Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease.
One of the few papers giving clear support to ivermectin as a prophylactic drug against covid19.
Has been partially refuted by politifact, and accused 1st author Andrew Bryant of hiding conflict-of-interest.
There was however a marked reduction of self-reported anosmia/hyposmia, a reduction of cough and a tendency to lower viral loads and lower IgG titers which warrants assessment in larger trials.
A well-structured research about non-severe case protocol pre-announced on Jun 2020 concludes that it reduces anosmia!
The respected paper abut in-vitro results of ivermectin against covid19
Based on the very low-certainty evidence for inpatients, we are still uncertain whether ivermectin prevents death or clinical worsening or increases serious adverse events, while there is low-certainty evidence that it has no beneficial effect regarding clinical improvement, viral clearance and adverse events. No evidence is available on ivermectin to prevent SARS-CoV-2 infection.
Study of trials by german researcher is dismissive of any therapeutic value.
IvermectinThis FDA-approved antiparasitic drug has demonstrated a degree of efficacy in vitro against SARS-CoV-2 infection (Caly et al., 2020; Yang et al., 2020), and uncontrolled, interventional studies have reported a degree of efficacy or no benefits (Amhed et al., 2020; Chachar et al., 2020; Khan et al., 2020). However, the NIH Panel indicates that there is insufficient evidence for COVID-19 treatment and recommended against its use (COVID-19 Treatment Guidelines Panel, 2022).
Big position-paper from Lincei Academy focusing mostly on other drugs, is NOT dismissive of ivermectin, provides x2 for in-vitro and x3 in-vivo refs, and repeats the FDA mantra at the end.
Interesting route of administration for ivermectine: nasal
Even though ivermectin had no effect on viral load, SARS-Cov-2-associated pathology was greatly attenuated. IVM had a sex-dependent and compartmentalized immunomodulatory effect, preventing clinical deterioration and reducing olfactory deficit in infected animals. Importantly, ivermectin dramatically reduced the Il-6/Il-10 ratio in lung tissue, which likely accounts for the more favorable clinical presentation in treated animals. Our data support IVM as a promising anti-COVID-19 drug candidate.
Impressive pro-ivermectin results, but paper probably has low sciscore.
In conclusion, ivermectin seems to be effective to diminish MHV viral load and disease in mice, being a useful model for further understanding new therapies against coronavirus diseases.
Impressive result for ivermectine.
Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2
That's the generic's equivalent for [[paxlovid]].
Nerd, G. M.-K. H. (2022, February 25). The Jury is Still Out on Ivermectin. Medium. https://gidmk.medium.com/the-jury-is-still-out-on-ivermectin-7d0a1895549
Yang, M. (2022, February 14). Arkansas jail’s ivermectin experiments recall historical medical abuse of imprisoned minorities. The Guardian. https://www.theguardian.com/us-news/2022/feb/14/arkansas-prison-covid-19-ivermectin-experiment-minorities-medical-abuse
Nerd, G. M.-K. H. (2021, December 29). Ivermectin Didn’t Save Uttar Pradesh From Covid-19. Elemental. https://gidmk.medium.com/ivermectin-didnt-save-uttar-pradesh-from-covid-19-17684f49d8b3
Glenn Beck has Covid again after refusing vaccine: ‘It’s going into my lungs.’ (2022, January 13). The Independent. https://www.independent.co.uk/news/world/americas/us-politics/glenn-beck-covid-ivermectin-mark-levin-b1992427.html
Zaidi, A. K., & Dehgani-Mobaraki, P. (2021). RETRACTED ARTICLE: The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article. The Journal of Antibiotics, 1–1. https://doi.org/10.1038/s41429-021-00430-5
Man whose wife won a lawsuit to treat his COVID-19 with ivermectin has died. (n.d.). Retrieved December 17, 2021, from https://ca.news.yahoo.com/man-whose-wife-won-lawsuit-203019784.html
Yang, M. (2021, November 23). Seven doctors contract Covid after attending Florida anti-vaccine summit. The Guardian. https://www.theguardian.com/us-news/2021/nov/23/florida-doctors-covid-coronavirus-bruce-boros
Robins-Early, N. (2021, November 3). How anti-vaxxers and ivermectin advocates have co-opted US local news. The Guardian. https://www.theguardian.com/media/2021/nov/03/how-anti-vaxxers-and-ivermectin-advocates-have-co-opted-local-news
Richard Sever. (2021, October 30). The article is on ivermectin but the sunk intellectual cost fallacy has lessons for us all: "Publicly backtracking when the results refute your idea requires a very large dose of humility” Such humility has been notably lacking among Nobels and other COVID inexperts [Tweet]. @cshperspectives. https://twitter.com/cshperspectives/status/1454483988031152137
Vaccine rap battle full of misinformation. (15:07:48.208508+00:00). Full Fact. https://fullfact.org/health/covid-vaccine-rap-battle/
Alexander, H. (2021, October 21). How a false science ‘cure’ became Australia’s contribution to the pandemic. The Sydney Morning Herald. https://www.smh.com.au/national/how-a-false-science-cure-became-australia-s-contribution-to-the-pandemic-20211013-p58zp3.html
Aeschlimann, J. R. (2021, October 15). Ivermectin Treats Many Infections in Humans – Just Not COVID-19. The Wire Science. https://science.thewire.in/health/ivermectin-treats-many-infections-in-humans-just-not-covid-19/
ICMR drops Ivermectin, Hydroxychloroquine drugs from Covid treatment. (2021, September 24). The Times of India. https://timesofindia.indiatimes.com/india/icmr-drops-ivermectin-hydroxychloroquine-drugs-from-covid-treatment/articleshow/86475906.cms?__twitter_impression=true
Davey, M. (2021, September 24). Fraudulent ivermectin studies open up new battleground between science and misinformation. The Guardian. https://www.theguardian.com/australia-news/2021/sep/25/fraudulent-ivermectin-studies-open-up-new-battleground-between-science-and-misinformation
Robins-Early, N. (2021, September 24). Desperation, misinformation: How the ivermectin craze spread across the world. The Guardian. https://www.theguardian.com/world/2021/sep/24/ivermectin-covid-peru-misinformation
“Vigilante treatments”: Anti-vaccine groups push people to leave ICUs. (n.d.). Retrieved September 26, 2021, from https://www.nbcnews.com/tech/tech-news/vigilante-treatments-anti-vaccine-groups-push-people-leave-icus-rcna2233
Ben Collins on Twitter: “A quick thread: It’s hard to explain just how radicalized ivermectin and antivax Facebook groups have become in the last few weeks. They’re now telling people who get COVID to avoid the ICU and treat themselves, often by nebulizing hydrogen peroxide. So, how did we get here?” / Twitter. (n.d.). Retrieved September 26, 2021, from https://twitter.com/oneunderscore__/status/1441395300002848769?s=20
Ohio judge reverses court order forcing hospital to treat Covid patient with ivermectin. (2021, September 7). The Guardian. https://www.theguardian.com/us-news/2021/sep/07/ivermectin-ohio-judge-reverses-court-order-covid-patient
Seth Trueger on Twitter: “@IdiotTracker @RyanMarino from the makers of ivermectin https://t.co/oEhAaWhqK3” / Twitter. (n.d.). Retrieved August 27, 2021, from https://twitter.com/MDaware/status/1404856892812316677
Infectious Diseases on Twitter. (n.d.). Twitter. Retrieved 27 August 2021, from https://twitter.com/InfectiousDz/status/1430643623876517888
Commissioner, O. of the. (2021). Why You Should Not Use Ivermectin to Treat or Prevent COVID-19. FDA. https://www.fda.gov/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19
mild
That's important. It seems what we should care about is the effect in severe cases.