for - progress trap - AI - Anthropic Claude 4 - blackmail - rare behavior - but still possible! It only has to happen once!

https://www.antikeychop.com/mostwantedtypewriters

for - critique - extreme wealth a reward for rare management skills - Andrew Carnegie - The Gospel of Wealth - Mondragon counterexample - to - stats - Mondragon pay difference between highest and lowest paid - article - In this Spanish town, capitalism actually works for the workers - Christian Science Monitor - Erika Page - 2024, June 7

critique - extreme wealth a reward for rare management skills - Andrew Carnegie - The Gospel of Wealth - Mondragon counterexample - This is invalidated today by large successful cooperatives such as Mondragon

to - stats - Mondragon corporation - comparison of pay difference between highest paid and lowest paid - https://hyp.is/QAxx-o14Ee-_HvN5y8aMiQ/www.csmonitor.com/Business/2024/0513/income-inequality-capitalism-mondragon-corporation

Disease: Von-Willebrand Disorder

Patient 2 Variant(s):

VWF NM_000552.5: c.4135C>T p.(Arg1379Cys) Exon 28 VWF NM_000552.5: c.4130C>T p.(Ala1377Val) Exon 28 VWF NM_000552.5: c.3797C>T p.(Pro1266Leu) Exon 28 VWF NM_000552.5: c.3835G>A p.(Val1279Ile) Exon 28

Note: Pro1266Leu and Val1279Ile are in trans with Ala1377Val and Arg1379Cys

Note2: MAF of Ala1377Val is present in Exome Variant Server (<0.01) and 1000 Genomes database (<0.02), designated as rare variant, typically found in indiv with African ethnicity

Family: Relatives molecular analysis showed Arg1379 and Ala1377Val variants mentioned above were in cis

Patient 2 Phenotype: Mild bleeding symptom Nearly normal VWF:Ag value, reduced VWF:RCo value slight loss of HMWM with smear decreased/slightly decreased proteolysis Slightly reduced RIPA VWFpp/VWF:Ag ratio shows increased VWF clearance VWF platelet levels reduced reduced rBpIba binding in VWF plasma VWF:GPIbM values slightly increased

Note: Treated with desmopressin in case of minor surgeries or delivery

Note 2: Slightly decreased RIPA may be explained by presence of 2B New York Variant (Pro1266Leu) that mitigates RIPA assay in 2M phenotype.

In silico analysis available:

I-Mutant 3.0 states decrease in A1 domain stability for both mutations (Ala1377Val = -0.91, Arg1379Cys = -1.36)

PYMOL predicts Ala1377Val does not alter formation of hydrogen bonds with Arg1374 residue and water. Predicts substitution of ARG 1379 with a cysteine results in the loss of hydrogen bonds with Lys1407 and Lys1408, predicted change in secondary structure of A1 domain

Ala1377Val was previously reported in 3 other patients Publications:

Millar CM, Riddel AF, Mellors G, Yee TT. The spectrum of VWD type 2 phenotypes associated with A1 domain mutations posters. J Thromb Haemost 2009; 7: 531–2.

Logsdon BA, Dai JY, Auer PL et al. A variational Bayes discrete mixture test for rare variant association. Genet Epidemiol 2014; 38: 21–30.

Final note: Authors suggest patients' 2M phenotype is due to the presence of Ala1377Val and Arg1379Cys together to create synergistic effect. Though difficult to discern with this specific patient having two other variants in addition to the two mentioned above.

reply to u/NoDoctor4602 at https://old.reddit.com/r/typewriters/comments/1fjrjns/ive_spent_a_few_days_searching_for_any_concrete/

In the mid to late-1950's and after several typewriter manufacturers made limited runs of gold plated typewriters for special anniversaries or for bonuses to salespeople. They're uncommon, but not rare. I've seen at least 6 or seven pop up on auction sites in the last 6 months. If you really want one, watch the lower end of Facebook Marketplace, ShopGoodwill, Craigslist, et al. where one will assuredly pop up for a much more reasonable price. I'm not sure if it was this one or another I've seen since April, but one of these went up for sale on ShopGoodwill.com recently and sold for about $600. A week later it was listed on eBay for several thousand just like this one. Given the timeframe, I doubt they spent any time cleaning, oiling, or adjusting it in any fashion—it was a pure flip. I've also seen this recently with Royal typewriters with a less common, but highly collectible Vogue typeface: a Royal P sold for about $900 there and was listed on eBay shortly after for over $1,500 with no indication that it was cleaned or adjusted. (If you watch some of the sites carefully, you can pick up a Vogue machine for under $100 easily enough depending on the type and condition.)

In my mind, as a collector, I'd try to find one in the wild and clean it up or I'd want it in stunning restored condition for over $2k. You might be just as well off picking up a working model for $100-$150 and gold plating the pieces yourself. It would probably be cheaper in the long run and you'd have a better machine in better condition. Some sucker with money to burn will eventually buy a Gold Olympia SM3 for over $2,000.

Here's a vew posts/videos as examples of gold plated machines:<br /> - A video of another Gold Olympia: https://www.youtube.com/watch?v=JnUHgyABjw0<br /> - Royal QDL https://typespec.com/weve-got-gold-in-them-thar-hills/<br /> - https://www.huffpost.com/entry/kasbah-mod-typewriters_n_1453776

If you're looking for something great that you'll use, I recommend visiting a repair shop that has some stock to try out some machines to see if you'd like their touch/fee/aesthetics first. Visiting a type-in or two might give you some experience with a wide variety of typewriter models as well. Then try to find a rare or exceptional version that's worth putting some money into. Why put so much into an Olympia if it turns out you're an Olivetti, Royal, or Smith-Corona person? https://site.xavier.edu/polt/typewriters/tw-repair.html (I desperately love Royals, but Smith-Coronas and Remingtons are much more forgiving of my mediocre typing technique, a fact which pains me dearly and cost a few hundred dollars and some sweat equity in cleaning and tuning machines to discover). Incidentally, I'll mention that for about $2,000 you could easily purchase a wide variety of about two dozen machines (even with shipping) and be able to get something truly exceptional in terms of condition and function.

Incidentally, the higher prices of $250-600 for repaired/refurbished/restored machines being sold by repair shops are usually what Harry Beercan is using as a pricing guide when he's selling his grandmother's musty, broken, old typewriter online not knowing that several hundred dollars in labor and parts has been calculated into the selling price.

• = example tradeoff
  • cobalt mine in Idaho’s Salmon River Mountains

• = example tradeoff
  • open pit Lithium mine in Nevada

• = energy transition
• = quotable

• = energy transition
• = quotable

• = energy transition
• = quotable

Reference https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=simon+michaux

= energy transitions

Reference: https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=simon+michaux

• = energy transition
• = quotable

Reference https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=simon+michaux

• = energy transition
• = quotable

Reference: https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=simon+michaux

GeneName: DICER1 PMID (PubMed ID): 29762508 HGNCID: Unavailable Inheritance Pattern: Autosomal Dominant Disease Entity: cancer, rare genetic disorder, pleuroplumonary blastomas, cystic nephroma, rhabdomyosarcoma, multinodular goiter, thyroid cancer, overian Sertoli-Leydig cell tumors, and other meoplasias Mutations: Germline mutations or Somatic mutations Zygosity: Heterozygosity Variant: unregistered Family Information: Cystic nephromas has been reported in approximately 12% of children with pleuripulmonary blastomas or those with a family member with cystic nephroma. Patient with two DICER1 mutations and several of his family members shared these mutations. All members developed a least one type of tumor with differing origins. The patient was an 11-year old boy with a rare Hodgkin lymphoma with DICER1 in 2016. (c.5299delC and c.4616C>T).

Jess Rohmann. (2021, March 16). New @PEI_Germany report provides much needed clarity to the #AstraZeneca ‘pause’ in Germany. Not yet available in English. I will try to summarize. /Thread https://t.co/Ev9p2TOdfD [Tweet]. @JLRohmann. https://twitter.com/JLRohmann/status/1371833745272156163

Deepti Gurdasani. (2022, January 10). Lots of people dismissing links between COVID-19 and all-cause diabetes. An association that’s been shown in multiple studies- whether this increase is due to more diabetes or SARS2 precipitating diabetic keto-acidosis allowing these to be diagnosed is not known. A brief look👇 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1480546865812840450

I really wouldn't have expected to read a sentence like this.

Simone, A., Herald, J., Chen, A., Gulati, N., Shen, A. Y.-J., Lewin, B., & Lee, M.-S. (2021). Acute Myocarditis Following COVID-19 mRNA Vaccination in Adults Aged 18 Years or Older. JAMA Internal Medicine. https://doi.org/10.1001/jamainternmed.2021.5511

Reuters. (2021, October 6). Sweden, Denmark pause Moderna COVID-19 vaccine for younger age groups. Reuters. https://www.reuters.com/business/healthcare-pharmaceuticals/sweden-pauses-use-moderna-covid-vaccine-cites-rare-side-effects-2021-10-06/

https://www.library.upenn.edu/about/exhibits-events/ljs_symposium14

(((Howard Forman))). (2021, April 23). Very useful slide from #JohnsonandJohnson/Jansen today at ACIP placing TTS/CVST as an adverse event with COVID vaccine against other common vaccines and their serious adverse events. Cc: @NateSilver538 https://t.co/BQsIf7Vp8m [Tweet]. @thehowie. https://twitter.com/thehowie/status/1385656051068964864

Science | AAAS. ‘What’s the Future of Vaccines Linked to Rare Clotting Disorders? Science Breaks down the Latest’, 3 May 2021. https://www.sciencemag.org/news/2021/05/what-s-future-vaccines-linked-rare-clotting-disorders-science-breaks-down-latest.

the Guardian. ‘How UK Doctor Linked Rare Blood-Clotting to AstraZeneca Covid Jab’, 13 April 2021. http://www.theguardian.com/society/2021/apr/13/how-uk-doctor-marie-scully-blood-clotting-link-astrazeneca-covid-jab-university-college-london-hospital.

Kai Kupferschmidt. ‘“Our Position Has Not Changed”, Says @EMA_News Head Emer Cooke about AZ Vaccine. “According to the Current Scientific Knowledge, There Is No Evidence That Would Support Restricting the Use of This Vaccine in Any Population."’. Tweet. @kakape (blog), 31 March 2021. https://twitter.com/kakape/status/1377268296739913728.

A Few People Developed a Rare Blood Disorder, Immune Thrombocytopenia, After Getting a COVID Vaccine | Health.com. (n.d.). Retrieved March 17, 2021, from https://www.health.com/condition/infectious-diseases/coronavirus/rare-blood-disorder-covid-vaccine-thrombocytopenia

rare to see "internet" used to mean an internetwork in the general sense

Megrims!

1. depression; low spirits.

2. a whim or fancy.

I love this word.

ReconfigBehSci on Twitter: “Fellow behavioural scientists, I had a lightbulb moment yesterday. I suspect I might have been unusually slow here, and you all clocked this months ago, but thought I’d share nevertheless: I’ve lost count of how often I’ve been told ‘You only have a 1/100 chance of dying’” / Twitter. (n.d.). Twitter. Retrieved June 27, 2020, from https://twitter.com/scibeh/status/1276434777856446464

the source of gallium.

Whoo!!! Now it's highlighted