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How to Control Blood Glucose Levels

Deepti Gurdasani. (2022, January 10). Lots of people dismissing links between COVID-19 and all-cause diabetes. An association that’s been shown in multiple studies- whether this increase is due to more diabetes or SARS2 precipitating diabetic keto-acidosis allowing these to be diagnosed is not known. A brief look👇 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1480546865812840450

Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014

Kamrath, C., Rosenbauer, J., Eckert, A. J., Siedler, K., Bartelt, H., Klose, D., Sindichakis, M., Herrlinger, S., Lahn, V., & Holl, R. W. (2022). Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry. Diabetes Care, dc210969. https://doi.org/10.2337/dc21-0969

Geddes, L. (2021, September 28). Covid can infect cells in pancreas that make insulin, research shows. The Guardian. https://www.theguardian.com/society/2021/sep/29/covid-can-infect-cells-in-pancreas-that-make-insulin-research-shows

Blakemore, E. (n.d.). New diabetes cases linked to covid-19. Washington Post. Retrieved February 11, 2021, from https://www.washingtonpost.com/health/2021/02/01/covid-new-onset-diabetes/

Mansfield, K. E., Mathur, R., Tazare, J., Henderson, A. D., Mulick, A., Carreira, H., Matthews, A. A., Bidulka, P., Gayle, A., Forbes, H., Cook, S., Wong, A. Y., Strongman, H., Wing, K., Warren-Gash, C., Cadogan, S. L., Smeeth, L., Hayes, J. F., Quint, J. K., … Langan, S. M. (2020). COVID-19 collateral: Indirect acute effects of the pandemic on physical and mental health in the UK. MedRxiv, 2020.10.29.20222174. https://doi.org/10.1101/2020.10.29.20222174

Müller, J.A., Groß, R., Conzelmann, C. et al. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab (2021). https://doi.org/10.1038/s42255-021-00347-1

(2020) COVID-19 and diabetes: a co-conspiracy? The Lancet Diabetes & Endocrinology. Retrieved from: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30315-6/fulltext

I found a study on acai and blood sugar, but they used healthy overweight subjects. The relative reduction in postprandial glucose was substantial. However, since the subjects' baseline fasting glucose was normal, the drop was not significant. We have every reason to think that fasting blood sugar would be reduced in diabetic subjects.

I was unable to find a study on baobab on diabetes or metabolic syndrome. However, given the effectiveness of amla, curcumin, and acai, it is likely effective. There is also some evidence for many other antioxidant sources, which backs up the idea that any source will do.

I've found one study on sumac for type 2 diabetes. There seems to be two separate write-ups on the same data.

Oddly, 3 grams sumac did not perform as well as 3 grams amla. I can think of several possible explanations. The most likely explanation is that they used the whole grain rather than the bran. I assume the grain is what's used traditionally, but I'm having difficulty finding information about this. The bran has over 3 times the ORAC compared to the whole grain. It's likely that the bran is both hard to find and expensive.

This backs up the two studies on fasting glucose in diabetes and per-diabetes. It is also a higher quality study (crossover design).

Killerby. M. E., (2020) Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020. Centers for Disease Control and Prevention. Retrieved from: https://www.cdc.gov/mmwr/volumes/69/wr/mm6925e1.htm

Endocrinology, T. L. D. &. (2020). Obesity and COVID-19: Blame isn’t a strategy. The Lancet Diabetes & Endocrinology, 0(0). https://doi.org/10.1016/S2213-8587(20)30274-6

Stokes, E. K. (2020). Coronavirus Disease 2019 Case Surveillance—United States, January 22–May 30, 2020. MMWR. Morbidity and Mortality Weekly Report, 69. https://doi.org/10.15585/mmwr.mm6924e2

Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., Barnaby, D. P., Becker, L. B., Chelico, J. D., Cohen, S. L., Cookingham, J., Coppa, K., Diefenbach, M. A., Dominello, A. J., Duer-Hefele, J., Falzon, L., Gitlin, J., Hajizadeh, N., Harvin, T. G., … Zanos, T. P. (2020). Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. https://doi.org/10.1001/jama.2020.6775

T1DM children

• annual flu vaccine
• pneumoccocal vaccine

immediate (same-day) referral to a specialist for

• adults diagnosed with T1DM
• children and young people with suspected type 1 diabetes

Serious hypoglycaemia = endocrinology referral

• Active foot problem = podiatry ferral within 1 day

• Longest CVOT in dpp4. - 6 years
• only active comparator CVOT
• 77 % relative risk reduction in hypoglycaemia in Lina
• early diabetics studied

This could be interesting as well. Metabolic issues run through chronic illness. As do circadian dysfunctions, diabetes susceptibility,

ADA-EASD Consensus Report reflects current treatment recommendations as endorsed by the ADA and the PPC.

On October 5, 2018, the consensus report “Management of Hyperglycemia in Type 2 Diabetes: ADA-EASD Consensus Report 2018” was published. The consensus report was developed by a writing group consisting of representatives from the ADA and EASD. The consensus report addresses approaches to glycemic management in adults with type 2 diabetes with the goal of reducing complications and maintaining quality of life in the context of comprehensive cardiovascular risk management and patient-centered care. The ADA Professional Practice Committee (PPC) was involved in the review and approval of the final consensus report. The consensus recommendations and approach to glycemic management in adults with type 2 diabetes presented within the report reflects the current view of the ADA. Please find a link to the consensus document here: http://dx.doi.org/10.2337/dci18-0033

Reference:

Davies MJ, D’Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB: Management of hyperglycemia in type 2 diabetes, 2018: a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care Oct 2018; DOI: 10.2337/dci18-0033

Rationale/Reason for Change:

Management of Hyperglycemia in Type 2 Diabetes: ADA-EASD Consensus Report 2018 reflects current treatment recommendations as endorsed by the ADA and the PPC.

Annotation published: October 5, 2018. Annotation approved by PPC: September 20, 2018.

Suggested citation: American Diabetes Association. 8. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes—2018 [web annotation]. Diabetes Care 2018;41(Suppl. 1):S73–S85. Retrieved from https://hyp.is/1p2zesvFEeioRdNqCoou5A/clinical.diabetesjournals.org/content/36/1/14

This is likely do to the reduced carbohydrate intake rather than increased fat intake. Since carbohydrates generally insulin sensitivity, it's likely that this additional insulin resistance is acting as a confounder (as well as, presumably, a standard deviation widener). Thus, I would expect similar results during hypocaloric carbohydrate restriction.

A visual exploration of the link between statin use and the risk of Diabetes in a subpopulation of patients with subclinical hypothyroidism.

This is an interactive graph created with Biovista Vizit; nodes and links can be further explored to view supporting bibliography and molecular mechanism of action.

The first note in Biovista Vizit the free unbiased visual pubmed search tool using hypothes.is

Here is an example graph (click to go to the live graph)

Very good explanation!

Wow, this is a very interesting application!

This reminds me of the diabetes and heart disease epidemic. If through forced choice you can engender a species of people to change the make up of their blood through outside chemicals and OVER FEEDING everyone sugar rendering most people diabetic you can in essence control the emerging medical needs of a society dependent on new forms of health care and medicines. The obama care state.