- Dec 2021
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twitter.com twitter.com
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Another record day for cases in the U.K yesterday. One of the worst Christmas presents we could have received. Please look after each other as well as you can this festive season.
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www.washingtonpost.com www.washingtonpost.com
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2021-12-24
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Omicron and children: Pediatric hospitals in parts of U.S. filling fast. (n.d.). Washington Post. Retrieved December 28, 2021, from https://www.washingtonpost.com/health/2021/12/24/omicron-children-hospitalizations-us/
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About 800 kids have been admitted nearly every day this week, with those in Ohio, Texas, Pennsylvania and New York hit particularly hard by the juggernaut variant.
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Omicron and children: Pediatric hospitals in parts of U.S. filling fast
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twitter.com twitter.com
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2021-12-28
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Andrew Account for lags Kunzmann. (2021, December 28). @ProfMattFox Fatalism can be fatal https://t.co/fa4mgVn3OZ [Tweet]. @1987Andrewk. https://twitter.com/1987Andrewk/status/1475825206564376579
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Fatalism can be fatal
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twitter.com twitter.com
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2021-12-26
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Trisha Greenhalgh. (2021, December 27). This is nothing short of scandalous. Unless and until those leading the public health response acknowledge the AIRBORNE nature of the virus and give transmission mitigation advice commensurate with how airborne viruses spread, we will be yo-yoing from wave to wave ad infinitum. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1475502337594646528
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Picture says a lot
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twitter.com twitter.com
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2021-12-27
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Trisha Greenhalgh. (2021, December 27). This is nothing short of scandalous. Unless and until those leading the public health response acknowledge the AIRBORNE nature of the virus and give transmission mitigation advice commensurate with how airborne viruses spread, we will be yo-yoing from wave to wave ad infinitum. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1475502337594646528
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This is nothing short of scandalous. Unless and until those leading the public health response acknowledge the AIRBORNE nature of the virus and give transmission mitigation advice commensurate with how airborne viruses spread, we will be yo-yoing from wave to wave ad infinitum.
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zeenews.india.com zeenews.india.com
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2021-12-28
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As India approves Corbevax, here’s all you need to know about the new COVID-19 vaccine. (2021, December 28). Zee News. https://zeenews.india.com/india/india-approves-corbevax-here-s-all-you-need-to-know-about-the-new-covid-19-vaccine-2423407.html
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According to Biological E. Limited, the CORBEVAX COVID-19 vaccine will be effective both in scale and affordability, providing sustainable access to low-and middle-income countries.
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As India approves Corbevax, here’s all you need to know about the new COVID-19 vaccine
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www.theguardian.com www.theguardian.com
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2021-12-28
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Murray, J. (2021, December 28). Omicron is ‘not the same disease’ as earlier Covid waves, says UK scientist. The Guardian. https://www.theguardian.com/world/2021/dec/28/omicron-is-not-the-same-disease-as-earlier-covid-waves-says-uk-scientist
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Sir John Bell says disease ‘appears less severe’ as other scientists criticise lack of new restrictions in England
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Omicron is ‘not the same disease’ as earlier Covid waves, says UK scientist
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www.nature.com www.nature.com
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2021-12-17
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Sefik, E., Israelow, B., Mirza, H., Zhao, J., Qu, R., Kaffe, E., Song, E., Halene, S., Meffre, E., Kluger, Y., Nussenzweig, M., Wilen, C. B., Iwasaki, A., & Flavell, R. A. (2021). A humanized mouse model of chronic COVID-19. Nature Biotechnology, 1–15. https://doi.org/10.1038/s41587-021-01155-4
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10.1038/s41587-021-01155-4
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Coronavirus disease 2019 (COVID-19) is an infectious disease that can present as an uncontrolled, hyperactive immune response, causing severe immunological injury. Existing rodent models do not recapitulate the sustained immunopathology of patients with severe disease. Here we describe a humanized mouse model of COVID-19 that uses adeno-associated virus to deliver human ACE2 to the lungs of humanized MISTRG6 mice. This model recapitulates innate and adaptive human immune responses to severe acute respiratory syndrome coronavirus 2 infection up to 28 days after infection, with key features of chronic COVID-19, including weight loss, persistent viral RNA, lung pathology with fibrosis, a human inflammatory macrophage response, a persistent interferon-stimulated gene signature and T cell lymphopenia. We used this model to study two therapeutics on immunopathology, patient-derived antibodies and steroids and found that the same inflammatory macrophages crucial to containing early infection later drove immunopathology. This model will enable evaluation of COVID-19 disease mechanisms and treatments.
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A humanized mouse model of chronic COVID-19
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twitter.com twitter.com
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2021-12-18
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ReconfigBehSci. (2021, December 18). One thing I keep coming back to in my thoughts is the formerly respected scientists who completely lost their way in this pandemic. Is there something we could be teaching young researchers that would help minimise this in future? Are there norms of science we could strengthen? [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1472172123829456897
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one thing I keep coming back to in my thoughts is the formerly respected scientists who completely lost their way in this pandemic. Is there something we could be teaching young researchers that would help minimise this in future? Are there norms of science we could strengthen?
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www.imperial.ac.uk www.imperial.ac.uk
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2021-12-17
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Omicron largely evades immunity from past infection or two vaccine doses | Imperial News | Imperial College London. (n.d.). Imperial News. Retrieved December 21, 2021, from https://www.imperial.ac.uk/news/232698/modelling-suggests-rapid-spread-omicron-england/
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The Omicron variant largely evades immunity from past infection or two vaccine doses according to the latest Imperial modelling.
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Omicron largely evades immunity from past infection or two vaccine doses
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www.theguardian.com www.theguardian.com
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2021-12-18
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Press, A. (2021, December 18). Court rules Biden’s vaccine mandate for large employers can take effect. The Guardian. https://www.theguardian.com/us-news/2021/dec/18/court-rules-bidens-vaccine-mandate-for-large-employers-can-take-effect
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Decision reverses previous ruling but Republican officials say they will appeal measure to supreme court
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Court rules Biden’s vaccine mandate for large employers can take effect
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www.businessinsider.com www.businessinsider.com
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2021-12-19
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Far-right lures recruits using COVID-19 conspiracy theories, alongside misogyny, anti-Semitism, and Islamophobia, says study. (n.d.). Retrieved December 21, 2021, from https://ca.movies.yahoo.com/far-lures-recruits-using-covid-134548878.html
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Far-right groups on Telegram have been using COVID-19 conspiracy theories to recruit new members.This finding comes from a study by the Institute of Strategic Dialogue, based in London.Far-right groups have mobilized emotions around COVID-19 restrictions and vaccinations.
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Far-right lures recruits using COVID-19 conspiracy theories, alongside misogyny, anti-Semitism, and Islamophobia, says study
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calgaryherald.com calgaryherald.com
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2021-12-15
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Calgary Herald. (n.d.). Calgaryherald. Retrieved December 21, 2021, from https://calgaryherald.com/news/local-news/anti-covid-vaccine-dad-loses-battle-with-ex-wife-over-whether-to-get-their-children-inoculated
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Court of Queen's Bench Justice Johnna Kubik noted that until the pandemic both parents had ensured their children received all childhood immunizations and annual flu vaccinations
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Anti-COVID vaccine dad loses battle with ex-wife over whether to get their children inoculated
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twitter.com twitter.com
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2021-12-20
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Travelling Tabby. (2021, December 20). Https://travellingtabby.com/scotland-coronavirus-tracker/ There were over 6,700 new cases reported today, which is one of the highest days we’ve had. And a positivity rate of over 15% too, which is the joint highest we’ve had since reporting began. #covid19scotland #coronavirusscotland #DailyCovidUpdate https://t.co/ZvrVGc2J3I [Tweet]. @TravellingTabby. https://twitter.com/TravellingTabby/status/1472952525544255489
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https://travellingtabby.com/scotland-coronavirus-tracker/… There were over 6,700 new cases reported today, which is one of the highest days we've had. And a positivity rate of over 15% too, which is the joint highest we've had since reporting began. #covid19scotland #coronavirusscotland #DailyCovidUpdate
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news.sky.com news.sky.com
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2021-12-21
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Doctor dismantles typical COVID vaccine hesitancy arguments by putting forward alternative scenario. (n.d.). Sky News. Retrieved December 21, 2021, from https://news.sky.com/story/doctor-dismantles-typical-covid-vaccine-hesitancy-arguments-by-putting-forward-alternative-scenario-12501207
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Dr Ed Patrick said that for those who don't want the vaccine put in their body, they will need a "cocktail of drugs" when they come into hospital with all kinds of side effects.
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Doctor dismantles typical COVID vaccine hesitancy arguments by putting forward alternative scenario
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twitter.com twitter.com
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2021-12-21
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Peter den Haan. (2021, December 21). @dgurdasani1 Two headlines, one year apart. ~74,000 dead. Nothing learned whatsoever. Https://t.co/pjEmUoXxfA [Tweet]. @revpdh. https://twitter.com/revpdh/status/1473252947903590402
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Two headlines, one year apart. ~74,000 dead. Nothing learned whatsoever.
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scitechdaily.com scitechdaily.com
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2021-12-19
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Zewe, A., & Technology, M. I. of. (2021, December 19). MIT Scientists Find Clues to Why Fake News Snowballs on Social Media. SciTechDaily. https://scitechdaily.com/mit-scientists-find-clues-to-why-fake-news-snowballs-on-social-media/
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A new model shows that the more polarized and hyperconnected a social network is, the more likely misinformation will spread.
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MIT Scientists Find Clues to Why Fake News Snowballs on Social Media
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www.bmj.com www.bmj.com
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2021-12-20
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Richterman, A., Scott, J., & Cevik, M. (2021). Covid-19 vaccines, immunity, and boosters. BMJ, 375, n3105. https://doi.org/10.1136/bmj.n3105
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10.1136/bmj.n3105
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Many people still lack essential (and enduring) protection from primary vaccination
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Covid-19 vaccines, immunity, and boosters
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www.theguardian.com www.theguardian.com
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2021-12-20
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Reuters. (2021, December 20). Moderna says booster produces strong antibody response to Omicron. The Guardian. https://www.theguardian.com/world/2021/dec/20/moderna-booster-strong-antibody-response-omicron-covid-vaccine-variant
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Pharmaceuticals firm says third dose of its Covid vaccine increases antibodies against variant by 37-fold
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Moderna says booster produces strong antibody response to Omicron
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twitter.com twitter.com
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2021-12-20
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Colin Davis. (2021, December 20). Update for 20th Dec. The trend line still reflects 1.8 day doubling (it’s 1.7 days if we look at just the last week). Today’s number is down, but I wouldn’t read too much into that at this point. Https://t.co/kOCjxhRbop [Tweet]. @ProfColinDavis. https://twitter.com/ProfColinDavis/status/1472969632705392640
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Update for 20th Dec. The trend line still reflects 1.8 day doubling (it's 1.7 days if we look at just the last week). Today's number is down, but I wouldn't read too much into that at this point.
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2021-11-26
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Harry Spoelstra. (2021, November 26). Breaking: ECDC has designated B.1.1.529 today as a #VOC https://t.co/WyLnc9xUoJ [Tweet]. @HarrySpoelstra. https://twitter.com/HarrySpoelstra/status/1464261361370910721
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New restrictions go into effect on Sunday night * One case of Omicron confirmed, seven under investigation
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Israel bans foreigners from entering country to stop Omicron variant
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twitter.com twitter.com
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2021-11-26
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Harry Spoelstra. (2021, November 26). Breaking: ECDC has designated B.1.1.529 today as a #VOC https://t.co/WyLnc9xUoJ [Tweet]. @HarrySpoelstra. https://twitter.com/HarrySpoelstra/status/1464261361370910721
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Breaking: ECDC has designated B.1.1.529 today as a #VOC
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twitter.com twitter.com
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2021-11-27
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Eric Topol. (2021, November 27). View of key mutations of Omicron’s 50, with 30 in the spike protein, 15 in its receptor binding domain https://ft.com/content/42c5ff3d-e676-4076-9b9f-7243a00cba5e http://covariants.org @EllingUlrich @_b_meyer https://t.co/onMoNFVLFJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1464452102382448643
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View of key mutations of Omicron's 50, with 30 in the spike protein, 15 in its receptor binding domain https://ft.com/content/42c5ff3d-e676-4076-9b9f-7243a00cba5e… http://covariants.org @EllingUlrich @_b_meyer
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twitter.com twitter.com
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2021-12-02
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World Health Organization (WHO). (2021, December 2). Dr @mvankerkhove updates on what we know so far about the new #COVID19 variant of concern, Omicron ⬇️ https://t.co/43jqMUotrX [Tweet]. @WHO. https://twitter.com/WHO/status/1466376465990180864
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Dr @mvankerkhove updates on what we know so far about the new #COVID19 variant of concern, Omicron
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twitter.com twitter.com
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2021-12-07
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ReconfigBehSci. (2021, December 7). Given an estimate whereby the average person knows ca. 600 people, assuming 50% vaxxed, the average person would know 8 people who died of the vaccine. It is hard to believe numeracy is so low that people cannot see how crazy these “statistics” are... [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1468163579069280258
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Given an estimate whereby the average person knows ca. 600 people, assuming 50% vaxxed, the average person would know 8 people who died of the vaccine. It is hard to believe numeracy is so low that people cannot see how crazy these "statistics" are...
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twitter.com twitter.com
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2021-11-26
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Arieh Kovler. (2021, November 26). Israel has identified four cases of the B.1.1.529 variant, all recent travellers. One case, a 32-year-old woman returning from South Africa, was triple vaccinated with Pfizer and had her 3rd dose just two months ago. [Tweet]. @ariehkovler. https://twitter.com/ariehkovler/status/1464190991204859919
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Update: only one of these four is a fully confirmed case of Omicron. The other three (plus three more) are suspected cases, but their viral loads are too low now to confirm fully. Which itself might be a good sign?
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As this thread is being shared to support all sorts of different views, here's my spotters' guide to Covid conspiracy theorists
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Clarification here: No reports IF they had symptoms or not. I'm not saying for sure that they are asymptomatic.
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On the one hand, B.1.1.529 became the dominant variant in SA frighteningly quickly; on the other, it did so from a very low base number of cases, which makes it easier to be dominant in percentage terms.
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Tiny sample size of course, very early days, etc. We still no next to nothing about this variant.
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No reports yet if these people are suffering from any symptoms at all; all travelers are screened with PCR tests on arrival, which is how they were identified.
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Another, a hotel worker from Malawi, had her second dose of AZ in mid-July. A third had her second J&J dose two months ago.
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Israel has identified four cases of the B.1.1.529 variant, all recent travellers. One case, a 32-year-old woman returning from South Africa, was triple vaccinated with Pfizer and had her 3rd dose just two months ago.
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twitter.com twitter.com
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2021-12-14
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Eric Topol. (2021, December 14). The bottom line that is worth a few seconds for you to read https://t.co/nOzyaxO9od [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1470767386810884100
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The bottom line that is worth a few seconds for you to read
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twitter.com twitter.com
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2021-12-13
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Acme Birch Beer. (2021, December 13). A long thread on @NYTimes/@washingtonpost/@TheAtlantic’s favorite prediction-making expert, Monica Gandhi. Feb 22, 2021: “I need to say variants, shmariants, okay? I’m sorry, I don’t know what kind of trouble that’s going to get me in...” https://t.co/CwQL6QBG78 [Tweet]. @KindAndUnblind. https://twitter.com/KindAndUnblind/status/1470389931679883268
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A long thread on @NYTimes/@washingtonpost/@TheAtlantic's favorite prediction-making expert, Monica Gandhi. Feb 22, 2021: "I need to say variants, shmariants, okay? I'm sorry, I don't know what kind of trouble that's going to get me in..."
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ir.novavax.com ir.novavax.com
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2021-12-17
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Novavax and Serum Institute of India Announce World Health Organization Grants Emergency Use Listing for NVX-CoV2373 COVID-19 Vaccine—Dec 17, 2021. (n.d.). Retrieved December 18, 2021, from https://ir.novavax.com/2021-12-17-Novavax-and-Serum-Institute-of-India-Announce-World-Health-Organization-Grants-Emergency-Use-Listing-for-NVX-CoV2373-COVID-19-Vaccine?sf156899079=1
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First EUL granted by WHO for a protein-based COVID-19 vaccine EUL vaccine manufactured and marketed by SII as COVOVAX™ WHO EUL for Nuvaxovid™ currently under assessment; will be completed following European Medicines Agency (EMA) review
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Novavax and Serum Institute of India Announce World Health Organization Grants Emergency Use Listing for NVX-CoV2373 COVID-19 Vaccine
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www.frontiersin.org www.frontiersin.org
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2021-12-16
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Courtney, D. S., & Bliuc, A.-M. (2021). Antecedents of Vaccine Hesitancy in WEIRD and East Asian Contexts. Frontiers in Psychology, 12, 5873. https://doi.org/10.3389/fpsyg.2021.747721
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10.3389/fpsyg.2021.747721
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Following decreasing vaccination rates over the last two decades, understanding the roots of vaccine hesitancy has become a public health priority. Vaccine hesitancy is linked to scientifically unfounded fears around the MMR vaccine and autism which are often fuelled by misinformation spread on social media. To counteract the effects of misinformation about vaccines and in particular the falling vaccination rates, much research has focused on identifying the antecedents of vaccine hesitancy. As antecedents of vaccine hesitancy are contextually dependent, a one-size-fits-all approach is unlikely to be successful in non-WEIRD (Western, Educated, Industrialised, Rich, and Democratic) populations, and even in certain (non-typical) WEIRD sub-populations. Successful interventions to reduce vaccine hesitancy must be based on understanding of the specific context. To identify potential contextual differences in the antecedents of vaccine hesitancy, we review research from three non-WEIRD populations in East Asia, and three WEIRD sub-populations. We find that regardless of the context, mistrust seems to be the key factor leading to vaccine hesitancy. However, the object of mistrust varies across WEIRD and non-WEIRD populations, and across WEIRD subgroups suggesting that effective science communication must be mindful of these differences.
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Antecedents of Vaccine Hesitancy in WEIRD and East Asian Contexts
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www.cbc.ca www.cbc.ca
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2021-12-13
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News ·, P. P. · C. (2021, December 13). How neighbours and communities are divided over COVID-19 in this rural Alberta county | CBC News. CBC. https://www.cbc.ca/news/canada/edmonton/northwest-alberta-has-lowest-vaccination-rate-in-province-1.6280652
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Some in Mackenzie County continue to resist public health guidance, while others try to keep virus at bay
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How neighbours and communities are divided over COVID-19 in this rural Alberta county
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Annotators
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twitter.com twitter.com
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2021-12-14
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Timothy Caulfield. (2021, December 14). @LuisSchang @joerogan The Great Conspiracy Theory Paradox! Https://t.co/sEPuwvXJKp [Tweet]. @CaulfieldTim. https://twitter.com/CaulfieldTim/status/1470818785867153408
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The Great Conspiracy Theory Paradox!
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twitter.com twitter.com
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2021-12-14
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Benjy Renton. (2021, December 14). New data from CDC finds that the Omicron variant represented 2.9% of new cases in the US last week. Https://covid.cdc.gov/covid-data-tracker/#variant-proportions https://t.co/AqM8a1vekm [Tweet]. @bhrenton. https://twitter.com/bhrenton/status/1470765699907870729
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New data from CDC finds that the Omicron variant represented 2.9% of new cases in the US last week. https://covid.cdc.gov/covid-data-tracker/#variant-proportions
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www.usatoday.com www.usatoday.com
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2021-12-13
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Man whose wife won a lawsuit to treat his COVID-19 with ivermectin has died. (n.d.). Retrieved December 17, 2021, from https://ca.news.yahoo.com/man-whose-wife-won-lawsuit-203019784.html
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Keith Smith, whose wife had gone to court to have his COVID-19 infection treated with ivermectin, died Sunday evening, a week after he received his first dose of the controversial drug.
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Man whose wife won a lawsuit to treat his COVID-19 with ivermectin has died {"longForm":{"weekday":"short","day":"numeric","hour":"numeric","hourCycle":"h12","minute":"2-digit","month":"long","year":"numeric"},"shortForm":{"day":"numeric","month":"long","year":"numeric"}} {"videoDockingCfg":{"enableOnMuted":true,"enableOnScrollDown":true,"enableOnScrollUp":false,"fadeInAnimation":true,"height":225,"positionBottom":0,"positionLeft":-1,"positionRight":20,"positionTop":-1,"showInfoCard":false,"width":400,"threshold":10}} {"twitter":{"timeout":5000}} Read full article
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twitter.com twitter.com
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2021-12-16
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Kim Willsher. (2021, December 16). Let’s try again...new “drastic” regulations for anyone planning to come to France from UK. There must be a “compelling” reason. This does not include tourism or business French nationals/residents can return but must have a negative Covid test within 24hrs before departure. 1/2 [Tweet]. @kimwillsher1. https://twitter.com/kimwillsher1/status/1471401803828764682
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*Returning French nationals/residents must register (guessing this is similar to UK "locator" form) and isolate for 7 days "in a place of their choice". This can be reduced to 48hrs if they take another Covid test that is negative. 2/2
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Let's try again...new "drastic" regulations for anyone planning to come to France from UK. *There must be a "compelling" reason. This does not include tourism or business *French nationals/residents can return but must have a negative Covid test within 24hrs before departure. 1/2
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twitter.com twitter.com
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2021-12-17
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Tom Moultrie. (2021, December 17). A 1-figure Gauteng update, bringing in data through Wednesday 15/12 (PCR only; by date of collection). The turn continues. On similar metrics (not shown) ALL northern provinces (NW, GT, MP, LP) seem to have now turned. Https://t.co/6Bh3kZsooK [Tweet]. @tomtom_m. https://twitter.com/tomtom_m/status/1471723711287996416
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A 1-figure Gauteng update, bringing in data through Wednesday 15/12 (PCR only; by date of collection). The turn continues. On similar metrics (not shown) ALL northern provinces (NW, GT, MP, LP) seem to have now turned.
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twitter.com twitter.com
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2021-12-16
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Jay Varma. (2021, December 16). Um, we’ve never seen this before in #NYC. Test positivity doubling in three days 12/9—3.9% 12/10—4.2% 12/11—6.4% 12/12—7.8% Note: Test % is only for PCR & NYC does more per capita daily than most places ~67K PCR/day + 19K [reported] antigen over past few days (1/2) https://t.co/PhxsZq55jn [Tweet]. @DrJayVarma. https://twitter.com/DrJayVarma/status/1471485885447389186
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This is #SARSCoV2 evading both vaccine & virus induced immunity *against infection* unlike any variant before. That's only explanation for dramatic jump in positivity. Consensus for now (but subject to change) is that immunity *against severe disease* should be far better. (2/2)
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Um, we've never seen this before in #NYC. Test positivity doubling in three days 12/9 - 3.9% 12/10 - 4.2% 12/11 - 6.4% 12/12 - 7.8% Note: Test % is only for PCR & NYC does more per capita daily than most places ~67K PCR/day + 19K [reported] antigen over past few days (1/2)
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vancouversun.com vancouversun.com
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227 B.C. chiropractors threaten to sue regulatory college if vaccines ordered. (n.d.). Vancouversun. Retrieved December 17, 2021, from https://vancouversun.com/news/local-news/227-b-c-chiropractors-threaten-to-sue-regulatory-college-if-vaccines-ordered
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2021-12-14
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About 15 per cent of the province’s 1,389 chiropractors are warning they will sue regulatory college directors personally if they back a provincial COVID-9 vaccination mandate.
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227 B.C. chiropractors threaten to sue regulatory college if vaccines ordered
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twitter.com twitter.com
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2021-12-15
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Carl Zimmer. (2021, December 15). Connecticut has gone practically vertical https://nytimes.com/interactive/2021/us/covid-cases.html?referringSource=articleShare https://t.co/mBlybyTpAA [Tweet]. @carlzimmer. https://twitter.com/carlzimmer/status/1470986172583317506
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Connecticut has gone practically vertical https://nytimes.com/interactive/2021/us/covid-cases.html?referringSource=articleShare…
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medicalxpress.com medicalxpress.com
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2021-12-13
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Convalescent plasma not efficacious in hospitalized COVID-19 patients. (n.d.). Retrieved December 17, 2021, from https://medicalxpress.com/news/2021-12-convalescent-plasma-efficacious-hospitalized-covid-.html
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For hospitalized patients with COVID-19 receiving noninvasive supplemental oxygen, COVID-19 convalescent plasma (CCP) is not efficacious compared with placebo, according to a study published online Dec. 13 in JAMA Internal Medicine.
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Convalescent plasma not efficacious in hospitalized COVID-19 patients
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twitter.com twitter.com
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2020-11-28
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Eric Topol. (2020, November 28). This will go down in history as one of science and medical research’s greatest achievements. Perhaps the most impressive. I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months. Https://t.co/BPcaZwDFkl [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1332771238771630080
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4. Whose idea was OWS and when did it kick in? Peter Marks @US_FDA https://nytimes.com/2020/11/21/us/politics/coronavirus-vaccine.html?searchResultPosition=1… @SharonLNYT It was announced May 15th https://defense.gov/Explore/Spotlight/Coronavirus/Operation-Warp-Speed/
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3. The 5 days from sequencing the virus to design of an mRNA vaccine, relayed by Tony Fauci in our conversation https://twitter.com/EricTopol/status/1284503783045623809… @Medscape
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2. 3 scientists led the way Katalin Karikó, worked on a mRNA vaccine for ~30 years, was demoted from @PennMedicine d/t losing her grants, went to @moderna_tx https://statnews.com/2020/11/10/the-story-of-mrna-how-a-once-dismissed-idea-became-a-leading-technology-in-the-covid-vaccine-race/… and the husband and wife team @BioNTech_Group https://nytimes.com/2020/11/10/business/biontech-covid-vaccine.html…
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There are several points noteworthy related to this timeline: 1. Moderna had a head-start, so why didn't their Phase 3 trial finish first? Part of #OperationWarpSpeed (OWS), they were requested to slow down enrollment to get better minority representation https://nytimes.com/2020/11/21/us/politics/coronavirus-vaccine.html?searchResultPosition=1
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This will go down in history as one of science and medical research's greatest achievements. Perhaps the most impressive. I put together a preliminary timeline of some key milestones to show how several years of work were compressed into months.
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www.medrxiv.org www.medrxiv.org
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2021-12-08
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Wilhelm, A., Widera, M., Grikscheit, K., Toptan, T., Schenk, B., Pallas, C., Metzler, M., Kohmer, N., Hoehl, S., Helfritz, F. A., Wolf, T., Goetsch, U., & Ciesek, S. (2021). Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies (p. 2021.12.07.21267432). https://doi.org/10.1101/2021.12.07.21267432
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10.1101/2021.12.07.21267432
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Due to numerous mutations in the spike protein, the SARS-CoV-2 variant of concern Omicron (B.1.1.529) raises serious concerns since it may significantly limit the antibody-mediated neutralization and increase the risk of reinfections. While a rapid increase in the number of cases is being reported worldwide, until now there has been uncertainty about the efficacy of vaccinations and monoclonal antibodies. Our in vitro findings using authentic SARS-CoV-2 variants indicate that in contrast to the currently circulating Delta variant, the neutralization efficacy of vaccine-elicited sera against Omicron was severely reduced highlighting T-cell mediated immunity as essential barrier to prevent severe COVID-19. Since SARS-CoV-2 Omicron was resistant to casirivimab and imdevimab, genotyping of SARS-CoV-2 may be needed before initiating mAb treatment. Variant-specific vaccines and mAb agents may be required to treat COVID-19 due to Omicron and other emerging variants of concern.
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Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies
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twitter.com twitter.com
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2021-12-16
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Theo Sanderson. (2021, December 16). 71.9% of cases in London with specimens from 13 December were Omicron. Overall London cases are already reaching the maximum values ever seen in the pandemic. Https://t.co/CJF5kQqBpl [Tweet]. @theosanderson. https://twitter.com/theosanderson/status/1471537690650812420
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71.9% of cases in London with specimens from 13 December were Omicron. Overall London cases are already reaching the maximum values ever seen in the pandemic.
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healthydebate.ca healthydebate.ca
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2021-12-10
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Vaccination among the pregnant lagging despite growing evidence of safety and efficacy. (2021, December 10). Healthy Debate. https://healthydebate.ca/2021/12/topic/vaccination-pregnant-safe-efficacy/
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Despite data showing the safety and effectiveness of the COVID-19 vaccine for pregnant women and numerous recommendations from health organizations around the world, uptake is still lagging.
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Vaccination among the pregnant lagging despite growing evidence of safety and efficacy
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twitter.com twitter.com
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2021-12-16
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Sam Coates Sky. (2021, December 16). For posterity this is what the Joy Morrissey now deleted tweet said: Https://t.co/IZHX2tZrGs [Tweet]. @SamCoatesSky. https://twitter.com/SamCoatesSky/status/1471428868573732876
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For posterity this is what the Joy Morrissey now deleted tweet said:
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www.nature.com www.nature.com
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2021-12-16
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Mallapaty, S., Callaway, E., Kozlov, M., Ledford, H., Pickrell, J., & Van Noorden, R. (2021). How COVID vaccines shaped 2021 in eight powerful charts. Nature. https://doi.org/10.1038/d41586-021-03686-x
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10.1038/d41586-021-03686-x
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The extraordinary vaccination of more than four billion people, and the lack of access for many others, were major forces this year — while Omicron’s arrival complicated things further.
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How COVID vaccines shaped 2021 in eight powerful charts
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www.medrxiv.org www.medrxiv.org