1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling
    7
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    pmc.ncbi.nlm.nih.gov/articles/PMC6561723/
  3. www.sciencedirect.com www.sciencedirect.com
    Ebselen sensitizes multidrug-resistant cancer cells to doxorubicin by disrupting cellular redox homeostasis and inducing ferroptosis
    2
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    sciencedirect.com/science/article/pii/S0024320526004911
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder
    16
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    pmc.ncbi.nlm.nih.gov/articles/PMC13571666/
  5. 54.241.53.176 54.241.53.176
    '-html.html
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    54.241.53.176/b66822b2907bb6d00b9e83a81725f62d71cd041a/'-html.html
  6. www.sciencedirect.com www.sciencedirect.com
    Tumor microenvironment responsive CuV/DTPA@Catalase/5-fluorouracil nanodrug for reactive oxygen species modulation and breast cancer imaging
    1
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    sciencedirect.com/science/article/pii/S0141813026043254
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    Balancing growth and immunity of potato by humidity-dependent expression of a late blight resistance gene
    22
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    sciencedirect.com/science/article/pii/S0960982226010997
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    Norway spruce spatiotemporal programs of conifer reproductive development
    4
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    sciencedirect.com/science/article/pii/S0092867426010068
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    Copper ion-induced MYH9 polymerization executes cuproptosis
    41
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    sciencedirect.com/science/article/pii/S0092867426010032
  10. www.sciencedirect.com www.sciencedirect.com
    Epithelial HSD11β2 as an immunometabolic checkpoint in head and neck cancer: Restoring local steroid inactivation reinvigorates T cell immunity
    4
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    sciencedirect.com/science/article/pii/S030438352600604X
  11. analyticalsciencejournals.onlinelibrary.wiley.com analyticalsciencejournals.onlinelibrary.wiley.com
    Fate of Aflatoxins and Fumonisins During Gluten-Free Pasta Processing: Untargeted 13C-Labelling LC-HRMS Based Approach
    1
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    analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.70106
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13553065/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13554099/
  14. www.sciencedirect.com www.sciencedirect.com
    Amygdalostriatal transition zone neurons encode sustained cue responses to guide defensive behaviors
    1
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    sciencedirect.com/science/article/pii/S0896627326006422
  15. docs.google.com docs.google.com
    Untitled document
    2
    1. yelanh 15 Sep 2026
      Tell me this is what you want.

      女主也是被监视的人，怎么感觉男主在责怪女主？按照后面女主vo，她害怕男主因为她失去继承权害怕男主的人生被爸爸毁掉，那么此处应该是两人有亲密接触，然后女主发现有佣人在监视，于是主动拉开距离划清界限，但现在完全没体现

    2. yelanh 15 Sep 2026
      Report to the outer perimeter. Now.

      太高深了，虽然我知道servant是想阻止男女主见面或者监视女主，但仅凭现在的对话根本看不懂servant是在干嘛

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    docs.google.com/document/u/0/d/1Kc5yPMJo3ad7j30vJB4nviPzGSE-o1a6wxzb92kmvMI/mobilebasic
  16. staging-optimality.subhamsubhasis2002.workers.dev staging-optimality.subhamsubhasis2002.workers.dev
    Sizing LLM inference without a GPU run
    11
    1. tarunnava 15 Sep 2026
      Figure 1. Too few GPUs and you miss your target; too many and you pay for idle cards. The right panel is the surprising part: the same eight GPUs, arranged two different ways, differ by nearly 2× in throughput - and which way wins depends on your traffic.

      what is the y axis? also pls read the text of right side bottom part. 50 requests vs 56 concurrency. why compare these two?

    7. tarunnava 15 Sep 2026
      This series explains how - and how close the predictions land to real hardware.

      "this series explains how you get to the most optimal GPU deployment configuration fast."

    9. tarunnava 15 Sep 2026
      search the whole space in minutes

      "run all the possible permutation & combinations of the configurations in less than 10 minutes." - try using language like this instead of saying "whole space".

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    staging-optimality.subhamsubhasis2002.workers.dev/
  17. www.ebay.com www.ebay.com
    Globe-Typewriters | eBay Stores
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    ebay.com/str/vintageretrogems
  18. interconnected.org interconnected.org
    How would I improve RSS? Three ideas (Interconnected)
    1
    1. mrcolbyrussell 15 Sep 2026
      I’d like to see a website called something like what is rss .com which explains RSS, feeds, and readers for a general audience. Then provides download links to a couple of readers for different platforms with animations that show how to subscribe to feeds. The site should be designed to be linked to from a small “what is this?” link next to every RSS feed on every site, maybe even customising the site for that feed. Perhaps I’ll built that site myself.

      He did. He made aboutfeeds.com.

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    interconnected.org/home/2020/07/29/improving_rss
  19. www.youtube.com www.youtube.com
    Creativity isn't a gift, it's a system
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    youtube.com/watch
  20. www.klimaateffectatlas.nl www.klimaateffectatlas.nl
    Waterdiepte bij korte extreme regen - Klimaateffectatlas
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    klimaateffectatlas.nl/nl/waterdiepte-bij-korte-extreme-regen
  21. open.overheid.nl open.overheid.nl
    Open overheid
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    open.overheid.nl/details/6ba92fae-f8e6-48f0-a5d2-bf334b14ac5e
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Phenotype–genotype correlations in a pseudodominant Stargardt disease pedigree due to a novel ABCA4 deletion–insertion variant causing a splicing defect
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC7336727/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABCA4 midigenes reveal the full splice spectrum of all reported noncanonical splice site variants in Stargardt disease
    1
    1. Vibhor 15 Sep 2026
      Patient 1

      Case#: Patient 1, Female, age 40

      DiseaseAssertion: STGD1

      FamilyInfo: n/a

      CasePresentingHPOs: HP:0007722, HP:0000608, HP:0000007

      CaseHPOFreeText: Patient diagnosed with STGD type 1, presenting with retinal pigment atrophy as well as other symptoms typical of STGD1 with reduced visual acuity. Patient daignosed at age 16.

      CaseNotHPOs: n/a

      CaseNotHPOFreeText: n/a

      Genotyping Method: Patient ABCA-4 gene sequenced via Sanger sequencing of all 50 exons, Splice variants were identified by synthesized cDNA from RNA isolation with RT-PCR analysis with exonic primers.

      PreviouslyPublished: Variant 1 identified in association with retinal dystrophy in these PMC articles: 23982839, 25082829, 25082885, 28327576

      Variant: NM_000350.3(ABCA4):c.859-9T>C, NM_000350.3(ABCA4):c.303-3C>G

      ClinVar: 3249248, 859348

      gnomAD total allele frequency: 0.005% of var . 1

      CAID: n/a

      SupplementalData: Fig 1: Minigene RNA analysis of splice variants. A: genomic region of exon 40 on ABCA-4. B: genomic regions of exons 39-41 to investigate specific variant:oncanonical splice site variant c.5714+5G>A Fig 2: overview of wild-type midigene splice constructs of ABCA-4 and locations of 47 different non canonical splice site variants Fig 3: Overview of splice defects from nine different non canonnical splice variants in ABCA-4 gene. Fig 4: percentages of normal ABCA-4 transcripts as a result of noncanonical splice variants using electrophoresis system analysis. Table 1: Non canonical splice variants and observed protein affects.

      Gene: ABCA4 InheritancePattern: autosomal recessive HGNC: 34 FamilyInfo CaseInfo Zygosity: CompoundHeterozygous AllelicOrigin: Somatic Disease: STGD SupplementalInfo inferred_gene_hgnc:34 inferred_gene_source:Gene_Name ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC5749174/pdf/100.pdf
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    genes-10-00959.pdf
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC6947411/pdf/genes-10-00959.pdf
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unusual clinical phenotype of Stargardt disease
    1
    1. Vibhor 15 Sep 2026
      48-year-old woman

      Case#: Patient female, 48y, ethnicity not reported

      DiseaseAssertion: Stargardt disease (STGD1) with unusual phenotype resembling pattern dystrophy

      FamilyInfo: autosomal recessive inheritance; segregation analysis confirms each parent carries one variant (heterozygous). Pedigree shown in Figure 3. Proband is compound heterozygous for ABCA4 variants.

      CasePresentingHPOs: HP:0007663, HP:0007754, HP:0030636, HP:0000548

      CaseHPOFreeText: mild visual impairment (BCVA 20/25 and 20/20), perifoveal yellow fleck-like lesions, hyperautofluorescent lesions with lipofuscin accumulation, foveal sparing, subretinal material accumulation, phenotype resembling pattern dystrophy, bilateral macular involvement, decreased p50 values on pattern ERG

      CaseNotHPOs: HP:0000510 (normal ERG responses except pattern ERG component)

      CaseNotHPOFreeText: normal full-field ERG (scotopic and photopic responses), normal electrooculography, preserved outer retina structure, minimal photoreceptor disruption at fovea

      Genotyping Method: targeted next-generation sequencing (Illumina NextSeq500) with SeqCap EZ enrichment panel; Sanger sequencing used for confirmation and segregation analysis

      PreviouslyPublished: n/a

      Variant: ABCA4 NM_000350.2: c.428C>T (p.Pro143Leu); c.3113C>T (p.Ala1038Val)

      ClinVar: 99273; 7894

      CAID: n/a

      SupplementalData: clinical imaging and genetic/segregation data in supplemental data (Figures 1–3, Table 1)

      InheritancePattern:AutosomalRecessive DiseaseEntity:STGD1 AlleleOrigin:Germline Zygosity:CompoundHeterozygous ClinVarID:99273 ClinVarID:7894 MacularFlecks FundusAlbipunctatus DecreasedCentralVA DecreasedERGResponses PreviousTesting FamilyInfo SupplementalData inferred_gene_hgnc:986 inferred_gene_source:ClinVar ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC11826603/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Case Report of Pseudoxanthoma Elasticum with Rare Sequence Variants in Genes Related to Inherited Retinal Diseases
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC8534466/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Non-exomic and synonymous variants in ABCA4 are an important cause of Stargardt disease
    3
    1. Vibhor 15 Sep 2026
      V1 H1 Exon 36.1–3 G>A chr1:94,484,001 c.5196+1137G>A 4 4 0 0

      Case#: Braun Family 1 Proband (from left to right, top to bottom of available pedigrees), female

      DiseaseAssertion: Stargardt

      FamilyInfo: Both parents are unaffected heterozygotes. c.4139C>T (p.P1380L) paternally inherited, c.5196+1137G>A maternally inherited. Proband has 2 unaffected, heterozygous children.

      CasePresentingHPOs:

      CaseHPOFreeText: "five or more of the following features of ABCA4-associated retinal disease: decreased visual acuity before age 20, decreased visual acuity as the first visual symptom, symmetrical fundus findings, pisciform flecks, beaten metal macular atrophy, bulls-eye maculopathy, peripapillary sparing, vermillion fundus, masked choroid on fluorescein angiography, nummular pigment overlying extensive macular atrophy, central outer retinal atrophy on optical coherence tomography and central scotomas on Goldmann perimetry."

      CaseNotHPOs:

      CaseNotHPOFreeText:

      GenotypingMethod: one plausible disease-causing mutation detected in ABCA4 after assessing the entire coding sequence and canonical retinal splice junctions with automated bidirectional Sanger sequencing using an ABI 3730 sequencer

      PreviouslyPublished: n/a

      Variant: c.5196+1137G>A; c.4139C>T (p.P1380L)

      ClinVar: 438100

      CAID: CA26843511

      SupplementalData: pedigree in fig s2

      CaseInfo Individual FamilyInfo CAID:CA26843511 ClinVarID:438100 inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
    2. Vibhor 15 Sep 2026
      V1 H1 Exon 36.1–3 G>A chr1:94,484,001 c.5196+1137G>A 4 4 0 0

      Case#: Braun Family 7 Proband (from left to right, top to bottom of available pedigrees), female

      DiseaseAssertion: Stargardt

      FamilyInfo: Unaffected carrier parents. c.5196+1137G>A maternally inherited; c.4561-10T>C paternally inherited

      CasePresentingHPOs:

      CaseHPOFreeText: "five or more of the following features of ABCA4-associated retinal disease: decreased visual acuity before age 20, decreased visual acuity as the first visual symptom, symmetrical fundus findings, pisciform flecks, beaten metal macular atrophy, bulls-eye maculopathy, peripapillary sparing, vermillion fundus, masked choroid on fluorescein angiography, nummular pigment overlying extensive macular atrophy, central outer retinal atrophy on optical coherence tomography and central scotomas on Goldmann perimetry."

      CaseNotHPOs:

      CaseNotHPOFreeText:

      GenotypingMethod: one plausible disease-causing mutation detected in ABCA4 after assessing the entire coding sequence and canonical retinal splice junctions with automated bidirectional Sanger sequencing using an ABI 3730 sequencer

      PreviouslyPublished: n/a

      Variant: c.5196+1137G>A; c.4561-10T>C

      ClinVar: 438100

      CAID: CA26843511

      SupplementalData: pedigree in fig s2

      CaseInfo Individual SupplementalTable FamilyInfo ClinVarID:438100 CAID:CA26843511 inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
    3. Vibhor 15 Sep 2026
      V1 H1 Exon 36.1–3 G>A chr1:94,484,001 c.5196+1137G>A 4 4 0 0

      Case#: Braun Family 2 Proband (from left to right, top to bottom of available pedigrees), female

      DiseaseAssertion: Stargardt

      FamilyInfo: Both parents are unaffected carriers. c.1622T>C (p.L541P) and c.3113C>T (p.A1038V) complex variants were paternally inherited, c.5196+1137G>A maternally inherited.

      CasePresentingHPOs:

      CaseHPOFreeText: "five or more of the following features of ABCA4-associated retinal disease: decreased visual acuity before age 20, decreased visual acuity as the first visual symptom, symmetrical fundus findings, pisciform flecks, beaten metal macular atrophy, bulls-eye maculopathy, peripapillary sparing, vermillion fundus, masked choroid on fluorescein angiography, nummular pigment overlying extensive macular atrophy, central outer retinal atrophy on optical coherence tomography and central scotomas on Goldmann perimetry."

      CaseNotHPOs:

      CaseNotHPOFreeText:

      GenotypingMethod: one plausible disease-causing mutation detected in ABCA4 after assessing the entire coding sequence and canonical retinal splice junctions with automated bidirectional Sanger sequencing using an ABI 3730 sequencer

      PreviouslyPublished: n/a

      Variant: c.5196+1137G>A; c.1622T>C (p.L541P) and c.3113C>T (p.A1038V) complex variant

      ClinVar: 438100

      CAID: CA26843511

      SupplementalData: pedigree in fig s2

      CaseInfo Individual ClinVarID:438100 CAID:CA26843511 FamilyInfo inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC3842174/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PERIPAPILLARY ATROPHY IN STARGARDT DISEASE
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC2743754/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic epidemiology of inherited retinal diseases in a large patient cohort followed at a single center in Italy
    1
    1. Vibhor 15 Sep 2026
      We identified 1319 distinct causative variants (Supplementary Table S1) in 132 different genes (Table ​(Table3).3). The ten most commonly mutated genes were ABCA4 (n = 535 [26.3%]), USH2A (n = 228 [11.2%]), RPGR (n = 102 [5%]), CHM (n = 72 [3.5%]), RHO (n = 72 [3.5%]), MYO7A (n = 69 [3.4%]), CRB1 (n = 55 [2.7%]), RPE65 (n = 40 [2%]), RP1 (n = 37 [1.8%]), and GUCY2D (n = 34 [1.7%]) (Table ​(Table3,3, Fig. 2a). The other 122 genes had a lower contribution to IRDs. One hundred genes were mutated in 15 patients or less and were collectively responsible for disease pathogenesis in 18% of the solved cohort (Fig. 2a, Table ​Table3).3). Thirty-two genes were mutated in only one patient (Table ​(Table3).3). Mutations in the mitochondrial DNA accounted for 2.1% of the cohort and were implicated almost exclusively in the pathogenesis of LHON.

      This variant is in supplementary table S1 as being found in an Italian IRD "solved" case with AR inheritance, but no further details are provided.

      NoEvidence ClinVarID: 99455 CA227399 inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    ncbi.nlm.nih.gov/pmc/articles/PMC9718770/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    THE VALUE OF RETINAL IMAGING WITH INFRARED SCANNING LASER OPHTHALMOSCOPY IN PATIENTS WITH STARGARDT DISEASE
    1
    1. Vibhor 15 Sep 2026
      14F/34320/200, 20/250OU: Severe RPE and choroidal atrophic changes in macula and throughout posterior pole and midperiphery, flecks throughout posterior poleCompound heterozygous: G818E and C1488RSubnormal rod, subnormal cone

      Case#: Patient #14, female, 34yo

      DiseaseAssertion: Stargardt

      FamilyInfo:

      CasePresentingHPOs:

      CaseHPOFreeText: stage 3, BCVA: OD=20/200 OS=20/250, fundus findings: OU: Severe RPE and choroidal atrophic changes in macula and throughout posterior pole and midperiphery, flecks throughout posterior pole, full field ERG: Subnormal rod, subnormal cone,

      CaseNotHPOs:

      CaseNotHPOFreeText:

      GenotypingMethod: direct sequencing of the ABCA4 gene

      PreviouslyPublished:

      Variant: Compound heterozygous: G818E and C1488R

      ClinVar:

      CAID:

      SupplementalData:

      CaseInfo Individual CA227000 ClinVarID: 99135 inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    ncbi.nlm.nih.gov/pmc/articles/PMC4098760/
  31. www.ajo.com www.ajo.com
    mmc1.pdf
    1
    1. Vibhor 15 Sep 2026
      MD-0723 STGD1 23 c.3386G>T p.(Arg1129Leu) 47 c.6410G>A p.(Cys2137Tyr) - 13 13 Yes 15y Cone-pattern 0.2/0.2 This study

      This variant is found in compound heterozygosity with c.3386G>T p.(Arg1129Leu) in family MD-0723 in this study. Proband is 13yo at onset of VA loss and VF loss with night blindness. 15yo at opthalmological exam. Cone pattern on ERG. BCVA=0.2/0.2. Eligible for PP4.

      CaseInfo Individual ClinVarID: 2202779 CA341277358 PP4 inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    ajo.com/cms/10.1016/j.ajo.2020.06.027/attachment/2c3c8baa-ae3a-4cb6-a3ad-ae429569a986/mmc1.pdf
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal choroidal excavation in Stargardt’s dystrophy
    1
    1. Vibhor 15 Sep 2026
      35-year-old woman

      **Case#: ** Female, 35yo

      FamilyInfo: Unremarkable

      CasePresentingHPOs: HP:0000529 Progressive visual loss, HP:0030532 Visual acuity, HP:0007401 Macular atrophy

      CaseHPOFreeText: 35-year-old woman presented with symptom of gradually progressive diminution of vision in both eyes since childhood. Patient gave no history of defective night vision.

      CaseNotHPO n/a

      GenoTypeMethod: n/a (optical coherence tomography (OCT))

      CasePresentingHPOs: n/a DiseaseEntity: SD InheritancePattern: Autoflourescence revealed Hypoautofluorescence Hypoautofluorescence autoflourescence Gene: ABCA4 inferred_gene_hgnc:34 inferred_gene_source:Gene_Name ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC7449287/
  33. www.ajo.com www.ajo.com
    Genotype–Phenotype Correlations in a Spanish Cohort of 506 Families With Biallelic ABCA4 Pathogenic Variants
    1
    1. Vibhor 15 Sep 2026
      STGD1 was determined according to initial symptoms of VA loss; fundus images showing orange-yellow flecks in the retina, a beaten-bronze appearance; and normal or cone-altered ffERG results

      This variant was found in homozygosity 3 times in table S1 (Families MD-0991, MD-1164, and MD-1302). All with a STGD1 phenotype.

      MD-0991 had onset of VA loss at 25yo, cone-rod pattern on ERG, and BCVA was 1.2/1.2. Segregation was mentioned, but no details provided.

      MD-1164 had onset of VA loss at 42yo, no VF loss, and BCVA was 0.2/0.3. Segregation was not mentioned.

      MD-1302 had no clinical details available.

      GenotypingMethod: Index cases were studied by different next-generation sequencing (NGS) strategies, including targeted gene panels, clinical exome, and/or whole-exome sequencing

      CaseInfo Individual CA227192 ClinVarID: 99283 SupplementalTable inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    ajo.com/article/S0002-9394(20)30323-8/fulltext
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Novel compound heterozygous mutations in ABCA4 in a Chinese pedigree with Stargardt disease
    1
    1. Vibhor 15 Sep 2026
      The proband (K206–2) was 25-years-old

      Case#: 25-year old female, juvenile onset

      DiseaseAssertion: STGD1

      FamilyInfo: Figure 1 shows family pedigree. Table 1 shows clinical features of a Chinese pedigree. Cosegregation analysis was done and shown in Figure 1A, C.

      CasePresentingHPOs: HP:0007663, HP:0007722, HP:0007401, HP:0030329, HP:0030610, HP:0003621, HP:0011507, HP:0007984

      CaseHPOFreeText: The uncorrected visual acuity of each eye was 20/400, which has progressively decreased for 13 years.

      CaseNotHPOs: n/a

      CaseNotHPOFreeText: The retinal vessels were normal.

      Genotyping Method: Whole Exome Sequencing, Sanger Sequencing

      PreviouslyPublished: n/a

      Variant: NM_000350.3(ABCA4):c.3523-2A>G, NM_000350.3(ABCA4):c.5646G>A (p.Met1882Ile)

      ClinVar: 866764, 377407

      SupplementalData: n/a

      DecreasedCentralVA CaseInfo Individual DiseaseEntity:STGD1 MacularFlecks InheritancePattern:AutosomalRecessive MacularAtrophy DecreasedERGResponses Zygosity:CompoundHeterozygous ClinVarID:866764 ClinVarID:377407 PigmentaryRetinopathyAttenuatedVessels inferred_gene_hgnc:53 inferred_gene_source:ClinVar ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC5204459/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Next-generation sequencing-based molecular diagnosis of 82 retinitis pigmentosa probands from Northern Ireland
    1
    1. Vibhor 15 Sep 2026
      Rp125 arRP ABCA4 NM_000350 Heterozygous c.6416G > C p.(Arg2139Pro) Novel Heterozygous c.1519G > T p.(Asp507Tyr) (Fujinami et al. 2013b)

      Case#: Zhao Case Rp125, N. Ireland

      DiseaseAssertion: arRP

      FamilyInfo: familial case. affected sister with the same genotype

      CasePresentingHPOs:

      CaseHPOFreeText: "Retinitis pigmentosa was diagnosed on the basis of the typical fundal features (bone spicule retinal pigmentation, arteriolar attenuation, and optic disc pallor), visual field constriction, and an attenuated or abolished electroretinogram." 7yo at onset. BCVA= CF, HM. ERG findings: extinguished OU

      CaseNotHPOs:

      CaseNotHPOFreeText:

      GenotypingMethod: Targeted next-generation sequencing using a retinal capture panel to test 55 RP genes and 131 other retinal disease genes. All putative mutations identified by NGS were validated using Sanger sequencing and tested for co-segregation if additional affected family members are available

      PreviouslyPublished: n/a

      Variant: NM_000350 c..6416G>C p.(Arg2139Pro); c.1519G>T p.(Asp507Tyr)

      CAID: CA956878

      SupplementalData: table s6, figure s1

      CaseInfo Individual CAID:CA956878 SupplementalTable inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC4347882/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Preclinical Development of Antisense Oligonucleotides to Rescue Aberrant Splicing Caused by an Ultrarare ABCA4 Variant in a Child with Early-Onset Stargardt Disease
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC11011354/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ABCA4-associated retinopathy complicated by didanosine-associated retinal toxicity
    1
    1. Vibhor 15 Sep 2026
      ABCA4-associated retinopathy complicated by didanosine-associated retinal toxicity

      PMID: 41561667

      Gene: ABCA4

      HGNC ID: 34

      Case#: patient 66, male, Italy

      DiseaseAssertion: STGD

      FamilyInfo: N/A

      CasePresentingHPOs: HP:0000505, HP:0000551, HP:0000546

      CaseHPOFreeText: best-corrected visual acuity (BCVA) was 20/400 in both eyes, mild myopia, both eyes were pseudophakic, extensive bilateral chorioretinal atrophy involving both the posterior pole and the peripheral retina, widespread mottled hypoautofluorescence in the mid-periphery, along with pronounced macular hypoautofluorescence, significant central retinal thinning, an enlarged foveal depression, outer retinal hyper-reflectivity associated with extensive atrophy of both the RPE and the underlying choroid, dense epiretinal membrane (ERM) was also identified in the right eye, large central hypofluorescent zone involving the macular region and extending beyond the vascular arcades

      CasePreviousTesting: n/a

      GenotypingMethod: Next-Generation Sequencing

      PreviouslyPublished: n/a

      Variant: c.1714C > T p. (Arg572∗)

      ClinVar: 620085 https://www.ncbi.nlm.nih.gov/clinvar/variation/620085/?term=620085%5BVariation+ID%5D

      gnomAD: 0.000001859 https://gnomad.broadinstitute.org/variant/1-94063158-G-A?dataset=gnomad_r4

      Variant: c.2461T > A p. (Trp821Arg)

      ClinVar: 99136 https://www.ncbi.nlm.nih.gov/clinvar/variation/99136/?term=99136%5BVariation+ID%5D

      gnomAD: 0.000008054 https://gnomad.broadinstitute.org/variant/1-94055237-A-T?dataset=gnomad_r4

      Variant: c.4417C>А p. (Leu1473Met)

      ClinVar: 546600 https://www.ncbi.nlm.nih.gov/clinvar/variation/546600/?term=546600%5BVariation+ID%5D

      gnomAD: 0.00005762 https://gnomad.broadinstitute.org/variant/1-94029567-G-T?dataset=gnomad_r4

      General Gene:ABCA4 HGNC:34 PMID:41561667 inferred_gene_hgnc:34 inferred_gene_source:hgnc_tag ClinGen ABCA4 Annotations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12813201/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy
    1
    1. Vibhor 15 Sep 2026
      Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy

      PMID: 31618812

      Gene: ABCA4

      HGNCID: HGNC:34

      Patients: a group of 31 Stargardt disease/fundus flavimaculatus patients (14 males, 17 females) with an established ABCA4 genotype, accumulated prospectively over an interval of 12 months at the outpatient service of the Institution, were included in this study.

      MonDO: MONDO:0019353

      CaseInfo: Case 11, Male, 12yo. Compound het c.5882G > A; p.Gly1961glu (Pathogenic in ClinVar); c.6764G > T,p.Ser2255Ile

      DiseaseAssertion: Stargardt disease/fundus flavimaculatus

      FamilyInfo: Not provided

      CasePresentingHPOs: HP:0007769, HP:0000608, HP:0012045 (Peripheral retinal degeneration, Macular degeneration, Retinal flecks)

      CaseHPOFreeText: cone-rod pattern of retinal dysfunction

      GenotypingMethod: Mutation screening was performed by single-strand conformation polymorphism (SSCP) strategy of the whole coding region of ABCA4. Direct sequencing was also performed on siblings of probands and parents, when available, to confirm segregation of alleles.

      MultipleGeneVariants: (1) GeneName: ABCA4

      (1)Variant: c.5882G > A; p.Gly1961glu

      (1) CAID: CA119132

      (1) gnomAD: 0.01250 (gnomadv4.0.0, Grpmax Filtering AF, South Asian) https://gnomad.broadinstitute.org/variant/1-94008251-C-T?dataset=gnomad_r4

      (2) GeneName: ABCA4

      (2) Variant: c.6764G>T (p.Ser2255Ile)

      (2) CAID: CA202970

      (2) gnomAD: 0.4845 (gnomadv4.0.0, Grpmax Filtering AF, African/African-American) https://gnomad.broadinstitute.org/variant/1-93996161-C-A?dataset=gnomad_r4

      PMID:31618812 Gene:ABCA4 HGNC:34 General CAID:CA202970 Individual CAID:CA119132 MONDO:0019353 inferred_gene_hgnc:34 inferred_gene_source:hgnc_tag ClinGen ABCA4 Annotations
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    ncbi.nlm.nih.gov/pmc/articles/PMC6835540/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Psychophysical Measurement of Rod and Cone Thresholds in Stargardt Disease with Full-Field Stimuli
    1
    1. Vibhor 15 Sep 2026
      13. 34/F31.021.06OD−68.3−23.32p.Gly818Glu; p.Cys1488Arg

      Case#: Pt 13, 34yo, female

      DiseaseAssertion: Stargardt

      FamilyInfo: n/a

      CasePresentingHPOs:

      CaseHPOFreeText: stage 3 (resorbed flecks), logMAR acuity: OD=1.02 OS 1.06, FST Rod Blue Stimulus (dB) OD= −68.3, FST Cone Red stimulus (dB) OD=−23.3, FST Group 2 (elevated cone and normal rod FST thresholds)

      CaseNotHPOs:

      CaseNotHPOFreeText:

      GenotypingMethod:

      PreviouslyPublished:

      Variant: p.Gly818Glu; p.Cys1488Arg

      ClinVar: 99135

      CAID: CA227000

      SupplementalData: n/a

      ClinVarID: 99135 CA227000 CaseInfo Individual inferred_gene_hgnc:34 inferred_gene_source:CAID ClinGen ABCA4 Annotations
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    ncbi.nlm.nih.gov/pmc/articles/PMC4145077/
  40. www.youtube.com www.youtube.com
    Stop Buying Field Notes.
    1
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    youtube.com/watch
  41. worldclass.regis.edu worldclass.regis.edu
    The%20Political%20Economy%20of%20Health.pdf
    2
    1. RebeccaO 15 Sep 2026
      However, regardless of vote choice, there does seem to be a closeconnection between good health and political participation. Numerous studies have found thata range of illnesses lead to depressed likelihood of voting at the individual and aggregate levels,with the magnitude of effects often similar to or greater than that of traditional predictors (

      Poor health may create another barrier to political participation. When people experiencing illness are less likely to vote, their needs may also be less represented in decisions about health care and public health policies. This shows how health and political participation can influence each other.

    2. RebeccaO 15 Sep 2026
      It matters not only that (some) people are able to vote, but also who they vote for, whoseinterests their representatives promote in policy, and whether politicians can in fact achieve theirpolicy goals.

      This explains how voting can eventually influence health outcomes through policy decisions. Having the right to vote is important, but the policies supported by elected officials can also determine access to health services, funding, and other resources that affect population health.

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    worldclass.regis.edu/content/enforced/387174-AN_NR455_AN01_26FSEM/The Political Economy of Health.pdf
  42. www.youtube.com www.youtube.com
    Most Pencils Are Terrible. Here Are 6 You Should Actually Buy.
    1
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    youtube.com/watch
  43. worldclass.regis.edu worldclass.regis.edu
    Preventing Chronic Disease
    2
    1. RebeccaO 15 Sep 2026
      Nationaltrends can be measured by using any of these data sources,state trends can be measured by using NVSS and BRFSS,and county trends can be measured by using NVSS.

      Using data at national, state, and county levels helps show how health outcomes may differ depending on the population being examined. For nurses, recognizing these trends can help identify health concerns that may require more focused prevention and community interventions.

    2. RebeccaO 15 Sep 2026
      “No single measure can capture the health of the nation”(24)

      Population health cannot be fully understood through one measure alone. Looking at life expectancy, mortality rates, disease patterns, and disparities together provides a clearer picture of a population’s health. Using multiple measures can also help identify communities that may need additional resources or targeted interventions.

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    worldclass.regis.edu/content/enforced/387174-AN_NR455_AN01_26FSEM/Measuring Population Health Outcomes.pdf
  44. 4cd.instructure.com 4cd.instructure.com
    Hypothesis Assignment Reading: Analyzing and Writing about Film and Media: 3251 - Intro to Film/Media Arts
    1
    1. mbarbadillo451 15 Sep 2026
      interpretive claim above might begin by describing how the film’s exposition introduces Lale’s teacher, who is a significant figure in her life. This introduces a pattern that carries through the rest of the film: Lale seeks assistance from important figures outside her family.

      The interpretive claim sounds like how a film critic content creator breaks down an analysis of a movie's themes.

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    4cd.instructure.com/courses/125091/pages/hypothesis-assignment-reading-analyzing-and-writing-about-film-and-media
  45. worldclass.regis.edu worldclass.regis.edu
    Population Health for Nurses
    2
    1. RebeccaO 15 Sep 2026
      Global nursing is the use of evidence-based nursing processes to promote sustainable planetary health andequity for all people. Global nursing considers social determinants of health, [and] includes individual andpopulation-level care, research, education, leadership, advocacy, and policy initiatives.

      This passage shows that nursing extends beyond direct patient care. Nurses can influence population health through education, advocacy, research, and policy. Understanding social determinants of health is also important because it helps nurses recognize the barriers that may contribute to health disparities among different populations.

    2. RebeccaO 15 Sep 2026
      Social determinants of health are additional factors that influence the health of populations, families, andindividuals. Social determinants of health are conditions and social factors that affect outcomes and risk related tohealth, functioning, and quality of life. Conditions or factors in hospitals, clinics, workplaces, homes, towns andcities, schools, and beyond influence health outcomes for the population. Economic stability, education access andquality, health care access and quality, neighborhood and built environment, and social and community context arefive domains that shape the social determinants of health (Office of Disease Prevention and Health Promotion,2022). Please see Social Determinants Affecting Health Outcomes for a comprehensive discussion of socialdeterminants of health

      This section stood out to me because it shows that a person’s health is influenced by much more than medical treatment. Factors such as income, education, access to health care, and the environment can affect health outcomes. As a nurse, understanding these factors is important because patients may face barriers outside of the hospital that affect their ability to follow a treatment plan or maintain their health.

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    worldclass.regis.edu/content/enforced/387174-AN_NR455_AN01_26FSEM/What is population health.pdf
  46. dion.vc dion.vc
    Dion
    4
    1. devilboi 15 Sep 2026

      Цели бизнеса должна быть напрямую связаны с целями проекта.

      проект делает то, что помогает бизнесу добиться своих целей.

      проект должен цель удовлетворить потребность пользователей.

      ох мне придётся изучать боли пользователей.

      полездно было бы записывать вопросы, чтоб потом было более интересно

    2. devilboi 15 Sep 2026

      proxor - это про операционные ценности. я автоматизирую работу Никиты.

      ценность мой проект имеет для него, но что вот дальше?

      какую ценность еще он моежт дать в будущем?

      какая может быть по итогу цель всего проекта? ускорить и автотизировать.

    3. devilboi 15 Sep 2026

      ит проект - нужны постоянно новые технологии. требования постоянно могут меняться.

      Нужно разговаривать на одном языке

    4. devilboi 15 Sep 2026

      Сроки - это фундамент.

      от срока завият ресурсы.

      до 1949 это проект. дальше операционная деятельность.

      ит-проект создаёт ит-продукт

      ит-услуга - это поддеркжа ит-продукта в течении долгого времени

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    dion.vc/event/ddpopov-pm_urfu
  47. www.dailykos.com www.dailykos.com
    The Psychology of Conservatism: Why Do People Keep Voting for Republicans?
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    dailykos.com/stories/2026/9/13/800079546/community/the-psychology-of-conservatism-why-do-people-keep-voting-for-republicans/
  48. callyzer.co callyzer.co
    How to Spot Low-Quality Leads in 10 Seconds
    2
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    callyzer.co/blog/the-real-roi-of-call-tracking-for-indian-automotive-dealerships/
  49. worldclass.regis.edu worldclass.regis.edu
    A%20(Brief)%20History%20of%20Health%20Policy%20in%20the%20United%20States.pdf
    2
    1. RebeccaO 15 Sep 2026
      Despite these gains, millions of Americans remain uninsured (see figure 2). Some are eligible forsubsidized coverage via Medicaid or the Marketplaces but have yet to enroll, or have lostcoverage. The Marketplaces offer challenges (i.e. a perceived lack of affordable options). 17Despite subsidies, affordability remains a barrier for some, especially those at the higher end ofincome ranges eligible for subsidies. Others are not eligible for subsidies at all, due to having anaffordable offer of employer insurance, or being part of the “family glitch:” if an employer-sponsored plan satisfied the affordability threshold for that year, the entire family becomesineligible for subsidies, even if a family plan through the employer would cost more than theaffordability threshold.

      This stood out to me because having health insurance options available does not necessarily mean that everyone can afford or access them. Eligibility requirements and the cost of coverage can still leave families without insurance. This shows how the structure of the U.S. health care system can contribute to differences in access to care.

    2. RebeccaO 15 Sep 2026
      Figure 2. The US Uninsured Population, by Subgroup, 2018

      I found this figure helpful because it shows that people can be uninsured for different reasons rather than one single cause. Some may qualify for assistance but remain unenrolled, while others may not qualify for subsidies. It makes me think about how complicated navigating health insurance can be for patients.

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    worldclass.regis.edu/content/enforced/387191-AN_NR455_AN02_26FSEM/A (Brief) History of Health Policy in the United States.pdf
  50. worldclass.regis.edu worldclass.regis.edu
    The Neoliberal Turn in American Health Care
    2
    1. RebeccaO 15 Sep 2026
      But could health care reform be forever deferred? As long as the ranks of theuninsured continued to grow, the presence of market failure was impossibleto deny, and the door would be left open to calls for universal health care.Furthermore, health care expenditures actually continued to accelerate during the2000s, further weakening the defense of the status quo. As soon became clear,the sort of health care system that neoliberals wanted—a “consumer-driven”system with an abundance of private insurance plans with high out-of-pocketexpenses—wasn’t necessarily mutually exclusive with a system of almost-universal health care.

      I found this interesting because it shows how rising numbers of uninsured people and increasing health care costs created pressure for reform. It also makes me wonder whether expanding insurance is enough if patients still face high out of pocket expenses.

    2. RebeccaO 15 Sep 2026
      The “consumer-driven health care” movement emerged directly from the“moral hazard” idea that people had to play with their own money when it cameto health care. As told by Jost in Health Care at Risk, its proponents have wonseveral policy achievements in recent decades, some of which were actuallyfirst championed by neoliberal think tanks.

      This stood out to me because making patients responsible for more of their health care costs may encourage careful spending, but it can also make people delay needed care because they cannot afford the out of pocket cost.

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    worldclass.regis.edu/content/enforced/387174-AN_NR455_AN01_26FSEM/The Neoliberal Turn in American Health Care.pdf
  51. www.youtube.com www.youtube.com
    What Reading Out Loud Does to Your Brain
    1
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  52. worldclass.regis.edu worldclass.regis.edu
    The%20US%20Health%20Care%20System.pdf
    2
    1. RebeccaO 15 Sep 2026
      Much research has shown that individuals without health insurance are less likely to seekpreventive medical care such as medical checkups (especially Pap smears and mammograms for women,and prostate cancer screening for men) and immunizations and are less likely to see a medical providerwhen sick (or they wait until they are very sick when the benefits of early detection are lost). They areless likely to have a regular source of medical care and are more likely to see a different provider on eachvisit.

      This stood out to me because having insurance affects more than whether a person can pay for care. Without a regular provider, patients may have difficulty receiving consistent follow up and preventive care.I think continuity of care is especially important for patients with chronic conditions because changes in their health may be missed when they repeatedly see different providers.

    2. RebeccaO 15 Sep 2026
      The lack of personal financial resources to pay for medical care and the lack of health insurance havea profound effect on the health of individuals and families.

      This stood out to me because lack of insurance can affect more than whether a patient can pay a medical bill. It can cause patients to delay preventive care or wait until they are much sicker before seeking treatment. As a nursing student, this makes me think about how access to care can directly affect patient outcomes and health disparities.

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    worldclass.regis.edu/content/enforced/387174-AN_NR455_AN01_26FSEM/The US Health Care System.pdf
  53. www.youtube.com www.youtube.com
    UsefulCharts
    1
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    youtube.com/channel/UC7o-UFkoAPCoKxpKOfrs4zQ
  54. en.wikipedia.org en.wikipedia.org
    The Swerve - Wikipedia
    1
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    en.wikipedia.org/wiki/The_Swerve
  55. cure53.de cure53.de
    pentest-report_peergos.pdf
    1
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    cure53.de/pentest-report_peergos.pdf
  56. time.com time.com
    Books: HitParade: 1895-1945
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    time.com/archive/6599995/books-hitparade-1895-1945/
  57. math.libretexts.org math.libretexts.org
    1.3: Using Letters to Symbolize Assertions
    1
    1. sky1381 15 Sep 2026
      In the remainder of this , we will discuss a logical language called . It provides a convenient way to describe the logical relationship between two (or more) assertions, by using capital letters to represent assertions. Considered only as a symbol of , the letter A could mean any assertion. So, when translating from English into , it is important to provide a symbolization key that specifies what assertion is represented by each letter.

      The name of the logical language and the symbol type A is supposed to be are never specified.

      Based upon 1.4, the name is probably supposed to be 'propositional logic.'

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    math.libretexts.org/Bookshelves/Mathematical_Logic_and_Proof/Proofs_and_Concepts_-_The_Fundamentals_of_Abstract_Mathematics_(Morris_and_Morris)/01:_Propositional_Logic/1.03:_Using_letters_to_symbolize_assertions
  58. www.nonviolent-conflict.org www.nonviolent-conflict.org
    The Success of Nonviolent Civil Resistance | CNCR
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    nonviolent-conflict.org/resource/success-nonviolent-civil-resistance/
  59. thewasteland.info thewasteland.info
    Current - T. S. ELIOT
    1
    1. jjackson27 15 Sep 2026
      What are the roots that clutch, what branches grow Out of this stony rubbish? Son of man,

      This is a vital passage, relating T.S. Eliot's understanding of poetry as dramatic human condition(s). I will discuss these lines in my conclusion, however, they (like much of this text) exist in duality: "roots" in reference to a sanctified humanity, and the anarchist nature of natural (mortal) life.

      First, I refer to Rupert Brooke's AN UNUSUAL YOUNG MAN. In response to the tragedy of warfare, the man (titled 'friend') summits a "hill of gorse" and sits alone "looking at the sea. His mind... full of confused images, and the sense of strain." Explicitly outlined, the man is pensive, in reflection and torture. His ascension to the top of a "Gorse hill," a yellow-petaled flower with a prickly body, mirrors a rite or religious ritual; willingly, almost obligatorily, he subjects himself to the prickles to contemplate while overlooking a vast and supreme ocean. (Two parallel symbols of human waste and the consummate eternal (ocean).) While this image alone holds weight, when applied to Eliot's theory of impersonality, however, the man aids in developing a recurrent motif of war.

      In the excerpt's following lines, the man's mental decrepitude (figurative)—illustrated by his irrational change in nationality & pledge to European nations—turns him into a symbol and actor in Eliot's theory of the Impersonal poem.

      Outlined as the condition of "Impersonality," a poem must elicit its designed visceral, bodily response separate from its creator. That is, a poem must largely function autonomously (this is at least one interpretation). As Eliot articulates, "the more perfect the artist [of the poem], the more completely separate in him will be the man who suffers and the mind which creates; the more perfectly will the mind digest and transmute the passions which are its material (Eliot, "Tradition and the Individual Talent"). Extended to Rupert Brooke's An Unusual Young Man, This character of poetry seems manifest in the protagonist. The man is the mind upon which war, as a poem, acts. With this analogy, war becomes a perfectly self-sustaining entity; war is the poem and the artist, and by their effect, the man ('friend') will "transmute the passions which are its [wars, not his own] material."

      With this, it's possible to equate the lines, “What are the roots that clutch, what branches grow/ Out of this stony rubbish? Son of man,” as man’s (humankind’s) roots that so tenuously clutch out “stony rubbish” body and mind and creator. Under the spell of war, man must transmute its passions—those of our own; those passions that drive humanity (in all its sectors, from barbarity to sophistication)—into something greater than its parts. Though, this is a puzzle the poem and excerpt do not willingly reveal: in deep thought, the man (‘friend’) concludes, “Something was growing in his heart, and he couldn't tell what.”

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    thewasteland.info/new-2/
  60. www.bbc.com www.bbc.com
    The '3.5% rule': How a small minority can change the world
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    bbc.com/future/article/20190513-it-only-takes-35-of-people-to-change-the-world
  61. en.wikipedia.org en.wikipedia.org
    3.5% rule - Wikipedia
    1
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    en.wikipedia.org/wiki/3.5%_rule
  62. www.mcgill.ca www.mcgill.ca
    The History of Hysteria
    1
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    mcgill.ca/oss/article/history-quackery/history-hysteria
  63. www.bbc.com www.bbc.com
    'Gender fluidity': The ever-shifting shape of identity
    2
    1. JayGlenn 15 Sep 2026
      on days when Hernando outwardly presents as more feminine, they don’t necessarily identify with being a woman.

      In another quote, the author explains, "on days when Hernando outwardly presents as more feminine, they don’t necessarily identify with being a woman. Here is an example of the gender fluidity dynamic. We are given context of how Hernando could feel a certain way but won't feel the need identify. I believe this is a good way for those to not feel pressured into these norms.

    2. JayGlenn 15 Sep 2026
      Everyone whom BBC Worklife spoke with for this article described gender fluidity in slightly different ways, but they all landed on roughly the same idea: it indicates that gender “is not a fixed point”, as Powell puts it, but rather flexible and able to shift depending on various factors, both within a person’s internal self as well as their external surroundings.

      The author states, "gender is not a fixed point, as Powell puts it, but rather flexible and able to shift depending on various factors, both within a person’s internal self as well as their external surroundings" (Klein). This quote stood out to me because it summarizes gender fluidity. The quote also establishes that there are many gender fluid minorities may have their own definition. It helps everyone understand the concept better.

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    bbc.com/worklife/article/20220914-gender-fluidity-the-ever-shifting-shape-of-identity
  64. www.gutenberg.org www.gutenberg.org
    On the Origin of Species, 1st Edition by Charles Darwin
    3
    1. clarajohnsonn 15 Sep 2026
      Why, again, do whole groups of allied species appear, though certainly they often falsely appear, to have come in suddenly on the several geological stages?

      Darwin realizes that the fossil record does not align with his views on the gradual evolutionary tract. I think this is important how he reflects on his own work even though it proves him wrong. This sentence really shows how Darwin thinks as a scientist rather than arguing that evolution is an established fact. I also did some digging to find more information on the Silurian system and it seems that Darwin already had a strong foundation for geology before he set out on his voyage due to all the geology references in this reading.

    2. clarajohnsonn 15 Sep 2026
      A grain in the balance will determine which individual shall live and which shall die,—which variety or species shall increase in number, and which shall decrease, or finally become extinct.

      I know that this quote is famous but I still find it very touching and eye opening. Even the tiniest of advantages one animal has over another can mean life or death for that individual. I remember learning about the peppered moths in first year anth100 and I think this is a really great example of Darwin's point. A small difference in colouration could determine whether a moth is camouflaged from predators or easily spotted. As Darwin states in this paragraph, one small trait such as the colouration of a moth can lead to major impacts on the species as it evolves.

    3. clarajohnsonn 15 Sep 2026
      So that, on the one hand, considerable changes in the conditions of life and crosses between greatly modified forms, lessen fertility; and on the other hand, lesser changes in the conditions of life and crosses between less modified forms, increase fertility.

      I find it mind blowing how Darwin came up with this theory without knowing anything about genomics or chromosomes. As we now know, sterile hybrids created by two separate species are sterile because of genetic incompatibilities such as a difference in chromosome numbers or structures. Despite not having any access to this information, Darwin still came up with this majour breakthrough in science that was the foundation for modern biology!

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    gutenberg.org/files/1228/1228-h/1228-h.htm
  65. idaho.pressbooks.pub idaho.pressbooks.pub
    Chapter 6: Document Design and Visuals
    1
    1. HaileyGreen 15 Sep 2026
      CRAP tells you to put related things close together (proximity) and to make like things look alike (repetition), but it does not explain why those moves work. The Gestalt principles, which come from early-twentieth-century perception research, do. They describe how the human eye automatically organizes what it sees into groups and wholes, before conscious thought. A handful matter most for document design: Proximity: elements placed near one another are read as related. (This is the same insight CRAP borrows.) Similarity: elements that share a color, shape, size, or font are read as belonging together, even when they sit far apart. Continuity: the eye follows lines and alignments and expects them to continue, which is part of why alignment feels orderly. Closure: the eye fills in gaps to perceive complete shapes, which is how a logo made of fragments still reads as a whole. Figure and ground: we separate a foreground object from its background, which is the work that white space and contrast quietly do. Common region: elements inside a shared boundary, such as a box or a shaded panel, are read as a group even without proximity.

      This is a great checklist to use when proofread, peer review, and just review any type of work. It makes things easier to read as well as scan.

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    idaho.pressbooks.pub/intelligenttechcomm/chapter/chapter-6-document-design-and-visuals/
  66. pressbooks.pub pressbooks.pub
    The Eighth Remove – The Open Anthology of Earlier American Literature: A PSU-Based Project
    2
    1. Elb1118 15 Sep 2026
      I could hardly bear to think of the many weary steps I had taken, to come to this place.

      At some points it seems like she is at ease with her situation, at some points she is disgusted. Very back and forth forth emotionally

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    pressbooks.pub/openeal/chapter/the-eighth-remove/