- Sep 2022
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www.foundersfamilymedicine.com www.foundersfamilymedicine.com
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Diabetes is a condition where the body does not make enough insulin or use the insulin it creates the way it should. As a result, the body isn’t processing food properly to produce energy. Instead, sugars build up in the blood leading to health complications.
Our team of pediatric experts offers diabetes diagnosis for children and adolescents. If we discover pediatric diabetes, we partner with the right specialists to give your child the best possible treatment. We offer compassionate and trustworthy care that puts both the physical and emotional needs of our pediatric patients at the forefront.
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www.haikudeck.com www.haikudeck.com
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How to Control Blood Glucose Levels
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- Feb 2022
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twitter.com twitter.com
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Deepti Gurdasani. (2022, January 10). Lots of people dismissing links between COVID-19 and all-cause diabetes. An association that’s been shown in multiple studies- whether this increase is due to more diabetes or SARS2 precipitating diabetic keto-acidosis allowing these to be diagnosed is not known. A brief look👇 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1480546865812840450
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Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014
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- Jan 2022
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diabetesjournals.org diabetesjournals.org
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Kamrath, C., Rosenbauer, J., Eckert, A. J., Siedler, K., Bartelt, H., Klose, D., Sindichakis, M., Herrlinger, S., Lahn, V., & Holl, R. W. (2022). Incidence of Type 1 Diabetes in Children and Adolescents During the COVID-19 Pandemic in Germany: Results From the DPV Registry. Diabetes Care, dc210969. https://doi.org/10.2337/dc21-0969
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- Sep 2021
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www.theguardian.com www.theguardian.com
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Geddes, L. (2021, September 28). Covid can infect cells in pancreas that make insulin, research shows. The Guardian. https://www.theguardian.com/society/2021/sep/29/covid-can-infect-cells-in-pancreas-that-make-insulin-research-shows
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- May 2021
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www.washingtonpost.com www.washingtonpost.com
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Blakemore, E. (n.d.). New diabetes cases linked to covid-19. Washington Post. Retrieved February 11, 2021, from https://www.washingtonpost.com/health/2021/02/01/covid-new-onset-diabetes/
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- Feb 2021
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Mansfield, K. E., Mathur, R., Tazare, J., Henderson, A. D., Mulick, A., Carreira, H., Matthews, A. A., Bidulka, P., Gayle, A., Forbes, H., Cook, S., Wong, A. Y., Strongman, H., Wing, K., Warren-Gash, C., Cadogan, S. L., Smeeth, L., Hayes, J. F., Quint, J. K., … Langan, S. M. (2020). COVID-19 collateral: Indirect acute effects of the pandemic on physical and mental health in the UK. MedRxiv, 2020.10.29.20222174. https://doi.org/10.1101/2020.10.29.20222174
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www.nature.com www.nature.com
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Müller, J.A., Groß, R., Conzelmann, C. et al. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab (2021). https://doi.org/10.1038/s42255-021-00347-1
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- Dec 2020
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www.thelancet.com www.thelancet.com
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(2020) COVID-19 and diabetes: a co-conspiracy? The Lancet Diabetes & Endocrinology. Retrieved from: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(20)30315-6/fulltext
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- Nov 2020
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www.superfoodly.com www.superfoodly.com
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Acai Berry Pulp/Skin/Puree Powder
I found a study on acai and blood sugar, but they used healthy overweight subjects. The relative reduction in postprandial glucose was substantial. However, since the subjects' baseline fasting glucose was normal, the drop was not significant. We have every reason to think that fasting blood sugar would be reduced in diabetic subjects.
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Baobab Fruit Powder, Dried
I was unable to find a study on baobab on diabetes or metabolic syndrome. However, given the effectiveness of amla, curcumin, and acai, it is likely effective. There is also some evidence for many other antioxidant sources, which backs up the idea that any source will do.
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Sumac Bran, Raw
I've found one study on sumac for type 2 diabetes. There seems to be two separate write-ups on the same data.
Oddly, 3 grams sumac did not perform as well as 3 grams amla. I can think of several possible explanations. The most likely explanation is that they used the whole grain rather than the bran. I assume the grain is what's used traditionally, but I'm having difficulty finding information about this. The bran has over 3 times the ORAC compared to the whole grain. It's likely that the bran is both hard to find and expensive.
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www.nature.com www.nature.com
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Curcumin, but not fish oil, reduces postprandial glycaemic response and insulin demand for glucose control.
This backs up the two studies on fasting glucose in diabetes and per-diabetes. It is also a higher quality study (crossover design).
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- Aug 2020
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www.cdc.gov www.cdc.gov
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Killerby. M. E., (2020) Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020. Centers for Disease Control and Prevention. Retrieved from: https://www.cdc.gov/mmwr/volumes/69/wr/mm6925e1.htm
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www.thelancet.com www.thelancet.com
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Endocrinology, T. L. D. &. (2020). Obesity and COVID-19: Blame isn’t a strategy. The Lancet Diabetes & Endocrinology, 0(0). https://doi.org/10.1016/S2213-8587(20)30274-6
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- Jun 2020
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www.cdc.gov www.cdc.gov
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Stokes, E. K. (2020). Coronavirus Disease 2019 Case Surveillance—United States, January 22–May 30, 2020. MMWR. Morbidity and Mortality Weekly Report, 69. https://doi.org/10.15585/mmwr.mm6924e2
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- Apr 2020
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jamanetwork.com jamanetwork.com
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Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., Barnaby, D. P., Becker, L. B., Chelico, J. D., Cohen, S. L., Cookingham, J., Coppa, K., Diefenbach, M. A., Dominello, A. J., Duer-Hefele, J., Falzon, L., Gitlin, J., Hajizadeh, N., Harvin, T. G., … Zanos, T. P. (2020). Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. https://doi.org/10.1001/jama.2020.6775
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- Feb 2020
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cks.nice.org.uk cks.nice.org.uk
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Annual immunization against influenza (for children and young people with diabetes over the age of 6 months).Immunization against pneumococcal infection (for children and young people with diabetes who need insulin or oral hypoglycaemic drugs).
T1DM children
- annual flu vaccine
- pneumoccocal vaccine
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Immediate (same-day) referral for all adults diagnosed with type 1 diabetes
immediate (same-day) referral to a specialist for
- adults diagnosed with T1DM
- children and young people with suspected type 1 diabetes
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People with diabetes who have experienced hypoglycaemia requiring medical attention are referred to a specialist diabetes team.
Serious hypoglycaemia = endocrinology referral
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People with diabetes with an active foot problem that is not limb-threatening or life-threatening are referred to the multidisciplinary foot care service within 1 working day and triaged within 1 further working day.
- Active foot problem = podiatry ferral within 1 day
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- Jul 2019
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www.boehringer-ingelheim.com www.boehringer-ingelheim.com
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- Longest CVOT in dpp4. - 6 years
- only active comparator CVOT
- 77 % relative risk reduction in hypoglycaemia in Lina
- early diabetics studied
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- Jun 2019
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cshperspectives.cshlp.org cshperspectives.cshlp.org
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rhythms in the uptake of the glucose analog 2-deoxyglucose (2-DG) precede the development of a functional TTFL
This could be interesting as well. Metabolic issues run through chronic illness. As do circadian dysfunctions, diabetes susceptibility,
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- Dec 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Alzheimer's disease (AD) is not normally diagnosed until later in life, although evidence suggests that the disease starts at a much earlier age. Risk factors for AD, such as diabetes, hypertension and obesity, are known to have their affects during mid-life, though events very early in life, including maternal over-nutrition, can predispose offspring to develop these conditions. This study tested whether over-nutrition during pregnancy and lactation affected the development of AD in offspring, using a transgenic AD mouse model. Female triple-transgenic AD dam mice (3xTgAD) were exposed to a high-fat (60% energy from fat) or control diet during pregnancy and lactation. After weaning (at 3 weeks of age), female offspring were placed on a control diet and monitored up until 12 months of age during which time behavioural tests were performed. A transient increase in body weight was observed in 4-week-old offspring 3xTgAD mice from dams fed a high-fat diet. However, by 5 weeks of age the body weight of 3xTgAD mice from the maternal high-fat fed group was no different when compared to control-fed mice. A maternal high-fat diet led to a significant impairment in memory in 2- and 12-month-old 3xTgAD offspring mice when compared to offspring from control fed dams. These effects of a maternal high-fat diet on memory were accompanied by a significant increase (50%) in the number of tau positive neurones in the hippocampus. These data demonstrate that a high-fat diet during pregnancy and lactation increases memory impairments in female 3xTgAD mice and suggest that early life events during development might influence the onset and progression of AD later in life.
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- Oct 2018
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clinical.diabetesjournals.org clinical.diabetesjournals.org
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Pharmacologic Therapy for Type 2 Diabetes
ADA-EASD Consensus Report reflects current treatment recommendations as endorsed by the ADA and the PPC.
On October 5, 2018, the consensus report “Management of Hyperglycemia in Type 2 Diabetes: ADA-EASD Consensus Report 2018” was published. The consensus report was developed by a writing group consisting of representatives from the ADA and EASD. The consensus report addresses approaches to glycemic management in adults with type 2 diabetes with the goal of reducing complications and maintaining quality of life in the context of comprehensive cardiovascular risk management and patient-centered care. The ADA Professional Practice Committee (PPC) was involved in the review and approval of the final consensus report. The consensus recommendations and approach to glycemic management in adults with type 2 diabetes presented within the report reflects the current view of the ADA. Please find a link to the consensus document here: http://dx.doi.org/10.2337/dci18-0033
Reference:
Davies MJ, D’Alessio DA, Fradkin J, Kernan WN, Mathieu C, Mingrone G, Rossing P, Tsapas A, Wexler DJ, Buse JB: Management of hyperglycemia in type 2 diabetes, 2018: a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care Oct 2018; DOI: 10.2337/dci18-0033
Rationale/Reason for Change:
Management of Hyperglycemia in Type 2 Diabetes: ADA-EASD Consensus Report 2018 reflects current treatment recommendations as endorsed by the ADA and the PPC.
Annotation published: October 5, 2018. Annotation approved by PPC: September 20, 2018.
Suggested citation: American Diabetes Association. 8. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes—2018 [web annotation]. Diabetes Care 2018;41(Suppl. 1):S73–S85. Retrieved from https://hyp.is/1p2zesvFEeioRdNqCoou5A/clinical.diabetesjournals.org/content/36/1/14
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- Apr 2018
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www.nature.com www.nature.com
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Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
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Annotators
URL
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- Jan 2018
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elifesciences.org elifesciences.org
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Dnmt3a is an epigenetic mediator of adipose insulin resistance
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- Dec 2017
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%).
This is likely do to the reduced carbohydrate intake rather than increased fat intake. Since carbohydrates generally insulin sensitivity, it's likely that this additional insulin resistance is acting as a confounder (as well as, presumably, a standard deviation widener). Thus, I would expect similar results during hypocaloric carbohydrate restriction.
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- diabetes / insulin sensitivity/resistance / blood sugar
- diabetes insulin sensitivity resistance blood sugar
- saturated fatty acid fat LCSFAs unsaturated ceramide intramuscular triglycerides intramyocellular lipid
- fatty acid / fat / LCSFA(s) /
- research note
- diet health lifestyle disease prevention and reversal food nutrients nutrition eat
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URL
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- Nov 2017
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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A visual exploration of the link between statin use and the risk of Diabetes in a subpopulation of patients with subclinical hypothyroidism.
This is an interactive graph created with Biovista Vizit; nodes and links can be further explored to view supporting bibliography and molecular mechanism of action.
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- Aug 2017
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www.biovista.com www.biovista.com
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The first note in Biovista Vizit the free unbiased visual pubmed search tool using hypothes.is
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- Jul 2017
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www.wired.com www.wired.com
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Insulin sends a message to our cells that nutrients are available, meaning it’s time to grow and proliferate. When the levels of the hormones drop, it’s a signal to cells that its time to enter a life-extending mode of conservation. Such a system makes evolutionary sense.
Very good explanation!
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- Apr 2017
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She and her colleagues are using neural networks—complex mathematical systems for identifying patterns in data—to recognize diabetic retinopathy, a leading cause of blindness among US adults.
Wow, this is a very interesting application!
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- Jul 2016
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wn.rsarchive.org wn.rsarchive.org
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spiritual senses of the occultist as are externally perceptible colors to the physical eye. This etheric body can actually be seen by the clairvoyant. It is the principle which calls the inorganic materials into life, which, summoning them from their lifeless condition, weaves them into the thread of life's garment.
This reminds me of the diabetes and heart disease epidemic. If through forced choice you can engender a species of people to change the make up of their blood through outside chemicals and OVER FEEDING everyone sugar rendering most people diabetic you can in essence control the emerging medical needs of a society dependent on new forms of health care and medicines. The obama care state.
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- May 2016
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Slower metabolisms were not the only reason the contestants regained weight, though. They constantly battled hunger, cravings and binges. The investigators found at least one reason: plummeting levels of leptin. The contestants started out with normal levels of leptin. By the season’s finale, they had almost no leptin at all, which would have made them ravenous all the time. As their weight returned, their leptin levels drifted up again, but only to about half of what they had been when the season began, the researchers found, thus helping to explain their urges to eat.Leptin is just one of a cluster of hormones that control hunger, and although Dr. Hall and his colleagues did not measure the rest of them, another group of researchers, in a different project, did. In a one-year study funded by Australia’s National Health and Medical Research Council, Dr. Joseph Proietto of the University of Melbourne and his colleagues recruited 50 overweight people who agreed to consume just 550 calories a day for eight or nine weeks. They lost an average of nearly 30 pounds, but over the next year, the pounds started coming back.
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