- Nov 2024
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onlinelibrary.wiley.com onlinelibrary.wiley.com
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Disease: Platelet-type Von-willebrand Disorder (PT-VWD)
Patient: 17 yo, male, adopted
Variant: GP1BA NM_000173.7: c:580C>T p.(P.Leu194Phe), Heterozygous, gain-of-function
Phenotypes: moderate bleeding phenotype, ISTH-BAT bleeding score of 3, recurrent epistaxis, easy bruising, mild thrombocytopenia
Family: Adopted, no other family history mentioned, segregation studies not performed.
Genetic analysis performed: found variant in GP1BA, results obtained by sanger sequencing.
Variant present in gnomAD(rs368111193): low allele frequency, contradictory classifications
Variant is not present in ClinVar, LOVD, or HGMD databases
According to this paper, ACMG guidelines classified this variant as a VUS.
This paper entered it into Clinvar (var ID 1693270)
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- Sep 2024
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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heterozygous c.G380A variant in GP1BA (NM_000173.7) (Figure 1B), resulting in a missense substitution of an arginine with a glutamine at position 127
Disease: platelet-type von Willebrand disease (PT-VWD)
Patient: 14 yo, Male
Variant: GP1BA NM_000173.7:c.389G>A p.(Arg127Gln), Heterozygous, Gain-of-Function (GOF)
Located in LRR5 domain of GP1BA
Family: Mother did not refer any bleeding symptoms (variant absent in mother) Father not available for collection of clinical history or platelet function testing
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- Jan 2023
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hypothes.is hypothes.is
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Finally, a culture that rewards big personal accomplishments over smaller social ones threatens to create a cohort of narcissists
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- Dec 2022
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agupubs.onlinelibrary.wiley.com agupubs.onlinelibrary.wiley.com
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It is crucial to establish the key feedbacks regulating, or destabilizing, each safety variable, and how they interact on different timescales. To quantitatively assess and combine these feedbacks, an established but under-used approach of calculating and combining feedback “gain” factors (Lashof, 1989) can provide a useful framework.
!- Feedback Gain Factors : used to assess and combine feedbacks - this helps establish the key feedbacks regulating or destabilizing safety variables
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- Jun 2022
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Local file Local file
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* This is called “detachment gain,” as explained in The Detachment Gain: TheAdvantage of Thinking Out Loud by Daniel Reisberg, and refers to the“functional advantage to putting thoughts into externalized forms” such asspeaking or writing, leading to the “possibility of new discoveries that might nothave been obtained in any other fashion.” If you’ve ever had to write out aword to remember how it’s spelled, you’ve experienced this
Each word you write triggers mental cascades and internal associations, leading to further ideas, all of which can come tumbling out onto the page or screen.*
Did he pull this from Reisberg originally or from Annie Murphy Paul who he's quoted before?
This concept is an incredibly powerful one and definitely worthy of underlining in a book about thinking and note taking. It's rather sad that he hides the entire concept in the footnotes where the majority of the audience he's trying to reach will completely miss it.
tie this into Feynman technique and generation effect
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- Nov 2021
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www.statnews.com www.statnews.com
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Asch, D. A., & Allison, K. C. (2021, November 26). The pandemic is deeply affecting many people with eating disorders. STAT. https://www.statnews.com/2021/11/26/pandemic-deeply-affected-many-people-with-eating-disorders/
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- Sep 2021
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www.nytimes.com www.nytimes.com
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As the title of a research paper that the Vallée-Tourangeaus wrote with Lisa G. Guthrie puts it, “Moves in the World Are Faster Than Moves in the Head.”
Perhaps this is some of the value behind the ability to resort index cards within a zettelkasten over the prior staticness of the commonplace tradition? The ideas aren't anchored to the page, but can be moved around, rearranged.
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Moving mental contents out of our heads and onto the space of a sketch pad or whiteboard allows us to inspect it with our senses, a cognitive bonus that the psychologist Daniel Reisberg calls “the detachment gain.”
Moving ideas from our heads into the real world, whether written or potentially using other modalities, can provide a detachment gain, by which we're able to extend those ideas by drawing, sketching, or otherwise using them.
How might we use the idea of detachment gain to better effect in our pedagogy? I've heard anecdotal evidence of the benefit of modality shifts in many spaces including creating sketchnotes.
While some sketchnotes don't make sense to those who weren't present for the original talk, perhaps they're incredibly useful methods for those who are doing the modality shifts from hearing/seeing into writing/drawing.
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- Jul 2021
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Abbasi, K. (2020). Covid-19: Politicisation, “corruption,” and suppression of science. BMJ, 371, m4425. https://doi.org/10.1136/bmj.m4425
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- May 2021
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psyarxiv.com psyarxiv.com
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Bedder, R., Vaghi, M., Dolan, R., & Rutledge, R. (2020). Risk taking for potential losses but not gains increases with time of day. PsyArXiv. https://doi.org/10.31234/osf.io/3qdnx
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- Aug 2020
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www.thelancet.com www.thelancet.com
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Lozano, R., Fullman, N., Mumford, J. E., Knight, M., Barthelemy, C. M., Abbafati, C., Abbastabar, H., Abd-Allah, F., Abdollahi, M., Abedi, A., Abolhassani, H., Abosetugn, A. E., Abreu, L. G., Abrigo, M. R. M., Haimed, A. K. A., Abushouk, A. I., Adabi, M., Adebayo, O. M., Adekanmbi, V., … Murray, C. J. L. (2020). Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)30750-9
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Hassan, T. A., Hollander, S., van Lent, L., & Tahoun, A. (2020). Firm-level Exposure to Epidemic Diseases: Covid-19, SARS, and H1N1 (Working Paper No. 26971; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w26971
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- Jul 2020
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osf.io osf.io
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Hameleers, M. (2020). Prospect Theory in Times of a Pandemic: The Effects of Gain versus Loss Framing on Policy Preferences and Emotional Responses During the 2020 Coronavirus Outbreak [Preprint]. SocArXiv. https://doi.org/10.31235/osf.io/7pykj
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osf.io osf.io
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Dou, Z., Stefanovski, D., Galligan, D., Lindem, M., Rozin, P., Chen, T., & Chao, A. M. (2020). The COVID-19 Pandemic Impacting Household Food Dynamics: A Cross-National Comparison of China and the U.S. [Preprint]. SocArXiv. https://doi.org/10.31235/osf.io/64jwy
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- Jun 2020
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www.researchgate.net www.researchgate.net
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Sharma, N., Uttrani, S., & Dutt, V. (2020, June 19). Modeling the Absence of Framing Effect in an Experience-based Covid-19 Disease Problem. 18th Annual Meeting of the International Conference on Cognitive Modelling. https://www.researchgate.net/publication/342313460_Modeling_the_Absence_of_Framing_Effect_in_an_Experience-based_Covid-19_Disease_Problem
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users will not want to see data mining expanding across their WhatsApp metadata. But if that’s the price to maintain encryption, one can assume it will be a relatively easy sell for most users.
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- May 2020
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www.fastcompany.com www.fastcompany.com
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Google encouraging site admins to put reCaptcha all over their sites, and then sharing the resulting risk scores with those admins is great for security, Perona thinks, because he says it “gives site owners more control and visibility over what’s going on” with potential scammer and bot attacks, and the system will give admins more accurate scores than if reCaptcha is only using data from a single webpage to analyze user behavior. But there’s the trade-off. “It makes sense and makes it more user-friendly, but it also gives Google more data,”
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For instance, Google’s reCaptcha cookie follows the same logic of the Facebook “like” button when it’s embedded in other websites—it gives that site some social media functionality, but it also lets Facebook know that you’re there.
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psyarxiv.com psyarxiv.com
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Chwaszcz, J., Palacz-Chrisidis, A., Wiechetek, M., Bartczuk, R. P., Niewiadomska, I., Wośko, P., & Sławska, P. (2020). Quality of life and its factors in the COVID19 pandemic situation. Results of Stage 1 studies during the pandemic growth period [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/ryv8g
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- Apr 2020
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theconversation.com theconversation.com
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de nouvelles approches utilisent des dispositifs numériques pour virtualiser ou animer les files d’attente afin que les visiteurs gagnent du temps et qu’ils soient accueillis dans de meilleures conditions.
Point de vue de l'auteur : des solutions grâce au numérique vont pouvoir aider à solutionner le problème lié à l'affluence. C'est ce point de vue qui sera développé dans l'article. Il comporte aussi des arguments épistémiques inductifs sous forme d'exemples qui permettent de généraliser : en partant de ces exemples, on peut en déduire qu'il y a de nouvelles approches liées au numérique.
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- Mar 2020
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techcrunch.com techcrunch.com
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Earlier this year it began asking Europeans for consent to processing their selfies for facial recognition purposes — a highly controversial technology that regulatory intervention in the region had previously blocked. Yet now, as a consequence of Facebook’s confidence in crafting manipulative consent flows, it’s essentially figured out a way to circumvent EU citizens’ fundamental rights — by socially engineering Europeans to override their own best interests.
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The deceitful obfuscation of commercial intention certainly runs all the way through the data brokering and ad tech industries that sit behind much of the ‘free’ consumer Internet. Here consumers have plainly been kept in the dark so they cannot see and object to how their personal information is being handed around, sliced and diced, and used to try to manipulate them.
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design choices are being selected to be intentionally deceptive. To nudge the user to give up more than they realize. Or to agree to things they probably wouldn’t if they genuinely understood the decisions they were being pushed to make.
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For mainly two reasons: I pay for things that bring value to my life, and when something's "free", you're usually really just giving away your privacy without being aware.
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complianz.io complianz.io
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Google Recaptcha and personal dataBut we all know: there’s no such thing as a free lunch right? So what is the price we pay for this great feature? Right: it’s personal data.
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- Feb 2020
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www.healthlinetalk.com www.healthlinetalk.com
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Apart from their delightful flavour, dates, also known as “Khajoor” are incredibly healthy and there are colossal benefits of eating dates in the morning.
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- Jul 2019
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livebook.datascienceheroes.com livebook.datascienceheroes.com
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However, the gain ratio is the most important metric here, ranged from 0 to 1, with higher being better.
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- Oct 2016
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teaching.lfhanley.net teaching.lfhanley.net
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He who was living is now dead We who were living are now dying
The circle of life, revolves around death and life but also the in-between and what we don't know about the after life is a big mystery, which takes us back to the unseen, the living dead, or just the dead. It reminds me of the lilacs that bloom from dead land, which could possibly signify that even though we lose people, we also gain new life.
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