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My summary:

Biology: * Life = energy + self preservation * Neanderthals could be the reason why wolves/dogs are living closely with humans. Maybe in the past generations, dogs had no choice but to live with humans as they were scared of our power? * People evolved from the deep ocean (we're made in 70% of water). We're like transporting the sea with us now * Dolphins as mammals came back into the water * RNA invented proteins. Later RNA and proteins created DNA * Life is like any kind of self-reinforcement such as self-reinforcement of RNA molecules which lead to the evolution process * Europa (moon of Jupiter) already evolves some non-DNA life there. Life could exist in its under-ice ocean, perhaps in an environment similar to Earth's deep-ocean hydrothermal vents. It will be fascinating to get to know it

Life: * Don't focus on goals but have a path to prevent the "rat race" sort of feeling * Almost every Hollywood movie has a happy ending. It prepares us, humans, really poorly for the bad times in life We need to read/watch more stories with a bad ending * Life is about accomplishing things, not about being happy all the time * As a parent, don't ask your kid if he's happy but what he's struggling to achieve * Most likely, we live on the best planet during the best time as the most beautiful mammals * If you understand yourself, you won't seek self-assurance in what other people think of you * It's hard to get to know your true self if you live all the time in the same location/environment and have the same friends who would like to have a stable image of you

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Another receptor involved in covid19

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• Denature
• Annealing primer
• Synthesize new DNA with polymerase

• High speed
• Extreme sensitivity

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Polymers are combinations of smaller molecules. This is impressive.

This is helpful information. Phosphate is critical.

Ah ha! Histones are molecules. And proteins.

Are histones molcules?

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!- references : evolutionary biology * Evolutionary biologists have developed similar ideas to explain how throughout history, groups of individual organisms that clustered together and discovered better fitness as a result of symbiotic relationships began to reproduce as a whole new entity. Hence the collective became the new individual * Robin et al. paper: https://hyp.is/go?url=https%3A%2F%2Fwww.frontiersin.org%2Farticles%2F10.3389%2Ffevo.2021.711556%2Ffull&group=world * Robin et al. video presentation: https://hyp.is/go?url=http%3A%2F%2Fdocdrop.org%2Fvideo%2F6J-J72GoqhY%2F&group=world * Stuart West video: https://hyp.is/go?url=http%3A%2F%2Fdocdrop.org%2Fvideo%2FVUfNEHl44hc%2F&group=world

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https://www.scientificamerican.com/article/the-complicated-legacy-of-e-o-wilson/

I can see why there's so much backlash on this piece.

It could and should easily have been written without any reference at all to E. O. Wilson and been broadly interesting and true. However given the editorial headline "The Complicated Legacy of E. O. Wilson", the recency of his death, and the photo at the top, it becomes clickbait for something wholly other.

There is only passing reference to Wilson and any of his work and no citations whatsoever about who he was or why his work was supposedly controversial. Instead the author leans in on the the idea of the biology being the problem instead of the application of biology to early anthropology which dramatically mis-read the biology and misapplied it for the past century and a half to bolster racist ideas and policies.

The author indicates that we should be better with "citational practices when using or reporting on problematic work", but wholly forgets to apply it to her own writing in this very piece.

I'm aware that the magazine editors are most likely the ones that chose the headline and the accompanying photo, but there's a failure here in both editorial and writing for this piece to have appeared in Scientific American in a way as to make it more of a hit piece on Wilson just days after his death. Worse, the backlash of the broadly unsupported criticism of Wilson totally washed out the attention that should have been placed on the meat of the actual argument in the final paragraphs.

Editorial failed massively on all fronts here.

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This article seems to be a clear example of the following:

Any time one uses the word "problematic" to describe cultural issues, it can't stand alone without some significant context building and clear arguments about exactly what was problematic and precisely why. Otherwise the exercise is a lot of handwaving and puffery that does neither side of an argument or its intended audiences any good.

The author is going in two opposite directions here and neither match up. A massive swath of our medicine research is wholly based on translational genetics. (That is, our basic research on organisms like flies (drosophila), worms (C. elegans), zebrafish, mice, rats, primates, etc. is contingent on moving medicines applicable to simpler genetic models in these animals will also work for humans who share large amounts of genetic material as the result of evolutionary dynamics. Sure some of it may not be relevant for humans because of both genetic and epigenetic (environmental) factors, but generally we expect that more will than won't.

This basic fact is wholly separate from the health disparities issue. While there are some (and few of these are generally scientists in my experience) who believe that culture is the driving factor, there is enough proof to show that structural racism is the driving factor in almost all cases. I'm unaware of any translational genetic work on ant culture into human culture in any of the scientific literature and she certainly doesn't cite any to provide any sort of evidence to the contrary. As a result, she isn't providing any context at all.

https://whyevolutionistrue.com/2021/12/30/scientific-american-does-an-asinine-hit-job-on-e-o-wilson-calling-him-a-racist/

Richard Lewontin was Jerry Coyne's Ph.D. thesis advisor.

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<details open> <summary>

Nanotate Annotations Samples

</summary> ```json [ { "id":"d5JrdABbEeuatj9X3vvoXw", "authority":"__world__", "url":"https://protocolexchange.researchsquare.com/article/pex-1069/v1", "created":"2020-09-27T00:50:41.265044+00:00", "updated":"2020-09-27T00:50:41.265044+00:00", "title":[ "Sample preparation and imaging procedures for fast and multiplexed superresolution microscopy with DNA-PAINT-ERS" ], "refs":[ ], "isReply":false, "isPagenote":false, "user":"acct:miguel.ruano@hypothes.is", "displayName":null, "text":"", "prefix":"for 10 minutes. Wash with PBS3. ", "exact":"Add imaging buffer with desired ratios of Buffer C (500 mM), ethylene carbonate, and IS-CF660R at 1-2 nM final concentration. The exact concentration of IS may need to be adjusted depending on the target and based on the imaging kinetics.", "suffix":"", "start":15158, "end":15396, "tags":[ "step" ], "group":"__world__", "ontologies":[ ] }, { "id":"FrhgjABcEeu5B4dnXgvb_A", "authority":"__world__", "url":"https://protocolexchange.researchsquare.com/article/pex-1069/v1", "created":"2020-09-27T00:55:08.276888+00:00", "updated":"2020-10-05T14:15:00.764415+00:00", "title":[ "Sample preparation and imaging procedures for fast and multiplexed superresolution microscopy with DNA-PAINT-ERS" ], "refs":[ ], "isReply":false, "isPagenote":false, "user":"acct:miguel.ruano@hypothes.is", "displayName":null, "text":"my other text modificate", "prefix":"ed ratios of Buffer C (500 mM), ", "exact":"ethylene carbonate", "suffix":"", "start":15219, "end":15237, "tags":[ "reagent" ], "group":"__world__", "ontologies":[ "CHEBI" ], "settings":{ "bio_annotations":[ "" ] } }, { "id":"7Z1sugBbEeu9_wtvk1iAjw", "authority":"__world__", "url":"https://protocolexchange.researchsquare.com/article/pex-1069/v1", "created":"2020-09-27T00:53:59.317703+00:00", "updated":"2020-09-30T00:39:50.822216+00:00", "title":[ "Sample preparation and imaging procedures for fast and multiplexed superresolution microscopy with DNA-PAINT-ERS" ], "refs":[ ], "isReply":false, "isPagenote":false, "user":"acct:miguel.ruano@hypothes.is", "displayName":null, "text":"", "prefix":"10 minutes. Wash with PBS3. Add ", "exact":"imaging buffer", "suffix":"", "start":15162, "end":15176, "tags":[ "reagent" ], "group":"__world__", "ontologies":[ "CHEBI" ], "settings":{ "bio_annotations":[ "http://purl.obolibrary.org/obo/CHEBI_35225" ] } } ] </summary>