- Dec 2024
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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Disease: Von-willebrand Disorder Type 3
Patient: 26 yo, female
Variant: VWF NM_000552.5 c:997+118 T>G g.(6073501 A>C), homozygous, intronic
Phenotypes: No detectable VWF in plasma, early onset bleeding complications, epistaxis, easy bruising, bleeding following injury, menorrhagia, iron-deficient anemia
Note: underwent prophylaxis replacement therapy, on-demand antihemorrhagic treatments, oral contraceptives, and replacement therapy.
Family: not mentioned
Predictions:
VEP SpliceAI tool predicted variant likely deleterious (delta score 0.95)
Used Polyphen-2 and SIFT which determined pathogenic likelihood.
Neural Network Splicing, Alternative Splice Site Predictor, plug-in MaxEnt(For 5' donor site) of Human Splicing Finder all concur this variant can create a new donor splice site in intron 8. Contains premature stop codon and susceptible to NMD.
Functional work:
qRT-PCR performed to identify levels of VWF in IP-derived endothelial cells.
histochemical immunostaining for IP-derived endothelial cells confirm no VWF production, only a residual amount present. Suggests leaky mutation.
performed RNA sequencing to assess co-regulated gene networks
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www.youtube.com www.youtube.com
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the best way to make a company erodic is by putting it into an ecosystem of other companies that all work together to have robust circulatory flows throughout the entire ecosystem by doing that we counteract these losses we make the ecosystem orotic and then each company can contribute at its maximum its maximum regenerative potential
for - regenerative company - principle 7 of 8 - robust circulatory flow - ergodic flow - adjacency - Fairschare Company - FSC - regenerative organization - ergodic flow - robust circulatory flow - ecosystem of companies - backcasting from 2030 - cross-scale translation of earth system boundaries
adjacency - between - ergodic flows - ecosystem of companies - robust circulatory flows - Fairshare Commons (FSC) - regenerative company - regenerative organization - backcasting from 2030 - cross-scale translation of earth system boundaries - adjacency relationship - To implement principle 7 and work with an ecosystem of other companies: - For a company to relate well with other companies, - this is like an individual relating well to other individuals - The Indyweb is a people-centered, interpersonal information system architecture that supports both: - people-centered and interpersonal conversations as well as - organization-centered and inter-organizational conversations - Backcasting and cross-scale translating earth system boundaries from 2030 the present is critical to fulfill any FSC's modus operandi in the present. - In other words, knowing what a world that has successfully and dramatically reduced - carbon emissions and - threats to the biosphere - looks like at all scales (including community and company) in 2030 (5 years from now), we need to project backwards to the present and see what actions make sense and are aligned to take us to that envisioned scenario - If we don't have targets that are aligned to regenerating nature that we have globally harmed in measurable ways, what point is there in the word "regenerative" in the title of "regenerative company"?
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fortunately this is perfectly possible within existing company law by taking the concept the properties in law of legal personhood to their fullest extent
for - regenerative company - principle 1 of 8 - agency-based instead of ownership-based - implementation - via leveraging full extent of legal personhood
Comment - Graham points out an interesting insight, that organisations are given legal personhood status -namely, we test a group of people as a person itself - This reminds me of Michael Levin's Multi Scale Competency Architecture
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there are eight principles that a company has to maximally fulfill in order to truly be regenerative
for - regenerative company - 8 principles - Graham Boyd - Fairshare Commons
Comment - I found the short video interview of Graham Boyd (link in the Page Notes) useful in contextualising these principles
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for - YouTube - What is the best way to turn a regenerative company? - Fairshare Commons - 8 principles of - Graham Boyd - to - YouTube - interview - Graham Boyd
to - YouTube - interview - Graham Boyd - https://hyp.is/V_pmiLXqEe--vkvZJO7ehw/www.youtube.com/watch?v=wGwtwDQW1do
Tags
- to - YouTube - interview - Graham Boyd
- regenerative company - principle 1 of 8 - agency-based instead of ownership-based - implementation - via leveraging full extent of legal personhood
- regenerative company - 8 principles - Graham Boyd - Fairshare Commons
- YouTube - What is the best way to turn a regenerative company? - Fairshare Commons - 8 principles of - Graham Boyd
- adjacency - Fairschare Company - FSC - regenerative organization - ergodic flow - robust circulatory flow - ecosystem of companies - backcasting from 2030 - cross-scale translation of earth system boundaries
- regenerative company - principle 7 of 8 - robust circulatory flow - ergodic flow
Annotators
URL
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www.youtube.com www.youtube.com
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for - YouTube - Fairshare Commons - interview - Graham Boyd - etymology - company - Fairshare Commons principle of inclusivity - reflects influence of unfairness of Apartheid exclusivity - from - YouTube - Fairshare Commons - 8 principles of - Graham Boyd
from - YouTube - What is the best way to turn a regenerative company? - Fairshare Commons - 8 principles of - Graham Boyd - https://hyp.is/6aAtWLXpEe-CbZPjBOu6ew/www.youtube.com/watch?v=AEIMB-odmRU
Summary - It was insightful to hear the association between Fairshare Commons company and Eleanor Ostrom's work on the commons and to recast the company as a group of people stewarding a commons - Graham introduces the etymology of the word "company", as an intentional community that has its roots of people " gathering in the company of others to break bread" - Also interesting to know he is Sorry African and his experience with Apartheid informs his inclusivity principle off the Fairshare Commons
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- Oct 2024
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ageoftransformation.org ageoftransformation.org
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The 'polycrisis' is real enough. But it’s a surface level symptom of multiple, simultaneous phase transitions at the core of the ‘hardware’ and ‘software’ systems that define human civilisation – which together can be understood as a planetary phase shift. But if all we see and respond to is the polycrisis – the symptoms of this process as it weakens industrial structures – that will derail the planetary phase shift to a new life cycle.
for - comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein - quote - making sense of the polycrisis - a symptom of multiple phase transitions - (see below) - The 'polycrisis' is real enough. - But it’s a surface level symptom - of multiple, simultaneous phase transitions at the core of the ‘hardware’ and ‘software’ systems that define human civilisation - which together can be understood as a planetary phase shift. - But if all we see and respond to is the polycrisis - the symptoms of this process as it weakens industrial structures - that will derail the planetary phase shift to a new life cycle.
comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein - Ahmed's writing about the polycrisis masking the planetary phase shift is very reminiscent of Charles Eisenstein's writing in the Ascent of Humanity in which he compares the great transition we are undergoing to - the perilous journey a neonate takes as it leaves the womb and enters the greater space awaiting
to - book - The Ascent of Humanity - Chapter 8 - The Gaian Birthing - Charles Eisenstein - https://hyp.is/r8scTpG_Ee-gLTujlli5hQ/charleseisenstein.org/books/the-ascent-of-humanity/eng/the-gaian-birthing/
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for - rapid whole system change - Nafeez Ahmed - planetary phase shift - Nafeez Ahmed - planetary adaptive cycle - Nafeez Ahmed - essay - The End of Scarcity? From ‘Polycrisis’ to Planetary Phase Shift - Nafeez Ahmed - 2024 Oct 16 - to - book - The Ascent of Humanity - chapter 8 Self and Cosmos: The Gaian Birthing - stillborn and the perilous journey through the womb - Charles Eisenstein
summary - This is a good article that makes sense of the inflection point that humanity now faces as it contends with multiple existential crisis - It summarizes the complexity of our polycrisis and its precarity and lays the theory for looking at the polycrisis from a different perspective: - as a planetary phase shift towards the potential end of scarcity and the next stage of our species evolution - Through the lens of ecologist Crawford Stanley Holling's lens of the adaptive cycle of ecological population dynamics, - and especially his 2004 paper "From Complex Regions to Complex Worlds" - Nafeez extends Holling's argument that we are undergoing a planetary adaptive cycle in which the back-loop is the dying industrial era. - In this sense, it is reminiscent of the writings of Charles Eisenstein in his book "The Ascent of Humanity", chapter 8: Self and Cosmos:, The Gaian Birth. - Eisenstein uses the the perilous journey of birth through the womb door as a metaphor of the transition we are currently undergoing.
to - paper - From Complex Regions to Complex Worlds - Crawford Stanley Holling - 2004 - https://hyp.is/KYCm2pFrEe-_PEu84xshXw/www.ecologyandsociety.org/vol9/iss1/art11/main.html?ref=ageoftransformation.org - book - The Ascent of Humanity - Chapter 8 - The Gaian Birthing - Charles Eisenstein - https://hyp.is/r8scTpG_Ee-gLTujlli5hQ/charleseisenstein.org/books/the-ascent-of-humanity/eng/the-gaian-birthing/
Tags
- planetary adaptive cycle - Crawford Stanley Holling
- comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein
- rapid whole system change - Nafeez Ahmed
- to - book - The Ascent of Humanity - chapter 8 Self and Cosmos: The Gaian Birthing - stillborn and the perilous journey through the womb - Charles Eisenstein
- quote - making sense of the polycrisis - a symptom of multiple phase transitions
- planetary adaptive cycle - Nafeez Ahmed
- planetary phase shift - Nafeez Ahmed
- to - paper - From Complex Regions to Complex Worlds - Crawford Stanley Holling - 2004
- to - book - The Ascent of Humanity - Chapter 8 - The Gaian Birthing - Charles Eisenstein
- essay - The End of Scarcity? From ‘Polycrisis’ to Planetary Phase Shift - Nafeez Ahmed - 2024 Oct 16
Annotators
URL
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charleseisenstein.org charleseisenstein.org
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for - book - The Ascent of Humanity - chapter 8 Self and Cosmos: The Gaian Birth - stillborn and the perilous journey through the womb - Charles Eisenstein - from - essay - The End of Scarcity? From 'polycrisis' to planetary phase shift - Nafeez Ahmed
from - essay - The End of Scarcity? From 'polycrisis' to planetary phase shift - Nafeez Ahmed - https://hyp.is/7t2GpJF7Ee-DjHfBgrshcQ/ageoftransformation.org/the-end-of-scarcity-from-polycrisis-to-planetary-phase-shift/
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www.chalkbeat.org www.chalkbeat.org
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He described state ballot laws in the United States as “the worst in the Western world, by orders of magnitude.”
Explore ballot laws in another Western democracy and find either support for or against Nader's claim. Cite your source(s).
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www.sciencedirect.com www.sciencedirect.com
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Disease: Von Willebrand Disease (VWD) Type 2A
Patient: 31 yo, Female
Variant1: VWF NC_000012.12: c.875-5T>Gdel, p.(Ser292_Glu333delinsLys) Causes complete exon 8 skipping
Variant2: VWF NM_000552.5: c.813C>G, p.(Tyr271*)
Phenotypes: History of bleeding (epistaxis, uncontrollable by conventional hemostatic treatment), Easy bruising, gum bleeding, excessive menstrual bleeding, mild decrease in plasma VWF:Ag, severe impairment in VWF function, VWF:Ab/VWF:Ag ratio decreased, VWF:CB/VWF:Ag ratio decreased, FVIII:C lvs slighly below normal range
Family: Son had bleeding diathesis and spontaneous epistaxis (less severe than proband), normal parents
In silico data available: SpliceAI delta score of 0.51 for loss of splice acceptor caused by variant 1
Alamut showed small to moderate effects of the variant on normal splicing of VWF
NetGene2 showed weak strength of 3' splice sites in exon 8
SpliceAid2 showed TIA-1 and TIAL 1, which bind to U-rich motifs and facilitate 5' splice site recognition where destroyed in the mutated sequence
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usrussiarelations.org usrussiarelations.org
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British tobacco merchants monopoly rights in Russia, expanding the market for a key colonial American export.
Explain this chain! British tobacco merchants sold to Russia, yet it expanded the US market. How did this work?
Cite your sources.
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assets.openstax.org assets.openstax.org
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The key is tobe your own best advocate, becauseno one else is obliged to advocate on your behalf.
10/8 interesting: When I enter the college three weeks. I deeply aware of taking responsibility for myself.
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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#15947
DOI: 10.1038/s41598-018-21343-8
Resource: RRID:BDSC_15947
Curator: @maulamb
SciCrunch record: RRID:BDSC_15947
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- Sep 2024
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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43803
DOI: 10.1038/s41586-024-07613-8
Resource: RRID:Addgene_43803
Curator: @olekpark
SciCrunch record: RRID:Addgene_43803
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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72655
DOI: 10.1038/s41567-024-02438-8
Resource: RRID:Addgene_72655
Curator: @olekpark
SciCrunch record: RRID:Addgene_72655
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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pSpCas9(BB)-2A-GFP
DOI: 10.1038/s41419-024-07015-8
Resource: RRID:Addgene_48138
Curator: @olekpark
SciCrunch record: RRID:Addgene_48138
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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KRAS(G12D)
DOI: 10.1038/s41413-024-00350-8
Resource: Addgene (RRID:SCR_002037)
Curator: @olekpark
SciCrunch record: RRID:SCR_002037
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www.nature.com www.nature.com
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RRID:CVCL_0539
DOI: 10.1038/s41598-024-72121-8
Resource: (ICLC Cat# HTL10002, RRID:CVCL_0539)
Curator: @mzhang007
SciCrunch record: RRID:CVCL_0539
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www.creativitypost.com www.creativitypost.com
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Many famous inventors or artists didn't stop trying. They faced obstacles that could cause most people to stop trying, instead by knowing who you are and who you can be is worth facing any obstacle.
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- Aug 2024
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington stock #: 54591
DOI: 10.1038/s41598-024-69946-8
Resource: RRID:BDSC_54591
Curator: @anisehay
SciCrunch record: RRID:BDSC_54591
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link.springer.com link.springer.com
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Necitumumab
DOI: 10.1007/s10967-019-06933-8
Resource: AB_3111823
Curator: @bandrow
SciCrunch record: RRID:AB_3111823
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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ya130
DOI: 10.7554/eLife.82249
Resource: ZFIN_ZDB-ALT-230316-8
Curator: @olekpark
SciCrunch record: RRID:ZFIN_ZDB-ALT-230316-8
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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54967
DOI: 10.1038/s42003-024-06605-8
Resource: RRID:Addgene_54967
Curator: @olekpark
SciCrunch record: RRID:Addgene_54967
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- Jul 2024
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC
DOI: 10.1186/s12979-023-00354-8
Resource: RRID:BDSC_33610
Curator: @olekpark
SciCrunch record: RRID:BDSC_33610
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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18115
DOI: 10.1038/s41556-021-00813-8
Resource: RRID:BDSC_18115
Curator: @olekpark
SciCrunch record: RRID:BDSC_18115
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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3605
DOI: 10.1186/s13578-021-00567-8
Resource: RRID:BDSC_3605
Curator: @mpairish
SciCrunch record: RRID:BDSC_3605
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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29514
DOI: 10.1038/s41598-021-95309-8
Resource: RRID:BDSC_29514
Curator: @mpairish
SciCrunch record: RRID:BDSC_29514
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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1495
DOI: 10.1038/s41467-021-25809-8
Resource: RRID:BDSC_1495
Curator: @mpairish
SciCrunch record: RRID:BDSC_1495
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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UAS-Hsc70.3WT
DOI: 10.1038/s41598-022-12191-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @anisehay
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC_3039
DOI: 10.1038/s41467-022-31266-8
Resource: (BDSC Cat# 3039,RRID:BDSC_3039)
Curator: @anisehay
SciCrunch record: RRID:BDSC_3039
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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1774
DOI: 10.1038/s41467-022-32408-8
Resource: (BDSC Cat# 1774,RRID:BDSC_1774)
Curator: @anisehay
SciCrunch record: RRID:BDSC_1774
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Oregon-R
DOI: 10.1186/s12915-022-01435-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @anisehay
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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ELAV-GAL4
DOI: 10.1038/s41467-019-13477-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @bandrow
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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7133
DOI: 10.1186/s13578-022-00820-8
Resource: BDSC_7133
Curator: @mpairish
SciCrunch record: RRID:BDSC_7133
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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6596
DOI: 10.1007/s12264-022-00908-8
Resource: (BDSC Cat# 6596,RRID:BDSC_6596)
Curator: @mpairish
SciCrunch record: RRID:BDSC_6596
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www.nature.com www.nature.com
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RRID:4645
DOI: 10.1038/s41416-024-02783-8
Resource: (RCB Cat# RCB1682, RRID:CVCL_4645)
Curator: @dhovakimyan1
SciCrunch record: RRID:CVCL_4645
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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23245
DOI: 10.1007/s00018-022-04674-8
Resource: (BDSC Cat# 23245,RRID:BDSC_23245)
Curator: @mpairish
SciCrunch record: RRID:BDSC_23245
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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3605
DOI: 10.1038/s41467-022-35577-8
Resource: (BDSC Cat# 3605,RRID:BDSC_3605)
Curator: @mpairish
SciCrunch record: RRID:BDSC_3605
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC_58181
DOI: 10.1038/s41598-020-65348-8
Resource: (BDSC Cat# 58181,RRID:BDSC_58181)
Curator: @bpowell22
SciCrunch record: RRID:BDSC_58181
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington Drosophila Stock Center
DOI: 10.1186/s13064-020-00144-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @bpowell22
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BL17985
DOI: 10.1038/s41467-020-14761-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @maulamb
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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31882
DOI: 10.1038/s41586-023-06013-8
Resource: (BDSC Cat# 31882,RRID:BDSC_31882)
Curator: @mpairish
SciCrunch record: RRID:BDSC_31882
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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5905
DOI: 10.1038/s42003-020-0902-8
Resource: (BDSC Cat# 5905,RRID:BDSC_5905)
Curator: @olekpark
SciCrunch record: RRID:BDSC_5905
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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31489
DOI: 10.1038/s41467-020-17399-8
Resource: (BDSC Cat# 31489,RRID:BDSC_31489)
Curator: @olekpark
SciCrunch record: RRID:BDSC_31489
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington
DOI: 10.1038/s41576-020-0262-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @olekpark
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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5578
DOI: 10.1038/s41598-020-70759-8
Resource: RRID:BDSC_5578
Curator: @olekpark
SciCrunch record: RRID:BDSC_5578
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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30181
DOI: 10.1038/s41467-019-13237-8
Resource: RRID:BDSC_30181
Curator: @bandrow
SciCrunch record: RRID:BDSC_30181
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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7648
DOI: 10.1038/s42003-021-01663-8
Resource: BDSC_7648
Curator: @olekpark
SciCrunch record: RRID:BDSC_7648
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington
DOI: 10.1186/s13059-021-02345-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @olekpark
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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3605
DOI: 10.1038/s41514-021-00073-8
Resource: (BDSC Cat# 3605,RRID:BDSC_3605)
Curator: @olekpark
SciCrunch record: RRID:BDSC_3605
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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29652
DOI: 10.1038/s41467-019-12211-8
Resource: RRID:BDSC_29652
Curator: @bandrow
SciCrunch record: RRID:BDSC_29652
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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27507
DOI: 10.1038/s41422-023-00800-8
Resource: (BDSC Cat# 27507,RRID:BDSC_27507)
Curator: @olekpark
SciCrunch record: RRID:BDSC_27507
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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86271
DOI: 10.1038/s41598-023-34632-8
Resource: RRID:BDSC_86271
Curator: @olekpark
SciCrunch record: RRID:BDSC_86271
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC_56986
DOI: 10.1038/s41467-019-12435-8
Resource: BDSC_56986
Curator: @bpowell22
SciCrunch record: RRID:BDSC_56986
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docdrop.org docdrop.org
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within six months we saw a real increase in um in in organic matter from from one percent to eight percent
for - stats - seawater farming - soil nutrition impacts - 8% increase in 6 months
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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91368
DOI: 10.1038/s41467-024-46956-8
Resource: RRID:BDSC_91368
Curator: @bandrow
SciCrunch record: RRID:BDSC_91368
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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3954
DOI: 10.1038/s41467-024-47623-8
Resource: (BDSC Cat# 3954,RRID:BDSC_3954)
Curator: @bandrow
SciCrunch record: RRID:BDSC_3954
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington Deficiency Kit covering the right arm of the third chromosome
DOI: 10.1038/s42003-024-06184-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @bandrow
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC, 35162
DOI: 10.1038/s41420-023-01587-8
Resource: RRID:BDSC_35162
Curator: @mpairish
SciCrunch record: RRID:BDSC_35162
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RRID_BDSC_ 92758
DOI: 10.1038/s41586-024-07516-8
Resource: BDSC_92758
Curator: @AniH
SciCrunch record: RRID:BDSC_92758
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RRID_BDSC_ 76600
DOI: 10.1038/s41586-024-07516-8
Resource: RRID:BDSC_76600
Curator: @AniH
SciCrunch record: RRID:BDSC_76600
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RRID_BDSC_ 67142
DOI: 10.1038/s41586-024-07516-8
Resource: BDSC_67142
Curator: @AniH
SciCrunch record: RRID:BDSC_67142
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RRID_BDCS_ 35785
DOI: 10.1038/s41586-024-07516-8
Resource: (BDSC Cat# 35785,RRID:BDSC_35785)
Curator: @AniH
SciCrunch record: RRID:BDSC_35785
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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yw
DOI: 10.1038/s41419-024-06720-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @bandrow
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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UAS-TNT-C
DOI: 10.1038/s41586-024-07451-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @bandrow
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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5138
DOI: 10.1038/s41467-024-48851-8
Resource: (BDSC Cat# 5138,RRID:BDSC_5138)
Curator: @bandrow
SciCrunch record: RRID:BDSC_5138
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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86330
DOI: 10.1038/s41467-024-45493-8
Resource: BDSC_86330
Curator: @mpairish
SciCrunch record: RRID:BDSC_86330
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC#8751
DOI: 10.1038/s41467-024-48344-8
Resource: (BDSC Cat# 8751,RRID:BDSC_8751)
Curator: @bandrow
SciCrunch record: RRID:BDSC_8751
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www.nature.com www.nature.com
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NIH NeuroBioBank
DOI: 10.1038/s41380-024-02441-8
Resource: NIH NeuroBioBank (RRID:SCR_003131)
Curator: @evieth
SciCrunch record: RRID:SCR_003131
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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BDSC#27390
DOI: 10.1038/s41420-022-01250-8
Resource: (BDSC Cat# 27390,RRID:BDSC_27390)
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_27390
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BDSC#26882
DOI: 10.1038/s41420-022-01250-8
Resource: BDSC_26882
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_26882
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BDSC#38198)
DOI: 10.1038/s41420-022-01250-8
Resource: BDSC_38198
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_38198
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(BDSC#5137)
DOI: 10.1038/s41420-022-01250-8
Resource: (BDSC Cat# 5137,RRID:BDSC_5137)
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_5137
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BDSC#25351
DOI: 10.1038/s41420-022-01250-8
Resource: BDSC_25351
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_25351
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BDSC
DOI: 10.1038/s41420-022-01250-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @DavidDeutsch
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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CRL-2577
DOI: 10.1038/s44318-024-00102-8
Resource: (ATCC Cat# CRL-2577, RRID:CVCL_0504)
Curator: @evieth
SciCrunch record: RRID:CVCL_0504
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- Jun 2024
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington Drosophila Stock Center
DOI: 10.1038/s41586-023-06671-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @maulamb
SciCrunch record: RRID:SCR_006457
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www.letudiant.fr www.letudiant.fr
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En cas de désaccord sur l'orientation, le chef d'établissement a l'obligation de recevoir en entretien la famille avant de rendre sa décision finale. "Tout désaccord avec la proposition du conseil de classe fait l'objet d'un entretien préalable à la décision du chef d'établissement (Article L.331-8 - Code de l'éducation)."
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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RRID:ZFIN_ZDB-ALT-190307-8
DOI: 10.7554/eLife.95980
Resource: ZFIN_ZDB-ALT-190307-8
Curator: @scibot
SciCrunch record: RRID:ZFIN_ZDB-ALT-190307-8
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docdrop.org docdrop.org
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le dialogue social 00:26:44 n'occulte pas non plus les élèves les syndicats d'élèves sont plutôt des associations qui peuvent se constituer librement mais qui doivent être autorisés par le chef par le chef d'établissement et le conseil d'administration pour pouvoir exercer 00:26:57 leur activité au sein des lycées j'en revois à l'article R 511-9 du code d'éducation la liberté de réunion des élèves est prévue et encadrée aux articles 00:27:11 l511-2 et r51-10 du code d'éducation ainsi que leur liberté d'expression qui est consacrée elle à l'article R 511-8 si le chef d'établissement doit 00:27:24 permettre aux associations d'élèves de jouir de leurs droits et de leur donner quelques é là encore boîte au lettres panneau d'affichage il doit surtout savoir qu'il est garant du fait que l'objet comme l'activité de 00:27:36 l'association n'est ni politique ni religieux et doit être compatible avec les principes du service public de l'enseignement le tout dans le respect du code pénal il en va de l'ordre public 00:27:48 scolaire et par conséquent d'un dialogue social apaisé
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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(#53,331)
DOI: 10.1186/s40478-022-01476-8
Resource: RRID:BDSC_53331
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_53331
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(#27,570)
DOI: 10.1186/s40478-022-01476-8
Resource: RRID:BDSC_27570
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_27570
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Bloomington Drosophila Stock Center
DOI: 10.1186/s40478-022-01476-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @DavidDeutsch
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bloomington Drosophila Stock Center
DOI: 10.1186/s13578-023-01147-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @maulamb
SciCrunch record: RRID:SCR_006457
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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(#28977)
DOI: 10.1038/s43587-022-00323-8
Resource: BDSC_28977
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_28977
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(#57415)
DOI: 10.1038/s43587-022-00323-8
Resource: BDSC_57415
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_57415
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(#50663)
DOI: 10.1038/s43587-022-00323-8
Resource: BDSC_50663
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_50663
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(#84277)
DOI: 10.1038/s43587-022-00323-8
Resource: (BDSC Cat# 84277,RRID:BDSC_84277)
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_84277
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(#57501)
DOI: 10.1038/s43587-022-00323-8
Resource: (BDSC Cat# 57501,RRID:BDSC_57501)
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_57501
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(#36304)
DOI: 10.1038/s43587-022-00323-8
Resource: (BDSC Cat# 36304,RRID:BDSC_36304)
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_36304
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(#31621)
DOI: 10.1038/s43587-022-00323-8
Resource: BDSC_31621
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_31621
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(#31603)
DOI: 10.1038/s43587-022-00323-8
Resource: (BDSC Cat# 31603,RRID:BDSC_31603)
Curator: @DavidDeutsch
SciCrunch record: RRID:BDSC_31603
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Bloomington stock center
DOI: 10.1038/s43587-022-00323-8
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @DavidDeutsch
SciCrunch record: RRID:SCR_006457
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- May 2024
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cancerci.biomedcentral.com cancerci.biomedcentral.com
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RRID: Addgene_12259
DOI: 10.1186/s12935-024-03364-8
Resource: RRID:Addgene_12259
Curator: @AniH
SciCrunch record: RRID:Addgene_12259
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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#7459
DOI: 10.1038/s41467-023-43566-8
Resource: (BDSC Cat# 7459,RRID:BDSC_7459)
Curator: @maulamb
SciCrunch record: RRID:BDSC_7459
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#7457
DOI: 10.1038/s41467-023-43566-8
Resource: (BDSC Cat# 7457,RRID:BDSC_7457)
Curator: @maulamb
SciCrunch record: RRID:BDSC_7457
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- Apr 2024
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sul-dlss.github.io sul-dlss.github.io
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DIMES
This one was wrong in the reference transcript, where it was "dimes video surveys"
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- Feb 2024
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www.heise.de www.heise.de
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Für mich passt "mündiger Bürger" und "ich will das alles nicht wissen" einfach nicht zusammen. Und ich bleibe bei der Bezeichnung "Recht auf Dummheit".
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www.heise.de www.heise.de
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Die meisten User bestehen auf ihr "Recht zur Dummheit".
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- Jan 2024
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What to Listen For in Jazz
What to listen for in jazz Kernfeld 1995
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- Dec 2023
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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RRID:ZFIN_ZDB-GENO-141113-8
DOI: 10.1016/j.isci.2023.108678
Resource: ZFIN_ZDB-GENO-141113-8
Curator: @scibot
SciCrunch record: RRID:ZFIN_ZDB-GENO-141113-8
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www.ebay.com www.ebay.com
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https://www.ebay.com/itm/305300436363
Vintage Imperial card catalog for 5 x 8" index cards
Listed for auction in December 2023. After 14 bids, sold for $158.50 on 2023-12-11. Seems rare for these to actually sell by auction.
Cost per drawer: $39.63.
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- Nov 2023
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www.fcpe.asso.fr www.fcpe.asso.fr
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Les pubLications des Lycéenssont-eLLes Libres ?Elles sont libres, mais contrôlées. L’article R.511-8du code de l’éducation
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- Oct 2023
- Aug 2023
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www.ebay.com www.ebay.com
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https://www.ebay.com/itm/195958563431
A relatively uncommon 5 x 8" index card box from Yawman & Erbe.
Listed for $61.50 on 2023-08-31
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www.independent.co.uk www.independent.co.uk
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Working with programmer Noah Rubin, Damien Riehl built software capable of generating 300,000 melodies each second, creating a catalogue of 68 billion 8-note melodies.
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- Jul 2023
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gateway.ipfs.io gateway.ipfs.io
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Ven. Jichan (寄禪, 1852–1912), also known as “theascetic Eight Fingers” (Bazhi Toutuo 八指頭陀) because he had burned off twoof his fingers as an act of devotion.
[[Jichan]] ~ [[Eight Fingers]]
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- Jun 2023
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journals.biologists.com journals.biologists.com
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ZL1085 ZDB-ALT-011017-8
DOI: 10.1242/dev.193409
Resource: (ZFIN Cat# ZDB-ALT-011017-8,RRID:ZFIN_ZDB-ALT-011017-8)
Curator: @Naa003
SciCrunch record: RRID:ZFIN_ZDB-ALT-011017-8
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www.ebay.com www.ebay.com
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Most older card indexes are common enough, but I thought I'd tip off anyone who is all in on 5x8" index cards and may be looking for a permanent home for their growing collection that there's a reasonably rare, but lovely looking Yawman & Erbe card catalog for sale right now.
Syndication link: https://www.reddit.com/r/antinet/comments/14jlk69/beautiful_18_drawer_yawman_erbe_card_catalog/
Tags
Annotators
URL
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rebuke
to speak angrily to someone because you disapprove of what they have said or done 斥責；指責；訓斥
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ensue
to happen after something else, especially as a result of it （尤指作爲結果而）接著發生，繼而發生，因而産生
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vouchsafed
to tell or give something to someone 告知；提供；給予
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piazza
especially in Italy, an open area with a hard surface in a town, especially where there is no traffic （尤指義大利城鎮中無車輛行駛的）露天廣場
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sundry
several different; various 幾個不同的；各種各樣的
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docdrop.org docdrop.org
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Chapter 19 provides an analysis of Charlie Parker’s “Moose the Mooche” and Hank Jones’simprovised solo on the tune. This chapter also proposes a pedagogy of rhythm changesimprovisation.
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- May 2023
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www.reddit.com www.reddit.com
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"So when they continued asking him, he lifted himself up and said to them, he who has not misfiled an idea among you, let him cast the first zettel at her." —Iēsū's zettelkasten, card 8/7,1 #John ⚡🗃️
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www.defenseurdesdroits.fr www.defenseurdesdroits.fr
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Procéder chaque fois que nécessaire à la reconstitution de l’état civil des MNA conformémentà l’article 8 de la CIDE.
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datascience.codata.org datascience.codata.org
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articulates requirements for readability sating that identifiers must be: Any printable characters from the Universal Character Set of ISO/IEC 10646 (ISO 2012):UTF-8 encoding is required; Case insensitive:Only ASCII case folding is allowed.
{UTF-8} {ASCII Case Folding}
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micro.blog micro.blog
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For $1,900.00 ?
reply to rogerscrafford at tk
Fine furniture comes at a fine price. 🗃️🤩 I suspect that it won't sell for quite a while and one could potentially make an offer at a fraction of that to take it off their hands. It might bear considering that if one had a practice large enough to fill half or more, then that price probably wouldn't seem too steep for the long term security and value of the contents.
On a price per card of storage for some of the cheaper cardboard or metal boxes you're going to pay about $0.02-0.03 per card, but you'd need about 14 of those to equal this and those aren't always easy to stack and access regularly. With this, even at the full $1,900, you're looking at storage costs of $0.10/card, but you've got a lot more ease of use which will save you a lot of time and headache as more than adequate compensation, particularly if you're regularly using the approximately 20,400 index cards it would hold. Not everyone has the same esthetic, but I suspect that most would find that this will look a lot nicer in your office than 14 cheap cardboard boxes. That many index cards even at discount rates are going to cost you about $825 just in cards much less beautiful, convenient, and highly usable storage.
Even for some of the more prolific zettelkasten users, this sort of storage is about 20 years of use and if you compare it with $96/year for Notion or $130/year for Evernote, you're probably on par for cost either way, but at least with the wooden option, you don't have to worry about your note storage provider going out of business a few years down the line. Even if you go the "free" Obsidian route, with computers/storage/backups over time, you're probably not going to come out ahead in the long run. It's not all apples to apples comparison and there are differences in some of the affordances, but on balance and put into some perspective, it's probably not the steep investment it may seem.
And as an added bonus, while you're slowly filling up drawers, as a writer you might appreciate the slowly decreasing wine/whiskey bottle storage over time? A 5 x 8 drawer ought to fit three bottles of wine or as many fifths of Scotch. It'll definitely accommodate a couple of magnums of Jack Daniels. 🥃🍸🍷My experience also tells me that an old fashioned glass can make a convenient following block in card index boxes.
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- Apr 2023
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aught
anything 任何話
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yonder
something that is or is in an indicated more or less distant place 旁邊
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zounds
used as a mild oath 誓言
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eath
easy 簡單
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noddle,
head, pate 點頭
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hindrance
the act of interfering with or slowing the progress of someone or something : the action of hindering 阻礙、阻力
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prating
to talk long and idly 啐唸、喋喋不休
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friar,
a member of a mendicant order 修士
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abode
a temporary stay 暫住
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multitude
the state of being many 多數
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lest
for fear that 免得
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amicable
characterized by friendly goodwill 友好的
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eke
also 也
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avowed
openly acknowledged or declared 宣達、宣布
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dainty
something delicious to the taste 可口的
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thence
from that fact or circumstance 因此
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fillies
a young female horse usually of less than four years 年輕母馬 ; a young girl 女孩
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whence
from what place, source, or cause 何處
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comrades
an intimate friend or associate 同伴們、同志們
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confections
something confected 醋漬物
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fortify
to make strong 強化
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cavalier
a gentleman trained in arms and horsemanship 騎士
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behoved
chiefly British spelling of BEHOOVE: to be necessary, proper, or advantageous for 理應、應該、必須
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exultation
the act of exulting : the state of being exultant: filled with or expressing great joy or triumph 狂喜
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requital
something given in return, compensation, or retaliation 回禮、還禮
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consolation
the act or an instance of consoling, the state of being consoled 安慰
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whilst
while 當
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sagely
in a sage or wise manner 有禮的、明智的
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limned
to outline in clear sharp detail 被描繪輪廓的
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groat
hulled grain broken into fragments larger than grits 碎穀物、燕麥
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blest
to hallow or consecrate by religious rite or word 祝福
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hither;
being on the near or adjacent side 在附近、靠近
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guise
a form or style of dress 裝扮成
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delectation
Pleasure, delight, and enjoyment 快樂、喜悅
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avai
to be of use or advantage 有用、能用
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hath
archaic present tense third-person singular of HAVE 有著、懷抱著
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sendeth
the person to whom something is sent 發送、收件人
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irketh
furious, angry 憤怒
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affright
frighten, alarm 驚嚇、使恐懼
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bade
past tense and past participle of BID: to issue an order to 命令
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mar
to ruin or diminish the perfection or wholeness of 掃興、毀壞
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gospel
something accepted or promoted as infallible truth or as a guiding principle or doctrine 真理
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scant
barely or scarcely sufficient 不足
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you fort
adj. free from ambiguity or evasiveness : going straight to the point
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shalt
archaic present tense second-person singular of shall 將
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woeful
full of woe : grievous 可悲的、多災多難的
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bout
a spell or period of activity 一回合、一段時間
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, leaving h
adj. cheerless, dejected, downcast
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mayst
archaic present tense second-person singular of MAY 可能
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celestial
As in heavenly: of, relating to, or suggesting heaven 天堂的
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suffering
n. the state of being interfered with, held back, or slowed down : the state of being hindered
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disparage
As in to dismiss: to express scornfully one's low opinion of 貶損、批評
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e, studi
Adj. assiduous in the pursuit of learning
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drubbing
As in whipping: to defeat by a large margin 以很大差距輸掉（動詞）; As in defeat: failure to win a contest 輸掉（名詞）
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h a tran
n. The act of exulting : the state of being exultant
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cudge
As in cane: a heavy rigid stick used as a weapon or for punishment 棍棒/長杖
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stout
As in sturdy: able to withstand hardship, strain, or exposure 穩固的 ; As in stocky: being compact and broad in build and often short in stature 粗壯的 ; As in valiant: feeling or displaying no fear by temperament 勇敢的 ; As in solid: not showing weakness or uncertainty 堅定的、堅固的、堅強的
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ere
As in before: earlier than 在...之前
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orisons
As in prayers: an address to God or a deity 禱告(名詞）
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chastised
to inflict a penalty on for a fault or crime 懲罰、懲戒、責罵
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bespoke
to make known (something abstract) through outward signs 展示/顯示
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whenas
when當
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Local file Local file
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2.7-8 Theorem (Finite dimension).
Linear operator, and bounded linear operators are equivalent when the vector space is finite dimensional.
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- Mar 2023
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abstinence
not doing something, such as drinking alcohol or having sex 節制；戒絕
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meek
quiet, gentle, and not willing to argue or express your opinions in a forceful way 溫順的；謙和的
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solicit
to ask someone for money, information, or help 請求，索求，乞求
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countenance
the appearance or expression of someone's face面容；臉色；面部表情
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enamoured
liking something a lot 喜愛的；迷戀的
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drive.google.com drive.google.comview11
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resurrection
1.the rising of Christ from the dead 2.the rising again to life of all the human dead before the final judgement 3.the state of one risen from the dead
復活、復興、恢復、耶穌復活
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tombs
An excavation in which a corpse is buried. 墓穴
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\eil
A length of cloth worn by women as a covering for the head and shoulders and often especially in Eastern countries for the face. 面紗
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abusivcl)
Using or involving physical violence or emotional cruelty. 爛用地、辱罵地、虐待地
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blasphemed
To speak in way that shows irreverence for God or something sacred 褻瀆
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gall
Something bitter to endure 膽汁、苦味
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crucified
To put to death by nailing or binding the wrists or hands and feet to a cross 釘在十字架上
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malice
Desire to cause pain, injury, or distress to another. 怨恨、惡意
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notorious
Generally known and talked of 惡名昭彰的、眾人皆知的
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multitude
A state of being many 大量、多數、群眾
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was accustomed to
習慣於
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