DOI: 10.1016/j.cels.2024.11.013

Resource: (Bio X Cell Cat# BE0086, RRID:AB_1107791)

Curator: @scibot

SciCrunch record: RRID:AB_1107791

---

What is this?

DOI: 10.1016/j.cels.2024.11.013

Resource: (Bio X Cell Cat# BE0164, RRID:AB_10949609)

Curator: @scibot

SciCrunch record: RRID:AB_10949609

---

What is this?

DOI: 10.1016/j.cels.2024.11.013

Resource: None

Curator: @scibot

SciCrunch record: RRID:CVCL_B0CG

---

What is this?

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

DOI: 10.1016/j.celrep.2024.115096

Resource: (Cell Signaling Technology Cat# 3195, RRID:AB_2291471)

Curator: @scibot

SciCrunch record: RRID:AB_2291471

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Cell Signaling Technology Cat# 48111, RRID:AB_2799334)

Curator: @scibot

SciCrunch record: RRID:AB_2799334

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Bio-Rad Cat# 170-6515, RRID:AB_11125142)

Curator: @scibot

SciCrunch record: RRID:AB_11125142

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Thermo Fisher Scientific Cat# 13-5800, RRID:AB_2533023)

Curator: @scibot

SciCrunch record: RRID:AB_2533023

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Cell Signaling Technology Cat# 59854, RRID:AB_2799575)

Curator: @scibot

SciCrunch record: RRID:AB_2799575

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: None

Curator: @scibot

SciCrunch record: RRID:AB_2889265

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Santa Cruz Biotechnology Cat# sc-13551, RRID:AB_628282)

Curator: @scibot

SciCrunch record: RRID:AB_628282

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Cell Signaling Technology Cat# 2462, RRID:AB_2078085)

Curator: @scibot

SciCrunch record: RRID:AB_2078085

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Bio-Rad Cat# 170-6516, RRID:AB_11125547)

Curator: @scibot

SciCrunch record: RRID:AB_11125547

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Cell Signaling Technology Cat# 13116, RRID:AB_2687616)

Curator: @scibot

SciCrunch record: RRID:AB_2687616

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (BD Biosciences Cat# 610227, RRID:AB_2077667)

Curator: @scibot

SciCrunch record: RRID:AB_2077667

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: (Cell Signaling Technology Cat# 14906, RRID:AB_2798644)

Curator: @scibot

SciCrunch record: RRID:AB_2798644

---

What is this?

DOI: 10.1016/j.celrep.2024.115096

Resource: None

Curator: @scibot

SciCrunch record: RRID:AB_3669027

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: RRID:Addgene_27150

Curator: @scibot

SciCrunch record: RRID:Addgene_27150

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: RRID:Addgene_61408

Curator: @scibot

SciCrunch record: RRID:Addgene_61408

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: None

Curator: @scibot

SciCrunch record: RRID:Addgene_82166

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: (Cell Signaling Technology Cat# 13820, RRID:AB_2493181)

Curator: @scibot

SciCrunch record: RRID:AB_2493181

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: (Cell Signaling Technology Cat# 3670, RRID:AB_561049)

Curator: @scibot

SciCrunch record: RRID:AB_561049

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: (Millipore Cat# MABN50, RRID:AB_10807410)

Curator: @scibot

SciCrunch record: RRID:AB_10807410

---

What is this?

DOI: 10.1016/j.celrep.2024.115077

Resource: (BD Biosciences Cat# 556604, RRID:AB_396479)

Curator: @scibot

SciCrunch record: RRID:AB_396479

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Imaris (RRID:SCR_007370)

Curator: @scibot

SciCrunch record: RRID:SCR_007370

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: FlowJo (RRID:SCR_008520)

Curator: @scibot

SciCrunch record: RRID:SCR_008520

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Python Programming Language (RRID:SCR_008394)

Curator: @scibot

SciCrunch record: RRID:SCR_008394

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Adobe Photoshop (RRID:SCR_014199)

Curator: @scibot

SciCrunch record: RRID:SCR_014199

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Cellpose (RRID:SCR_021716)

Curator: @scibot

SciCrunch record: RRID:SCR_021716

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: ZEISS ZEN Microscopy Software (RRID:SCR_013672)

Curator: @scibot

SciCrunch record: RRID:SCR_013672

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: CRAN (RRID:SCR_003005)

Curator: @scibot

SciCrunch record: RRID:SCR_003005

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Leica Application Suite X (RRID:SCR_013673)

Curator: @scibot

SciCrunch record: RRID:SCR_013673

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Bioconductor (RRID:SCR_006442)

Curator: @scibot

SciCrunch record: RRID:SCR_006442

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (IMSR Cat# JAX_006234,RRID:IMSR_JAX:006234)

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:006234

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: R Project for Statistical Computing (RRID:SCR_001905)

Curator: @scibot

SciCrunch record: RRID:SCR_001905

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: RRID:IMSR_JAX:007909

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:007909

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Molecular Probes Cat# A-21247, RRID:AB_141778)

Curator: @scibot

SciCrunch record: RRID:AB_141778

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: RRID:IMSR_JAX:000664

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:000664

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# A-21434, RRID:AB_2535855)

Curator: @scibot

SciCrunch record: RRID:AB_2535855

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: RRID:IMSR_JAX:001800

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:001800

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# A-21448, RRID:AB_2535865)

Curator: @scibot

SciCrunch record: RRID:AB_2535865

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (IMSR Cat# JAX_006148,RRID:IMSR_JAX:006148)

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:006148

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# A-21436, RRID:AB_2535857)

Curator: @scibot

SciCrunch record: RRID:AB_2535857

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# A-11039, RRID:AB_2534096)

Curator: @scibot

SciCrunch record: RRID:AB_2534096

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# A-31573, RRID:AB_2536183)

Curator: @scibot

SciCrunch record: RRID:AB_2536183

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# 13-1900, RRID:AB_2533005)

Curator: @scibot

SciCrunch record: RRID:AB_2533005

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Jackson ImmunoResearch Labs Cat# 703-545-155, RRID:AB_2340375)

Curator: @scibot

SciCrunch record: RRID:AB_2340375

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Thermo Fisher Scientific Cat# A-11016, RRID:AB_2534083)

Curator: @scibot

SciCrunch record: RRID:AB_2534083

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BD Biosciences Cat# 563855, RRID:AB_2869528)

Curator: @scibot

SciCrunch record: RRID:AB_2869528

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: None

Curator: @scibot

SciCrunch record: RRID:AB_2299396

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 116203, RRID:AB_313704)

Curator: @scibot

SciCrunch record: RRID:AB_313704

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (Abcam Cat# ab13970, RRID:AB_300798)

Curator: @scibot

SciCrunch record: RRID:AB_300798

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 905503 (also 905504), RRID:AB_2734679)

Curator: @scibot

SciCrunch record: RRID:AB_2734679

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 116212, RRID:AB_313713)

Curator: @scibot

SciCrunch record: RRID:AB_313713

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (R and D Systems Cat# AF5715, RRID:AB_2102093)

Curator: @scibot

SciCrunch record: RRID:AB_2102093

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 103112, RRID:AB_312977)

Curator: @scibot

SciCrunch record: RRID:AB_312977

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 103506, RRID:AB_313029)

Curator: @scibot

SciCrunch record: RRID:AB_313029

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 102503, RRID:AB_312910)

Curator: @scibot

SciCrunch record: RRID:AB_312910

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 108139, RRID:AB_2565957)

Curator: @scibot

SciCrunch record: RRID:AB_2565957

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 102410, RRID:AB_312905)

Curator: @scibot

SciCrunch record: RRID:AB_312905

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 103104, RRID:AB_312969)

Curator: @scibot

SciCrunch record: RRID:AB_312969

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (R and D Systems Cat# FAB6524A, RRID:AB_10889851)

Curator: @scibot

SciCrunch record: RRID:AB_10889851

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 123316, RRID:AB_10645329)

Curator: @scibot

SciCrunch record: RRID:AB_10645329

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (R and D Systems Cat# FAB6524P, RRID:AB_10891351)

Curator: @scibot

SciCrunch record: RRID:AB_10891351

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 123309, RRID:AB_940582)

Curator: @scibot

SciCrunch record: RRID:AB_940582

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 104307, RRID:AB_313084)

Curator: @scibot

SciCrunch record: RRID:AB_313084

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 141209 (also 141210), RRID:AB_2564068)

Curator: @scibot

SciCrunch record: RRID:AB_2564068

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 127417, RRID:AB_2629803)

Curator: @scibot

SciCrunch record: RRID:AB_2629803

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 102226, RRID:AB_2128076)

Curator: @scibot

SciCrunch record: RRID:AB_2128076

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 102205, RRID:AB_312882)

Curator: @scibot

SciCrunch record: RRID:AB_312882

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: (BioLegend Cat# 101819, RRID:AB_572010)

Curator: @scibot

SciCrunch record: RRID:AB_572010

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: Illumina NextSeq 500 (RRID:SCR_014983)

Curator: @scibot

SciCrunch record: RRID:SCR_014983

---

What is this?

DOI: 10.1016/j.celrep.2024.115073

Resource: None

Curator: @scibot

SciCrunch record: RRID:AB_2742155

---

What is this?

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

DOI: 10.1016/j.celrep.2024.115007

Resource: None

Curator: @scibot

SciCrunch record: RRID:AB_3105777

---

What is this?

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

DOI: 10.1016/j.cell.2024.11.014

Resource: Python Programming Language (RRID:SCR_008394)

Curator: @scibot

SciCrunch record: RRID:SCR_008394

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: Fiji (RRID:SCR_002285)

Curator: @scibot

SciCrunch record: RRID:SCR_002285

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (IMSR Cat# JAX_022363,RRID:IMSR_JAX:022363)

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:022363

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (IMSR Cat# JAX_016963,RRID:IMSR_JAX:016963)

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:016963

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (IMSR Cat# JAX_032536,RRID:IMSR_JAX:032536)

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:032536

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (IMSR Cat# JAX_025807,RRID:IMSR_JAX:025807)

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:025807

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: RRID:IMSR_JAX:029846

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:029846

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: MATLAB (RRID:SCR_001622)

Curator: @scibot

SciCrunch record: RRID:SCR_001622

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (Aves Labs Cat# GFP-1020, RRID:AB_10000240)

Curator: @scibot

SciCrunch record: RRID:AB_10000240

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (Aves Labs Cat# NFH, RRID:AB_2313552)

Curator: @scibot

SciCrunch record: RRID:AB_2313552

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (Proteintech Cat# 15146-1-AP, RRID:AB_2254244)

Curator: @scibot

SciCrunch record: RRID:AB_2254244

---

What is this?

DOI: 10.1016/j.cell.2024.11.014

Resource: (Takara Bio Cat# 632496, RRID:AB_10013483)

Curator: @scibot

SciCrunch record: RRID:AB_10013483

---

What is this?

DOI: 10.1016/j.cell.2024.11.008

Resource: RRID:IMSR_JAX:000664

Curator: @scibot

SciCrunch record: RRID:IMSR_JAX:000664

---

What is this?

DOI: 10.1016/j.cell.2024.11.008

Resource: (IZSLER Cat# BS CL 8, RRID:CVCL_1915)

Curator: @scibot

SciCrunch record: RRID:CVCL_1915

---

What is this?

DOI: 10.1016/j.cell.2024.11.008

Resource: (IZSLER Cat# BS CL 86, RRID:CVCL_0059)

Curator: @scibot

SciCrunch record: RRID:CVCL_0059

---

What is this?

DOI: 10.1016/j.cell.2024.11.008

Resource: (CCLV Cat# CCLV-RIE 0583, RRID:CVCL_RW96)

Curator: @scibot

SciCrunch record: RRID:CVCL_RW96

---

What is this?

DOI: 10.1016/j.cell.2024.11.008

Resource: None

Curator: @areedewitt04

SciCrunch record: RRID:CVCL_0542

---

What is this?

DOI: 10.1016/j.brainresbull.2024.111169

Resource: Parkinson's Progression Markers Initiative (RRID:SCR_006431)

Curator: @scibot

SciCrunch record: RRID:SCR_006431

---

What is this?

DOI: 10.1016/j.bbadis.2024.167633

Resource: (IZSLER Cat# BS TCL 165, RRID:CVCL_0201)

Curator: @scibot

SciCrunch record: RRID:CVCL_0201

---

What is this?

DOI: 10.1016/j.bbadis.2024.167633

Resource: (RRID:CVCL_0063)

Curator: @scibot

SciCrunch record: RRID:CVCL_0063

---

What is this?

DOI: 10.1016/j.bbadis.2024.167633

Resource: (CLS Cat# 300342/p657_SK-OV-3, RRID:CVCL_0532)

Curator: @scibot

SciCrunch record: RRID:CVCL_0532

---

What is this?

DOI: 10.1016/j.bbadis.2024.167633

Resource: (ATCC Cat# HTB-161, RRID:CVCL_0465)

Curator: @scibot

SciCrunch record: RRID:CVCL_0465

---

What is this?

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

DOI: 10.1002/cam4.70495

Resource: R Project for Statistical Computing (RRID:SCR_001905)

Curator: @scibot

SciCrunch record: RRID:SCR_001905

---

What is this?

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

DOI: 10.1158/1535-7163.mct-24-0140

Resource: None

Curator: @mzhang007

SciCrunch record: RRID:IMSR_GPT:N000013

---

What is this?

DOI: 10.1158/1535-7163.mct-24-0140

Resource: None

Curator: @sjvitug

SciCrunch record: RRID:IMSR_GPT:N000013

---

What is this?

DOI: 10.1158/0008-5472.can-24-2450

Resource: None

Curator: @mzhang007

SciCrunch record: RRID:IMSR_JAX:002019

---

What is this?

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

Traceback (most recent call last): File "/home/ubuntu/dashboard/py/create_release_tables.py", line 54, in format_anno_for_release parsedanno = HypothesisAnnotation(anno) File "/home/ubuntu/dashboard/py/hypothesis.py", line 231, in init self.links = row['document']['link'] TypeError: string indices must be integers

DOI: 10.1016/j.xpro.2024.103484

Resource: None

Curator: @inessasarian

SciCrunch record: RRID:IMSR_JAX:000664

---

What is this?

DOI: 10.1016/j.crmeth.2024.100930

Resource: None

Curator: @inessasarian

SciCrunch record: RRID:AB_2722750

---

What is this?

Чужой.

Чужой.

Чужой.

Чужой.

Чужой.

Чужой.

Чужой.

Вот тут не понимаю, на всякий случай лучше проверить, тот ли скрин.

Чужой.

На скрине вижу Post Comment. Это подразумевалось и надо заменить или где-то что-то другое есть?

Чужой.

Чужой.

Чужой.

Чужой.

Чужой.

جملة "Zebra Stripes" تعني "خطوط الحمار الوحشي".

في سياق تصميم الويب أو جداول HTML، يشير المصطلح إلى استخدام ألوان متناوبة للصفوف (عادةً لون فاتح ولون غامق) لجعل البيانات أكثر وضوحًا وسهولة في القراءة، كما تبدو مثل نمط خطوط الحمار الوحشي

Welcome back and in this lesson I want to talk in a little bit of detail about gateway load balances.

Now these are a relatively new addition to the load balancer family and are designed for very specific sets of use cases which I'll cover in this lesson.

Now we have a lot of architectural theory to cover so let's jump in and get started straight away.

Now before we talk about gateway load balances, I want to step through the type of situation where you might choose to use one.

Consider this architecture, the Categorum Application Server in a public subnet communicating with the public internet.

Now what's missing here is some kind of inspection based security appliance, something which can check data for any exploits to protect our application server.

Now if this is an important application, which it is because it involves cats, we can improve the architecture, we can add a security appliance and this would be a transparent security device.

It would sit in the flow of traffic inbound and outbound transparently reviewing traffic as it enters the application from the public internet so protecting the application against any known exploits and then filtering any traffic on the way back out.

For example, detecting and preventing any information leakage.

Now this works well assuming that we don't really have to think about scaling.

The issue comes when we grow or shrink our application.

Remember AWS pushes the concept of elasticity where applications can grow and shrink based on increasing and decreasing load on a system.

When you need to deal with a growing and shrinking number of application instances and where this growth is extreme you need an appropriate number of security appliances and this can be complex and prone to failures.

Now this solution is tightly coupled where the application and security instances are tied together.

The failure of one can impact the other.

It doesn't scale well even in a single application environment and it's even more complex if you're trying to build multi-tenant applications.

It's this type of situation where you need to use some kind of security appliance at scale and have flexibility around network architecture when you might choose to use a gateway load balancer and over the remainder of this lesson I want to step through what they do, how they function and how to use them.

A gateway load balancer is a product which AWS have developed to help you run and scale third-party security appliances things such as firewalls, intrusion detection systems or intrusion prevention systems, even data analysis tools.

You might use these for example to perform inbound and outbound transparent traffic inspection or protection.

Now AWS have a lot of awesome networking products but there are many large businesses who use third-party security and networking products.

You might do this because you have existing skills on those products and want to use them inside AWS or you might have a formal requirement to use those products or a specific feature or set of features which only one specific vendor can deliver.

So in those cases you'll need to use a third-party appliance and to do that at scale in a manageable way you'll need to use a gateway load balancer.

At a high level a gateway load balancer has two major components.

First, gateway load balancer endpoints which run from a VPC where the traffic you want to monitor, filter or control originates from or is destined to.

So in the example I'll be using the VPC where the Category Application Instance is hosted.

Now gateway load balancer endpoints are much like interface endpoints within VPCs which you've experienced so far but with some key improvements which I'll talk about in a second.

The other component is the gateway load balancer or GWLB itself and this load balancers packets across multiple back-end instances and these are just normal EC2 instances running security software.

In order for this type of architecture to work the gateway load balancer needs to forward packets without any alteration.

The security appliance needs to review packets as they're sent or as they're received.

After all that's the whole point.

These packets have source and destination IP addresses which might be okay on the original network but which might not work on the network where the security appliances are hosted from.

And so gateway load balancers use a protocol called Geneva and this is a tunnelling protocol.

A tunnel is created between the gateway load balancer and the back-end instances so the security appliances.

Packets are encapsulated and sent through this tunnel to the appliances.

Now let's review this visually which should help you understand how all of the components fit together.

Let's say that we have a laptop and this is accessing the Categorum application.

Now I'm keeping this simple for now and not including any VPC boundaries.

I'll show you this in a moment.

So traffic leaves this source laptop and moves into a VPC through an internet gateway and arrives at a gateway load balancer endpoint.

So gateway load balancer endpoints this is like a normal VPC interface endpoint with one major difference.

It can be added to a route table as the next hop and this allows it to be part of traffic flows controlled by that route table.

So traffic via a route table is directed at this endpoint and then the traffic flows through to a gateway load balancer.

So gateway load balancers allow three and four devices similar in many ways to a network load balancer.

But it integrates with gateway load balancer endpoints and it encapsulates all traffic that it handles between it and the targets using the Geneva protocol.

And this means that packets are unaltered.

They have the same source IP destination IP source port destination port and contents as when they were created and sent.

This allows the security appliances to scan the packets review them for any security issues block them as required perform analysis or adjust them as needed.

And when finished the packets are returned over the same tunnel encapsulated back to the load balancer where the Geneva encapsulation is removed and then the packets move back to the gateway load balancer endpoint and through to the intended destination.

Now the benefits of this architecture are that gateway load balancers will load balance across security appliances so you can horizontally scale.

The gateway load balancer manages flow stickiness so one flow of data will always use one appliance and this is useful because it allows that appliance to monitor the state of flows through a system.

It provides abstraction.

It means that you can use multiple security appliances to provide resilience.

If one of them fails then packets are just moved over to another available security appliance.

So in this way it's much like other load balancers within AWS.

Now just before we finish up with this lesson I wanted to provide a little bit more of a detailed typical architecture where you might use a gateway load balancer.

So this is the category application.

It's running in a pair of private subnets at the bottom behind an application load balancer which is running in a pair of public subnets.

Off to the right we have a separate VPC running a set of security appliances inside an auto scaling group so this can grow and shrink based on load to the application.

Now what I want to do now is to step through traffic flow through this architecture and show you how the gateway load balancer architecture works to ensure we can scale this security platform.

So we start at the top with a client which is accessing the web application.

Now this flow is going to be arriving at the application load balancer which uses public addressing and so logically it first hits the internet gateway.

The internet gateway is configured with an ingress route table also known as a gateway route table which influences what happens as traffic arrives at the VPC.

In this case our packets are destined for the public IP that the application load balancer on the right is using.

The internet gateway first translates the destination public IP address onto the corresponding private IP of that application load balancer and this will be running inside the 10.16.96.0/20 subnet.

So this is the subnet where the application load balancer is running from.

So the third route is used because it's the most specific route for the 10.16.96.0/20 range and traffic is sent towards the gateway load balancer endpoint in the right availability zone.

Remember gateway load balancer endpoints are like interface endpoints but they can be the targets within routes.

So the gateway load balancer endpoint receives these packets and then moves these packets through to the gateway load balancer itself which is running in the security VPC.

At this point the packets still have the original IP addressing and normally this would be a problem since the security VPC might be using a different or maybe even conflicting IP range.

So while the source and destination addressing remains the same the packets are encapsulated using the Geneva protocol and sent through unaltered to the security appliance chosen by the gateway load balancer.

The exact nature of the analysis which takes place depends on the security appliance and that's one of the benefits of using a gateway load balancer.

It just allows third party appliances to be used in a scalable way.

It doesn't inflict a particular feature set on us as network engineers or architects.

So once the analysis has happened the packets are returned encapsulated to the gateway load balancer.

The encapsulation is stripped and returned via the endpoint to the Category VPC.

Since the original IP addressing is maintained the route table on the top public subnet is used which has a local route for the VPC side arrange.

This as the most specific route available is used and packets flow through to the application load balancer and from there through to the chosen application instance.

And of course this logic is decided upon by the application load balancer.

Now the return path uses the same logic data leaves the application instance in response to the initial communication from the laptop and so it will return via the application load balancer.

The load balancer is in a subnet which has a local route but the default route goes towards the gateway load balancer endpoint in the same availability zone.

Now since traffic is going back to the client device who originally accessed the Category application it will have a public IP version 4 destination IP address and so the default route will be used.

This means the packets will flow back to the gateway load balancer endpoint and then from there through to the gateway load balancer where they'll be encapsulated passed through to the appliances then back to the load balancer de-encapsulated and passed back to the gateway load balancer endpoint.

Once they're back at the gateway load balancer endpoint the subnet which the gateway load balancer endpoints are in has the internet gateway as the default route and so this will be used and traffic moves through the internet gateway where its source IP will be changed to the corresponding public one of the application load balancer and then the data will be sent on through to the original client device.

And that's it transparent inline network security done in a scalable resilient and abstracted way.

Now I'm going to be talking more about some of the more nuanced features in other lessons but for now that's the basics covered of gateway load balancers.

In terms of other architecture they share many elements with network and application load balancers including the target group architecture but they have a very specific purpose network security at scale.

Now with that being said that's everything which I wanted to cover in this video so go ahead and complete the lesson and then when you're ready I look forward to you joining me in the next.

eLife Assessment

This study investigated mitochondrial dysfunction and the impairment of the ciliary Sonic Hedgehog signaling in Lowe syndrome (LS), a timely topic given the limited research in this area. The data from patient iPSC-derived neurons and a mouse model were collected using solid methods, but the evidence supporting key claims is incomplete, and some technical aspects fall short of expectations. Despite these limitations, the study provides a useful foundation for exploring the relationship between mitochondrial defects and primary cilia in neural development.

Reviewer #1 (Public review):

Summary:

This study by Lo et al. seeks to explain the cellular defects underlying the brain phenotypes of Lowe syndrome (LS). There have been limited studies on this topic and hence this is a timely study.

Strengths:

Studies such as these can contribute to an understanding of the cellular and developmental mechanisms of brain disorders.

Weaknesses:

This study by Lo et al. seeks to explain the cellular defects underlying the brain phenotypes of Lowe syndrome (LS). There have been limited studies on this topic and hence this is a timely study.

The study uses two models: (1) an LS IOB knockout mouse and (2) neurons derived from iPSC lines from LS patients. These two models are used to present three separate findings: (1) altered mitochondria function, (2) altered numbers of neurons and glia in both models, and (3) some evidence of altered Sonic Hedgehog signaling projected as a defect in cilia.

Conceptually, there are some problems of serious concern which must be carefully considered:<br /> (1) The IOB mouse was very extensively phenotyped when it was generated by Festa et.al HMM, 2019. It does not have any obvious phenotypes of brain deficits although the studies in this paper were very detailed indeed.<br /> (2) Reduced brain size is reported as a phenotype of the IOB mouse in this study. Yet over the many clinical studies of LS published over the years, altered brain size has not been noted, either in clinical examination or in the many MRI reports of LS patients.

While reading through these results it is striking that the link between the three reported phenotypes is at least tenuous, and in fact may not exist at all. The link between mitochondria and neurogenesis is based on a single paper that has been cited incorrectly and out of context. There is no evidence presented for a link between the Shh signaling defect reported and the mitochondrial phenotype.

General comments

(1) The preparation of the manuscript requires improvement. There are many errors in the presentation of data.<br /> (2) The use of references needs to be re-considered. Sometimes a reference is used when in fact the results included in that paper are the opposite of what the authors intend.<br /> (3) The authors conclude the paper by claiming that mitochondrial dysfunction and impairments of the ciliary SHH contribute to abnormal neuronal differentiation in LS, but the mechanism by which this sequence of events might happen hasn't been shown.

Final comments:

(1) Phenotype of increased astrocytes:<br /> The phenotype of increased astrocytes in both the IOB mouse brain or iPSC-derived cultures iN cells requires clarification as one of the markers used as an astrocyte marker, BRN2, is commonly used as a neuronal marker. As LS is a neurodevelopmental disorder, and the phenotype in question is related to differentiation, it is crucial to shed light on the developmental timeline in which this phenotype is seen in the mouse brain.

(2) Ciliary homeostasis:<br /> Mitochondrial dysfunction in astrocytes has been shown to induce a ciliogenic program. However, almost the opposite is shown in this paper, with regards to ciliation. Morphology of the cilia was not assessed either, which is an important feature of ciliary homeostasis. The improper ciliary homeostasis here appears to be the improper Shh signalling, which has not been shown to be related to mitochondrial dysfunction. This leaves one wondering how exactly the different phenotypes shown in this paper are connected.

(3) This paper lacks a clear mechanistic approach. While the data validates the 3 broad phenotypes mentioned, there is a lack of connection between these phenotypes or an answer to why these phenotypes appear. While the discussion attempts to shed light on this by referencing previous studies, some of the referenced studies show contradicting results. Hence, it would be beneficial to clarify these gaps with further experiments and address the larger question of the connection between the mitochondria, Shh signalling, and astrocyte formation.

(4) Most importantly, there is no mention of how the loss of OCRL, a 5-phosphatase enzyme, results in the appearance of the mentioned phenotypes. Since there are multiple studies in the field of Lowe Syndrome that shed light on the various functions of OCRL, both catalytic and non-catalytic, it is important to address the role of OCRL in resulting in these phenotypes.

(5) There are numerous errors in the qPCR experiments performed with regard to the genes that were assayed. The genes mentioned in the text section do not match those indicated in the graphs or legends. This takes away the confidence of the reader in this data.