DOI: 10.1002/1873-3468.70462

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DOI: 10.1002/1873-3468.70462

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What is this?

DOI: 10.1002/1873-3468.70462

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What is this?

DOI: 10.1002/1873-3468.70462

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What is this?

DOI: 10.1002/1873-3468.70462

Resource: RRID:BDSC_28894

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What is this?

DOI: 10.1002/1873-3468.70462

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What is this?

DOI: 10.1002/1873-3468.70462

Resource: RRID:BDSC_43633

Curator: @scibot

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What is this?

DOI: 10.1002/1873-3468.70462

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What is this?

It should be noted that this does not work for everyone or even most people. It takes you around in a loop on other devices before pretending your name doesn't exist, basically just acting as a way to insert itself into other devices of yours. There are whole publicized conversations in other places where people come in to complain they cannot get back into their X name after doing everything that is asked. Before I came to this point, I was TYL80737692 in the X community (and if all goes well, I still am). I have made myself memorabilia just in case the complete removal occurs that happens when someone is inactive for more than 30 days. This is the recommendation.

DISCORD: Which are literally shaped like books, which you can flip through!

DISCORD: My files include lots of former characters from Care Bears, a few Supermarionation series and - dare I say it - those scary giant transforming robots ponies aren't allowed to be friends with. Most of them are autistic bronies who are dead by now.

DISCORD: That shredder was literally....snorts with laughter THE Shredder, from the '80s Ninja Turtles cartoon! He's a friend of mine, you know!

ME: If only I can, with all my favourite characters.

• DISCORD: Oh don't worry, darling, someday I will help you find peace with the other ponies and rescue agent outsiders you call 'family'.

And thus, Pinkie Pie and her dragon Flash, not to mention her alligator, Gummy, gained a new best friend.

DISCORD: Well Rainbow Dash loves playing video games, and Pinkie loves baking, so Fluttershy so loves gardening. Isn't it a nice surprise how I help her plant the prettiest roses?

DISCORD: You know my home. Everything is upside down there - the furniture, the fridge, even the drinks and cakes are upside down.

• The Mane 6: "HOORAY!"
• Discord bows

DISCORD: "That is, if the bin turns out to be a giant frog, who swallows your rubbish and then burps it back out as new comics!"

HIs view is technically not fully nature because this particular element is related to social influences of the environment.

It is labeled nature because he believed the primary reason for language development was innate. Not that it was 100% just nature.

Copilot's explanation:

"Chomsky's view A baby is born with: * An inborn Language Acquisition Device (LAD) * Built-in rules for understanding grammar * A natural tendency to learn language.

The environment only provides the specific language."

Case#: Patient #32, male, 60yo at baseline visit, "late" age of onset

DiseaseAssertion: ABCA4-related retinopathy with secondary RPE atrophy

FamilyInfo: n/a

CasePresentingHPOs:

CaseHPOFreeText: Inclusion criteria were defined as 1) presence of at least one mutated allele in ABCA4 (NM_000350.2) in Sanger sequencing with multiplex ligation-dependent probe amplification analysis or next-generation sequencing 2) a compatible phenotype with flecks at the level of the RPE consistent with ABCA4 -related Stargardt disease 3) presence of RPE atrophy, and 4) serial examinations with an interval of at least 6 months. RPE atrophy to the end-stage (i.e., demarcated lesions with ≥90% darkness of the optic disc under short-wavelength excitation light, DDAF) that previously showed highest interreader agreement.7 The size of DDAF has to be at least 0.05 mm 2 (each single atrophic area in cases of multifocality), and the entire lesion must be completely visualized on the AF image at each visit to be advanced for analysis. Self-reported symptom onset into early-onset (≤10 years), intermediate-onset (11–44 years), and late-onset (≥45 years). ff-ERG based Category: Group 1 contained eyes with normal scotopic and photopic responses; Group 2, eyes with normal scotopic responses, but reduced (over 2 SDs) photopic B-wave and 30-Hz flicker amplitudes; and Group 3, eyes with impairment of both rod- and cone-driven responses. BCVA: OD=0, OS=0 [LogMAR] .

CaseNotHPOs:

CaseNotHPOFreeText: Insufficient pupil dilation, additional retinal pathology, previous retinal treatment, or other ocular comorbidities substantially affecting image quality led to exclusion from the study

GenotypingMethod: Sanger sequencing with multiplex ligation-dependent probe amplification analysis or next-generation sequencing

PreviouslyPublished: n/a

Variant: allele 1: c.52C>T/p.(Arg18Trp) // c.1715G>A/p.(Arg572Gln) // c.2828G>A/p.(Arg943Gln) allele 2: c.1588G>A/p.(Gly863Ala) // c.5603A>T/p.(Asn1868Ile)

ClinVar: 7900

CAID: CA226918

SupplementalData: The supplemental table linked here contains genotype and phenotype information.

This variant was found in 92 of the 670 alleles in this cohort (Supplement 4). Supplement 5 has the individuals listed with their genotypes, but only mentions variants that were classified as VUS/LP/P, so it is unknown which individuals specifically had this variant or which other variants they also had.

This variant is listed for Stargardt DNAID#070982 in trans with c.4253+43G>A. No phenotype information provided. This genotype was also reported in PMID: 32619608 and the first author of that paper is listed under authorship for this paper. Cannot confirm this isn't the same individual

Case#: Family MD-0247 Proband, 12yo at onset

DiseaseAssertion: AR cone rod dystrophy

FamilyInfo:

CasePresentingHPOs:

CaseHPOFreeText: STGD diagnosed based on "bilateral central vision loss; fundus presenting with a beaten-bronze appearance and/or the presence of orange-yellow flecks in the retina from the posterior pole to the mid-periphery; fluorescein angiography showing typical dark choroid; and normal to subnormal electroretinogram (ERGs)." VA loss, VF loss, BCVA=0.05/0.1, cone-pattern on ERG

CaseNotHPOs:

CaseNotHPOFreeText:

PreviouslyPublished: Aguirre-Lamban et al. 2009 (8); PMID: 19959634

Variant: c.6410G>A (p.Cys2137Tyr); c.3386G>T (p.Arg1129Leu) found by ABCR400 + dHPLC + HRM

ClinVar: 2202779; 99224

CAID: CA341277358; CA227116

SupplementalData:

PMID:31836589

Gene: ABCA4

HGNC ID: 34

Case#: Patient 19, female, age 16

DiseaseAssertion: STGD

FamilyInfo: diagnosis of autosomal recessive STGD based on the pedigree and clinical phenotype of fleck deposits with or without genetic testing

CasePresentingHPOs: HP:0000608, HP:0000007, HP:0030610, HP:0030500

CaseHPOFreeText: Macular degeneration. autosomal recessive, Photoreceptor outer segment loss on macular OCT, Yellow/white lesions of the macula

CaseNotHPOs: n/a

CaseNotHPOFreeText: n/a

Genotyping Method: n/a

PreviouslyPublished: n/a

Variant: Allele 1: NM_000350.3:c.5714+5G>A Allele 2: NM_000350.3:c.4469G>A

ClinVar: Allele 1: NM_000350.3(ABCA4):c.5714+5G>A Allele 2: NM_000350.3(ABCA4):c.4469G>A (p.Cys1490Tyr)

CAID: Allele 1: CA227338 Allele 2: CA227198

SupplementalData: composite mask analysis shown in figure 3 for patient 19, show large areas of matched degeneration and isolated IS/OS loss

Case#: DNAID 072962/Pat272, male

DiseaseAssertion: STGD1

FamilyInfo: n/a

CasePresentingHPOs:

CaseHPOFreeText: "In classic STGD1, loss of central vision starts around the second decade of life, but both early- and late-onset subtypes have been extensively described." No patient-specific details provided

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: smMIPs sequencing of the complete ABCA4 locus

PreviouslyPublished: n/a

Variant: c.6416G>A (p.Arg2139Gln); c.6445C>T (p.Arg2149Ter)

CAID: CA956878

SupplementalData: tables s9 and s11

Case#: 14-year-old, female, asian (Chinese) patient

DiseaseAssertion: ABCA-4 associated retinal dystrophy

FamilyInfo: The effect of the deep intronic variant on splicing was validated by a minigene assay in our previous study (Tian et al., 2022). Co-segregation analysis result exhibited that the variant c.1222C>T p.(Arg408Ter) came from the female parent, and the deep intronic variant c.2919-884G>T p.[Phe973LeufsTer3,=] from the male parent

ParentalTesting: Co-segregation analysis result exhibited that the variant c.1222C>T p.(Arg408Ter) came from the female parent, and the deep intronic variant c.2919-884G>T p.[Phe973LeufsTer3,=] from the male parent

CasePresentingHPOs: HP:0000556

CasePhenotypeFreeText: ABCA4-associated retinal dystrophy

CaseNotHPOs: NR

CaseNotPhenotypeFreeText: NR

CasePreviousTesting:NR

GenotypingMethod:

In the present study, we recruited a 14-year-old female patient diagnosed with ABCA4-RD. Biallelic variants were found in this patient, including the nonsense variant c.1222C>T p.(Arg408Ter) detected by Sanger sequencing and the deep intronic variant c.2919-884G>T p.[Phe973LeufsTer3,=] identified by next-generation sequencing.

We isolated peripheral blood mononuclear cells (PBMCs) from the patient’s peripheral venous blood and introduced three episomal plasmids containing transcription factors OCT4, SOX2, NANOG, LIN28, c-MYC, KLF4, and SV40LT into PBMCs. The reprogramming iPSC line, named BIOi003-A, showed stabilized morphology (Fig. 1A) and a normal karyotype in culture (Fig. 1B). Then, the endogenous expression of two pluripotent biomarkers, POU5F1 and NANOG, was detected (Table 2). The expression levels were compared with human embryonic stem cell line H1(hESC-H1) and mesenchymal stem cell line P3 (MSC-P3) by qRT-PCR (Fig. 1C). Surface markers SSEA4 and TRA-1–81 were analyzed by flow cytometry (Fig. 1D). the ABCA4 compound heterozygous variants c.(1222C>T;2919-884G>T) p.[Arg408Ter;Phe973LeufsTer3,=] were verified by Sanger sequencing (Fig. 1E). Furthermore, the teratoma assay exhibited the differentiation capacity of this iPSC line in vivo (Fig. 1F). Short tandem repeats (STR) analysis exhibited that the PBMCs and the iPSC line came from the same patient. PCR proved negative for mycoplasma contamination

Variant: NM_000350.3(ABCA4):c.1222C>T (p.Arg408Ter) and NM_000350.3(ABCA4):c.2919G>T (p.Leu973Phe)

LegacyVariant: c.1222C>T (p.Arg408Ter) and c.2919G>T (p.Leu973Phe)

ClinVar: 99035 and NR

CAID: CA179692 and CA341275270

gnomeAD: 1:94544895 G / A and NR

MultipleGeneVariants: No

PreviouslyPublished:No

AdditionalInfo: One patient was homozygous at the ABCA-4 gene, so there is information about both variants in one annotation because there is only one patient.

Case#: Patient 23, Female

DiseaseAssertion: STGD

FamilyInfo: Not evaluated

CasePresentingHPOs: HP:0000609, HP:0012632, HP:0007906

CaseHPOFreeText: The patient also had a history of bilateral optic nerve hypoplasia, labile intraocular pressure (IOP), and ocular hypertension without glaucoma.

CaseNotHPOs: n/a

CaseNotHPOFreeText:n/a

Genotyping Method: Not listed

PreviouslyPublished: n/a

Variant: p.Arg2107Cys:c.6319C>T and p.Gly607Arg:c.1819G>A

ClinVar: 635988, 99087

CAID: CA956906, CA226936

SupplementalData: Phenotype shown in case report with continued treatment below

Case#: Patient 37 yo, F, Eastern Asian, onset at 8yo (early onset), Heterozygous, AR inheritance patterns

DiseaseAssertion:Retinitis Pigmentosa (RP)

FamilyInfo: Two brothers with RP and father with poor vision at 30 yo but no formal diagnosis

CasePresentingHPOs: HP:0003581, HP:0007737, HP:0000510, HP:000133

CaseHPOFreeText: N/A

CaseNotHPOs: HP: 0000007, HP:0007663, HP:0000505, HP:0000662

CaseNotHPOFreeText: N/A

Genotyping Method: N/A

PreviouslyPublished: Panel of genes; RP1L1, RP-GRIP1, ABCA4, and GRM6

Variant: c.5501T>C p.(Met1019Ille)

ClinVar: 1481089

SupplementalData: see tables 1 and 2 for genetic variant panel

Supplementary table 4 contains this variant, but this table is for single variants found in a recessive gene. Thus, PM3 would not be able to be used and neither would PP4

Case#: Patient#010633, Chinese, female, 20yo at onset

DiseaseAssertion: stargardt

FamilyInfo: n/a

CasePresentingHPOs: STGD1 diagnosis based on the following criteria: "a bilateral central vision defect; fundus displaying a beaten-bronze appearance and/or orange-yellow flecks in the retina from the macula to the midperiphery; fluorescein angiography presenting with a typical dark choroid; and normal to subnormal ERG results." BCVA=0.05/ 0.05

CaseHPOFreeText:

CaseNotHPOs:

CaseNotHPOFreeText:

PreviouslyPublished: n/a

Variant: p.P2097S; c.3468C>G p.(Tyr1156*) phase unknown

ClinVar: 2202780;

CAID: CA341277622;

SupplementalData: supplementary table S4 has phenotype information

Case#: 1

DiseaseAssertion: stargardt disease originally but didn;t have fishtail flecks

FamilyInfo: both unaffected parents carrying heterozygous MFSD8 variants

CasePresentingHPOs:HP:0001272

CaseHPOFreeText:at 5 years old BCVA was measured at a Snellen equivalent at 0.13 in both eyes, at age 8, BCVA had decreased to 0.07 in both eyes, complete absence of all retinal responses on full‐field flash ERG, No fishtail flecks typical of Stargardt disease were observed

CaseNotHPOs: n/a

CaseNotHPOFreeText:n/a

Genotyping Method: HaloPlex target enrichment kit amplified and sequenced using illumina, then WES

PreviouslyPublished: n/a

Variant: c.3113C>T p.(Ala1038Val)

ClinVar: https://www.ncbi.nlm.nih.gov/clinvar/variation/7894/

SupplementalData: MFSD8 variants identified

Case#: Family MD-0247/ARDM-247 Proband, 12yo at onset

DiseaseAssertion: AR cone rod dystrophy

FamilyInfo:

CasePresentingHPOs:

CaseHPOFreeText: STGD diagnosed based on "bilateral central vision loss; fundus presenting with a beaten-bronze appearance and/or the presence of orange-yellow flecks in the retina from the posterior pole to the mid-periphery; fluorescein angiography showing typical dark choroid; and normal to subnormal electroretinogram (ERGs)." VA loss, VF loss, BCVA=0.05/0.1, cone-pattern on ERG

CaseNotHPOs:

CaseNotHPOFreeText:

PreviouslyPublished: PMID: 19028736

Variant: c.6410G>A (p.Cys2137Tyr); c.3386G>T (p.Arg1129Leu) found by ABCR400 + dHPLC + HRM

ClinVar: 2202779

CAID: CA341277358

SupplementalData: n/a

Case#: Maia-Lopes Family 17 Proband 5137, Portuguese, 25yo at onset

DiseaseAssertion: STGD

FamilyInfo: Family 17

CasePresentingHPOs:

CaseHPOFreeText: moderate central fundus changes, vision: 3/10 / FC

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: ABCR400 microarray, dHPLC

PreviouslyPublished: n/a

Variant: ND / c.32T>C(1); ND/p.Leu11Pro

ClinVar: 99217

CAID: CA227106

SupplementalData: n/a

This variant was found in 2 control alleles. No additional details

Case#:2, 29-year-old woman

DiseaseAssertion:NR

FamilyInfo:NR

CasePresentingHPOs:

CaseHPOFreeText:decreased ability to focus, increasing difficulty to adapt in the dark, normal visual acuity in both eyes (logMar BCVA OD/OS: 0.02), PERG responses were diminished in both eyes.

CaseNotHPOs:

CaseNotHPOFreeText:

Genotyping Method: ”Analysis of the ABCA4 gene”

PreviouslyPublished:No

Variant:NM_000350.3:c.1805G>A, NM_000350.3:c.6079C>T

ClinVar: 99085, 7882

CAID:CA226933, CA119129

SupplementalData:

This variant is found on pg 2 in proband 11019. Compound heterozygous for c.4532C>A, (p.Pro1511His). JHU institute (US). Said to have Stargardt based on the following criteria: "(1) patients (at least 6 years old) with at least two ABCA4 variants or one ABCA4 variant associated with a typical STGD1 phenotype and (2) presence of a well-defined atrophic lesion with/without flecks at the most recent visit of at least 300 µm in diameter (the total area of all lesions <12 mm2)." No additional details provided

This variant is found on pg 21 in proband 13047. Compound heterozygous for c.5882G>A p.Gly1961Glu. Said to have Stargardt based on the following criteria: "(1) patients (at least 6 years old) with at least two ABCA4 variants or one ABCA4 variant associated with a typical STGD1 phenotype and (2) presence of a well-defined atrophic lesion with/without flecks at the most recent visit of at least 300 µm in diameter (the total area of all lesions <12 mm2)." No additional details provided

PMID: 16917483

Gene: ABCA4

Disease: Stargardt

This paper was referenced by PMID: 23755871 as containing variant c.6410G>A (p.Cys2137Tyr), but this variant foes not appear to be in the text or tables

Gen: Buyer bears the loss.

When item is lost through fortuitous event, when there is a perfected contract, buyer bears the loss.

XPN: When there is stipulation to the contrary. Delay/mora/fault in the delivery leaves seller with loss. If reservation of title, seller bears the loss.

Even when there is constructive delivery, but there is a stipulation that there must be actual delivery, seller bears the loss.

Capable of being made specific later even if it is not designated right away.

Tuossa on virhe. Valinta tehdään toimikaudeksi eli 4 vuotta. Eli p.o. 2029.

``` Thus like a Learned Conclave Poets sit, Catholique Judges both of Sense and Wit, And Damn or Save, as they themselves think fit. Yet those who to others faults are so severe, Are not so perfect but themselves may Erre. Some write Coract indeed, but then the whole

(Bating their own Dull stuff i'th' Play) is stole: As Bees do suck from Flowers their Honey dew, So they rob others striving to please you. Some write their Characters Gentile and fine, But then they do so Toyl for every line, ```

システムソフトウェアはデバイスの代替インターフェースを選択したことによるパイプのxHCの変化を知らせるためにConfigure Endpoint Commandを使います。通常は代替インターフェースセッティングはパイプのペイロードや帯域幅の変化要求に使われます、しかしそれは一つ以上の有効/無効パイプを使います。インプットコンテキストのインプットコントロールコンテキストはソフトウェアが有効/無効/代替インターフェースによって変更された/パイプを識別するのを許可します。有効/変更されたパイプ用のインプットエンドポイントコンテキストのパラメータはパイプセッティングに関係しますもしConfigure Endpoint Commandが完全に完了していない場合ソフトウェアはSET_INTERFACE要求をデバイスへ発行していません。

Configure Endpoint CommandはInput Contextを指し、xHC用の狙いのコンフィギュレーションパラメータを定義します。すべての正しいxHCの命令にとってすべてのエンドポイントは各エンドポイントコンテキストのインプットコンテキストで定義されたデバイスコンフィグレーションにより利用可能になり、エンドポイントコンテキストのパラメータはエンドポイントのセッティングと関係します。xHCとデバイスは適合しないとき未定義の振る舞いを見せます。これはConfigure Endpoint Commandが完全に終わっておらず、ソフトウェアがSET_CONFIGURATION要求をデバイスに発行していない場合を意味しています。

This is actually not that long ago!

treaties protect land and water rights

not able to afford neccessities

ethnic cleansing would be attempting to get rid of member through deportation , displacement or even masses of killings! This can be forced removal

Decolonization means breaking away from the unfair systems and ideas created by colonization. It means listening to Native people and respecting their land, culture, knowledge, and right to make their own choices. It also makes me wonder what schools can do besides giving a land acknowledgment to truly support local tribes.

This section emphasizes how Indigenous sovereignty is not something granted by the U.S. government but an inherent right that existed long before colonization. The chapter shows sovereignty as relational tied to land, culture, and community rather than just a political structure. This expands my understanding because I used to think sovereignty was mostly legal, but here it’s shown as something lived and practiced daily within Indigenous nations.

taking things through force and fear

sovereignty- key term.

Sovereignty means Native nations have the power to govern their own people without outsiders controlling every decision. Self-determination is how they put that power into action by creating their own courts, schools, and police departments. This connects to resistance because Native communities continue fighting to protect their rights, culture, and future.

Extremely important! Dr. Cutcha describes how California is like for the average woman today and how the significance of intergenerational truama doesn't just "hurt" the victim but affections generations to come and native people in California are deem sacred.

This is actually extremely important! Through what they plant and harvest comes from these very storytellings, it's what makes them, THEM. That's extremely interesting as they pass on their ways of living and expectations and overall beliefs through stories.

Important Information was passed down through generations? Does that mean it was more of story telling of their beliefs and other ideologies? I love how deeply rooted their are to the land that forms around them!

They believe they're one with the land, they find beauty and appreciation to any and all that's around them. They believe as they're created here so they shall remain here which stood out to me as something extremely beautiful.

This passage stood out to me because Indigenous stories carry real knowledge about the land, medicine, culture, and survival. That wisdom has been passed down through generations and should be respected just like knowledge taught in schools. It shows that education can come from the community and lived experience too.

I actually didn't know that the American Indian Studies had began in the late 1960s as an academic discipline like how black studies had started

★

★

a

★

★

Counterargument: Completely open borders would put our security at risk.

Response: The writer agrees that open borders could create some security problems. However, they argue that there are other ways to control the border without criminalizing immigrants.

The author believes that people sometimes cross the border illegally because they are in difficult or dangerous situations and want a better life for themselves and their families. The author understands that open borders could cause security problems, but believes there are better ways to handle immigration. Overall, the author thinks immigrants should be treated with respect, empathy, and understanding instead of being treated like criminals.

Definition of Bad Faith

In this day in age, we see a lot more of this in communities. A lot of communities will also have a shared political view on how things should work. I think this goes for the whole world but especially in America.

I feel like this is true for a lot of communities. You really do adopt different traits that come along with that community, weather you know or not. It makes you feel more connected with the community.

I never really thought about this statement and how true it is. When you are part of a community, you look back at that history and share those story's with other people. Looking back gives you a lot of information on what that community has gone though and what they are now.

I think this is true when it comes to politicians and officials. They say it a lot to feel like they are part of the community they are representing and trying to voice for. For me however, I think when they use it so much the meaning of community go's away.

When I think of community I think about having shared identity like this quote suggests. That it is more about shared experiences than anything else.

Can people still be part of the community even if they aren't proud of it like the author is? I feel like even if you aren't proud of it what surrounds you really influences who you are.

I think this point is interesting. I believe that even a group of people can be your community or your family can be part of it since they create a sense of belonging.

This is an interesting perspective that I have never heard before. I can see how community can be misused for bad. It kind of reminds me of how people fall into cults or bad leadership because they are lonely and promised the sense of community.

Example: “Social media can be harmful to teenagers.” This is a claim of value because it gives an opinion about whether something is good or bad.

Example: “Temperatures around the world are increasing because of climate change.” This is a claim of fact because it can be supported or challenged using evidence and data.

Example: “Schools should allow students to use their phones during lunch.” This is a claim of policy because it suggests what schools should do.

Does whether this question is considered rude depend on the culture or country? Could it be rude in one culture but normal in another?

This is a claim of fact because it is something that can be proven through research and evidence. It is arguable because saying that caffeine “boosts performance” is very general. For example, I am from San Lucas Tolimán, Guatemala, where coffee is very common and people drink it at different times of the day, even at night. Since coming to the United States, I have often heard people say that coffee helps when you are tired or need more energy. This makes me question what “boosts performance” really means and whether it works the same for everyone.

This shows how humans get used to a good thing and think that its basic needs but when they lose it they are distrought

The golden retriever has been alerted that they are playing catch

Some boy probably has swung from them at some point

They themselves are a ninny for using the word ninny

so a ruler whom rules with an iron fist

It is telling you to be kind in most instructions

https://www.facebook.com/groups/TypewriterCollectors/posts/10164123477489678/

The Sybil's words reflect a distinction that I think is present in both Heart of Darkness and Metamorphoses. As the prophetess aged and succumbed to frailty, her size became progressively more diminished, eventually enabling her imprisonment in a jar or a cage. Such an environment implicates constricting containment in a physical sense, though this rigidity is contradicted by the human voice. Due to the Sybil's relationship with Greek deities, her words were recognized and revered for their prophetic excellence and foresight. So, while the Sybil was physically imprisoned, her words contained a transcendental wisdom - arguably able to provide an escape from the stagnation and befuddlement of humanity's pursuits. A similar phenomenon occurs in Heart of Darkness, in that Kurtz's disseminated voice becomes an entity distinct from his body. Marlow references his voice as one of "purity," even acknowledging that his wonder for Kurtz relies not necessarily in the man but rather in the unique and wondrous properties of his voice. Indeed, when Kurtz dies, his voice does seem to carry a permanence that surpasses not just his infirm body, but also the corruption and horrors of human nature - represented by the colonizers and the tribes throughout the story. Lastly, in Metamorphoses, the priestess discusses how the fates will bequeath her a voice, even in transformation, even in nonexistence. Together, these three examples seem to evince a similar dichotomy: the physical (in this case the waste land) is subject to cyclical corrosion and decay, while the voice remains elevated on a plane that is semi-divine. It is perhaps this that the poem investigates very closely: language, in its purity, can provide a panacea, though its efforts may be insufficient to find salvation for the physical. The human voice is indefatigable - the human body and soul are not.

I found this line quite interesting upon reading the satyricon and ultimately I think it was a better choice to begin the text than the quote from Heart of Darkness. This is because I think this quote speaks to the overall themes of the text, those being a cultural stagnation and lack of spirituality, better than the other quote. In this, Trimalchio explains how he saw Sybil, the women who wished for eternal life without asking for eternal youth, in a cage, asking for death. I think this illustrates the idea that Elliot presents in the poem, that being that death is favorable to a life without purpose and spirituality. Thus, the people of England after World War 1 are likened to Sybil, trapped in cages, and better off dead than continuing their existences without faith.

Oops!

The "doll test" has been repeated even for the supreme court and still the preference and mindset that dark skin is bad and light skin is good is the mindset.

Due to the amount of melanin in their skin.

picture 7.2.1 seems to say to Guam, Philippines, etc... "And you're next" . Also they say the Indian chief still is learning by showing him read the book upside down.

Yet they had been caring for themselves and their communities long before they even knew of a "white" race. Portrayed like heroes coming to save the day end civilized the people. They became unfit due to all of their resources being stripped away.

How much of the risks would really be prevented if we implemented better cyber security practices.

If we are hearing everyone from Bill Gates to Jason Binoski say that AI is heralding our doom, why aren't we doing anything about it?

Has this always been the case? Adversaries have generally been more adept. I agree that it speeds up threat actors capabilities, but threat actors have always been more adept.

What is "operational reality"? I think for businesses, it is staying in the "green," so checking the boxes for programs and policies. Whereas, in the scope of the "defender's dilemma," the defenders users these programs and policies to their advantage.

How did you determine these arc lengths? Wasn't it necessary to use the angle to find the arc length? This argument is circular.

I wanted this as part of my notes for exponential models.

It's interesting to think how much ai has changed our lives. More interesting to me is how much will it grow in the future is there a ceiling to it? Or will it keep growing and growing until it's taken over everything.

This section would be better set up if you put the exponential growth/decay first, then the half-life/doubling-time. This is confusing to take notes from as it is and there's a lot of back-and-forth. The relation between y=a(b^x) and y=A_0e^(kt) was not made clear early enough.

This should have been written at the beginning of the section.

With no 0-value, I used the ratio of two points fitted into y=ae^(kx), found that 3.297/24.365=(ae^k)/(ae^(5k) yields k=.5, then used that information and the first point to determine a=2. Not much practice doing this prior to now.

What are b and c? How did you get from b^ct to e^(ln(b^ct))??

12 grams?

what is ln(1/2)=ktv?

-ln(2)k=t? shouldn't this be -ln(2)/k=t?

Found the information for the graphs previously shown.

Interested in why the points chosen were chosen, but not seeing anything about it.

This work was published in EMBO Rep. at https://link.springer.com/article/10.1038/s44319-026-00804-6

Will says:

I think this needs to be expanded on and provided in the Prolog

Will says:

I find this argument quite strong.

Will says:

Good summation. It simplifies the multi-step game theory to something quite get-able.

Will says:

“imagine doing this….”

I'm not so sure. Suggesting they try it might make them realize how hard it actually is(?)

Will says:

Liking this part, relatable

Will says:

Maybe. Though I suspect mostly it’s that he fears the darkness in himself and to convince himself he is good, he must point to others who are more bad. Just like you wrote earlier.

I agree (and fixed the wording a bit). The idea is that he fears that what he's doing is dark because you're redeemable / innocent. If you were just an object (like contempt says you are) then his behavior wouldn't feel dark.

Will says:

He’s not calling you going against your conscience, that’s the second stranger right? So not sure if this stands.

My response: yes, he doesn't know he's doing it, but he's doing it. That's what makes this section so hard to write: we have to track that he knows that you knows that etc.

Will says:

Might need to explain this a little. Like the kind of person who’s disingenuous, or unforgiving?

Will says:

To be honest, no, I genuinely can't recall such an event. I think this needs to be softened to hook the reader. The “at the time” is the main problem here. Perhaps: have you ever done something you felt justified in doing at the time but it left a vaguely bad taste in your mouth for some reason

Critical Race Theory is important to social work because it helps us understand how racism can go beyond individual beliefs and be built into systems and institutions. As a future social worker, this reminds me to consider how a client’s race and experiences with discrimination may affect their opportunities and access to resources. It also encourages me to advocate for fairness, challenge inequalities, and make sure my clients feel heard, respected, and supported.

Antigone loves Haemon and wishes that they could have a normal life together.

Etocles has become greedy for power. He refuses to follow the agreement with his brother.

The fight between the two brothers has raised conflict within their city, which shows how power can destroy a society,

The fear that Creon put in everyone including his own family is immense. Fear of punishment , death imprisonment is definitely great example of that power and control that Creon has over his peoples

The paragraph assumes that social policies outside of healthcare can have a significant impact on people’s health. Policies related to education, unemployment, and pensions may influence things like financial stability, access to resources, and overall quality of life, which can ultimately affect health outcomes.

The paragraph assumes that the way a public health system is organized and provides services may influence how well it performs and the health outcomes of the population. It also assumes that simply having the recommended public health services does not necessarily mean that a system is effective.

https://www.youtube.com/@Woodys-corner<br /> James Wood, typewriter collector<br /> aka u/Wooden_Underpants on Reddit aka elwoody.typewriters on Instagram

match via<br /> - https://www.reddit.com/r/typewriters/comments/1wbs1wq/day_in_the_life/ - https://www.instagram.com/p/DdEvO6Aol-j/?hl=en

I think this is a useful way to identify health disparities because it shows how much life expectancy and mortality can vary between different counties within the same state. Looking at these differences can help communities understand where additional health resources or interventions may be needed. I wonder which factors could contribute to such large differences in mortality rates between counties?

I think age-adjusted mortality rates are useful because they allow us to make more accurate comparisons between populations that may have different age distributions. Looking at specific characteristics like age, sex, or geographic location can also help identify which groups may be experiencing higher health risks. How could nurses use this information to identify health disparities and improve care within a specific population?

This stood out to me because population health focuses on improving the health of an entire group rather than treating one patient at a time. I think care coordination and population-level data are especially important because they can help identify common health problems, health disparities, and areas where communities need more support. As nurses, this reminds us that our role can extend beyond individual patient care to helping improve health outcomes across a larger population.

Yes, this is so accurate! I got my first undergraduate degree in public health, and it is all-encompassing. It is a very interesting shift to go from learning about macro health to conditions on an individual level. I feel like we are learning the physical and pharmacological aspects of nursing, but an individual's health involves so much more than just the issue at hand. As nurses, we must look at the patient using a holistic mindset, as opposed to the medical model. When I was deciding between pursuing the PA vs. NP route, I chose nursing for this very reason. We have to look at psychosocial factors and social determinants of health to truly understand our patients.

A solution to reduce carbon emissions can be using solar power instead of burning fossil fuels

This sentence shows that less trees equals less carbon.

This states that Methane is a stronger gas than carbon dioxide.

Again, I'm not sure why you would be running this check multiple times. If you always reported accuracy in the past n months of the cars with all the data, you'd better need a really strong prior to believe that you should filter out these exact training data matches, otherwise you're just p-hacking by doing multiple hypothesis testing (like treating each month as as new hypothesis for changing your reporting)

This sounds like you want the human to plan out exactly what computation to do and then asks the AI to do it. I feel like it's somewhat valid to just ask the AI the investigation question and then prompt based on what it gives you back.

I don't know if this is intended, but my first reaction to whether or not I would trust this paper didn't actually involve opening up the paper at all. It just involved going to Google Scholar and looking at where the paper was published and seeing that it has 1100 citations. I think if it was published in a good conference in 2021 and it has that many citations, it's probably trustworthy.

What is the delegation scenario?

Edit: Oh, I see now. It refers to step 4. I don't think we should call it the delegation scenario. It's kind of unclear.

Again, there's no way that you're going to allow people to not use AI here, right?

I don't think the teammate should read the session transcript. When you communicate results, I think you should be the meat proxy between your LLM and the person you are communicating to. Ideally, they would be unable to tell that you used an LLM at all

Why is using AI optional?

I feel like the goal should just be to recommend a model for the team to use, and what you're looking for is that the student should try to understand the model well. Though I think this also overlaps strongly with scenario 2, so you could delete it.

What does this mean? Need help understanding in what way?

Overall, I think there is too much text right now to read.

To me, when I see 87.8% and 86.2% so close together, I want to calculate the error bars on each of the individual accuracy scores (e.g. like the 95% Wilson confidence interval). If the error bars are on the order of 1% already just from re-sampling the data, then I personally wouldn't spend all that time trying to figure out which accuracy score to report, and I would just report either one of them with the error bars included, since it's just a difference of noise anyways.

I feel like we can delete this text. This should be common sense for the student / something that staff can catch during checkoffs if e.g. they claim a causal relationship or something, and it's not directly related to the data description.

so it's a 1-NN model (k=1). Might be good to just state that directly.

Edit: Oh, I see. There is a flag to change the value of k. I think this should be clarified up front.

validation? why development?

Does this just mean that each feature is normalized, or do you not subtract the mean?

Don't hyperlink here. It makes it seem like it's going to open up a new external page or tab

I don't see why the recurring script would be doing today's calculation though. The choice of whether to report with or without the exact training data matches should be a one-time decision, and then the recurring script should just always report with or without.

I feel like with 200 features you probably want to have the AI go through the features and help you filter down to a few that are more interesting that you can take a closer look at.

I think even more generally, learning the algorithm should be the first step. It might not be possible to verify the algorithm if it's like using a transformer or something.

Even ignoring the confidence interval thing, I feel like there's a right answer here, and the right answer is just to report the entire data set that you use for evaluation. I feel like the null hypothesis should be that you report everything and you need a reason to leave out the 11 cars with an exact training match. Comparing the matched records shows that it's not training data leakage, and cars with identical feature match in the training data don't necessarily have the same label.

Imagine you go up to your boss and you're like, "Hey, our model might do 87.8% good, and it might do 86.2% good, and this is with slightly different evaluation settings, which I don't really have a good concrete reason why I excluded some for the second statistic." I feel like you should just make a claim, state your uncertainty (ideally, quantitatively with error bars), and then take responsibility for the claim.

Probably no one is going to be this dumb, and your staff are smart enough to call out either of these proposals as bs

Single-blind: Only researcher knows who is being assigned to what group. Double-blind: Both the researcher and the participants don't know which group the participants will be put into.

A random sample is a subset of a larger population in which every member of the population has an equal chance of being selected. With random assignment, all participants have an equal chance of being assigned to either group.

Illusory correlations, or false correlations, occur when people believe that relationships exist between two things when no such relationship exists.

Longitudinal research: A research design in which data-gathering is administered repeatedly over an extended period of time. Very informative, but incredible time and financial investment. Sometimes, both participants and researcher cannot see these projects to their end. High attrition rate (reduction in the number of research participants due to dropouts)

In cross-sectional research, a researcher compares multiple segments of the population at the same time.

Archival research: Using existing records or data sets to try to answer various research questions, like looking for interesting patterns or relationships.

Surveys: List of questions to be answered by participants. Not the most accurate, but very good for getting a lot of information from a large sample size.

Naturalistic Observation is where the researcher will observe the subjects' behavior in its natural environment. Observer bias is a major problem in this type of research, where the subjects might change their behavior just because they are being watched.

Clinical/Case Studies are where scientists focus on one person or just a few individuals for their observational research.

Of course they don't. Go, Rust, and Zig are programming languages. Programming languages are neither fast nor slow. They're languages. They're inert. The author is conflating programming languages with compilers (or, really, compiler output), i.e. programming language implementations.

Nederland moet aktief eraan werken, om buitenlands beleid een Europeese competentie te maken.

Why are equation 4.6.4 and 4.6.5 the same?

'the unstable material' not before mentioned?

Kevin's discussion of learning environments was very helpful. I agree with having your own space to interact, collaborate, and work together. Also, I liked the discussion about how your desk is placed in your classroom. and on having enough room to walk between students' desks. It is a must-do. The reason is that I have been in so many classrooms, while subbing, and I can definitely tell a difference. And the one thing I like about subbing is being in the room where the students can see you, and you can see them. It makes it much easier to see what they are actually doing.

This was very helpful for arranging your classroom. The one I liked was the table arrangement. for high school. because it allows students to work in groups in the classroom rather than move their desks closer together.

I like this video. It is a great discussion on how to arrange your desk in the classroom.

Also read this prompt, right?

appears smaller, allso i didnt mean to set my name to that i meant to set that as my passcode.

As a reader, I feel like I start entering into the timeline and technical component without really understanding the context or what the real issues of concern are.

Therefore I would suggest putting in as a second slide some context before you go into 'The response begins"

I suggest the context cover:

First, I think you need a new slide something simple that helps the reader to understand the problem that satellite damage assessments solve, their limitations, and why that poses challenges to responders. For example, what used to happen after an earthquake (before we had these type of assessments)? What do these assessments help with (ie. to determine where to deploy SAR, potential people in need humanitarian assistance)? What are the downsides of satellite damage assessments (ie. foreshadow why you can have assessments that come up with such different levels of building damage, or why it might show a building damaged when it's not), And therefore why is it a challenge for humanitarian's that there are so many assessments now?

2) You need to briefly explain what the Centre's role was in Venezuela (later you reference a 'viewer') and its connection to Copernicus EMS. Otherwise you go straight into Copernicus and the reader doesn't understand why.

I didn't really understand this one, but as long as it's using language that evaluators understand that's fine.

Make each 'audience' in bold or brighter so it stands out.

What do you mean by 'reference is silent'

maybe put in the technical brief unless you think this will be widely understood.

? Meaning this is what we provided through the 'viewer' that can put all the assessments together?

This feels like it comes out of nowhere and it needs some clarity eg. "who had looked where" - meaning responders to see what satellite data was available? Part of what gap and what does 'nothing had planned for it'.

Perhaps this needs to be part of the beginning context - because this is the first time we're seeing what role the Centre had this.

Same area or had the same coverage? Cause there is a place where all six overlap.

Maybe this sentence could be reworded, I had to read it a few times to understand it.

The conclusion at the bottom of the graph is good and should be its own box to the side. Also does using the assessments then help to overcome the issue raised in the slide above that ranking by neighborhood only works where it's in an area already known to be damaged? If so, I think it should be clearer that by using the assessments together you can use it not only within a neighborhood to identify with greater confidence what buildings are damaged, but also in areas where you may not have an EMT deployed yet (presumably).

Postscript :) I see you then go back into the neighborhoods with the next slide.

This didn't make sense to me, so perhaps it needs to be reworded.

This part of the answer is good but then the caveat confused me - meaning we couldn't say the same for another area where EMS weren't on the ground verifying?

The Answer and the blurb at the bottom of the graph "Even on the most generous reading..." Is good. It needs to be its own box and pulled out. The answer is too buried. I want to see the answer and analysis before I look at the graph - it helps the reader to understand it.

Very good, it gives an idea of the challenge.

It took me a few reads to get this and I wonder if it's just a placement issue. I wonder if this would be better placed in the next section after the questions and before the baseline - meaning the first step is looking at where the assessments can be compared in relation to where Copernicus was operating.

I would also suggest deleting "manual mapping on very-high resolution imagery, not modeling). I don't think it's necessary to understand the story and so anywhere you can cut technical detail I would.

This is great, but give a bit more info as to why this is hard for humanitarians.

The S&R audience probably have a pretty good idea, but for those providing these assessments giving them a clear picture of why this is difficult - the types of decisions that have to be made and why having different assessments makes that harder – will be very helpful and eye opening to them. You want to give this audience the "ah-ha moment" now I get it why this would be hard.

This is quite technical, you could perhaps streamline to "Two further products arrived in the same window but are not evaluated here" and then put the note more detailed explanation in the methodology. The fuller explanation interrupts the flow.

suggest inserting "buildings" after the figure to keep it consistent with previous slides.

spell this out. There's a lot of acronyms so avoid where you can.

Not sure I understand this? Meaning it detects where there is debris tonnage or the data that comes from it giving an estimate of debris tonnage based on the damage?