- Dec 2024
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Grecian Coffee House near Fleet Street
for - trivia / history - coffee house - Grecian Coffee House - Isacc Newton and other members of Royal Society frequented - Newton dssected a dolphin on a table at this coffee house - another coffee house introduced the ballot box for voting
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- Sep 2024
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www.youtube.com www.youtube.com
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the inside and the outside
for - adjacency - inside / outside - complexity / simplicity - multi scale competency architecture - black box - example - human consciousness
adjacency - between - inside / outside - black box - multi scale competency architecture - complexity / simplicity - adjacency relationship - inside / outside complexity /simplicity relationship articulates - the black box phenomenal prevalent in design and also - what Michael has been talking about with the complexity naturally found at lower levels of multi scale competency architectures - As he noted earlier, in this lab experiments, - it's practical to make use of the higher level signals in the living system - and virtually impossible to make use of trying to manage the lower level system signals - I like to think of human consciousness in the same terms - What appears to consciousness are signals like intero-ception signals of hunger that creates the thought ' I'm hungry, I want to get some food ' - whilst countless lies level signals that operate all the cells in our body are invisible
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www.youtube.com www.youtube.com
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Assembling Box Joint Pliers with Peter Ross by [[NESMforged]]
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- Aug 2024
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www.youtube.com www.youtube.com
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When switching, do this only at the end of a chapter, not in media res (in the middle of action).
Also summarize the last thing that happened/got explained for an easy refresher the next time you get back.
Bib-Card? Potentially Marginaelia? Feeling more like a dedicated notebook for this. Need to work out.
Vashik does this summary of a chapter on index cards... Useful to do in a Zettelkasten, or too much effort?
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www.youtube.com www.youtube.com
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KS keeps a bibliography section for her own works... Interesting, very useful.
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Doesn't this method of bib-card IDs get cumbersome to write? I simply use the author's last name... In the case of Adler it would be "Adler/1" and "Adler/1(b)" for the bib-card... Referencing the source on a main note would be "Adler, page number" If I then read another source by Adler, for example "Intellect: Mind over Matter" which I plan to read, it would be "Adler1/1", "Adler1/1(b)" and "Adler1, page number" Seems much easier to remember for me, and also more readable.
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Kathleen Spracklen keeps an index specific to the bibliography, detailing all the works in the bib-box. This is quite useful, and an index card is not too big to need alphabetical sorting, which would be cumbersome on paper.
I will adopt this practice most likely.
The additional benefit is that you can see which bib-card IDs you have already used, preventing duplicate entries.
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The people box is used to: - Keep collections of authors and their works located within the bib-box - Keep cards on other people than sources in the book Such as friends and contacts.
Useful to see at a glance how many sources you have read from an author and what the author writes a lot about.
Also useful to find the bib-card codes for any particular work by an author.
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- Nov 2023
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www.ebay.com www.ebay.com
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https://www.ebay.com/itm/305189692899
The Merchants Box Co. manufactured a variety of wooden index card boxes in the 1960s.
I've seen some marked 1960 and 1962. Dates of manufacture? Sizes? Definitely 4x6".
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www.thenation.com www.thenation.com
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What sense is there in an argument that values a lesser evil when the evil is still so great?
Because it's not about evil but about policy consequenes. The only way to discipline politicians is at the ballot box, so this is a dilemma.
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- Sep 2023
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arxiv.org arxiv.org
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Adaptive Stress Testing with Reward Augmentation for Autonomous Vehicle Validation
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hypothes.is hypothes.is
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"Surrendering" by Ocean Vuong
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He moved into United State when he was age of five. He first came to United State when he started kindergarten. Seven of them live in the apartment one bedroom and bathroom to share the whole. He learned ABC song and alphabet. He knows the ABC that he forgot the letter is M comes before N.
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He went to the library since he was on the recess. He was in the library hiding from the bully. The bully just came in the library doing the slight frame and soft voice in front of the kid where he sit. He left the library, he walked to the middle of the schoolyard started calling him the pansy and fairy. He knows the American flag that he recognize on the microphone against the backdrop.
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- My family immigrated to the U.S. from Vietnam in 1990, when I was two. We lived, all seven of us, in a one-bedroom apartment in Hartford, Connecticut, and I spent my first five years in America surrounded, inundated, by the Vietnamese language. When I entered kindergarten, I was, in a sense, immigrating all over again, except this time into English. Like any American child, I quickly learned my ABCs, thanks to the age-old melody (one I still sing rapidly to myself when I forget whether “M” comes before “N”). Within a few years, I had become fluent—but only in speech, not in the written word.
- Weeks earlier, I’d been in the library. It was where I would hide during recess. Otherwise, because of my slight frame and soft voice, the boys would call me “pansy” and “fairy” and pull my shorts around my ankles in the middle of the schoolyard. I sat on the floor beside a tape player. From a box of cassettes, I chose one labelled “Great American Speeches.” I picked it because of the illustration, a microphone against a backdrop of the American flag. I picked it because the American flag was one of the few symbols I recognized.
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- Aug 2023
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www.ruby-forum.com www.ruby-forum.com
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I ran into the same problem and never really found a good answer via the test objects. The only solution I saw was to actually update the session via a controller. I defined a new action in one of my controllers from within test_helper (so the action does not exist when actually runnning the application). I also had to create an entry in routes. Maybe there’s a better way to update routes while testing. So from my integration test I can do the following and verfiy: assert(session[:fake].nil?, “starts empty”) v = ‘Yuck’ get ‘/user_session’, :fake => v assert_equal(v, session[:fake], “value was set”)
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- May 2023
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impedagogy.com impedagogy.com
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human values and ethics, rather than solely pursuing technological progress.
I ask whether technology is classic Pandora's Box--once the attitude is out, you cannot re-box it. Or at least we haven't figured out a way.
Once this margin has been populated with annotations I want to redo the prompt to include them as an alternative point of view in the dialogue.
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- Mar 2023
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web.archive.org web.archive.org
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Die schiere Menge sprengt die Möglichkeiten der Buchpublikation, die komplexe, vieldimensionale Struktur einer vernetzten Informationsbasis ist im Druck nicht nachzubilden, und schließlich fügt sich die Dynamik eines stetig wachsenden und auch stetig zu korrigierenden Materials nicht in den starren Rhythmus der Buchproduktion, in der jede erweiterte und korrigierte Neuauflage mit unübersehbarem Aufwand verbunden ist. Eine Buchpublikation könnte stets nur die Momentaufnahme einer solchen Datenbank, reduziert auf eine bestimmte Perspektive, bieten. Auch das kann hin und wieder sehr nützlich sein, aber dadurch wird das Problem der Publikation des Gesamtmaterials nicht gelöst.
Google translation:
The sheer quantity exceeds the possibilities of book publication, the complex, multidimensional structure of a networked information base cannot be reproduced in print, and finally the dynamic of a constantly growing and constantly correcting material does not fit into the rigid rhythm of book production, in which each expanded and corrected new edition is associated with an incalculable amount of effort. A book publication could only offer a snapshot of such a database, reduced to a specific perspective. This too can be very useful from time to time, but it does not solve the problem of publishing the entire material.
While the writing criticism of "dumping out one's zettelkasten" into a paper, journal article, chapter, book, etc. has been reasonably frequent in the 20th century, often as a means of attempting to create a linear book-bound context in a local neighborhood of ideas, are there other more complex networks of ideas which we're not communicating because they don't neatly fit into linear narrative forms? Is it possible that there is a non-linear form(s) based on network theory in which more complex ideas ought to better be embedded for understanding?
Some of Niklas Luhmann's writing may show some of this complexity and local or even regional circularity, but perhaps it's a necessary means of communication to get these ideas across as they can't be placed into linear forms.
One can analogize this to Lie groups and algebras in which our reading and thinking experiences are limited only to local regions which appear on smaller scales to be Euclidean, when, in fact, looking at larger portions of the region become dramatically non-Euclidean. How are we to appropriately relate these more complex ideas?
What are the second and third order effects of this phenomenon?
An example of this sort of non-linear examination can be seen in attempting to translate the complexity inherent in the Wb (Wörterbuch der ägyptischen Sprache) into a simple, linear dictionary of the Egyptian language. While the simplicity can be handy on one level, the complexity of transforming the entirety of the complexity of the network of potential meanings is tremendously difficult.
Tags
- linear narratives
- Lie theory
- local vs. global
- zettelkasten complexity
- media studies
- thinking inside of the box
- rhetoric
- insight
- small local wastes in exchange for greater global efficiencies
- network theory
- Wörterbuch der ägyptischen Sprache
- card index as autobiography
- thinking outside of the box
- Lie groups
- open questions
- XX
- complex narratives
- dumping out one's zettelkasten
Annotators
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- Dec 2022
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www.youtube.com www.youtube.com
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https://www.youtube.com/watch?v=XPuqBdPULx4
Mostly this is a lot of yammering about what is to come and the trials and tribulations it's taken him to get set up for making the video tutorials. Just skip to the later videos in the series.
He did mention that he would be giving a sort of "peep show" of his note taking method, though he didn't indicate whether or not we might be satisfied with it. This calls to mind Luhmann's quote about showing his own zettelkasten being like a pornfilm, but somehow people were left disappointed.
cross reference: https://hyp.is/GFj15IcbEe21OIMwT2TOJA/niklas-luhmann-archiv.de/bestand/zettelkasten/zettel/ZK_2_NB_9-8-3_V
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niklas-luhmann-archiv.de niklas-luhmann-archiv.de
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9/8,3 Geist im Kasten? Zuschauer kommen. Sie bekommen alles zusehen, und nichts als das – wie beimPornofilm. Und entsprechend ist dieEnttäuschung.
https://niklas-luhmann-archiv.de/bestand/zettelkasten/zettel/ZK_2_NB_9-8-3_V
I've read and referenced this several times, but never bothered to log it into my notes.
Ghost in the box? Spectators visit. They get to see everything, and nothing but that - like in a porn movie. And the disappointment is correspondingly high.
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Local file Local file
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Zettelkasten, which in American English means notebox, and in Euro-pean English translates to slip box.
What really supports this distinction? The closest historical American English translation is probably "card index" from the early 1900s while the broader academic historical translation is "slip box".
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- Oct 2022
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archive.org archive.org
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As is common in the tradition of the zettelkasten, Goutor advises "that each note-card should contain only one item of information, whether a quotation, a summary, or anything else". (p28) He ascribes this requirement to his earlier need for clarity. (cross reference: https://hypothes.is/a/SfWFwENIEe2KfGMbR5n7Qg)
He indicates that while it may seem wasteful to have only one item on each card that the savings in time, efficiency in handling, classification, and retrieval will more than compensate for the small waste.
This sort of small local waste being compensated for by a larger global savings and efficiency can be seen in the design of the shipping container industry as discussed in Mark Levinson's The Box (Princeton University Press, 2008). Was this the exact sort of efficiency mentioned by Ahrens'? (Compare at https://hypothes.is/a/t4i32IXoEeyF2n9jQxu6BA)
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- Aug 2022
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psyarxiv.com psyarxiv.com
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Rebitschek, F., Ellermann, C., Jenny, M., Siegel, N. A., Spinner, C., & Wagner, G. (2021). How skeptics could be convinced (not persuaded) to get vaccinated against COVID-19. PsyArXiv. https://doi.org/10.31234/osf.io/f4nqt
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www.star-telegram.com www.star-telegram.com
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Mccarthy, C. (2022, February 22). This Fort Worth inventor created a DIY air filter that traps coronavirus particles. Fort Worth Star-Telegram. https://www.star-telegram.com/news/local/crossroads-lab/article258052148.html
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- Jul 2022
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www.zylstra.org www.zylstra.org
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https://www.zylstra.org/blog/2022/06/spring-83/
I've been thinking about this sort of thing off and on myself.
I too almost immediately thought of Fraidyc.at and its nudge at shifting the importance of content based on time and recency. I'd love to have a social reader with additional affordances for both this time shifting and Ton's idea of reading based on social distance.
I'm struck by the seemingly related idea of @peterhagen's LindyLearn platform and annotations: https://annotations.lindylearn.io/new/ which focuses on taking some of the longer term interesting ideas as the basis for browsing and chewing on. Though even here, one needs some of the odd, the cutting edge, and the avant garde in their balanced internet diet. Would Spring '83 provide some of this?
I'm also struck by some similarities this has with the idea of Derek Siver's /now page movement. I see some updating regularly while others have let it slip by the wayside. Still the "board" of users exists, though one must click through a sea of mostly smiling and welcoming faces to get to it the individual pieces of content. (The smiling faces are more inviting and personal than the cacophony of yelling and chaos I see in models for Spring '83.) This reminds me of Stanley Meyers' frequent assertion that he attempted to design a certain "sense of quiet" into the early television show Dragnet to balance the seeming loudness of the everyday as well as the noise of other contemporaneous television programming.
The form reminds me a bit of the signature pages of one's high school year book. But here, instead of the goal being timeless scribbles, one has the opportunity to change the message over time. Does the potential commercialization of the form (you know it will happen in a VC world crazed with surveillance capitalism) follow the same trajectory of the old college paper facebook? Next up, Yearbook.com!
Beyond the thing as a standard, I wondered what the actual form of Spring '83 adds to a broader conversation? What does it add to the diversity of voices that we don't already see in other spaces. How might it be abused? Would people come back to it regularly? What might be its emergent properties?
It definitely seems quirky and fun in and old school web sort of way, but it also stresses me out looking at the zany busyness of some of the examples of magazine stands. The general form reminds me of the bargain bins at book stores which have the promise of finding valuable hidden gems and at an excellent price, but often the ideas and quality of what I find usually isn't worth the discounted price and the return on investment is rarely worth the effort. How might this get beyond these forms?
It also brings up the idea of what other online forms we may have had with this same sort of raw experimentation? How might the internet have looked if there had been a bigger rise of the wiki before that of the blog? What would the world be like if Webmention had existed before social media rose to prominence? Did we somehow miss some interesting digital animals because the web rose so quickly to prominence without more early experimentation before its "Cambrian explosion"?
I've been thinking about distilled note taking forms recently and what a network of atomic ideas on index cards look like and what emerges from them. What if the standard were digital index cards that linked and cross linked to each other, particularly in a world without adherence to time based orders and streams? What does a new story look like if I can pull out a card either at random or based on a single topic and only see it or perhaps some short linked chain of ideas (mine or others) which come along with it? Does the choice of a random "Markov monkey" change my thinking or perspective? What comes out of this jar of Pandora? Is it just a new form of cadavre exquis?
This standard has been out for a bit and presumably folks are experimenting with it. What do the early results look like? How are they using it? Do they like it? Does it need more scale? What do small changes make to the overall form?
For more on these related ideas, see: https://hypothes.is/search?q=tag%3A%22spring+%2783%22
Tags
- web standards
- Fraidyc.at
- experimental fiction
- yearbooks
- atomic idea links
- Spring '83
- Markov monkey
- media studies
- alternate universes
- Pandora's box
- combinatorial creativity
- read
- index cards
- Dragnet
- atomic notes
- Lindy library
- cadavre exquis
- narrative forms
- experimental media
- calmness
- Now Now Now
- quiet
- Derek Sivers
Annotators
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- Jun 2022
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en.itpedia.nl en.itpedia.nl
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Black Box testing: Software on the rack
Black Box testing: Software on the rack
Black Box testing is defined as a testing technique in which the functionality of an application is tested without looking at the internal code structure, implementation details and knowledge of internal paths of the software. This type of testing is completely based on software requirements and specifications.
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before you can think out of the box, you have tostart with a box
Can it be?! Twyla Tharp has an entire chapter in her book on creativity that covers a variation of the zettelkasten note taking concept!!!
Does the phrase "thinking outside of the box" make a tacit nod to the idea of using a card index (or the German zettelkasten) for note taking, sense making, and thinking?
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- May 2022
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Local file Local file
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We reduce risk in the shaping process by solving open questions before we commit the project to a time box.
We don't give a project to a team that still has rabbit holes or tangled interdependencies.
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Local file Local file
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»BlackBoxing« genannt. Diese verschleiert die Genese von Akteuren. Der Begriff be-schreibt dabei den Umstand, dass jedes technische Artefakt bereits das Ende einerHandlungskette darstellt.
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- Apr 2022
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www.toutfait.com www.toutfait.com
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In 1934, Marcel Duchamp announced the publication of his Green Box (edition of 320 copies) in a subscription bulletin — an enormous undertaking since each box contains 94 individual items mostly supposed “facsimiles” (Duchamp’s word) of notes first written between 1911 and 1915, each printed and torn upon templates to match the borders of the scribbled originals for a total of 30,080 scraps and pages.
Marcel Duchamp announced his project the Green Box in 1934 as an edition of 320 copies of a box of 94 items. Most of the items were supposed "facsimiles" as described by Duchamp, of notes he wrote from 1911 to 1915.
How is or isn't this like a zettelkasten or card index, admittedly a small collection?
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- Feb 2022
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you can't see the beetle in my box nor I the one in yours ludwig wittgenstein use the beetle in the Box analogy to suggest that the meaning of sensation words such as pain isn't given 00:01:10 by referring to some private inner introspected something a sensation to which you alone have access in his view there can't be more to the public meaning of our language than we are capable of teaching each other and the 00:01:23 private something the beetle can't have a role in that teaching because we can't get at
The duality of self and other is the peculiar symmetrical asymmetry of being human, and possibly of being life itself.
Similarity and differences in the meaning of words between individuals is unavoidable because we all seem to share this quality of consciousness, as well as the quality of experiencing others as objects of our consciousness.
Nature instills the quality of "unique conscious experience" to each of us. Biological replication is the basis for the repetition of this pattern in all members of our species.
Why was I drawn to the content of this youtube, which came from this article interviewing Teodora Petkova: https://medium.com/content-conversations/a-semantic-text-strategy-conversation-teodora-petkova-fa6d8ad7c72f Through this youtube and through the interview with Teodora Petkova, I became aware of Ludwig Wittgenstein's beetle-in-a-box analogy for private thoughts.A meme is reproduced and shared over and over, drawing people who resonate with it.
Hence, my own discovery of this idea demonstrates the mechanics of self and other consciosness. In any rendition of the present, my semantic state has been influenced by countless number of other writers, content developers or consciousnesses, echoing Husserl's Lebenswelt. Once we are bootstrapped into language through a long gestation period of child development, we simply grow our vocabulary of words, and continuously upgrade their individual meaning through the unique experiences of our unique lifeworlds.
This symmetrical asymmetry is a distinct and unique property of the individual human, showing just how entangled the individual is with the collective, the self with the other.
It is said that the most obvious is at the same time the most difficult to see. The metaphor "a fish does not know of the water that surrounds it" is apt. Our symmetrical asymmetry of experience is so universal that its salience and peculiarity is easily overlooked and not explicitly discussed except by the philosophically inclined. It is more often subconsciously felt than made into an explicit subject of discourse. It is recognized as obvious and coming with the territory of being human.
Indeed, we might say that this common peculiarity of the private, subjective world is paradoxically one of the strangest and yet one of the most common at the same time. Its obviousness does not lessen its profound sense of magic.
The fact that we live in these two kinds of worlds, the private inner and the public outer, and that these terms "private inner" and "public outer" are themselves abstractions, also explains how our participation in collective reality may often not live up to expectations.
For example, in a time when the world needs to undergo a monumental whole system change, it is a challenge to mobilize sufficient number of people to drive the needed change. Part of the reason for this could be that the individual pole, the salience of the "private, inner" pole could prioritize it above even such collective action. The ideas and feelings in our own life as an individual, driven by our private inner lives may dominate our individual actions. Getting on with life often supersedes even threats to society.
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- Sep 2021
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github.com github.com
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The current supported languages out-of-the-box are Sass, Stylus, Less, CoffeeScript, TypeScript, Pug, PostCSS, Babel.
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- Jun 2021
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www.mutuallyhuman.com www.mutuallyhuman.com
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We were not strictly blackbox testing our application. We wanted to simulate a user walking thru specific scenarios in the app which required that we have corresponding data in the database. This helps ensure integration between the frontend and backend was wired up successfully and would give us a foundation for testing critical user flows.
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docs.gitlab.com docs.gitlab.com
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White-box tests at the system level (formerly known as System / Feature tests)
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en.wikipedia.org en.wikipedia.org
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Levels
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White-box testing (also known as clear box testing, glass box testing, transparent box testing, and structural testing) is a method of software testing that tests internal structures or workings of an application, as opposed to its functionality (i.e. black-box testing)
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- Mar 2021
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www.jackfranklin.co.uk www.jackfranklin.co.uk
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but I like that Svelte comes with a good CSS story out the box.
comes with a good CSS story out the box
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- Feb 2021
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www.sciencedaily.com www.sciencedaily.com
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Koo's discovery makes it possible to peek inside the black box and identify some key features that lead to the computer's decision-making process.
Moving towards "explainable AI".
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Neural nets learn and make decisions independently of their human programmers. Researchers refer to this hidden process as a "black box." It is hard to trust the machine's outputs if we don't know what is happening in the box.
Counter-argument: Why do we trust a human being's decisions if we don't know what is happening inside their brain? Yes, we can question the human being but we then have to trust that what they tell us about their rationale is true.
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www.technologyreview.com www.technologyreview.com
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We've developed scientific methods to study black boxes for hundreds of years now, but these methods have primarily been applied to [living beings] up to this point
It's called psychology.
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- Jan 2021
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developer.mozilla.org developer.mozilla.org
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The background-origin CSS property sets the background's origin: from the border start, inside the border, or inside the padding.
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developer.mozilla.org developer.mozilla.org
- Oct 2020
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Supporting JSX out of the box is the engineering equivalent of Mozilla supporting DRM out of the box in FireFox.
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- Aug 2020
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kwokchain.com kwokchain.com
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In a pure cloud world, this atomic unit of documents seems increasingly archaic. Documents are more a constraint of a pre-cloud world. And once you assume storing them online is table stakes, the question becomes where is actual collaboration happening that then leads people to wherever they need to do work.
The document model, stored in the cloud, as pioneered by Dropbox and Box, hinges on the archaic metaphor of "a document". Kwok points out that: "documents are a constraint of a pre-cloud world". When storing documents online becomes trivial, people still need to coordinate on where (i.e. in which document) the collaboration is happening.
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uw.pressbooks.pub uw.pressbooks.pub
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Amylin interacts cooperatively with leptin. The anorexigenic effects of lepin when paired with amylin are greater than the sum of leptin and amylin’s independent anorexigenic effects. In other words, there is a greater-than-additive effect on satiety when leptin and amylin signaling pathways are simultaneously activated. The ventromedial nucleus of the hypothalamus (VMH) is one site of amylin-leptin interactions. The administration of amylin enhances leptin binding in the VMH, and both leptin and amylin receptor activation initiate some of the same signaling cascades (e.g., STAT3, Akt, and ERK). The STAT3 pathway seems to be particularly important in the interaction between leptin and amylin. Amylin-enhanced leptin signaling in the VMH requires amylin’s induction of interleukin 6 (IL-6). Notably, even following the development of leptin insensitivity (e.g., in obese individuals), amylin administration can restore leptin sensitivity.
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Pramlintide is an amylin agonist approved for the treatment of T1DM and T2DM. Pramlintide is co-administered with insulin analogs and contributes to suppression of postprandial blood glucose by delaying gastric emptying, inhibiting glucagon secretion, and reducing food consumption. Like amylin, pramlintide is primarily deactivated by renal clearance, which also likely involves degradation by insulin-degrading enzyme. In obesity, satiety signals often have a diminished capacity to elicit their anorexigenic effects due to decreased receptor sensitivity. This is particularly true in the case of the adipose tissue-derived satiety signal leptin. In obesity, leptin insensitivity (also called leptin resistance) is profound. However, amylin receptor agonists remain potent appetite-suppressing agents in obese individuals but require continuous administration to effectively treat obesity. Furthermore, in some cases, amylin enhances the anorexigenic effects of other satiety signals (e.g., CCK, PYY, insulin, leptin) when co-administered.
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The delay in gastric emptying induced by amylin is most likely achieved through central effects on the dorsal vagal complex of the hindbrain. The dorsal vagal complex contains multiple nuclei and plays a critical role in regulating gastric motility. The dorsal vagal complex includes the area postrema, the nucleus of the solitary tract (NTS), and the dorsal motor nucleus of the vagus nerve (DMV). The area postrema mediates some of the physiological and behavioral effects of amylin, and projects to the NTS. The NTS integrates both neural and endocrine signals (including amylin) and relays the integrated signals to the DMV. The DMB projects preganglionic axons toward the stomach, providing autonomic control over gastric motility. One proposed (though not yet validated) mechanism by which amylin delays gastric emptying is through excitation of the NTS. Amylin may accomplish this excitation of the NTS by interacting with the area postrema to promote the area postrema’s excitation of the NTS (possibly complimenting excitatory glutamatergic vagal input to the NTS) or by directly exciting the NTS. When the NTS is excited by amylin (whether directly or indirectly), the NTS could then modulate the activity of the DMV, resulting in DMV-mediated reductions in gastric motility and delayed gastric emptying. In support of this proposed pathway, gastric emptying is accelerated during hypoglycemia to increase the rate of glucose absorption to raise blood glucose to normal levels. Amylin-activated neurons in the area postrema have been shown to exhibit significant reductions in activity when exposed to low plasma glucose, which, through the same proposed pathway, would yield the increased rate in gastric emptying evident in hypoglycemia. Hypoglycemia may also diminish these neurons’ responsiveness to amylin.
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Due to its reliable (albeit reduced) incretin effect, GLP-1 signaling has received more attention than GIP as a viable target for the treatment of T2DM and certain related disorders. By potentiating glucose-dependent insulin secretion, impairing glucose-dependent glucagon secretion, and delaying gastric emptying, exogenous administration of GLP-1 can completely normalize blood glucose in T2DM patients. However, GLP-1 itself is not a practical treatment for T2DM and related disorders because of its short half-life.
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In addition to the roles of GLP-1 in regulating energy homeostasis at the level of the hypothalamus, another interesting hypothalamic effect of GLP-1R activation is to promote the secretion of gonadotropin releasing hormone (GnRH) into the hypophyseal portal system, at which point GnRH can stimulate gonadotropin release from the anterior pituitary. This promotion of GnRH secretion is accomplished through an interesting signaling pathway. In GnRH neurons, there is continuous production of 2-arachidonoylglycerol (2-AG, an endocannabinoid) by the enzyme diacylglycerol lipase (DGL) and a tonic retrograde release of 2-AG. The tonic retrograde release of 2-AG inhibits excitatory GABAergic inputs (GABA is usually inhibitory, but GABA is excitatory to GnRH neurons). GLP-1R activation on GnRH neurons increases the production of anandamide (another endocannabinoid). Anandamide in GnRH neurons activates TRPV1 receptors, leading to the inhibition of DGL. This prevents the production and tonic retrograde release of 2-AG. Furthermore, GLP-1R activation also increases the activity of adenylyl cyclase, leading to increased cAMP production, and the consequent activation of protein kinase A (PKA). PKA activates nitric oxide synthase (nNOS), which produces nitric oxide (NO). Nitric oxide is released as a retrograde signal to the excitatory GABAergic inputs, where it promotes GABA release. Thus, GLP-1R activation suppresses 2-AG-mediated inhibition of GABAergic excitation, while also promoting GABAergic excitation through retrograde NO signaling. Both of these effects of GLP-1R activation increase the excitatory GABAergic input to GnRH neurons, resulting in increased excitation of GnRH neurons.
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The role of histamine in the stomach explains how antihistamines alter digestive processes: by blocking histamine-mediated excretion of hydrochloric acid.
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www.theguardian.com www.theguardian.com
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Sample, I. (2020). Secrecy has harmed UK government's response to Covid-19 crisis, says top scientist. Retrieved 4 August 2020, from https://www.theguardian.com/world/2020/aug/02/secrecy-has-harmed-uk-governments-response-to-covid-19-crisis-says-top-scientist
Tags
- transparency
- lang:en
- policymaking
- scientific evidence
- UK
- black box
- is:news
- government response
- Sir Paul Nurse
- COVID-19
- scrutiny
- secrecy
Annotators
URL
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- Jul 2020
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projecteuclid.org projecteuclid.org
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BOX,G.E.P.andCOX, D. R. (1964). An analysis of transformations (with discussion).J. Roy.Statist. Soc. Ser. B26211–252.
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- Dec 2019
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frankensteinvariorum.github.io frankensteinvariorum.github.io
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Paradise Lost
PLACEHOLDER -- box-highlight
couldn't find any extra-textual marks on this page pertaining to Paradise Lost.
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Coleridge's Antient Mariner.
In the Thomas Copy, the allusion to Coleridge, "but I shall kill no albatross" is not attributed in text, but rather added by hand as a citation at the bottom of the page: "x Coleridge's Ancient Mariner x"
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This letter ought to be re-written
In the Thomas copy, a note at the bottom of the page stipulates: "This letter ought to be re-written". The first three paragraphs and the final paragraph were to be substantively rewritten in the 1831 edition.
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If there were ever to be another edition of this book, I should re-write these two first chapters. The incidents are tame and ill-arranged—the language sometimes childish.—They are unworthy of the rest of the w booknarration.
In the Thomas Copy, Mary's marginal note outlines her dissatisfaction with the opening chapters of the 1818 edition. Indeed, these chapters would be heavily augmented and revised for the 1831, presumably in accordance with Shelley's observations here.
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impossible:
In the Thomas copy beneath the line "This manuscript will doubtless afford you the greatest <u>pleasure</u>," is written a the single word: "impossible." We cannot tell if this was Mary's comment or was put in by another reader.
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you said your family was not sientific.
In the Thomas Copy, at the bottom of this page, an unknown hand states: "You said your family was not scientific." If this notation is in Mary's hand, she may be speaking to her character Victor, noting a discrepancy in his account of their familiarity with the sciences.
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bad
In the Thomas copy this passage, deleted in 1831, is tagged by Shelley in the margins as "bad".
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survivejs.com survivejs.com
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Second, there are some fantastic projects out there like Create React App, preact-cli, nwb, and much more that avoid the boilerplate problem but at the expense of some other tradeoffs. Your configuration could be black-boxed and not able to be modified. They could force you to eject your configuration, making maintenance of the entire build dependency tree and configuration your responsibility again, and also preclude future configuration updates.
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- Nov 2019
- Feb 2019
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static1.squarespace.com static1.squarespace.com
- Apr 2018
- Mar 2017
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web.stanford.edu web.stanford.edu
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Any communication between people about the same thing isa common revelatory experience about informational models of that thing.Each model is a conceptual structure of abstractions formulated initially inthe mind of one of the persons who would communicate, and if the conceptsin the mind of one would-be communicator are very different from those inthe mind of another, there is no common model and no communication
cf. Wittgenstein Beetle in a Box
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rhetcompnow.com rhetcompnow.com
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What I do know is that I get the very distinct feeling that certain systems I use are not convivial. Google+, Facebook, WordPress, Twitter while full of humans, feel closed, feel like templates to be filled in not spaces to be lived in. Hence, the need for outsiders more than ever to raise the question especially in this week of connected courses where we are talking about the why of why.
Absolutely.
Very much depends from which perspective we are looking.
This is absolutely key.
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System B is oppressive, closed, degenerative, and exhausting.
Order Box Capitalism
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tachesdesens.blogspot.com tachesdesens.blogspot.com
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Mia talked about translating meaning through boxes, inside boxes.
Key. translation of meaning through boxes, inside boxes
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tachesdesens.blogspot.com tachesdesens.blogspot.com
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The people on the other end were targets. They were nothing. They were nobody.
Alienation.
Targets.
Capitalism
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I was left in my doorless empty box,
meaningless box. prison. jail. hell.
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tachesdesens.blogspot.com tachesdesens.blogspot.com
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system B, I think Terry called it? too structured?)
This is important question.
Structure or structureless.
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- Jan 2017
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thefunambulist.net thefunambulist.net
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An anomaly is thus a mere difference in degree for which the norm will serve as metric.
Normal is a powerful, potent, and potentially pernicious black box. And it is frequently a black box deployed against rhetoric.
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- Jun 2016
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hypothes.is hypothes.is
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reate a note by selecting some text and clicking the button
This is not a test
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- Apr 2016
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According to Stemler, consistency estimates of interrater reliability assume that it is not necessary for judges to share a common meaning of the rating scale, so long as each judge is consistent in their classifications.
Wittgenstein's beetle in a box
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- Feb 2016
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bavatuesdays.com bavatuesdays.com
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the MLA Commons is built on top of Commons in a Box
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- Jan 2016
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www.wired.com www.wired.com
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the internet has become essential to our everyday life
What if we had pockets of non-Internet connectivity, though? A mesh network doesn’t necessarily need to have nodes on the Internet. For instance, a classroom could have a “course in a box”, with all sorts of resources provided on local network, but without a connection to the whole Internet… So many teachers keep complaining about their students’ use of the Internet that they end up banning devices. But what if we allowed devices and even encouraged them, as long as they’re not on the Internet? WiFi connections tend to be spotty, to this day, and some classes are cellular deadzones. A bit like Dogme 95, getting used to sans-Internet connectivity could help us “get creative”. What would we do if we were to do a tech-savvy course on the proverbial “desert island”, without Internet?
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