Cells proliferate in the presence of Edn3. The cells that are produced are melanoblasts, which subsequently become melanocytes. (DB)

Researchers isolated Edn1 to determine its function. Edn1 was shown to be responsible for an increase in blood pressure. Expression of the gene was controlled by factors that affect blood vessels, suggesting that there is a cardiovascular control system. (DB)

Glynn, P.W. (1985). “El Nino-Associated disturbance to coral reefs and post disturbance mortality by Acanthaster planci.” Marine Ecology Progress Series, 26(17): pp. 295–300.

Another study shows how in 1985 the coral reefs in eastern Pacific (Panama included) got ruined by El Nino due to very high water temperatures (average of 31 Celsius) and depth penetration (over 100 m). Since most habitats in coral reefs were destroyed, many species were easily exposed to predators. This may affect the results obtained by Mills and co. because barely a decade has passed for the marine habitats in Panama to recuperate.

~(J.D.A.)

A study in 2 June 2009 conducted by Philip P. Molloy explored the relations with the age of the marine reserves and of the recovery of different species of fish. The studies showed that older marine reserves (15 years and older) were more effective than younger ones. They harbored more fish.

Our social work education accrediting organization fetishizes competencies, thereby inducing stress in instructors, which then gets passed along to the students. I use hypothes.is extensively and can directly observe the students transition from coping to engagement.

Step 1 in any process: decide how you are going to make decisions.

the danger zone is in between being a beginner and an expert

I like what this article says, but this sentence nails the weakness in the article. There is no strong evidence for the assertion.

Another test to run with R!

The author claims here that Emma was inspired by the 1814 novel Discipline by Mary Brunton, which surely is not part of the male literary canon laid out earlier in the article. The author outlines the main themes of Discipline and explains the relationship between the two authors.

I feel like a broken record here, but again, this seems to be a very tenuous point without computational analysis. The author's own language belies this tenuousness as she says that the novel's inspiration "seems to have been a straightforward reaction" to another novel. The word "seems" does not inspire confidence.

Another test to run - Emma as compared to other quixotic novels, especially The Female Quixote!

Another possible tie for DH work - running comparisons on these sentimental novels and Emma.

I would like to perform quantitative analysis on Emma and these texts, in addition to other 18th century texts such as Evelina.

Once again, here is another point that I believe it could almost be irresponsible to make without quantitative analysis. I don't know that it is empirically true that Emma is "unique" in its "obsession" with other texts and "stock elements of the eighteenth-century and Romantic-era novel."

I believe that DH work could be instrumental in accomplishing this vision. Since the literature of this time is in the public domain, it is indeed possible to run tests of influence and similarity on all existing manuscripts.

Herbivorous insects are constantly eating plants, creating competition between the plants and insects. What is stated here is that optimal defense may be impacted by the plants environment, giving it access to certain nutrients and materials needed to produce the desired defense mechanism, such as poisonous leaves or indigestible tissues.

http://onlinelibrary.wiley.com.ezproxy.fiu.edu/doi/10.1890/12-1920.1/full#i0012-9658-94-8-1764-Coley2

-Otniel Gonzalez

Previous work said that the sharks were traveling to different habitats to find food.

McCauley, D.J., Young, H.S., Dunbar, R.B., Estes, J.A., Semmens, B.X., and Micheli, F. (2012). Assessing the effects of large mobile predators on ecosystem connectivity. Ecol. Appl. 22, 1711–1717.

-RKL

The scanning and tail probing behavior of fish is the process in which they use certain tail movement around an object in order to discover the depth and size of objects in their environment. Think about what happens when you put a goldfish into bowl after it has been in an plastic bag. It will immediately start swimming around and swishing its tail around. That is a process of scanning and tail probing behavior. - Kierra Hobdy

Certain marine and aquatic vertebrates have electric organs which allow the organism to produce electric fields ( electrogenesis) .The electric organs of these organisms contain electroreceptors , which provide the organism the ability to sense the electric fields in their environment. The sensory system created by the electroreceptores within these organism results in the electroreception and allows the organism to be better adapted to their underwater and salty environment . http://onlinelibrary.wiley.com/doi/10.1113/expphysiol.1988.sp003144/epdf -Michelle Oriana Gomez-Guevara

From previous articles, the testing IN Drosophila melanogaster, the gene Sex-lethal (Sxl) controls the processes of sex determination, sexual behavior, and dosage compensation (the products of the X-linked genes are present in equal amounts in males and females. Sxl produces two temporally distinct sets of transcripts corresponding to the function of the female-specific early and non-sex-specific late promoters, respectively -Melanie Learn more: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448812/

Individual work I believe to be critical in some professions. Educational systems should incorporate more group activities. Learning in groups, I believe an individual can learn a lot about themselves and even the content being discussed. The article discussed how some can lean on others during group activities, and potentially hinder others from learning or reaching their full potential. I do not believe there is a perfect system, but I do see the need for more group activities in educational programs.

Genes exist in genome as either single copy or duplication. The efficiency of gene expression ranges from low (producing few proteins) to very high (producing many proteins).

Mechanical property of single DNA molecule, assays of biomolecules with nanoscale control, single-molecule detection of ribosomes binding with other proteins, etc. add to our current understanding of transcriptional and translational events at molecular levels.

decision

no sponsorship needed for Turkish citizens

1. Brainstorm.
2. Break the idea and fix idea. (Scrutinize)
3. Permeate and let the idea seep into you.
4. Execute - execute -execute

figure out what you want to be and continue on that path, get better at it, and invest time and effort into it.

10 characteristics of a good manager

The list of remote jobs is fantastic.

Definition: "grammar, rhetoric, and logic," the first three of the seven liberal arts in the Middle Ages, considered initiatory and foundational to the other four: arithmetic, geometry, astronomy, and music.

Etymology: From Latin "trivium," tri (three) + via (road); a place where three roads meet.

Wikipedia has it broken down as "grammar, logic, and rhetoric" = "input, process, and output." This is pretty consistent with Enlightenment thinking that logic is the process and rhetoric is the presentation. I'm interested in how this gets appropriated to a trivium of "syntactics, semantics, and pragmatics."

Tips for remote workers and remote-friendly companies.<br> Andy Mention https://twitter.com/amention<br> http://andymention.com/remote-tooling/

Eddie Hall, the strongest man in the world is the first man to lift 500kg. That itself is an amazing feat, and by using the height of the 500kg in relevance to the ground, we can calculate the work lifted. Eddie Hall's height is 6ft 3, and since deadlifts require the person to lift a bar at their torse, we can estimate the lift height to be 3 feet or .91m. Knowing that the weight is (500kg)(9.8N), we can do (500kg)(9.8N) (.91m) to get 4459J which is the work lifted.

Interesting to ponder.

Springer Nature efforts.

Yes.

This is why interoperability should be a key selling point.

Protestant work ethic shit, undermining social safety nets for all.

The Four Pillars of Life

tag

double lifestyle

Working Hard

Electric eels have been used as a model in the study of bioelectrogenesis, which is the study of electricity produced by living organisms. The species is of some interest to researchers, who make use of its acetylcholinesterase and adenosine triphosphate.

a brief and single electric shock(stimulus) triggers a signal (action potential) in the muscle. After an activation delay ( due to the time it takes for the signal to reach its target) a muscle contraction occurs. The muscle usually relaxes after a few milliseconds unless another contraction signal is send out before the muscle fully relaxes where the muscle contracts again. The contraction that happens after the second contraction is greater that the first because it equals the sum of the tension from both signals being greater. Each of these signals causes the specie to involuntarily twitch and lose control over motor neuron and therefore movement.

Please annotate this!

Lots of difficult things with this text, including the title. The obsession on measurable “smarts” is an important topic and the possible measures to prevent this obsession from impacting (US) society make sense. But it’s really tricky to discuss intelligence in such ways. Part of the text reads as further essentialisation of measured intelligence. Yet it sounds clear from the possible measures described that this form of intelligence takes at least part of its meaning in a given social context.

Maybe the deep issue with a text like this is that it’s hard to get people to shift from one consistent mindframe (paradigm, episteme) to another. More specifically, it’s hard to discuss intelligence in a context where the concept has become so loaded.

Would have lots more to say about this from my parents’ experiences (an occupational therapist who spent a career with people labelled as having “intellectual disabilities” and a psychopedagogue who worked in “special education” with students from a low-income neighbourhood who had “learning disabilities”). Maybe later.

Marie Wallace's perspective on the potential of bigdata analytics, specifically analysis of human networks, in the context of creating a smarter workplace.

Definition: Work so that it produces value that is important to you in the world. Live your life (family & personal lifestyle) in a way that is consistent with the values that are important to you.

Quote from Ray Bradbury

Ideas are cheap.

Zach Holman on remote work. Tech companies need to start accepting remote workers, or they're going to have more trouble finding people. To use remote workers successfully, you have to put priority on asynchronous communication for everyone. Otherwise, the remote people get left out of the loop.

Jon Udell on pros and cons of remote work.

But they're okay with it...... ??? They seem to just accept the fact that these are the working conditions and it's "a part of the job"..

I remind myself of this when I get stuck not wanting to do something because it appears like it has already been done, especially when it looks like it was done and it failed. The use of “we” seems particularly significant, and inspiring.

Winnik and Manners et. al. used Karstedt's catalysts to cross-link polyisoprene in order to create micelles of varying morphologies. They were able to apply this technique for the development of noncentrosymmetric micelles.

Prior to this article, despite the usefulness of CDSA, many of the structures synthesized were centrosymmetric since growth can happen from both ends of the micelle core. This article presents the development of a method to overcome this limitation.

After the discovery of CDSA, the synthetic strategy has been used with a range polymers including conducting, biocompatible, metal-containing, etc.

Previous Work: During CDSA, the crystalline core of the micelle is partially "exposed" to the solvent. When unimers are added to the micelle solution, they are able to grow on existing micelle. However, if the chemical structure of the core prevents crystallization/is not a lattice match, then micelle growth will not happen. This technique has been widely used with a variety of materials such as diblock polymers and nanotubes to create unique self-assemblies.

This technique was first introduced in 2007 by Winnik and Manners et. al. where they discovered a "living" form of micellization. The term "living" in this scenario is derived from the phase "living polymerization" where monomers form long chains by continuous addition to the reactive chain ends, without termination. In the same way, certain micelles specifically those that had crystalline cores exhibited the ability to elongate when additional block copolymers are added to the micelle solution.


Previous study demonstrated that HDAC6 has the capacity to bind both polyubiquitinated misfolded proteins and dynein motors, thereby acting to recruit misfolded protein cargo to dynein motors for transport to aggresomes.

Cells deficient in HDAC6 fail to clear misfolded protein aggregates from the cytoplasm, cannot form aggresomes properly, and are hypersensitive to the accumulation of misfolded proteins.

This study reported the design and synthesis of a potent and selective HDAC6 inhibitor.

In a previous work, scientists investigated whether ubiquitin chain binding affects HDAC6 activity. To generate a ubiquitin-chain binding deficient mutant of HDAC6, they mutated several residues in the BUZ finger that were predicted to make contacts with ubiquitin. It was found that W1182A point mutation markedly disrupted the ability of HDAC6 to bind free ubiquitin chains.

In a previous work, scientists investigated whether ubiquitin chain binding affects HDAC6 activity. To generate a ubiquitin-chain binding deficient mutant of HDAC6, they mutated several residues in the BUZ finger that were predicted to make contacts with ubiquitin. It was found that W1182A point mutation markedly disrupted the ability of HDAC6 to bind free ubiquitin chains.

In a previous work, the authors found the histone deacetylase 8 was required for centrosome cohesion and influenza A virus entry.

Previously, the DNA analysis of the genome of prehistoric wolves and dogs support the idea of a two-step domestication process. The first one was the evolution of wolves through a mutually beneficial relationship with humans, sharing food and space. The second one was the active breeding of dogs by humans in order to select dogs which were adapted to the current needs (hunting, tracking, pet).

Furthermore, there are two main hypotheses to explain the first domestication step (http://www.americanscientist.org/issues/pub/early-canid-domestication-the-farm-fox-experiment):

1) “Self-domestication” by the wolves: Some wolves lived in the vicinity of the camps of the nomadic hunter-gatherers to eat the garbage left by the prehistoric people. Those that were less anxious thrived and continued to follow the humans, generation after generation, and gradually the first dogs emerged from this group.

2) The prehistoric people actively selected wolf pups and let only the most docile ones reproduce. After several generations, the first dogs emerged. This hypothesis has been being tested in Novosibirsk since 1959, where foxes are being bred for “tamability.”

In ref. 5, a genome-wide array of SNP between dogs and wolves suggest that dogs originate from Middle East.

However, ref. 6, the comparison between dog and wolf mitochondrial DNA suggests East Asia as the center of dog origin.

The authors collected the mtDNA sequences previously published by other teams in order to get more data to analyze and a larger diversity of samples.

Some of the phenotypic adaptation can be observed, such as: shorter fangs and claws alteration of some brain areas.

By comparing the DNA of phenotypically domesticated canids and actual dogs and identifying the genes which are responsible of the domesticate phenotype, it is possible to understand which genes have been altered by domestication and when they have been altered.

In ref. 5, a genome-wide array of SNP between dogs and wolves suggest that dogs originate from Middle East.

However, ref. 6, the comparison between dog and wolf mitochondrial DNA suggests East Asia as the center of dog origin.

I don't fully understand this but it was the most intriguing sentence in the piece for me. Are our social media services doing the care work of attending to our need for in-control socialization? Are they our new safe spaces that replace the therapist's office? I also wonder about whether people who work in a caring capacity have a unique relationship with social media.

an objective set for the Sprint that can be met through the implementation of Product Backlog. It provides guidance to the Development Team on why it is building the Increment. It is created during the Sprint Planning meeting. The Sprint Goal gives the Development Team some flexibility regarding the functionality implemented within the Sprint. The selected Product Backlog items deliver one coherent function, which can be the Sprint Goal. The Sprint Goal can be any other coherence that causes the Development Team to work together rather than on separate initiatives.

It's almost as if they saw this as a job.