1. Last 7 days
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    The Small Chemical Compound Repsox Potentiates Oct4-Driven Astrocyte-to-Neural Stem Cell Reprogramming via Notch1/Hes1/Smurf2 Pathway
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    Prognostic influence of small leucine-rich proteoglycans on serous ovarian cancer
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    Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk
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    AB‐MDMSBA—Not a Synthetic Cannabinoid Receptor Agonist
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    Hepatic Arterial Infusion Chemotherapy plus either Toripalimab or Sorafenib as First‐line Therapy for Locally Advanced Hepatocellular Carcinoma: A Non‐comparative, Randomized Phase 2 Trial
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    The Protein Phosphatase Inhibitor LB100 Targets the Mesenchymal Lineage of Pancreatic Ductal Adenocarcinoma
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    Viscoelastic and Morphologic Changes in the Lumbar Intervertebral Discs of the 5xFAD Mouse Model of Alzheimer's Disease
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    Evaluating Variability in Extracellular Vesicle Characterization Across Measurement Techniques
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    Replicability of Functional Brain Networks: A Study Through the Lens of Seven Resting‐State Networks
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    Cerebellar Transcranial Alternating Current Stimulation in the Theta Band Prevents Recall of the Initial Fear Association After Extinction Training
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    Proline‐Rich Transmembrane Protein 2 Is Variably Expressed Across Excitatory and Inhibitory Neurons in Mouse Motor Circuits
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    Multi‐omics analysis identifies a major histocompatibility complex class II‐associated antigen‐presenting cancer‐associated fibroblast‐like state linked to the nuclear factor erythroid 2‐related factor 2‐karyopherin subunit beta 1 axis in nonsmall cell lung cancer
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    Chemical Markers and Bioactivity of Algerian Royal Jelly: Influence of Bee Subspecies, Geography, and Lyophilization
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    Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies
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    PEGylation strategies for enhanced nanoparticle delivery to tumor‐associated immune cells
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    The Enhanced Whey Protein Oral Bioavailability and Muscle Anabolism Ability by a Simple and Effective Piperine‐Whey Protein Synergistic Codelivery System
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    Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer
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    PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer
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    Crosstalk with bone marrow adipocytes, but not osteoblasts, drives a cortical bone resorption phenotype in female mice with adult-onset deletion of the glucocorticoid receptor in Osterix-expressing cells
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    Effect of Buddhist music on intraoperative and postoperative opioid requirements during general anesthesia: A randomized controlled pilot study
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  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis
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  36. www.youtube.com www.youtube.com
    Video: Le grand défi de la parentalité au XXIè siècle par Isabelle Roskam (DocDrop)
    1
    1. tanemika 13 Jun 2026

      Le Grand Défi de la Parentalité au XXIè Siècle : Analyse et Prévention du Burn-out Parental

      Résumé Analytique

      La parentalité contemporaine fait face à un défi inédit : la montée du burn-out parental. Si élever un enfant a toujours été associé au bonheur et à l'épanouissement, le contexte socioculturel du XXIe siècle exerce une pression sans précédent sur les parents. Le burn-out parental n'est pas un simple phénomène de mode, mais une réalité physiologique et psychologique caractérisée par un épuisement profond, une distanciation émotionnelle et une perte de plaisir dans le rôle parental.

      Les recherches menées, notamment par Isabelle Roskam, démontrent que ce syndrome résulte d'un déséquilibre chronique entre les facteurs de stress et les ressources disponibles. Contrairement au burn-out professionnel, le burn-out parental ne permet aucune « démission », ce qui accroît la détresse des parents et peut mener à des conséquences graves : idées suicidaires, négligence ou violences envers l'enfant. La solution réside dans un rétablissement de l'équilibre de la « balance » parentale et une révision collective des injonctions à la perfection.

      I. Le Contexte de la Parentalité Moderne : Pourquoi le XXIe Siècle ?

      La parentalité est aujourd'hui investie d'une mission d'optimisation du développement de l'enfant qui n'existait pas pour les générations précédentes. Cinq facteurs majeurs expliquent cette pression accrue :

      • L'évolution des rôles de genre : La fin de la séparation traditionnelle des tâches (mère aux soins, père aux ressources) impose aux deux parents d'exceller sur tous les fronts. Cela introduit également la nécessité de la « coparentalité », obligeant les parents à s'accorder sur des valeurs et des méthodes éducatives, ce qui peut être source de conflits.- La montée de l'individualisme : Les parents sont soumis à des injonctions contradictoires. Ils doivent s'épanouir personnellement tout en se consacrant entièrement aux besoins de l'enfant. Cette dualité génère une culpabilité constante.- Le concept de l'enfant « choisi » : Grâce à la contraception et à la procréation médicalement assistée, l'enfant est le fruit d'un projet de vie délibéré. Socialement, cela rend la plainte inacceptable : « Tu l'as tellement voulu, comment peux-tu ne pas être heureux ? ».- La révolution du statut de l'enfant : En un siècle, l'enfant est passé d'une force de travail à un sujet de droits (Convention de 1989). Le parent n'est plus celui qui impose son autorité, mais celui qui doit garantir l'épanouissement et les droits de l'enfant, sous la surveillance constante de l'État et de la société.- L'avènement des sciences psychologiques : La vulgarisation des théories de l'attachement et de la parentalité positive a créé des standards de « bonnes pratiques » extrêmement élevés. Les réseaux sociaux amplifient ces injonctions, laissant croire que la parentalité peut et doit être parfaite 24h/24.

      II. Définition et Symptomatologie du Burn-out Parental

      Le burn-out parental est un trouble du stress chronique qui se distingue de la dépression par son caractère strictement contextuel (lié au rôle de parent).

      Les trois piliers du syndrome :

      • L'épuisement émotionnel et physique : Le parent se sent vidé, incapable de faire face aux demandes quotidiennes des enfants. Cet épuisement est souvent flagrant le matin, avec une difficulté réelle à sortir du lit.- La distanciation émotionnelle : Pour se protéger, le parent met une barrière entre lui et ses enfants. Il assure le strict minimum (nourriture, hygiène, école) mais ne parvient plus à se connecter aux émotions de l'enfant. La parentalité devient « froide ».- La saturation et la perte de plaisir : Le parent ne trouve plus aucun épanouissement dans son rôle. Le mot « maman » ou « papa » peut même être perçu comme un signal de torture.

      Un élément clé du diagnostic est le phénomène de contraste : le parent ne se reconnaît plus et son entourage constate un changement radical entre la personne investie qu'il était et le parent épuisé qu'il est devenu.

      III. Le Modèle de la Balance : Stresseurs vs Ressources

      Le burn-out survient lorsque les facteurs qui alourdissent la balance (stresseurs) l'emportent durablement sur les facteurs qui l'allègent (ressources).

      | Type de facteur | Exemples de Stresseurs | Exemples de Ressources | | --- | --- | --- | | Sociodémographique | Famille nombreuse, monoparentalité, manque de revenus, logement exigu. | Aide financière, logement adapté, soutien logistique. | | Situationnel | Enfant malade ou à besoins spécifiques (autisme, troubles de l'apprentissage). | Relais de soins, aide spécialisée. | | Personnel | Perfectionnisme, manque d'empathie, antécédents de dépression. | Capacité à lâcher prise, auto-compassion, santé mentale stable. | | Relationnel / Familial | Conflits de coparentalité, manque de soutien du conjoint, inconsistance éducative. | Soutien du conjoint, partage équitable des tâches, routines familiales. |

      Observation cruciale : Les recherches montrent que les stresseurs personnels (perfectionnisme) et relationnels (coparentalité) pèsent bien plus lourd dans le burn-out que les facteurs sociodémographiques (nombre d'enfants).

      IV. Données Scientifiques et Prévalence

      Preuves biologiques

      L'étude du cortisol capillaire (prélevé dans les cheveux) confirme la réalité physique du burn-out. Les parents en burn-out présentent des taux de cortisol deux fois supérieurs à ceux des parents épanouis. Ces doses sont jugées « toxiques » et sont comparables, voire supérieures, à celles observées chez des victimes de violences conjugales ou des patients souffrant de douleurs chroniques.

      Prévalence mondiale

      Une étude menée dans 42 pays révèle que :

      • Le burn-out parental touche 5 % à 8 % des parents dans les pays occidentaux (environ 200 000 en Belgique et 900 000 en France).- L'individualisme est le principal facteur expliquant la variation entre les pays. Les cultures collectivistes, où la solidarité est plus forte, sont moins touchées.- Le syndrome touche environ deux mères pour un père, partout dans le monde.

      V. Conséquences du Burn-out

      Le burn-out parental est particulièrement dangereux car il enferme le parent dans une situation sans issue apparente.

      • Pour le parent : Problèmes psychosomatiques (migraines, mal de dos, troubles digestifs) et risques suicidaires élevés. Contrairement au travail, on ne peut pas démissionner de ses enfants, ce qui conduit certains parents à envisager la disparition ou le suicide comme seule porte de sortie.- Pour l'enfant : Le manque d'empathie lié à la distanciation émotionnelle lève les barrières inhibitrices. Cela mène à une flambée de la négligence (abandon des soins, des devoirs) et de la violence (verbale ou physique), même chez des parents qui n'avaient pas de profil maltraitant initialement.- Pour le couple : Augmentation des conflits, perte de cohésion et pensées adultères.

      VI. Pistes de Solution et Prévention

      Approche individuelle : Rétablir l'équilibre

      Le traitement consiste à agir sur les quatre leviers de la balance :

      • Éliminer les stresseurs non vitaux : S'autoriser à abandonner certaines activités extrascolaires ou à simplifier les repas (ex: raviolis plutôt que bio-maison).- Alléger le poids des stresseurs inévitables : Déléguer les devoirs d'un enfant en difficulté ou renégocier les exigences avec les enseignants.- Identifier et activer les ressources existantes : Oser demander de l'aide au conjoint ou à l'entourage.- Ajouter de nouvelles ressources : Favoriser la solidarité entre parents (ex: groupes d'échange de garde).

      Approche collective et professionnelle

      • La dyade parent-enfant : Les professionnels doivent cesser de se focaliser uniquement sur l'intérêt de l'enfant et prendre en compte le bien-être du parent. Si le parent s'étouffe, il ne peut plus aider l'enfant (métaphore du masque à oxygène).- La métaphore du phare : La parentalité positive doit être vue comme un phare qui donne une direction, et non comme une cible à atteindre absolument. S'en approcher trop près (vouloir être parfait) risque de briser le parent.- Lutter contre l'isolement : Recréer le « village » nécessaire pour élever un enfant. La parentalité est devenue une activité trop solitaire au XXIe siècle.

      En conclusion, sortir du burn-out parental nécessite de briser le tabou de la « honte » et de la « culpabilité » pour permettre aux parents de dire leur souffrance et de retrouver, pas à pas, le plaisir d'être avec leurs enfants.

      2022 parentalité webinaire conférence parents famille
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  37. web.hypothes.is web.hypothes.is
    Annotating the law | Hypothes.is
    1
    1. Fradeet 13 Jun 2026
      Unlike commenting systems, the annotations are anchored to specific fragments of text. Hypothesis is also a great tool for Journal Clubs to annotate in public or using private groups. Here are some examples:

      Some example of annotations

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  38. socialsci.libretexts.org socialsci.libretexts.org
    5.2: Meaning and Purpose
    6
    3. jlweber4 13 Jun 2026
      “Imagine that your 109-year old self had access to a time machine. They jumped into that time machine and arrived to this very moment in time. They climb out, sit next to you and give you advice. What would they say?”

      Spend more time with friends and family, especially your kids and parents

    5. jlweber4 13 Jun 2026
      “Think about your life in the future you are 109 years old. Imagine that everything has gone as well as it possibly could. You have worked hard and succeeded at accomplishing all your life goals. Think of this as the realization of all your life dreams. Now, write about what you imagined”

      That I have great-great grandchildren who still come visit. That I have students who remember me. That my husband is 110 next to me.

    6. jlweber4 13 Jun 2026
      research suggests that finding meaning is a common human experience, often found in everyday aspects like relationships, positive emotions, and routine tasks.

      Everyday saints - everyday kindnesses

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  39. socialsci.libretexts.org socialsci.libretexts.org
    5.1: Introduction to Eudaimonia
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  40. www.theatlantic.com www.theatlantic.com
    Is Google Making Us Stupid?
    1
    1. ZehranM 13 Jun 2026
      Now my concentration often starts to drift after two or three pages

      I feel bad for Gen Alpha and kids going through grade school with no need to actually think, so much so that many of them can't even read.

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  41. read.clarebir.ch read.clarebir.ch
    Magnifica Humanitas — Pope Leo XIV
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  43. elcamino.instructure.com elcamino.instructure.com
    "Why Is the American Diet So Deadly?": 2026/SP ENGL-C1001-6486
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    1. nicolas07 13 Jun 2026
      in the second week that participants ate an ultra-processed diet, for example, their excess calorie consumption started to fall.

      I think the effects of eating UPFs excessively makes you not want to eat them as much because they give you irritable systems that make you not enjoy eating.

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  46. docdrop.org docdrop.org
    Nervous Conditions - Tsitsi Dangarembga
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  47. docdrop.org docdrop.org
    The Gloria Anzaldua Reader (Latin America Otherwise) -- Gloria E_ Anzaldúa; AnaLouise Keating, editor -- Latin america otherwise, Durham, North -- isbn13 9780822345558 -- 174cbeb4050c197ee1c8612d5a94fdf6 -- Anna’s Archive
    6
    1. AlexandraMRogers 13 Jun 2026
      My dear hermanas, the dangers we face as women writers of color are not the same as those ofwhite women

      I completely agree as there are more problems that other women face not just because they are women, but because they are not white..

    2. AlexandraMRogers 13 Jun 2026
      We cannot educate white women and take them by the hand. Most ofus are willing to help, but we can't do the white woman's homework for her.

      I feel as though this sentence is empowering in a way that they do not understand their advantage, especially in todays society, even though they are women, in America I feel like they are put to a higher standard than other women, just because of their ethnicity and that leading to those white women to not understand anyone else's limitations due to not just their gender but their ethnicity.

    4. AlexandraMRogers 13 Jun 2026
      Finally, I write because I'm scared ofwriting but I'm more scared ofnot writing.

      I get what they mean, since its like I kind of don't know what exactly to write about or how to articulate what I wanna express in my writing, but also scared that if I don't do it, I have missed a great opportunity to show what kind of person I really am.

    6. AlexandraMRogers 13 Jun 2026
      Find the muse within you. The voice that lies buried under you, dig it up.be dangerous and just fuck, hell, let it out and let everybody hear whether Do not fake it,

      This highlighted both sides but I really like both of these quotes. For me the being loud and letting everyone one hear is something I wish I could do. I love seeing support for women's speech. And for the other with not faking it and being genuine is important and making sure your authentic voice is heard.

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  48. glassmanlab.seas.harvard.edu glassmanlab.seas.harvard.edu
    Supporting Co-Adaptive Machine Teaching through Human Concept Learning and Cognitive Theories
    5
    2. elglassman 12 Jun 2026
      Alignment is a bilateral process; it refers not only to AI acting according to human intentions but also to humans better leveraging AI by understanding the mechanisms behind it [54].

      Any individual sentence that describes information designed to set the stage for the contribution of the paper.

      ai-pending context
    3. elglassman 12 Jun 2026
      Data labeling as a cognitive task—including defining a concept or determining how two similar objects may have different labels—requires both comparison and integration [62].

      Any individual sentence that describes information designed to set the stage for the contribution of the paper.

      ai-pending context
    4. elglassman 12 Jun 2026
      However, relying exclusively on existing examples is not ideal for tasks requiring nuanced understanding of user intentions, as these examples often fail to represent diverse and edge-case scenarios [31].

      Any individual sentence that describes information designed to set the stage for the contribution of the paper.

      ai-pending context
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    glassmanlab.seas.harvard.edu/papers/mocha_chi25.pdf
  49. legal.uworld.com legal.uworld.com
    Virginia Bar Exam | The Ultimate VA Exam Guide 2026-27
    1
    1. alicecminium 13 Jun 2026
      purpose – the desire

      Assault requires (both): Defendant intends to cause the plaintiff to anticipate imminent, harmful contact to their person AND (2) Defendant's conduct caused them to anticipate such contact. (Defendant's ACTIONS caused them to think so.)

      **What's intent?

      Intent REQUIRES either: * Purpose (Desire) i.e. they wanted to make the defendant think that they were at risk of imminent harm to their physical person OR * Knowledge **(Substantial Certainty) i.e. they knew with substantial certainty that the defendant was going to think that.

      So...

      • Delaney says she is going to [redacted] and physically moves close to A's person with her arm raised while screaming.
      • A ran from her, believing that D intended to harm her & that she was at imminent risk of D physically attacking her.
      • A starts crying and tells D not to touch her. D says that she is not going to touch her, then chases her down the hallway with her arm raised.
      • D did not touch her. D claims that she was not going to touch her and therefore is not responsible for harm to A.

      Is D liable for assault?

      Test: * D intended to cause A to believe that she was going to attack her. * D raising her fist, making oral threats, and chasing after A caused A to anticipate this contact.

      Is the intent requirement met? * Did D have purpose (desire) to cause A to anticipate imminent harm to her physical person as a result of D's actions? OR * * Did D have knowledge (substantial certainty) that A would genuinely believe such harmful or offensive contact with her person was imminent (Did D knew A would think that D is going to hurt her)?

      Application D DID have knowledge (substantial certainty). (A said this aloud.) * D DID intend to cause A to believe she was going to get physically attacked (whether or not D desired to attack her is irrelevant; D desired [intended] A to believe that she would be).

      ---> Did D's affirmative conduct cause A to anticipate... contact? * D's affirmative conduct DID cause A to anticipate such contact.

      SO: (1) Is met. (2) is met. --> D had knowledge. Intent requirement is met. Therefore: Yes, D is liable for assault.*

      Note

      "The intent to make contact is a requirement for battery, not assault."

      (Ref: Third Restatemnt of Torts. Intentional Torts to Person [Squiggley 105].)

      torts bar assault intent substantial certainty desire affirmative conduct
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    legal.uworld.com/bar-exam/states/virginia/
  50. socialsci.libretexts.org socialsci.libretexts.org
    3.4: Language, Society, and Culture
    2
    1. LeAndraOnys 13 Jun 2026
      Additionally, people who work or live in multilingual settings may code-switch many times throughout the day, or even within a single conversation.

      I watched code-switching a lot growing up in a bilingual household. Specifically, from my mother who not only code-switched at home but also at work. It was always kind of impressive to me how seamless a conversation could be even with a mix of two different languages involved. It wasn't until I was older and we spoke less Spanish in the house that she shared it isn't always easy. She explained to me that there are many different dialects of Spanish, some similar and some very different. Even though speaking with family is easy at work, it can start to get more complicated. Often making conversations longer as more descriptors are needed to make sure everyone is on the same page.

    2. LeAndraOnys 12 Jun 2026
      Conversations often begin with a standard greeting and then proceed to “safe” exchanges about things in the immediate field of experience of the communicators (a comment on the weather or noting something going on in the scene). At this point, once the ice is broken, people can move on to other more content-specific exchanges.

      I've never thought through the step-by-step process of a conversation with a stranger or new acquaintance. A lot of people joke that all people talk about the weather or the day of the week, but I find its often true. At least for the first moments of brief interactions. It's how I always start my conversations with customers. It helps having a neutral ground to then share some little details like how our day is going, what kind of weather we enjoy, or if we have plans. This usually creates a good segway to start a deeper conversation. Until reading this paragraph, I never realized how scripted and even ritualized the process was. Having a basic but successful conversation following these rules usually leads to a good first impression on the customers and a more comfortable checkout process.

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    socialsci.libretexts.org/Bookshelves/Communication/Introduction_to_Communication/Communication_in_the_Real_World_-_An_Introduction_to_Communication_Studies/03:_Verbal_Communication/3.04:_Language_Society_and_Culture
  51. Local file Local file
    Untitled document
    2
    1. keelyb 13 Jun 2026
      goal is to construct a computational model of the neuralcircuits involved in VWM function that can simulate abroad range of existing data and provides a frameworkfor understanding the functional mechanisms involved invisual memory storage.

      goal of binding theory model

    2. keelyb 13 Jun 2026
      (VWM), which specifically addresses the abilityto store and retrieve visual pattern information and isdistinct from a broader class of working memory capabil-ities (e.g., Baddeley & Hitch, 1974; Oberauer, 2009).

      more on VWM

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  52. www.infobae.com www.infobae.com
    A 40 años de Malvinas, cómo fue la verdadera economía de guerra que enfrentó la Argentina: causas y consecuencias
    2
    1. gaUriarte 13 Jun 2026
      Sin embargo, puertas adentro del país, Alemann tuvo que soportar la reacción antisemita de algunos integrantes de la Junta Militar, indignados por los fuertes vínculos del estudio Weil, Gothsam & Manges con la comunidad judía de Nueva York.

      !

    2. gaUriarte 13 Jun 2026
      Esta solución se le ocurrió al abogado Richard Davis, socio del estudio neoyorquino Weil, Gothsam & Manges, ex subsecretario de Finanzas del Tesoro durante la administración de James Carter y experto en sanciones económicas internacionales, contratado por el Ministerio de Economía por el temor a que el gobierno de Reagan cediera a la presión de Thatcher de embargar los bienes argentinos en territorio norteamericano.

      Very interesting

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    infobae.com/economia/2022/03/19/a-40-anos-de-malvinas-como-fue-la-verdadera-economia-de-guerra-que-enfrento-la-argentina-causas-y-consecuencias/
  53. arstechnica.com arstechnica.com
    https://arstechnica.com/tech-policy/2026/06/130-billion-in-data-center-projects-blocked-by-protests-so-far-this-year/
    3
    1. fxp007 12 Jun 2026
      53 million square feet of data centers have been constructed over the past 20 years

      劳登县在过去20年建造了5300万平方英尺的数据中心，平均每年约265万平方英尺。这一规模相当于约244个标准足球场的大小，表明该地区已成为重要的数据中心集群。然而，缺乏与全国其他地区的比较数据，无法确定这一规模是否异常突出。

      data-point statistics infrastructure-scale
    2. fxp007 12 Jun 2026
      the number of active opposition groups more than doubled to 833 across 49 states

      反对组织数量从约416个增加到833个，增长超过100%，覆盖49个州。这一增长速度表明数据中心反对运动在组织化和规模化方面取得了显著进展，可能反映了公众对AI基础设施环境和社会影响的担忧加剧。但缺乏2023年初始数据的绝对值，无法计算确切的增长率。

      data-point statistics organizational-growth
    3. fxp007 12 Jun 2026
      $130 billion in data center projects blocked by protests so far this year

      这一数据点表明，2026年前三个月因抗议而被阻止或延迟的数据中心项目价值高达1300亿美元，占2025年全年记录的1560亿美元的约83%。这一数字反映了数据中心反对运动的显著增长趋势，可能对AI基础设施建设产生重大影响，但需要确认这些数据的统计方法和来源可靠性。

      data-point statistics ai-infrastructure
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    arstechnica.com/tech-policy/2026/06/130-billion-in-data-center-projects-blocked-by-protests-so-far-this-year/
  54. www.tomtunguz.com www.tomtunguz.com
    https://www.tomtunguz.com/personal-cost-of-capital/
    4
    1. fxp007 12 Jun 2026
      His personal cost of capital made that possible.

      大多数人认为马斯克的融资成功主要归因于他公司的创新技术和市场地位，但作者将其归结为'个人资本成本'这一概念。这挑战了传统商业融资理论，暗示创始人的个人品牌和声誉可能比公司基本面更重要，是一个反直觉的因果关系主张。

      counterintuitive personal-brand capital-cost
    2. fxp007 12 Jun 2026
      Early wins lower the cost of the next raise. Cheaper capital funds bigger bets. Bigger bets produce bigger wins.

      大多数人认为融资成本主要受市场环境和公司规模影响，但作者认为早期成功才是降低后续融资成本的关键因素。这挑战了传统融资观念，暗示创始人应该优先考虑小规模但可展示的成功，而非大规模扩张，这是一个非主流的融资策略观点。

      non-consensus funding-strategy success-flywheel
    3. fxp007 12 Jun 2026
      At inception, cost of capital is purely personal. Founders & an idea. No business exists yet to evaluate.

      大多数人认为初创公司的融资成本主要取决于商业计划、市场分析和财务预测等客观因素，但作者提出早期阶段的资本成本纯粹是个人化的。这挑战了传统融资理论，暗示创始人个人特质在融资初期可能比商业计划更重要，这是一个反直觉的观点。

      counterintuitive early-stage-funding personal-branding
    4. fxp007 12 Jun 2026
      Despite raising 25x more than the typical founder, Musk retained ownership in the top decile.

      大多数人认为筹集更多资本必然导致创始人股权被大幅稀释，但作者认为马斯克是个例外，他筹集的资金远超普通创始人，却仍能保留前10%的股权。这挑战了传统认知中'融资越多，股权越少'的常识，展示了个人品牌和成功轨迹如何创造独特的资本优势。

      non-consensus founder-equity capital-advantage
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    tomtunguz.com/personal-cost-of-capital/
  55. www.biorxiv.org www.biorxiv.org
    EGFL7 promotes immune evasion in glioblastoma by interaction with integrin β2
    1
    1. lxkaip 12 Jun 2026

      Hello, this paper was very enjoyable to read and to learn from. Few things: The clinical correlation between high EGFL7 expression and reduced patient survival narrowly misses traditional statistical significance (p = 0.074). Explicitly discussing this statistical limitation in the text and validating the trend across additional public cohorts, such as the CGGA, would significantly strengthen your findings. Additionally, your data beautifully illustrates how EGFL7 expression correlates with local zones of T cell exclusion within the tumor core. However, the study leaves open which specific cell types, whether endothelial cells, microglia, or glioma cells, are the primary secretors of EGFL7 driving this local barrier. I believe it would be very intresting and novel to see that.

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    biorxiv.org/content/10.1101/2025.07.28.667281v2
  56. Local file Local file
    The Impact of Mental Health Problems in Adolescence on Educational Attainment
    3
    1. Agard17 12 Jun 2026
      Norwa

      Norway = Good basis for research because * Youths recieving mental health benefits at increasing rate * High non-completion rate for upper secondary education * Lots of prior data about youths and mental health

    2. Agard17 12 Jun 2026
      Internalising disorders refer to problems of withdrawal, generating distress in the individual,and include disorders such as depression, anxiety and emotional disorders. Externalising disordersare mental disorders characterised by behaviours directed toward an individual’s environment, andinclude disorders such as attention-deficit/hyperactivity disorder, conduct disorder and antisocialpersonality disorde

      Internalising = distress within (depression and anxiety) Externalising = Behaviors directed to environment (ADHD, ASPD)

    3. Agard17 12 Jun 2026
      mental health problemsin adolescence have been linked to poor educational outcomes

      I have had friends in high school that have struggled in school due to mental health. A large part of it is the lack of motivation to do homework or study.

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  57. docdrop.org docdrop.org
    models_for_writers_eleventh_edition_-_alfred_rosa__paul__eschholz
    1
    1. em_naegele 12 Jun 2026
      Content is more tangible than style, which always seems elusive

      I always think that style is something that has to be learned through rereading the work a few times through and truly understanding the piece as a whole. The style is also something that feels easier to understand when you have something to compare it to.

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    docdrop.org/download_annotation_doc/Reading-to-Writing-models_for_writers_eleventh_edition_-_alf-qqrlo.pdf
  58. docdrop.org docdrop.org
    UNL teaching
    1
    1. em_naegele 12 Jun 2026
      This is meant to ease the worry over grading for you! As long as you sincerely attempt the assignment you will get at least a B and may likely get an A depending on your work.

      I really appreciate this! I have had classes where the level that is expected to earn an a is wild. Thank you!

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    docdrop.org/download_annotation_doc/ENGL-215-Summer-2026-ktiei.pdf
  59. docs.google.com docs.google.com
    Dream of the Rood
    8
    1. mprado13 12 Jun 2026
      when he came with a multitude,a great host of souls, into God’s kingdom,the one Ruler almighty, the angels rejoicingand all the saints already in heavendwelling in glory, when almighty God,their Ruler, returned to his rightful home.

      This poem shows us Christ's return to heaven as a joyful event, highlighting divine triumph, salvation, and the restoration of order in God's kingdom.

    2. mprado13 12 Jun 2026
      May the Lord be my friend,He who here on earth once sufferedon the hanging-tree for human sin;He ransomed us and gave us life,a heavenly home.

      The speaker ends with a prayer, recognizing Christ's suffering and sacrifice as the source of redemption and the promise of eternal life

    3. mprado13 12 Jun 2026
      each day I look forwardto the time when the cross of the Lord,on which I have looked while here on this earth,will fetch me from this loaned life,and bring me where there is great bliss,joy in heaven,

      The speaker is expressing hope for salvation believing the Cross will lead them from temporary life to eternal heaven and joy.

    4. mprado13 12 Jun 2026
      It is now my life’s hopethat I might seek the tree of victoryalone, more often than all menand honor it well.

      Honoring the Cross has become the purpose of life showing how faith transforms from a symbol of suffering into hope, salvation, and victory.

    5. mprado13 12 Jun 2026
      Then I prayed to the tree with a happy heart,eagerly, there where I was alonewith little company.

      The speaker is praying to the cross as a symbol of salvation and showing that the vision transformed into devotion, hope and peace.

    6. mprado13 12 Jun 2026
      who for the Lord’s name would tastebitter death, as He did earlier on that tree.But they will tremble then, and little thinkwhat they might even begin to say to Christ.

      Those who follow Christ may endure suffering like he did, but everyone will stand before him in judgment, showing sacrifice, faith and accountability.

    7. mprado13 12 Jun 2026
      the Lord himself and his angels with him,and He will judge—He has the power of judgment—each one of them as they have earnedbeforehand here in this loaned life.

      God will one day judge every person according to their actions in this life, highlighting faith, accountability, and living righteously.

    8. mprado13 12 Jun 2026
      God sufferedfor mankind’s many sinsand Adam’s ancient deeds.

      Christ's suffering was a sacrifice made to save humanity from sin, which includes the original sin of Adam, showing the theme of redemption and salvation.

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    URL

    docs.google.com/document/d/e/2PACX-1vSHeJKEHm0yMDdaNf7IVm35D7wBfsXueBx1pyktv3n3Dwpfc8ym1-Y0zcgJSovjZdkkyOp_Ux6h3LFZ/pub
  60. www.infobae.com www.infobae.com
    Las “pocas neuronas de Galtieri” según el embajador inglés y la derrota en Malvinas que abrió la puerta a la Democracia
    1
    1. gaUriarte 12 Jun 2026
      “La Armada estaba convencida de que era menester dejar el gobierno, pero en condiciones de negociación fuertes como para que no ocurriera lo mismo que en 1973 (asunción de Héctor Cámpora y la izquierda montonera), y para esto la operación Malvinas era fundamental. Como la operación Malvinas no se podía hacer con Viola, la conclusión muy simple era sacarlo”.

      Important

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    infobae.com/sociedad/2023/12/10/las-pocas-neuronas-de-galtieri-segun-el-embajador-ingles-y-la-derrota-en-malvinas-que-abrio-la-puerta-a-la-democracia/
  61. glassmanlab.seas.harvard.edu glassmanlab.seas.harvard.edu
    Meta-HCI: Practising Reflection in HCI Research
    1
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    glassmanlab.seas.harvard.edu/papers/meta_HCI_CHI26meetup.pdf