628 Matching Annotations
  1. Aug 2025
  2. Jul 2025
  3. Jun 2025
  4. May 2025
  5. Apr 2025
  6. Mar 2025
    1. In this interactive challenge, see if you can guess what makes the system change its decision.

      DISCUSS After completing this interactive challenge share one of the following:

      • an observation about the process of completing the activity (the interactive challenge)
      • a question that arises from the activity
      • a concern that arises from the activity.
    1. KoponewtPelicram ❤️ Slug Goblin 3 points4 points5 points 3 hours ago (3 children)Do you know what's the serial number on that? Some manufacturers had special models mostly for export purposes with extra keys. For example Royal 11 is a 10 with extra keys, Underwood No. 46 is a 5/3/6 with extra keys. Remington No. 9 is an 8 with extra keys.

      via https://old.reddit.com/r/typewriters/comments/1jgg4kh/royal_kmm_extra_column_of_keys/miyumvn/

    1. Soiltrace evidence can also provide information about the origin of aparticular soil sample. Soil composition varies from one locationto another, and the presence of specific minerals or organicmatter can indicate the source of the soil. This information canbe valuable in determining the movement of suspects or objectsbetween different locations

      "linking the person to the crime scenes and tracing their travel order"

  7. southtexascollege.blackboard.com southtexascollege.blackboard.com
    1. Yet this enjoys before it woo,
      And pampered swells with one blood made of two,
      

      The seventh line calls the flea "insignificant;" yet, despite this, the flea likes the unity of blood, even though there is no connection in anyway.

  8. Feb 2025
    1. Begun, George M. “Making Your Own Punched Cards.” Journal of Chemical Education 32, no. 6 (June 1, 1955): 328. https://doi.org/10.1021/ed032p328.

      George Begun used a template of "heavy galvanized iron" to drill holes into his 5 x 8" index cards to create his own edge-noted card system for use in his chemistry work. Rather than using commercially made sorting needles, he recommended the use of a ice pick with a dulled point "for safety".

  9. Jan 2025
    1. “But to cook, you must kill. You make ghosts. You cook to make ghosts. Spirits that live on in every ingredient,” -The Hundred-Foot Journey. Hassan, the chef and main character of the movie, learns this from his mother while she's teaching him to cook.

      for - quote - to cook you must kill - line from movie "The Hundred-Foot Journey - source - post - LinkedIn - Nora Bateson - sharing - Sherry Hess - 2025, Jan 8 - posted a comment - post - LinkedIn - Nora Bateson - sharing - Sherry Hess - 2025, Jan 8

  10. Dec 2024
    1. Disease: Von-willebrand Disorder Type 3

      Patient: 26 yo, female

      Variant: VWF NM_000552.5 c:997+118 T>G g.(6073501 A>C), homozygous, intronic

      Phenotypes: No detectable VWF in plasma, early onset bleeding complications, epistaxis, easy bruising, bleeding following injury, menorrhagia, iron-deficient anemia

      Note: underwent prophylaxis replacement therapy, on-demand antihemorrhagic treatments, oral contraceptives, and replacement therapy.

      Family: not mentioned

      Predictions:

      VEP SpliceAI tool predicted variant likely deleterious (delta score 0.95)

      Used Polyphen-2 and SIFT which determined pathogenic likelihood.

      Neural Network Splicing, Alternative Splice Site Predictor, plug-in MaxEnt(For 5' donor site) of Human Splicing Finder all concur this variant can create a new donor splice site in intron 8. Contains premature stop codon and susceptible to NMD.

      Functional work:

      qRT-PCR performed to identify levels of VWF in IP-derived endothelial cells.

      histochemical immunostaining for IP-derived endothelial cells confirm no VWF production, only a residual amount present. Suggests leaky mutation.

      performed RNA sequencing to assess co-regulated gene networks

    1. the best way to make a company erodic is by putting it into an ecosystem of other companies that all work together to have robust circulatory flows throughout the entire ecosystem by doing that we counteract these losses we make the ecosystem orotic and then each company can contribute at its maximum its maximum regenerative potential

      for - regenerative company - principle 7 of 8 - robust circulatory flow - ergodic flow - adjacency - Fairschare Company - FSC - regenerative organization - ergodic flow - robust circulatory flow - ecosystem of companies - backcasting from 2030 - cross-scale translation of earth system boundaries

      adjacency - between - ergodic flows - ecosystem of companies - robust circulatory flows - Fairshare Commons (FSC) - regenerative company - regenerative organization - backcasting from 2030 - cross-scale translation of earth system boundaries - adjacency relationship - To implement principle 7 and work with an ecosystem of other companies: - For a company to relate well with other companies, - this is like an individual relating well to other individuals - The Indyweb is a people-centered, interpersonal information system architecture that supports both: - people-centered and interpersonal conversations as well as - organization-centered and inter-organizational conversations - Backcasting and cross-scale translating earth system boundaries from 2030 the present is critical to fulfill any FSC's modus operandi in the present. - In other words, knowing what a world that has successfully and dramatically reduced - carbon emissions and - threats to the biosphere - looks like at all scales (including community and company) in 2030 (5 years from now), we need to project backwards to the present and see what actions make sense and are aligned to take us to that envisioned scenario - If we don't have targets that are aligned to regenerating nature that we have globally harmed in measurable ways, what point is there in the word "regenerative" in the title of "regenerative company"?

    2. fortunately this is perfectly possible within existing company law by taking the concept the properties in law of legal personhood to their fullest extent

      for - regenerative company - principle 1 of 8 - agency-based instead of ownership-based - implementation - via leveraging full extent of legal personhood

      Comment - Graham points out an interesting insight, that organisations are given legal personhood status -namely, we test a group of people as a person itself - This reminds me of Michael Levin's Multi Scale Competency Architecture

    1. for - YouTube - Fairshare Commons - interview - Graham Boyd - etymology - company - Fairshare Commons principle of inclusivity - reflects influence of unfairness of Apartheid exclusivity - from - YouTube - Fairshare Commons - 8 principles of - Graham Boyd

      from - YouTube - What is the best way to turn a regenerative company? - Fairshare Commons - 8 principles of - Graham Boyd - https://hyp.is/6aAtWLXpEe-CbZPjBOu6ew/www.youtube.com/watch?v=AEIMB-odmRU

      Summary - It was insightful to hear the association between Fairshare Commons company and Eleanor Ostrom's work on the commons and to recast the company as a group of people stewarding a commons - Graham introduces the etymology of the word "company", as an intentional community that has its roots of people " gathering in the company of others to break bread" - Also interesting to know he is Sorry African and his experience with Apartheid informs his inclusivity principle off the Fairshare Commons

  11. Oct 2024
    1. The 'polycrisis' is real enough. But it’s a surface level symptom of multiple, simultaneous phase transitions at the core of the ‘hardware’ and ‘software’ systems that define human civilisation – which together can be understood as a planetary phase shift. But if all we see and respond to is the polycrisis – the symptoms of this process as it weakens industrial structures – that will derail the planetary phase shift to a new life cycle.

      for - comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein - quote - making sense of the polycrisis - a symptom of multiple phase transitions - (see below) - The 'polycrisis' is real enough. - But it’s a surface level symptom - of multiple, simultaneous phase transitions at the core of the ‘hardware’ and ‘software’ systems that define human civilisation - which together can be understood as a planetary phase shift. - But if all we see and respond to is the polycrisis - the symptoms of this process as it weakens industrial structures - that will derail the planetary phase shift to a new life cycle.

      comparison - to - book - The Ascent of Humanity - chapter 8 - The Gaian Birthing - Charles Eisenstein - Ahmed's writing about the polycrisis masking the planetary phase shift is very reminiscent of Charles Eisenstein's writing in the Ascent of Humanity in which he compares the great transition we are undergoing to - the perilous journey a neonate takes as it leaves the womb and enters the greater space awaiting

      to - book - The Ascent of Humanity - Chapter 8 - The Gaian Birthing - Charles Eisenstein - https://hyp.is/r8scTpG_Ee-gLTujlli5hQ/charleseisenstein.org/books/the-ascent-of-humanity/eng/the-gaian-birthing/

    2. for - rapid whole system change - Nafeez Ahmed - planetary phase shift - Nafeez Ahmed - planetary adaptive cycle - Nafeez Ahmed - essay - The End of Scarcity? From ‘Polycrisis’ to Planetary Phase Shift - Nafeez Ahmed - 2024 Oct 16 - to - book - The Ascent of Humanity - chapter 8 Self and Cosmos: The Gaian Birthing - stillborn and the perilous journey through the womb - Charles Eisenstein

      summary - This is a good article that makes sense of the inflection point that humanity now faces as it contends with multiple existential crisis - It summarizes the complexity of our polycrisis and its precarity and lays the theory for looking at the polycrisis from a different perspective: - as a planetary phase shift towards the potential end of scarcity and the next stage of our species evolution - Through the lens of ecologist Crawford Stanley Holling's lens of the adaptive cycle of ecological population dynamics, - and especially his 2004 paper "From Complex Regions to Complex Worlds" - Nafeez extends Holling's argument that we are undergoing a planetary adaptive cycle in which the back-loop is the dying industrial era. - In this sense, it is reminiscent of the writings of Charles Eisenstein in his book "The Ascent of Humanity", chapter 8: Self and Cosmos:, The Gaian Birth. - Eisenstein uses the the perilous journey of birth through the womb door as a metaphor of the transition we are currently undergoing.

      to - paper - From Complex Regions to Complex Worlds - Crawford Stanley Holling - 2004 - https://hyp.is/KYCm2pFrEe-_PEu84xshXw/www.ecologyandsociety.org/vol9/iss1/art11/main.html?ref=ageoftransformation.org - book - The Ascent of Humanity - Chapter 8 - The Gaian Birthing - Charles Eisenstein - https://hyp.is/r8scTpG_Ee-gLTujlli5hQ/charleseisenstein.org/books/the-ascent-of-humanity/eng/the-gaian-birthing/

    1. Disease: Von Willebrand Disease (VWD) Type 2A

      Patient: 31 yo, Female

      Variant1: VWF NC_000012.12: c.875-5T>Gdel, p.(Ser292_Glu333delinsLys) Causes complete exon 8 skipping

      Variant2: VWF NM_000552.5: c.813C>G, p.(Tyr271*)

      Phenotypes: History of bleeding (epistaxis, uncontrollable by conventional hemostatic treatment), Easy bruising, gum bleeding, excessive menstrual bleeding, mild decrease in plasma VWF:Ag, severe impairment in VWF function, VWF:Ab/VWF:Ag ratio decreased, VWF:CB/VWF:Ag ratio decreased, FVIII:C lvs slighly below normal range

      Family: Son had bleeding diathesis and spontaneous epistaxis (less severe than proband), normal parents

      In silico data available: SpliceAI delta score of 0.51 for loss of splice acceptor caused by variant 1

      Alamut showed small to moderate effects of the variant on normal splicing of VWF

      NetGene2 showed weak strength of 3' splice sites in exon 8

      SpliceAid2 showed TIA-1 and TIAL 1, which bind to U-rich motifs and facilitate 5' splice site recognition where destroyed in the mutated sequence

  12. Sep 2024
  13. Aug 2024
  14. Jul 2024
  15. Jun 2024
    1. le dialogue social 00:26:44 n'occulte pas non plus les élèves les syndicats d'élèves sont plutôt des associations qui peuvent se constituer librement mais qui doivent être autorisés par le chef par le chef d'établissement et le conseil d'administration pour pouvoir exercer 00:26:57 leur activité au sein des lycées j'en revois à l'article R 511-9 du code d'éducation la liberté de réunion des élèves est prévue et encadrée aux articles 00:27:11 l511-2 et r51-10 du code d'éducation ainsi que leur liberté d'expression qui est consacrée elle à l'article R 511-8 si le chef d'établissement doit 00:27:24 permettre aux associations d'élèves de jouir de leurs droits et de leur donner quelques é là encore boîte au lettres panneau d'affichage il doit surtout savoir qu'il est garant du fait que l'objet comme l'activité de 00:27:36 l'association n'est ni politique ni religieux et doit être compatible avec les principes du service public de l'enseignement le tout dans le respect du code pénal il en va de l'ordre public 00:27:48 scolaire et par conséquent d'un dialogue social apaisé
  16. May 2024
  17. Apr 2024
  18. Feb 2024
  19. Jan 2024
  20. Dec 2023
  21. Nov 2023
  22. Oct 2023
  23. Aug 2023
  24. Jul 2023
    1. Ven. Jichan (寄禪, 1852–1912), also known as “theascetic Eight Fingers” (Bazhi Toutuo 八指頭陀) because he had burned off twoof his fingers as an act of devotion.

      [[Jichan]] ~ [[Eight Fingers]]

  25. Jun 2023
  26. May 2023
    1. For $1,900.00 ?

      reply to rogerscrafford at tk

      Fine furniture comes at a fine price. 🗃️🤩 I suspect that it won't sell for quite a while and one could potentially make an offer at a fraction of that to take it off their hands. It might bear considering that if one had a practice large enough to fill half or more, then that price probably wouldn't seem too steep for the long term security and value of the contents.

      On a price per card of storage for some of the cheaper cardboard or metal boxes you're going to pay about $0.02-0.03 per card, but you'd need about 14 of those to equal this and those aren't always easy to stack and access regularly. With this, even at the full $1,900, you're looking at storage costs of $0.10/card, but you've got a lot more ease of use which will save you a lot of time and headache as more than adequate compensation, particularly if you're regularly using the approximately 20,400 index cards it would hold. Not everyone has the same esthetic, but I suspect that most would find that this will look a lot nicer in your office than 14 cheap cardboard boxes. That many index cards even at discount rates are going to cost you about $825 just in cards much less beautiful, convenient, and highly usable storage.

      Even for some of the more prolific zettelkasten users, this sort of storage is about 20 years of use and if you compare it with $96/year for Notion or $130/year for Evernote, you're probably on par for cost either way, but at least with the wooden option, you don't have to worry about your note storage provider going out of business a few years down the line. Even if you go the "free" Obsidian route, with computers/storage/backups over time, you're probably not going to come out ahead in the long run. It's not all apples to apples comparison and there are differences in some of the affordances, but on balance and put into some perspective, it's probably not the steep investment it may seem.

      And as an added bonus, while you're slowly filling up drawers, as a writer you might appreciate the slowly decreasing wine/whiskey bottle storage over time? A 5 x 8 drawer ought to fit three bottles of wine or as many fifths of Scotch. It'll definitely accommodate a couple of magnums of Jack Daniels. 🥃🍸🍷My experience also tells me that an old fashioned glass can make a convenient following block in card index boxes.

      A crystal old fashioned glass serves as a following block to some index cards and card dividers in a Shaw-Walker card index box (zettelkasten). On the table next to the index are a fifth of Scotch (Glenmorangie) and a bowl of lemons.

  27. Apr 2023