  
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Cell spheroid viscoelasticity is deformation-dependent

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  69058
  
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Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints

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  pX458
  
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Design of intrinsically disordered protein variants with diverse structural properties

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Cytokinin and ALOG proteins regulate pluripotent stem cell identity in the moss Physcomitrium patens

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  34890
  
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Top-down modulation of the retinal code via histaminergic neurons of the hypothalamus

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  62726
  
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AlphaFold2-guided engineering of split-GFP technology enables labeling of endogenous tubulins across species while preserving function

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  37465
  
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Local, Sustained, and Targeted Co-Delivery of MEK Inhibitor and Doxorubicin Inhibits Tumor Progression in E-Cadherin-Positive Breast Cancer

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  162011
  
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TRPV1 Activation Antagonizes High-Fat Diet-Induced Obesity at Thermoneutrality and Enhances UCP-1 Transcription via PRDM-16

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  104585
  
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In Vitro Insights into the Dietary Role of Glucoraphanin and Its Metabolite Sulforaphane in Celiac Disease

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  90398
  
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A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis

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  44361
  
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P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance

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  52961
  
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Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization

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  52961
  
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Structural basis of frizzled 7 activation and allosteric regulation

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  12456
  
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TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells

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  73178
  
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A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation

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  73178
  
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Treating late-onset Tay Sachs disease: Brain delivery with a dual trojan horse protein

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  Addgene
  
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Rapid and Highly Sensitive Detection of Mycobacterium tuberculosis Utilizing the Recombinase Aided Amplification-Based CRISPR-Cas13a System

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  Twinstrep-SUMO-huLwCas13a
  
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Adeno-Associated Virus (AAV)-Delivered Exosomal TAT and BiTE Molecule CD4-αCD3 Facilitate the Elimination of CD4 T Cells Harboring Latent HIV-1

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Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes

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  Addgene
  
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Rational Design of Pyrido[3,2-b]indolizine as a Tunable Fluorescent Scaffold for Fluorogenic Bioimaging

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  pETM33-Nsp1
  
  DOI: 10.1021/jacsau.4c00135
  
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CG-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins

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  pLJM1
  
  DOI: 10.1021/jacsau.4c00461
  
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Novel insights into vancomycin-loaded calcium sulfate and negative pressure wound therapy in preventing infections in open fractures

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  52,961
  
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Transcriptional and Post-Translational Roles of Calcineurin in Cationic Stress and Glycerol Biosynthesis in Cryptococcus neoformans

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  pDD162
  
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A Chimeric ORF Fusion Phenotypic Reporter for Cryptococcus neoformans

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  217316
  
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Engineering the cyanobacterial ATP-driven BCT1 bicarbonate transporter for functional targeting to C3 plant chloroplasts

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  162708
  
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Chemical genetic screens reveal defective lysosomal trafficking as synthetic lethal with NF1 loss

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  52961
  
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Two enzymes contribute to citrate production in the mitochondrion of Toxoplasma gondii

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  54467
  
  DOI: 10.1016/j.jbc.2024.107565
  
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Targeting ITGβ3 to Overcome Trastuzumab Resistance through Epithelial–Mesenchymal Transition Regulation in HER2-Positive Breast Cancer

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  113712
  
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Doxycycline-Mediated Control of Cyclin D2 Overexpression in Human-Induced Pluripotent Stem Cells

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  12260
  
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One-Step Genetic Modification by Embryonic Doral Aorta Injection of Adenoviral CRISPR/Cas9 Vector in Chicken

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  48139
  
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Development of a Bmi1+ Cardiac Mouse Progenitor Immortalized Model to Unravel the Relationship with Its Protective Vascular Endothelial Niche

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  12260
  
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ICAM1 (CD54) Contributes to the Metastatic Capacity of Gastric Cancer Stem Cells

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  86708
  
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Genome Mining and Genetic Manipulation Reveal New Isofuranonaphthoquinones in Nocardia Species

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  pCRISPomyces-2
  
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CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival

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  pSpCas9(BB)-2A-GFP
  
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Ethyl Acetate Fractions of Salvia miltiorrhiza Bunge (Danshen) Crude Extract Modulate Fibrotic Signals to Ameliorate Diabetic Kidney Injury

1
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  84394
  
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Hsp70 Negatively Regulates Autophagy via Governing AMPK Activation, and Dual Hsp70-Autophagy Inhibition Induces Synergetic Cell Death in NSCLC Cells

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  pMD2.G
  
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Identification of Site in the UTY Gene as Safe Harbor Locus on the Y Chromosome of Pig

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  50005
  
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Notch-Dependent Expression of the Drosophila Hey Gene Is Supported by a Pair of Enhancers with Overlapping Activities

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  pU6-BbsI-chiRNA
  
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Nanoparticle-Mediated Genetic Transformation in a Selaginella Species

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  179834
  
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Enhanced enrichment of extracellular vesicles for laboratory and clinical research from drop-sized blood samples

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  172118
  
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Opposing actions of co-released GABA and neurotensin on the activity of preoptic neurons and on body temperature

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  27056
  
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Stable germline transgenesis using the Minos Tc1/mariner element in the sea urchin Lytechinus pictus

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  198059
  
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Innovative Tools for DNA Topology Probing in Human Cells Reveal a Build-Up of Positive Supercoils Following Replication Stress at Telomeres and at the FRA3B Fragile Site

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  60495
  
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In Vivo Tracking and 3D Mapping of Cell Death in Regeneration and Cancer Using Trypan Blue

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  31789
  
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Elevated GRHL2 Imparts Plasticity in ER-Positive Breast Cancer Cells

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  1764
  
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The Role of TIM-1 and CD300a in Zika Virus Infection Investigated with Cell-Based Electrical Impedance

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  52961
  
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Characterization of human aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery

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  pAG426GAL-EGFP-ccdB
  
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The RNA Demethylases ALKBH5 and FTO Regulate the Translation of ATF4 mRNA in Sorafenib-Treated Hepatocarcinoma Cells

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  12259
  
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Pyrimidine Triones as Potential Activators of p53 Mutants

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  170427
  
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Exploring a Novel Role of Glycerol Kinase 1 in Prostate Cancer PC-3 Cells

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  pcDNA3.1/Hygro(+)
  
  DOI: 10.3390/biom14080997
  
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RNA Surveillance Factor SMG5 Is Essential for Mouse Embryonic Stem Cell Differentiation

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  23776
  
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Targeting Grb2 SH3 Domains with Affimer Proteins Provides Novel Insights into Ras Signalling Modulation

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  8455
  
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KIF1A, R1457Q, and P1688L Mutations Induce Protein Abnormal Aggregation and Autophagy Impairment in iPSC-Derived Motor Neurons

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  pCE-hOCT3/4
  
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Tetrazine Amino Acid Encoding for Rapid and Complete Protein Bioconjugation

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  85493
  
  DOI: 10.21769/BioProtoc.5048
  
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Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice

1
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  pcDNA3-EGFP-C4-Nrf2
  
  DOI: 10.3390/antiox13080896
  
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Chromatin Regulator SMARCA4 Is Essential for MHV-Induced Inflammatory Cell Death, PANoptosis

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  73633
  
  DOI: 10.3390/v16081261
  
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Membrane Retention of West Nile Virus NS5 Depends on NS1 or NS3 for Enzymatic Activity

1
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  26201
  
  DOI: 10.3390/v16081303
  
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Role of Protein VII in the Production of Infectious Bovine Adenovirus-3 Virion

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  pLOX.Ttag
  
  DOI: 10.3390/v16081323
  
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Protocol for assaying irreversible inhibitors of thioredoxin reductase 1

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  78865
  
  DOI: 10.1016/j.xpro.2024.103235
  
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Protocol for the purification of replisomes from the Xenopus laevis egg extract system for single-particle cryo-EM analysis

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  208796
  
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In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning

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TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells

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Symbolic recording of signalling and cis-regulatory element activity to DNA

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Neural circuit basis of placebo pain relief

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Optimising CNT-FET biosensor design through modelling of biomolecular electrostatic gating and its application to β-lactamase detection

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XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients

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  pKLV2-U6gRNA5(BbsI)-PGKpuro2AZsG-W
  
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Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair

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The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities

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Evaluation of the effect of RNA secondary structure on Cas13d-mediated target RNA cleavage

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Expanding science skills: teaching tissue culture, data analysis, and reporting through imaging the actin cytoskeleton

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  129020
  
  DOI: 10.1128/jmbe.00190-23
  
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Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress

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Different roles of the heterodimer architecture of galectin-4 in selective recognition of oligosaccharides and lipopolysaccharides having ABH antigens

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  31122
  
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Integrin α2 is an early marker for osteoclast differentiation that contributes to key steps in osteoclastogenesis

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  12259
  
  DOI: 10.3389/fcell.2024.1448725
  
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Adolescent Thalamoprefrontal Inhibition Leads to Changes in Intrinsic Prefrontal Network Connectivity

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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer

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  24130
  
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SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling

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  49386
  
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ECM stiffness regulates calcium influx into mitochondria via tubulin and VDAC1 activity

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  17843
  
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Multistep allelic conversion in mouse pre-implantation embryos by AAV vectors

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The metalloproteinase PAPP-A is required for IGF-dependent chondrocyte differentiation and organization

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Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion

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Gα13 restricts nutrient driven proliferation in mucosal germinal centers

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A TNIP1-driven systemic autoimmune disorder with elevated IgG4

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  66929
  
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Influenza vaccination stimulates maturation of the human T follicular helper cell response

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Mechanism for controlled assembly of transcriptional condensates by Aire

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SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis

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DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor

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Force and the α-C-terminal domains bias RNA polymerase recycling

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  109424
  
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Phosphoribosyl modification of poly-ubiquitin chains at the Legionella-containing vacuole prohibiting autophagy adaptor recognition

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  19506
  
  DOI: 10.1038/s41467-024-51273-1
  
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RAS-ON inhibition overcomes clinical resistance to KRAS G12C-OFF covalent blockade

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Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes

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  141375
  
  DOI: 10.1038/s41467-024-51959-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364864/
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A sophisticated mechanism governs Pol ζ activity in response to replication stress

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  Lentiweb Protocol
  
  DOI: 10.1038/s41467-024-52112-z
  
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Biolayer interferometry for adeno-associated virus capsid titer measurement and applications to upstream and downstream process development

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  105530
  
  DOI: 10.1016/j.omtm.2024.101306
  
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Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer

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  52961
  
  DOI: 10.1172/JCI175217
  
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Adeno-associated virus–based gene therapy treats inflammatory kidney disease in mice

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  32396
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364381/
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Tensing Flipper: Photosensitized Manipulation of Membrane Tension, Lipid Phase Separation, and Raft Protein Sorting in Biological Membranes

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  166905
  
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Oligonucleotide-based CRISPR-Cas9 toolbox for efficient engineering of Komagataella phaffii

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  plasmids
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364938/
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V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor

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  8453
  
  DOI: 10.1186/s13578-024-01288-4
  
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DNA Methylation in Recurrent Glioblastomas: Increased TEM8 Expression Activates the Src/PI3K/AKT/GSK-3β/Β-Catenin Pathway

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  M50 Super 8X TOPFlash
  
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Generation of a human induced pluripotent stem cell line (FSMi001-A) from fibroblasts of a patient carrying heterozygous mutation in the REEP1 gene

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  74947
  
  DOI: 10.1016/j.scr.2024.103472
  
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Digital spatial profiling identifies the tumor center as a topological niche in prostate cancer characterized by an upregulation of BAD

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  8778
  
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Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis

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  52961
  
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CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma

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  pSpCas9(BB)-2A-GFP (PX458
  
  DOI: 10.1038/s41388-024-03115-z
  
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Identification of direct connections between the dura and the brain

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  37825
  
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Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward

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  114472
  
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Drinkable in situ-forming tough hydrogels for gastrointestinal therapeutics

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  14080
  
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Phospholipid scrambling induced by an ion channel/metabolite transporter complex

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  52963
  
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Feedforward inhibition of stress by brainstem neuropeptide Y neurons

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  100838
  
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FGFR1 signaling facilitates obesity-driven pulmonary outgrowth in metastatic breast cancer

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  25812
  
  DOI: 10.1158/1541-7786.MCR-23-0955
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10923021/
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Fatty acid–binding proteins 3, 7, and 8 bind cholesterol and facilitate its egress from lysosomes

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  12259
  
  DOI: 10.1083/jcb.202211062
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10909654/
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Effects of Home Cage Tunnels on Within-cage Behaviors of Mice with Cranial Implants

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  Addgene
  
  DOI: 10.30802/AALAS-JAALAS-22-000087
  
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CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder

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  224929
  
  DOI: 10.1038/s42003-024-06770-w
  
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Reversible control of kinase signaling through chemical-induced dephosphorylation

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  12371
  
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Effect of leaflet asymmetry on the stretching elasticity of lipid bilayers with phosphatidic acid

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  108865
  
  DOI: 10.1016/j.bpj.2024.05.031
  
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Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1

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  48139
  
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FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production

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  86499
  
  DOI: 10.1016/j.redox.2024.103302
  
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LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression

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Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution

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  63800
  
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A unified purification method for actin-binding proteins using a TEV-cleavable His-Strep-tag

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  60409
  
  DOI: 10.1016/j.mex.2024.102884
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11367271/
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Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways

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  79749
  
  DOI: 10.1016/j.jbc.2024.107551
  
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A pre-B acute lymphoblastic leukemia cell line model reveals the mechanism of thalidomide therapy-related B-cell leukemogenesis

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  69048
  
  DOI: 10.1016/j.jbc.2024.107578
  
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Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

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  34965
  
  DOI: 10.7554/eLife.96699
  
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Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2

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  pX-330
  
  DOI: 10.1016/j.ebiom.2024.105281
  
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DOI:10.1016/j.ebiom.2024.105281

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Polyoxometalate inhibition of SOX2-mediated tamoxifen resistance in breast cancer

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  16577
  
  DOI: 10.1186/s12964-024-01800-w
  
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Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation

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  17360
  
  DOI: 10.1186/s12964-024-01795-4
  
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Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT

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  85,140
  
  DOI: 10.1038/s41598-024-71306-5
  
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Single-molecule imaging of SWI/SNF chromatin remodelers reveals bromodomain-mediated and cancer-mutants-specific landscape of multi-modal DNA-binding dynamics

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  17877
  
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Progression of herpesvirus infection is inhibited by calcium reporter

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  64977
  
  DOI: 10.17912/micropub.biology.001269
  
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New Flexon-based reagents for tissue-specific Auxin-Inducible Degradation and for characterizing Cre and Flp drivers in C. elegans

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  Addgene
  
  DOI: 10.17912/micropub.biology.001315
  
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Activating UCHL1 through the CRISPR activation system promotes cartilage differentiation mediated by HIF‐1α/SOX9

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  49157
  
  DOI: 10.1111/jcmm.70051
  
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Belamcanda chinensis extract inhibits non-small cell lung cancer proliferation and induces apoptosis via inhibiting the MAPK (Ras/Raf) and Akt pathways

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  22011
  
  DOI: 10.1016/j.heliyon.2024.e36032
  
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Hyd/UBR5 defines a tumor suppressor pathway that links Polycomb repressive complex to regulated protein degradation in tissue growth control and tumorigenesis

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  52050
  
  DOI: 10.1101/gad.351856.124
  
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Tolerance thresholds underlie responses to DNA damage during germline development

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  62208
  
  DOI: 10.1101/gad.351701.124
  
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SUMO promotes DNA repair protein collaboration to support alternative telomere lengthening in the absence of PML

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  80070
  
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Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration

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  19161
  
  DOI: 10.1038/s42003-024-06773-7
  
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Remote ischemic preconditioning prevents high‐altitude cerebral edema by enhancing glucose metabolic reprogramming

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  102548
  
  DOI: 10.1111/cns.70026
  
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Tracking induced pluripotent stem cell differentiation with a fluorescent genetically encoded epigenetic probe

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  162342
  
  DOI: 10.1007/s00018-024-05359-0
  
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The disruption of NEAT1-miR-125b-5p-SLC1A5 cascade defines the oncogenicity and differential immune profile in head and neck squamous cell carcinoma

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  89308
  
  DOI: 10.1038/s41420-024-02158-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369192/
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Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes

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  Addgene
  
  DOI: 10.1101/2024.09.09.611392
  
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SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

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  12260
  
  DOI: 10.1101/2024.09.09.612072
  
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Estrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis

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  24644
  
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CRISPR-CLEAR: Nucleotide-Resolution Mapping of Regulatory Elements via Allelic Readout of Tiled Base Editing

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  57822
  
  DOI: 10.1101/2024.09.09.612085
  
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PIP5K-Ras bistability initiates plasma membrane symmetry breaking to regulate cell polarity and migration

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  79574
  
  DOI: 10.1101/2024.09.15.613115
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11419139/
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Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system

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  14437
  
  DOI: 10.1038/s41392-024-01971-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11427461/
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Story of an infection: Viral dynamics and host responses in the Caenorhabditis elegans–Orsay virus pathosystem

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  pJJR50
  
  DOI: 10.1126/sciadv.adn5945
  
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Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube

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  46793
  
  DOI: 10.1126/sciadv.adp6285
  
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Drug-induced change in transmitter identity is a shared mechanism generating cognitive deficits

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  32481
  
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Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons

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  122139
  
  DOI: 10.1186/s13041-024-01139-w
  
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Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells

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  40973
  
  DOI: 10.1186/s12967-024-05627-4
  
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Distinct and Convergent Alterations of Entorhinal Cortical Circuits in Two Mouse Models for Alzheimer’s Disease and Related Disorders

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  AAV9.CAG.hChR2(H134R)-mCherry.WPRE.SV40
  
  DOI: 10.3233/JAD-231413
  
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ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF-1A signaling axis

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  pMD2.G
  
  DOI: 10.3892/ijo.2024.5693
  
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USP7 regulates growth and maintains the stemness of p53-mutant colorectal cancer cells via stabilizing of mutant p53

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  131257
  
  DOI: 10.3389/fonc.2024.1427663
  
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mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis

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  12259
  
  DOI: 10.1186/s11658-024-00638-x
  
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The Fluorinated NAD Precursors Enhance FK866 Cytotoxicity by Activating SARM1 in Glioblastoma Cells

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  52961
  
  DOI: 10.3390/biology13090649
  
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A New Chimeric Antibody against the HIV-1 Fusion Inhibitory Peptide MT-C34 with a High Affinity and Fc-Mediated Cellular Cytotoxicity

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  223966
  
  DOI: 10.3390/biology13090675
  
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Genome Engineering of Primary and Pluripotent Stem Cell-Derived Hepatocytes for Modeling Liver Tumor Formation

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  106280
  
  DOI: 10.3390/biology13090684
  
  Resource: RRID:Addgene_106280
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_106280
  
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  DOI:10.3390/biology13090684 RRID:Addgene_106280
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RRID:Addgene_106280

DOI:10.3390/biology13090684

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ncbi.nlm.nih.gov/pmc/articles/PMC11428634/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Putative Virulence Plasmid pYR4 of the Fish Pathogen Yersinia ruckeri Is Conjugative and Stabilized by a HigBA Toxin–Antitoxin System

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1. scibot 29 Sep 2024
  
  in Public
  
  67273
  
  DOI: 10.3390/biology13090652
  
  Resource: Addgene_67273
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_67273
  
  What is this?
  
  DOI:10.3390/biology13090652 RRID:Addgene_67273
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RRID:Addgene_67273

DOI:10.3390/biology13090652

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ncbi.nlm.nih.gov/pmc/articles/PMC11429247/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The Y498T499-SARS-CoV-2 spike (S) protein interacts poorly with rat ACE2 and does not affect the rat lung

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1. scibot 29 Sep 2024
  
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  12259
  
  DOI: 10.1099/acmi.0.000839.v3
  
  Resource: RRID:Addgene_12259
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_12259
  
  What is this?
  
  RRID:Addgene_12259 DOI:10.1099/acmi.0.000839.v3
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DOI:10.1099/acmi.0.000839.v3

RRID:Addgene_12259

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ncbi.nlm.nih.gov/pmc/articles/PMC11432600/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Bafilomycin A1 Inhibits HIV-1 Infection by Disrupting Lysosomal Cholesterol Transport

1
1. scibot 29 Sep 2024
  
  in Public
  
  104590
  
  DOI: 10.3390/v16091374
  
  Resource: Addgene_104590
  
  Curator: @olekpark
  
  SciCrunch record: RRID:Addgene_104590
  
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  RRID:Addgene_104590 DOI:10.3390/v16091374
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DOI:10.3390/v16091374

RRID:Addgene_104590

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URL

ncbi.nlm.nih.gov/pmc/articles/PMC11435809/

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