What stands out to me here is the efforts to which they went in defining the "constraints" on their pursuit of perpetual progress; specifically, they describe these constraints as "...political, cultural, biological, and psychological limits....". While I had earlier viewed religion as transhumanism's biggest constraint, this description makes me pause - the 'constraints' currently being referred to, such as our divisive political system, deeply embedded cultural practices, psychological issues stemming from society, and our ever-fragile health all now seem to be worthy nemeses to the transhumanist commitment.