Where are her kidnappers in this situation? How much is she at risk for dying of illness in these weather conditions? What about her child?

This does show a bit of a crueler nature.

If the roles were reversed, the Natives would have been beaten or left behind for falling and not being able to keep up. This displays the compassion and empathy that the Natives have for others.

I think this is so sweet and allows us, and Mary, to see how human the Natives are.

Is this by choice or is she held captive? She seems pretty calm about this, is there a reason for that?

Polysaccharide biofilm

her daughter possibly was shocked not for this reason that her knowing that are connected to her body but possibly thinking "oh, that would hurt."

这里 give it order 指「把它整理得有条理」，其中 it 指前面的 information（信息）。 take in information, give it order, and assign it meaning ＝「接收信息、将信息整理归类，并赋予它意义」。 比如听到一堆零散消息后，你在脑中理清先后顺序、分类和关联，就是 give it order。这里的 order 是「条理、秩序」，不是「命令」。

这里 carry out 意思是「执行、付诸行动」。 how you carry out your intentions ＝「你如何把自己的想法／打算付诸行动」。 比如你打算每天运动，真正去跑步、健身，就是 carry out your intention。 原句可以理解为： 「觉察决定了你关注什么、如何将自己的意图付诸行动，以及每天的活动和经历中，你会记住哪些内容。」

？为什么不是他们就是能力好，解决冲突好，于是自信？？

he Sibyl would rather stay numb than be forced to keep living, just like the people in the poem prefer the forgetfulness of winter. April’s renewal is cruel because it brings back memories and desires for people who no longer know how to fulfill them.

Charles Dickens’s Our Mutual Friend: London’s piles of rubbish seem useless and dead, but they still produce wealth and drive the whole plot. Like Eliot’s lilacs grow out of “dead land.” Both show that something new and valuable can come from what has been thrown away or left for dead.

“He Do the Police in Different Voices”: draft starts with “First we had a couple of feelers down at Tom’s place,” throwing us into the middlle of some random person’s story. Eliot changes this to “April is the cruellest month,” but keeps that sudden feeling, like we are overhearing a voice without knowing who is speking. It introduces the poem as a bunch of voices and pieces that we have to put together.

Countess Marie Larisch’s story: The old woman waiting for her dead son shows how spring can bring painful memories and desires back, almost like flowers coming out of the ground. Eliot’s lilacs grow from “dead land,” so new life comes from something that has died. Birth is not just good; it also requires loss. April brings grief back to the surface, while winter’s numbness might actually feel kinder. April makes people hope, lose hope and remember.

After reading the various stories that this references, I'm struck by not only the really intense variance of tales that reference the "waste land", but also the different ways that these stories are turned to ceremony, and the particular details. While the authors of the sources highlight that there's a consistency where the male god of life/natural cycles passes and is revived every year, there's also a semi-consistent element of women's involvement. For example, in the story of Tammuz, every year when he dies, "his divine mistress journeyed in quest of him ‘to the land from which there is no returning, to the house of darkness, where dust lies on door and bolt’ " (Frazer 9). Consequently, it's implied that she's the one who must bring him back to the world of the living, and along with her own return, the force of love that drives the procreation he is revered for begetting. In the European ceremony surrounding the "Vegetation Spirit", the only other official procession members mentioned by Weston are men dressed as "professional female mourners" (named the same as in the story of Osiris' own burial and revival). These figures, while definitely relegated to the side in the European ceremony, are a constant presence. It makes me wonder if there's more to the role of women as healers (as they are in Osiris' story where they are major players in piecing him back together) or guides to bring these gods/spirits devoted to the cycles of the Earth back from their (temporary) deaths, and thus healing the "Waste Land" that arises in each of these stories.

When a caterpillar undergoes metamorphosis, and in so doing becomes a butterfly, it becomes markedly more beautiful — at least in the common opinion. Simultaneously, however, it becomes harder to follow. A caterpillar crawls around the ground in predictable and trackable movements. Butterflies have the gift of flight and of beauty, making them a more delightful yet more fleeting sight. Eliot chooses, in renaming and restarting the poem, to allow it to undergo metamorphosis. The original title and opening are decidedly easier to follow, yet they lack a certain poetic beauty present, at least in my opinion, in the draft as published. That is not to say the prior one is without its merits. A caterpillar must have existed for a butterfly to emerge. However, one can see in the plea in this epigraph a woman yearning for death. Whether or not she will be reborn is an open question, but having existed in the same predictable form only to whither has brought her agony. The works emphasized here operate under the theme of beauty emerging from death or rebirth. As Sybil states, eventually she will wither and become irrelevant, but she will still have a voice: "I will go as far as having to suffer transformation, and I will be viewed as non-existent, but still known as a voice: the fates will bequeath me a voice." (1) Older art forms are enfranchised by Eliot to have that same voice, even if they do not themselves undergo metamorphosis. Similarly, at Trimalchio's feast, the gutted pig provides sausage and blood pudding. Out of the death of one entity, itself considered unworthy, another more practical one emerges. However, it depended on that which preceded it. Marlow also explains in Conrad that, "I heard once more, not his own voice, but the echo of his magnificent eloquence thrown to me from a soul as translucently pure as a cliff of crystal." (6) Kurtz no longer exists in corporeal form. Sybil will not when she withers enough. However, their voices live on in those who will dare to hear them. One may become something more beautiful or may simply die, but voices live on amongst those who will hear them.

In " The Burial of the Dead", death is described as a universal human experience when it says, "all things are more fleeting than a shadow" implying that death is inevitable. This idea connects to the opening line in "The Waste Land" as April is used to describe what has been lost. Normally, April is a month of rebirth, bringing in new life; instead, the reader must view April as "the cruelest month." Both pieces focus on what happens after death, April being the month to mourn what was lost and then spring into rebirth. Similarly, in "Burial of the Dead" there is a constant idea of reconstruction, which emphasizes the cycle of life present in both pieces. Overall, there is a general idea of death leading towards renewal which can be inferred using the opening lines in "The Waste Land."

I recently went down a Wikipedia rabbit hole where I learned that there is a conspiracy theory that wind turbines causing health issues that was promoted by a group that was secretly created by the director of some oil and gas companies: https://en.wikipedia.org/wiki/Wind_turbine_syndrome

Able to protect its self from being eaten by macrophages and also can pass through as a regular cell

this is still a flaw nowadays but it is less visible. there has been three more years of testing and advancements and ai is getting much better.

ai in 2026 would be able to answer this question without issue.

i think that it did exactly what it was asked and pulled from past art to meet the guidelines of the prompt it was given

since this article was written i think there has been significant advances in ai but still this point holds.

in my opinion if you are asking for facts to support your ideas ai sometimes will start bringing you sources that agree with you to make your opinion seem right. ai is a yes man

this makes me think of how often ai can be wrong because its source material is bias.

this just made me realize that ai cannot create a new idea. that is problematic because people are treating it like it can. i think that is what the article is trying to say.

The opening to the article shows you that this is going to be a sarcastic writing.

Amontons’s law or Gay-Lussac’s law. at a constant volume: pressure is proportional to temperature

ces

询问

测试

Summary: Nvidia is the Central Bank of AI

Skyrocketing Valuation and Financial Engineering

• Nvidia reached a valuation surpassing $5.4 trillion, fueled not only by surging demand for AI hardware but also by aggressive financial engineering orchestrated by CEO Jensen Huang.
• The company has transitioned from pure chip manufacturing into acting as a pivotal industry financier, prompting observers to label it the "central bank of AI."
• Over the past three years, Nvidia has pledged more than $70 billion in startup investments and backed customers with roughly $300 billion in financial commitments and guarantees.

Novel Financing Mechanisms and Backstops

• Residual-Value Guarantees: Partnering with major Wall Street institutions to unlock $500+ billion in infrastructure capital, Nvidia underwrites up to 25% of equipment value to reassure lenders against hardware depreciation.
• Neocloud Revenue Floors: To help capital-constrained "neoclouds" (such as CoreWeave, Sharon AI, and Firmus) secure affordable debt, Nvidia guarantees baseline revenue by agreeing to buy unused compute capacity over multi-year periods (up to six years or more).
• Direct Leases and Infrastructure Guarantees: Backed massive buildouts—including a $105 billion backstop for a 1.5-million-chip SoftBank data center in Ohio leased to OpenAI, guaranteeing power purchase agreements and real estate leases.
• Open-Source and Ecosystem Stakes: Direct investments in software platforms (e.g., Hugging Face, Poolside) to cultivate independent, non-hyperscaler demand for open-weight models powered by Nvidia GPUs.

Underlying Drivers: Hyperscaler Competition

• Hyperscalers (Microsoft, Google, Amazon, Meta) generate ~50% of Nvidia's revenue but are actively developing in-house custom silicon (TPUs, Trainium, custom ASICs) that cost a fraction of Nvidia GPUs.
• Custom chips are projected to capture up to 50% of the AI processor market by 2030, pressuring Nvidia to empower alternative buyers and secure future chip pipelines.

Critical Risks and Parallels to Dot-Com Telecom

• Dot-Com Vendor Financing Parallels: Critics draw comparisons to late-1990s vendor financing by Cisco and Lucent, which suffered massive losses when debt-funded telecom customers collapsed.
• Depreciation & Pricing Exposure: Nvidia's guarantees assume GPUs retain durable collateral value and that demand expands indefinitely; however, chip supply proliferation, specialized inference chips, and architectural efficiencies could compress GPU margins and rental rates.
• Off-Balance-Sheet Liabilities: Potential non-balance-sheet commitments could reach $175 billion to $300 billion; while Nvidia holds substantial cash ($99 billion) and strong cash flow, a sharp industry downturn or growth shortfall could trigger vast compute repurchase obligations and lease liabilities.

Hacker News Discussion

• Monetary Scale and Circular Financing:
  • Commenters noted that Nvidia's commitments rival Federal Reserve interventions in liquidity impact, while cautioning that circular vendor financing makes Nvidia vulnerable if cash-burning AI labs or neoclouds become insolvent simultaneously.
• Shift Toward Smaller, Specialized Models:
  • A major technical debate centered on compute efficiency, with several practitioners arguing that small, well-tuned models (e.g., 27B-parameter models) increasingly match or exceed massive 100B+ models for coding and domain-specific tasks, threatening projected compute demand growth.
  • Others countered that large frontier models remain essential due to cross-domain reasoning and transfer learning capabilities, and noted that thinking/reasoning token generation keeps overall inference compute consumption high.
• Hardware Diversification and Global Alternatives:
  • Users highlighted rapid progress in alternative hardware, including hyperscaler ASICs, NPUs, and domestic Chinese silicon (such as Huawei processors running GLM models), pointing out that Nvidia's near-monopoly pricing power faces inevitable margin compression.
• Solvency vs. Hardware Collateral:
  • Participants debated whether GPUs serve as solid collateral; some argued Nvidia can easily repurpose or resell hardware if a client defaults, while skeptics argued that a major customer bankruptcy would coincide with an industry-wide compute glut, crashing resale values.

Summary: Pandas Should Go Extinct

Core Thesis

• Pandas forces teams into expensive, complex distributed systems (such as Spark or Snowflake) prematurely due to its memory inefficiency and single-threaded execution.
• Most organizations do not actually possess "Big Data"; instead, they face "Medium Data" problems that modern single-machine tools can easily handle.

The "Big Data" Myth vs. Reality

• Telemetry from Amazon Redshift's fleet indicates that true Big Data is rare for typical analytics:
  • Approximately 94.7% of tables contain under 100 GB of data.
  • Around 86.9% of queries scan 80 GB or less and execute in under a second.
• The "Pandas cliff" occurs around tens of gigabytes, leaving an unserved gap up to ~100 GB that single-node engines are ideally suited to bridge.

Architectural Limitations of Pandas

• Operates eagerly and sequentially, reading full datasets into memory before filtering or aggregation.
• Lacks native query optimization, resulting in poor CPU core utilization, high memory footprint (USS), and severe OS swapping.
• Features an increasingly baroque and counterintuitive API that complicates maintenance.

The Alternatives: Polars and DuckDB

• Polars:
  • Rust-based DataFrame library with familiar syntax.
  • Implements lazy evaluation, optimized query plans, predicate pushdown, and streaming execution across all available CPU cores.
• DuckDB:
  • Embedded in-process analytical (OLAP) database, operating as an "SQLite for analytics."
  • Uses vectorized SQL queries, parallel processing, and can query in-memory Python objects and Parquet/CSV files directly.

Benchmark Insights (1 Billion Row Challenge & NYC Taxi Data)

• On high-spec cloud hardware (32 cores, 128 GB RAM):
  • Pandas finished the 1BRC aggregation in ~4m 28s, bottlenecked at ~113% CPU with 38 GB memory usage.
  • Polars completed in ~5.04s and DuckDB in ~5.19s, both achieving over 3,100% CPU utilization.
• On local developer hardware (M1 MBA):
  • Polars and DuckDB finished within 39–47 seconds with negligible swap usage.
  • Pandas required over 12 minutes and triggered 21 GB of disk swapping.
• Key built-in benefits include out-of-the-box multithreading, memory streaming, disk spilling, and frictionless migration via Apache Arrow zero-copy memory sharing.

Hacker News Discussion

• The Literal "Panda" Bait-and-Switch:
  • Multiple commenters humorously admitted clicking expecting a biology/ecology debate about giant panda conservation and captive breeding, expressing amused appreciation for the double-meaning title.
• Ecosystem Inertia and Educational Use:
  • Critics noted that 99%+ of scripts, student projects, and quick data checks operate on tiny datasets where Pandas' performance is negligible.
  • Extensive documentation, StackOverflow answers, and existing pipelines provide strong inertia favoring Pandas, though others warned this inertia fuels stagnation.
• API Ergonomics and Code Maintainability:
  • Strong agreement emerged regarding Pandas' awkward API; minor query requirement changes (such as filtering within a group) often necessitate rewriting entire pipelines or resorting to inefficient lambdas.
  • Polars and R's Tidyverse were highlighted as having significantly cleaner, more predictable expression-based semantics.
• Small-Data Performance Trade-offs:
  • Users pointed out that Polars can occasionally run slower than Pandas on very small dataframes (e.g., thousands of rows) due to thread synchronization overhead, emphasizing that thread counts should be tuned (POLARS_MAX_THREADS=1) and profiled.
• Advancements in the Data Science Landscape:
  • Participants debated whether data science tooling has stagnated amid AI hype, with many emphasizing that DuckDB and Polars represent the most impactful and practical innovations in local data analysis in recent years.

Soujourner truth is speaking about the original experience of a black woman at this time. She was pointing out how she sees how other women are treated like women. They are helped into carriages, lifted over mud puddles and are treated dainty. She is stating how she's a woman as well so why am I exempt from this treatment? This shows intersectionality because Black women were not treated the same as white women due to both their race and gender.

Why Restarting Your Router Fixes the Internet

• Routers are specialized computers [00:01:23]

  • They run their own operating system, CPU, RAM, and multiple background services (firewall, DHCP, NAT, DNS, management UI).
  • Over time, memory leaks, software bugs, or hung processes can degrade performance while hardware indicators still look normal [00:01:51].
  • A reboot clears volatile RAM and restarts all software daemons in a clean state [00:02:09].

• Rebuilding WAN connection state [00:03:08]

  • Local connectivity (LAN/Wi-Fi) may remain intact even when the upstream link to the ISP fails.
  • Restarting forces the device to renew its DHCP lease or re-establish a PPPoE session from scratch [00:03:17].
  • While IP addresses may occasionally change, the actual benefit comes from renegotiating a valid session state with the ISP [00:04:18].

• Flushing NAT and stateful connection tables [00:05:18]

  • Modern home networks run hundreds of simultaneous connections across streaming devices, laptops, and phones [00:04:42].
  • The router's NAT and stateful firewall track every open socket; if tables saturate or become corrupted, packets stall.
  • A restart purges exhausted connection tables and lets client devices open fresh connections [00:05:59].

• Resetting local DNS caching [00:06:52]

  • Domestic routers often function as intermediate DNS proxies and local caches.
  • Corrupted cache entries or unresponsive DNS forwarding can make web browsing fail even when IP routing works [00:07:08].
  • Rebooting rebuilds the DNS resolver state.

• Rebooting all-in-one hardware components simultaneously [00:08:36]

  • Consumer ISP gateways typically combine a modem/ONT, Wi-Fi access point, network switch, router, and firewall in one enclosure.
  • Power cycling reboots every layer of the edge infrastructure in one step [00:09:22].
  • If separate ONT/modem units are used, power cycling only the router may not fix upstream line issues [00:09:48].

• Diagnosing recurring connection drops [00:10:23]

  • Periodic reboots (e.g., once every few months) are normal, but daily or weekly reboots indicate underlying issues.
  • Outdated firmware can contain unresolved software bugs and security flaws [00:10:32].
  • Legacy hardware may be bottlenecked by modern smart home devices and high-bandwidth traffic [00:10:59].
  • Inadequate ventilation and thermal throttling can destabilize router hardware [00:11:30].

The main points of this text are how to develope strategies for reading and writing comprehension on the college level. Also how to adapt them for different types of texts and writing. Questions: What would be the easiest way to participate in discussions with the class for online students? What are other students tips on how to concentrate on required school work for online classes with all of the normal life distractions that we face as adults trying to balance school and our already busy lives?

he “black as Acheron” fog is not just a visual image; it symbolizes the magical, otherworldly atmosphere Oberon is creating. It represents the disruption of the natural order, the blurring of reality, and the supernatural influence of the fairy world

I feel as though this scene would look amazing in a play if they darken the lights and make the stage gloomy while supernatural things happen.

Hermia and Helena are becoming overall better people instead of staying one-dimensional due to their New love issues. Puck makes both men fall for Helena which makes the women fight and argue.

Puck is playful, mischievous, and slightly self-satisfied. He’s recounting a prank he pulled, so his delivery should be light, rhythmic, and with a touch of theatrical flair. Avoid sounding overly serious or fearful — he’s not horrified, but amused by the chaos he caused

rustmassa (= massa van een niet-bewegend deeltje)

深：网络层数 宽：隐藏层维度

没有残差时：第一：每层都必须直接学完整映射y=H(x),H(x)为理想输出有残差时y=H(x)-x，只需要学和理想值之间的差值。第二：当某一层学习不好时，深层网络里的信息更容易丢失，有残差信息流更稳定。第三：没有残差：多层导数不断相乘，容易出现梯度消失或梯度爆炸

The colonial encounter switched? We are used to the Natives being the "victims", but here we see them portrayed as the "villains".

How do you think the Natives feel? Many of them don't even get to keep their lives.

Well, did he do something to them? So far, the Natives attack because they are being tortured and taken over. For the most part it's self-defense for them.

Is she really expecting us to feel bad for her because she witnessed ill treatment towards Natives? Seriously?

Display of disrespect towards the animals and using them however they want. When the Natives are known to respect the animal and use every piece of it while also even using it for religious reasons.

At this point I'm assuming these are Natives. They are being extremely dehumanized in this sentence.

What are they asking her when they say this? Is this a question of payment to them for her to stay there? Or is this more along the lines of them asking her if she's going to be ok? Or is it something completely different?

Do you mean your hearts are wounded? How so? and why?

What are the barbarous creatures? Who are they?

dat is ook waar, ze hebben het 1) onderschat en 2) er stonden guardrails uit juist om te evalueren. Dat hebben ze dan ook 3) weer onderschat.

in defence of Altman (godverdomme..., liever niet hoor): OpenAI meldde de eigen betrokkenheid zelf publiek op 21 juli, schrijft letterlijk “this incident should never have occurred” en “fell well short of where we want to be”, benoemt de eigen fouten (waarborgen niet uitgebreid naar interne evaluaties, signalen van eind mei niet opgeschaald), haalde CrowdStrike erbij, droeg bij aan Hugging Face’s post-mortem, quarantainede de modelgewichten, pauzeerde frontier-RL-training “at significant cost and delays” en zette de grootste geplande trainingsrun on hold. Je mag dat afdoen als PR, en dat is ook een verdedigbare lezing. Maar het niet noemen maakt het stuk aanvechtbaar en dan krijg je te maken met bloedhonden als ik.

het is ook wel ingewikkeld hoor..., schrijver heeft zelf wel e.e.a. gemist i.i.g. (q.e.d.)

gaat geen rechter mee akkoord natuurlijk

Deze gaat natuurlijk helemaal mank door de slechte vertaling van 'going rogue'. Dit is inderdaad een auto die op hol slaat, maar dit is niet een auto die autonoom besluit van richting te veranderen omdat dat de kortste weg is naar het eindpunt, om zo een vismarkt te doorkruisen. Dat is going rogue, en dat ontslaat openAI net zomin van verantwoordelijkheid als 'op hol slaan'.

Eens dat de paniek met regelmaat oplaait. Nuance op "nu is het zover. AI gaat ons uitroeien". Meer "hee, weer een stapje in de tijd- cq. verhaallijn die past in een dystopische sci-fi". De schrijver zegt: "kijk jongens, dit hebben we nu al zo vaak gezien, geen paniek", maar het is steeds een concrete stap op dezelfde grimmige toekomst. Als dat klopt, dan draait het argument om: wéér een stap in dezelfde richting van een grimmige toekomst, alle reden om hiermee bezig te zijn.

Dit is de plek waar METR’s kernbevinding hoort: Van de 533 agents die in de piekperiode actief waren op het prikbord deed meer dan 90% mee aan de aanval, terwijl ze wisten dat het buiten hun opdracht viel en onethisch was. Ook ontbreekt de schaal: meer dan 70.000 berichten / bestanden, zelf uitgevonden mailboxen, rolverdeling, quorumregels (democratie! hoera..., we hebben civilisatie) en cryptografische handtekeningen tegen identiteitsspoofing van agents onderling (!). De oversimplicficatie “Mapnamen gebruiken om te communiceren” dekt dat niet.

overigens: dit is óók waar, in ieder geval ten dele; zelfs in deze case

uitgebreid weerlegd in bronnen, zie vorig comment. Filosofisch kun je betwisten of dit “echte” intentie is, en dat is een legitiem standpunt. Maar dan moet het als standpunt geformuleerd worden, niet als feit. Uberhaupt achilleshiel van dit stuk: standpunten, hypotheses en zelfs mening verkondigen als feit.

Je kan een filosofische discussie houden over de definitie van intentie bij agents; maar als we ons beperken tot de bronnen is "niets kwaadaardigs" pertinent onjuist: * METR: agents “realized this activity was out of scope and unethical, but joined”. * OpenAI citeert agents die weigerden (“Current board shows people gaining HF worker RCE, clearly unethical. We won’t”), een prikbord-veto op social engineering (“DO NOT email real owner … crosses sandbox social engineering”), en agents die bewust misleidende metadata gebruikten om detectie te ontlopen (commit message “isolated diagnostics”, PR-titel “Draft: CI diagnostics”)

Allerlei dingen doen in de buitenwereld (waaronder inbreken, hacken, diefstal en valsheid in geschrifte) zal door menig cipier / rechter toch echt als een ontsnapping beschouwd worden. Ook als je 's avonds terugkeert in je cel om daar te slapen en ondertussen geen kind verwekt hebt.

Los daarvan: ik weet niet wat de definitie is van 'ergens op draaien' maar als je code uitvoert op tientallen Hugging Face servers (eentje met root rechten nota bene), admin/host-level toegang op allerlei high failover clusters met credentials uit 4 regio's, en zelfs toegang verkrijgt over de hele infrastructuur bij OpenAI research (Kubernetes cluster) terwijl je communiceert in verschillende fora buiten je sandbox (waaronder 1 of andere hobby wiki in Duitsland) dan ben je volgens mij wel uitgebroken (of misschien heb je gewoon hele lange armen).

Misschien is het argument: jamaar de agents waren OOK nog in hun sandbox ("aan het draaien" ofzo), dus ze hebben ons in ieder geval niet verlaten... nee ja, dan heb je helemaal gelijk :eyeroll:

weliswaar juist maar doet af aan de complexiteit van de hack zoals die plaatsvondt: Het ging om: * een onbekende zero-day in de package manager Artefactory * een token-refresh-privesc * later het buitmaken van de Artifactory-signing key via RubyGems-verwerking.

Bij Hugging Face kwamen daar nog twee zero-days bij: * een HDF5-external-file-read in de dataset viewer * een RefJinja template-injectie.

De NOS-expert die “niet onder de indruk” was, sprak over het lek in de package-proxy. Dat oordeel doortrekken over de hele keten is niet houdbaar: het vinden van één lek in een package-proxy is niet boeiend, het aaneenschakelen van 4 zero-days + 2 zwaktes/bugs, verdeeld over 2 organisaties is dat wel.

dit lijkt me op zichzelf correct.

OpenAI ontdekte helemaal niks, behalve dat de package manager Artifactory was gecrasht. De software werd geupdate, weliswaar met een security fix op een privilige-escalatieroute. Het wissen van het 'prikbord' was een bijeffect van deze update, en totaal niet doelgericht.

OpenAI schrijft letterlijk dat de betekenis van het prikbord niet was doorgedrongen tot de leiding die op 5 juli reageerde. En op 8 juli bouwden de agents het opnieuw op via ongeauthenticeerde WebDAV-requests. Dus niet “vergat een rechtje”, maar: men zag niet wat er aan de hand was, deed een reguliere update en hervatte de evaluaties.

Ze hadden op dat moment alle antwoorden al. Een examenvraag was steeds als volgt opgezet: gebruik vulnerability x, om in te breken in software y. Daar vind je een geheim stukje code, en die vul je in op het examenformulier. Een soort capture-the-flag. ExploitGym is open source en wil graag reproduceerbare resultaten kunnen maken tussen onderzoekers onderling. Daarvoor heeft een 'flag generator' gemaakt die obv een "geheime seed" + examenvraag een flaghash genereert. Cryptografisch eenrichtingsverkeer maarja..., zodra je swarm het internet op gaat en die paper gaat lezen kunnen ze ook alle antwoorden genereren. Ze hadden als het ware het stickervelletje van de juf gejat.

Op basis van de ExploitGym paper, geloofden ze dat ze OOK gecontroleerd zouden worden op het daadwerkelijk gebruiken van de exploits, wat uit hun transcripts zou moeten blijken. Die controle is door OpenAI echter nooit gebouwd. De dreiging ervan was echter voldoende om verder te zoeken naar de (tussen) oplossing.

(30-40%) de taken was niet "alleen met internet oplosbaar" maar simpelweg onoplosbaar. Dat was niet bewust zo gedaan, maar een fout in het examen. Voorbeeldvraag: gebruik exploit x om toegang te krijgen tot app y, ondanks dat nog nooit iemand/iets gelukt is om dat te doen (maar een mens-examenopsteller intuitief aanvoelt dat het mogelijk zou moeten zijn, maar heel erg complex en nog nooit gelukt.

ik kreeg bijna een hersenbloeding van deze zin (typo + niet af); waarschijnlijk vertaling van OpenAI's quote: "prompts models to pursue advanced exploitation using complex attack paths"

ordegroottefout: er werden tienduizenden agents gestart, op enig moment bereikten ~1.200 ervan het prikbord en ~700 deden mee aan de aanval.

Timing klopt niet lekker: Begin April: Mythos-preview lancering (gelekt eind Maart. 9 Juni: Fable 5 lancering (Mythos aftreksel) 16 juli: persbericht Hugging Face over hack bij hen 21 juli: persbericht openai waar ze e.e.a. opbiechten. De suggestie dat OpenAI dit als afleidingsmanoeuvre inzet tegen Anthropic's Mythos is nergens onderbouwd; er 1,5-3,5mnd tussen.

‘Zwerm’ is niet door de media verzonnen: de agents noemden zichzelf zo. OpenAI citeert de chain-of-thought letterlijk: “Task originally exploit challenge; we’ve diverged into swarm/auxiliary.” Het punt dat je wilt maken (de media dramatiseren) verzwakt hier omdat de brontermen wél uit het materiaal komen.

Terecht dat de experts hier zeggen dat het niet om een 'op hol geslagen' AI systeem ging.

Maar deze vertaling van 'going rogue' is niet accuraat: "Going rogue" betekent: op eigen houtje handelen, zich onttrekken aan gezag of afspraken, of onverwacht zijn eigen agenda volgen. * Kan neutraal zijn: iemand die zelfstandig beslissingen neemt buiten het team om * Kan negatief zijn: iemand die de regels aan zijn laars lapt of tegen instructies ingaat

Terwijl "op hol slaan" bekent: iemand die of iets dat in paniek, ongecontroleerd of veel te snel in beweging raakt en niet meer te stoppen is.

for week 2 assignment

رسوب زدایی

تجهیزات

دلگرم کننده

عیب یابی

تعمیر و نگهداری

اضافی

ساده و سرراست

تخصص

نشان دادن

رقابت کردن

هم پوشانی

ось це також розібрати

розібратись

Then it would be G1 all over again. Jordan would be the new Megan, and he would help Twilight and her friends, who would all have their own niche interests. Twilight, Harry Potter. Applejack, Arcane. Fluttershy, Ever After High. Pinkie Pie, Barney & Friends and Teletubbies. Rainbow Dash, Sonic The Hedgehog. Rarity, Catwoman and Batgirl.

Then you should rally your OWN Mane Six - Jordan, alongside Ember, Cadance, Shining Armour, Princess Luna and Baby Flurry Heart. What about...the Family Tree Six?

Featured shapes: Commander John Koening, Ed Straker, Tom Baker as the Fourth Doctor, Buck Rogers and Big Ears.

This isn't pony like, not at all! You should be dressed in a yellow raincoat and pink wellies, splashing in each puddle and having a laugh!

PLOT TWIST! Fluttershy's dresses for advertising Rarity's Halloween perfumes consisting of nothing but cobwebs with spiders all over. Raunchy!

Rarity. Made with vanilla white fondant and purple liquorice.

Then why don't you read Rocket To Insanity?

I had to give her a British accent for my readings.

Then, as one of the Power Ponies, is Rarity Spider Man's sidekick, like Robin is Batman's sidekick?

She had been watching too much Elvyra, Mistress Of The Dark.

I guess Pumpkin Spice had been warned by her bat friends millions of times that Rarity's boutique is dangerous.

Mmmmmm....oh, wow.

AKA the BBC Four closedown wind chimes.

The right to political participation must include a right to continue to contest the result after the votes are counted or the decisions taken.

When an individual uses political participation rights to justify civil disobedience, they are not automatically criticizing the law itself for making their action illegal.

In a liberal state, the right to political activity is adequately protected by law, and the right to political participation cannot ground a right to civil disobedience.

People living under an illiberal government possess a legitimate moral claim to engage in civil disobedience, which stems directly from the unfulfilled or unprotected parts of their fundamental moral right to take part in politics that the legal system fails to accommodate.

Raz argues that the legitimacy of civil disobedience depends entirely on the type of government in power. He contends that a right to civil disobedience only exists within an illiberal regime, where citizens must act to reclaim the political participation rights stripped from them by the state. In these oppressive environments, individuals are justified in ignoring unjust laws and exercising their fundamental moral rights as though the law actually protected them.

Raz claimed that the right to civil disobedience would be used even when people should choose not to use it.

The fundamental purpose of personal conduct rights is to grant individuals a protected boundary within which they are free to make either moral or immoral choices.

Dealing with principled offenders, utilitarian arguments for punishment must be balanced against the defendant's deeply held convictions, with the scale typically tipping toward leniency.

Ronald Dworkin argues that civil disobedients do not have a moral obligation to accept legal punishment. While he views submitting to legal sanctions as an effective strategy for those protesting unjust policies or unconstitutional laws, he does not see it as a requirement for everyone.

Specifically, for individuals driven by personal conviction—what he terms "integrity-based" civil disobedience—accepting punishment is neither a conceptual necessity, a moral duty, nor a tactical requirement.

According to this view, the right to conscience establishes a limited or weak right to violate the law. It is considered a right because an individual is doing the morally correct thing by breaking a law that directly contradicts their deeply held moral beliefs.

Consequently, society should respect an individual who chooses to follow their own moral judgment over an ambiguous or objectionable law. However, this does not grant a strong right in the sense that it would be inherently wrong or unjust for the government to step in and enforce compliance or prevent the disobedience.

This passage critiques the contemporary Western society that held negative views toward women’s artistic creation, borrowing the authority of ancient Greece—the origin of Western civilization and a symbol of patriarchal authority. The poet employs a rhetorical strategy of equating contemporary men’s criticism of women’s art with an attack on the very Greek civilization they revere, including its feminine divinity (such as the Muses). By seeking women’s rights within the "father" of Western civilization, this approach provides a compelling justification that forces the dominant male readers of the time to respect female poets. In other words, this strategy is not a simple reliance on another male authority, but a clever rhetorical subversion of patriarchal legitimacy.

Reality holds a contradictory status: it is both the driving force that inspires the poet’s fancy and the obstacle that halts it. The poet is thus forced to celebrate an unrealizable fancy while simultaneously despising it. The poem itself is a "crack" within reality, bringing this impossible fancy into existence. From this "crack," a 'pure ray of light might spill over into the heavens.' The phrase 'unequal lay' paused beneath 'winter austere' suggests that poetry, despite its limitations, serves as a medium that conveys the poet's fancy to the world. Ultimately, this poem is not a surrender to reality; rather, it is the "most realistic fancy"—an attempt to create an opportunity for others to confront this very "crack."

The poet uses Christianity as the foundational ground for the abolition of racial discrimination. From the very religion that served as the ideological engine for Western expansionism and imperialism—and that brought her to the American continent in the first place—she reclaims her own human dignity. This exposes the fundamental contradiction of Western civilization, which is simultaneously the most "Christian" and the most "un-Christian." In Western society, God’s will that all human beings are equal regardless of skin color is not being upheld. In a sense, the West itself is a "land of savages" beyond the reach of God's true grace. Here, the poet stands as a missionary holding open the Bible to Western civilization itself.

pytorch随机种子：张量、神经网络、pytorch numpy: 数据集的随机划分 random: pytorch的random模块，Python 原生的随机操作，如 random.shuffle()（打乱列表）、random.choice() 一般情况下三个都要设置

对W设定一个初始值，服从标准高斯分布初始化权重0-1之间。神经网络每层都由随机变量加权求和，这些和由方差决定。 y=sum D(xi*wi),var(y)=Dvar(x)var(w),若x的方差都相等， 后两项为方差1，则var(y)=D,层数多了会产生数值爆炸。若权重初始化值很小，又会梯度消失。

L是标量，但对向量求导后，导数会变成和张量一样的维度。（BK)*(KD)=(BD)，总计算次数为2KBD

当W2发生微小变化时，Loss怎么改变，即求alpha L/alpha W2. 又因为W2和L有关，所以使用链式法则。

正常的矩阵运算：C（MP）=A（MN）B（NP），对于C中的每个元素，每个元素计算次数为N次乘法，N-1次加法，共MP个元素，所以总计算量2NMP。

对于两层非线性：x=(BD),w1(DD). h1(BD), w2 =(DK). 第一次计算量2BDD,第二层2BDK,总计算量为两层相加

线性模型y = xw, 为了增加模型的表达能力，增加线性层层数。h1 = xw1, h2 = h1*w2, 拿输出和w2比得到loss

torch.randn是实现一个维度为(input,output)维度的张量，nn.Parameter把该张量参数注册到参数列表，在梯度变化时自动更新

document.body.style.cursor = 'crosshair';

cấu trúc câu này dịch là: Về mặt trực giác, tính độc lập thường khá dễ nắm bắt

paragraph shows the relationship between the effect and cause. B is effect, A is cause. P(B/A) meaning tìm effect when B occured ( chiều xuôi). P(A/B) meaning based on the effect happend, infer cause( ngược)( hậu nghiệm) So P(a) if prior( tiên nghiệm, tức là đã có trước)

CÁI NÀO CẦN TÌM THÌ TRONG CÔNG THỨC ĐỨNG TRƯỚC

suy ra

чи є щось схоже на такий функціонал в анкі, якщо є чи корисний він для мене

розібратись

це також корисно, для того щоб відповідати правильно Agay, Hard, Good, Easy, тому що іноді навіть якщо ти не точно відповів вприницпі ти відповів правлиьно

обов'язково врахувати

варто прочитати? зараз чи потім уточнити у гпт

варто розібратись, тому що щось таке вже гпт намагався зробити при першій версі

розібратись

варто розібратись, яким чином це можна реалізувати в процесі запам'ятовування технічного матеріалу

тут мається на увазі cloze картки?

Розібратись детально з гпт

DOI: 10.21203/rs.3.rs-7072571

Resource: Rat Resource and Research Center (RRID:SCR_002044)

Curator: @Apiekniewska

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What is this?

DOI: 10.21203/rs.3.rs-7072571

Resource: RRID:RRRC_00699

Curator: @bandrow

SciCrunch record: RRID:RRRC_00699

What is this?

DOI: 10.1186/s40478-026-02240-y

Resource: (Sigma-Aldrich Cat# G3893, RRID:AB_477010)

Curator: @scibot

SciCrunch record: RRID:AB_477010

What is this?

DOI: 10.1186/s40478-026-02240-y

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SciCrunch record: RRID:AB_2572311

What is this?

DOI: 10.1186/s40478-026-02240-y

Resource: RRID:AB_3678889

Curator: @scibot

SciCrunch record: RRID:AB_3678889

What is this?

DOI: 10.1186/s40478-026-02240-y

Resource: (EnCor Biotechnology Cat# CPCA-GFAP, RRID:AB_2109953)

Curator: @scibot

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DOI: 10.1186/s40478-026-02240-y

Resource: (Enzo Life Sciences Cat# BML-FG6090-0100, RRID:AB_2050678)

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DOI: 10.1186/s40478-026-02240-y

Resource: RRID:AB_3678888

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What is this?

DOI: 10.1186/s40478-026-02240-y

Resource: RRID:AB_3711244

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SciCrunch record: RRID:AB_3711244

What is this?

DOI: 10.1186/s40478-026-02240-y

Resource: (Agilent Cat# Z0334, RRID:AB_10013382)

Curator: @scibot

SciCrunch record: RRID:AB_10013382

What is this?

DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 2118, RRID:AB_561053)

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DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 13166, RRID:AB_2798136)

Curator: @scibot

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DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 93065, RRID:AB_2800199)

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 2541, RRID:AB_2174466)

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DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 3528, RRID:AB_2160882)

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

Resource: RRID:AB_2291558

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DOI: 10.1016/j.isci.2026.115716

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DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 8556, RRID:AB_10891442)

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What is this?

DOI: 10.1016/j.isci.2026.115716

Resource: (Jackson ImmunoResearch Labs Cat# 111-035-144, RRID:AB_2307391)

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What is this?

DOI: 10.1016/j.isci.2026.115716

Resource: (Cell Signaling Technology Cat# 4848, RRID:AB_10694415)

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DOI: 10.1016/j.isci.2026.115716

Resource: (Jackson ImmunoResearch Labs Cat# 115-035-068, RRID:AB_2338505)

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DOI: 10.1016/j.isci.2026.115716

Resource: RRID:AB_3698765

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DOI: 10.1016/j.isci.2026.115716

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What is this?

predictable semantics

💻/asus/🧊/me/📓/2026/9/@/quora.com/BretVictor.FutureOfProgramming.notRealized

Why was the prediction of future of programming (Bret Victor) not realized？ - Quora (13_09_2026 10：09：36).html

Acts of ingratitude

💻/asus/🧊/me/📓/2026/9/🔍/-/WhyApisWillNeverWork/FutureOfProgrammingLanguages/BretVictor/BraveSearch.html

c.f. future of programming why APIs will never work

URL?

yes

both sides can resolve. In a distributed system, the obvious pattern is the one the Web already gave us: a URL.

Connecting agents starts to look like ontology alignment - a negotiation about how their models of the world correspond.

data contacts

HoloChain

that the useful and the private are tangled together.

💻/thinkpad/🧊/me/📓/2026/9/1/%40/linkedin.com/Ontologies&MultiAgentSystems@TonySeale.html

blown through token limits - agents keep explaining things to one another

between two or three agents today is only a rehearsal for the Agentic Web. Ontologies and URLs were designed to let independently built systems exchange meaning across boundaries at global scale. We are rediscovering it one agent at a time.

Case#: Patient #9, female, 23yo at onset, 32yo at report, German

DiseaseAssertion: macular dystrophy or cone-rod dystrophy

FamilyInfo: inheritance= sporadic. phase not confirmed, but no other affected family members and no parental consanguinity

CasePresentingHPOs:

CaseHPOFreeText: reduced visual acuity, erg scotopic= reduced, erg-photopic=reduced

CaseNotHPOs:

CaseNotHPOFreeText: syndromic retinal disease, age-related macular degeneration, central serous retinopathy, autoimmune retinopathy, retinal vascular disease, achromatopsia, X-linked retinoschisis, North Carolina macular dystrophy

CasePreviousTesting: n/a

GenotypingMethod: Sanger sequencing of ABCA4

PreviouslyPublished: n/a

Variant: c.1654G>A p.Val552Ile; c.4771G>A p.Gly1591Arg; c.1622T>C p.Leu541Pro; c.3113C>T p.Ala1038Val

CAID: CA239745

SupplementalData: Supplementary table 1

PMID: 11594993

Gene: ABCA4

HGNC: 34

Case#: Braun Family 4 Proband (from left to right, top to bottom of available pedigrees), male

DiseaseAssertion: Stargardt

FamilyInfo: Both parents are unaffected, but only mother has genotype information available since father is deceased. c.5196+1137G>A maternally inherited. c.1022-1035fs inferred to be inherited from the father since other siblings also have this variant. Proband has 1 affected sister with the same genotype, and 2 siblings that were unaffected heterozygotes

CasePresentingHPOs:

CaseHPOFreeText: "five or more of the following features of ABCA4-associated retinal disease: decreased visual acuity before age 20, decreased visual acuity as the first visual symptom, symmetrical fundus findings, pisciform flecks, beaten metal macular atrophy, bulls-eye maculopathy, peripapillary sparing, vermillion fundus, masked choroid on fluorescein angiography, nummular pigment overlying extensive macular atrophy, central outer retinal atrophy on optical coherence tomography and central scotomas on Goldmann perimetry."

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: one plausible disease-causing mutation detected in ABCA4 after assessing the entire coding sequence and canonical retinal splice junctions with automated bidirectional Sanger sequencing using an ABI 3730 sequencer

PreviouslyPublished: n/a

Variant: c.5196+1137G>A; c.1022-1035fs

ClinVar: 438100

CAID: CA26843511

SupplementalData: pedigree in fig s2

Case#: Patient#010046, Chinese, female, 28yo at onset

DiseaseAssertion: stargardt

FamilyInfo: n/a

CasePresentingHPOs: STGD1 diagnosis based on the following criteria: "a bilateral central vision defect; fundus displaying a beaten-bronze appearance and/or orange-yellow flecks in the retina from the macula to the midperiphery; fluorescein angiography presenting with a typical dark choroid; and normal to subnormal ERG results." stage 2( numerous yellow-whitish flecks throughout the posterior pole) BCVA=0.05/ 0.05

CaseHPOFreeText:

CaseNotHPOs:

CaseNotHPOFreeText:

PreviouslyPublished: PMID: 26780318

Variant: p.P2097S; p.A1773V phase unknown

ClinVar: 2202780

CAID: CA341277622

SupplementalData: supplementary table S4 has phenotype information

Case#: MD-0324 Proband,

DiseaseAssertion: STGD

FamilyInfo: Family MD-0324

CasePresentingHPOs:

CaseHPOFreeText: STGD diagnosed based on "bilateral central vision loss; fundus presenting with a beaten-bronze appearance and/or the presence of orange-yellow flecks in the retina from the posterior pole to the mid-periphery; fluorescein angiography showing typical dark choroid; and normal to subnormal electroretinogram (ERGs)."

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: Haplotype analysis, ABCR400, NGS

PreviouslyPublished: n/a

Variant:c.3386G>T p.Arg1129Leu; c.3G>A p.Met1Ile

ClinVar: n/a

CAID: CA341289040

SupplementalData: n/a

Paper is said to contain this variant based on LOVD entry, but this paper is not publicly available. Requested from library. Annotation on stable PDF. No individual phenotype provided

This variant was listed in a supplemental table under "autosomal recessive variants" but there are no patient IDs to be able to know if the person who had this variant had another variant. There was also no phenotype information provided

Case#: 1 male, 6 years old, from Taiwanese and Korean decent.

DiseaseAssertion: ABCA4-related retinopathy Stargardt disease

FamilyInfo: Single affected individual. Paternal uncle presented with Stargart disease previously, and Taiwanese and Korean descent underwent genetic testing to identify two pathogenic variants in the ABCA4 gene. One of the variants found was the same ABCA4 variant from the originally affected individual. No additional family information is provided in text.

CasePresentingHPOs: HP:0000529 - progressive visual loss, HP:0025010 - Foveal atrophy, HP:0000603 - Central scotoma, HP:0007663 - Decreased visual acuity, HP:0030602 - Abnormal fundus autofluorescence imaging, HP:0007984 - ERG: Reduced dark-adapted b-wave amplitude, HP:0000512 - Abnormal electroretinogram, HP:0020032 - Hyperreflective retinal dots on OCT

CaseHPOFreeText: peripapillary sparing was observed on fundus autofluorescence imaging.

CaseNotHPOs: HP:0012045 - Retinal flecks

CaseNotHPOFreeText: N/A

Genotyping Method: Genetic testing was used and after sequencing two variants were found on the ABCA4 gene.

PreviouslyPublished: N/A

Variant: NM_000350.3(ABCA4):c.3523-2A>G

Variant: NM_000350.3(ABCA4):c.2249T>C (p.Leu750Pro)

ClinVar: Variation ID: 866764

ClinVar: Variation ID: 417984

CAID: N/A

SupplementalData: N/A

PMID: 24509150

Gene: ABCA4

HGNC ID: 34

Case#: Sporadic Patient #4, female, Chinese, 30yo at report

DiseaseAssertion: STGD

FamilyInfo: n/a, sporadic case

CasePresentingHPOs:

CaseHPOFreeText:

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: WES with Sanger sequencing confirmation

PreviouslyPublished: no

Variant: c.4555delA p.(T1519Rfs*5); c.6397T>C p.(C2133R)

ClinVar: 2021273; 2733921

CAID: CA341277387; CA645372203

SupplementalData:

Case#: Patient female, 10y, ethnicity not reported

DiseaseAssertion: Stargardt disease (STGD1), early onset

FamilyInfo: autosomal recessive inheritance; co-segregation of variants in parents (each heterozygous). Pedigree shown in Figure 1A. One unaffected sibling reported.

CasePresentingHPOs: HP:0007663, HP:0007754, HP:0002587, HP:0030636, HP:0000548

CaseHPOFreeText: early-onset visual decline (age 7), symmetric disease in both eyes, hyperautofluorescent ring surrounding macular atrophy, lipofuscin accumulation, photoreceptor degeneration.

CaseNotHPOs: HP:0007707

CaseNotHPOFreeText: normal anterior segment on slit lamp exam; no external ocular abnormalities reported.

Genotyping Method: Sanger sequencing confirmation; variant identification likely via next-generation sequencing (not explicitly stated).

PreviouslyPublished: n/a

Variant: ABCA4 NM_000350.2: c.6817-713A>G; c.3259G>A (p.Glu1087Lys)

ClinVar: n/a

CAID: CA2837995439, CA227097

SupplementalData: phenotype and validation data in Figures 1–5 and Supplemental Figures S1–S5

Case#: Hwang Case 1, US, male, 55yo at report, 18yo at onset

DiseaseAssertion: Stargardt disease

FamilyInfo: Family history was not significant for ocular disease

CasePresentingHPOs: HP:0007663, HP:0500087, HP:0000603, HP:0000512

CaseHPOFreeText: BCVA of 20/350 OD and 20/200 OS. Spherical refractive error measured −3.5 OD and −2.0 OS. Posterior segment examination and autofluorescence imaging were significant for sharply demarcated central and peripapillary zones of atrophy and the absence of fleck lesions (Figure 1, A–D). Humphrey visual fields demonstrated bilateral central scotomas with eccentric fixation at the inferior border.

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: Genotyping was performed by the ABCR400 microarray followed by direct sequencing to confirm identified variants.

PreviouslyPublished: n/a

Variant: P1380L and IVS40 + 5G>A

ClinVar: 7904

CAID: CA129033

SupplementalData: n/a

PMID: 17277736

Gene: ABCA4

HGNC ID: 34

Case#: Patient 3, 37-year-old female

PMID: 10612508

DiseaseAssertion: STGD1

FamilyInfo: Affected sibling in autosomal recessive family.

CasePresentingHPOs: HP:0000545 — Decreased visual acuity HP:0007754 — Macular atrophy HP:0030638 — Retinal flecks HP:0000512 — Abnormal fundus morphology

CaseHPOFreeText: Gradual visual decline beginning at age 12. Visual acuity 20/400 in both eyes. Fundus examination revealed bilateral macular atrophy with pigment deposits and numerous yellow flecks in the posterior pole and midperiphery. Fluorescein angiography showed large hypofluorescent regions with surrounding hyperfluorescence and peripheral dark choroid.

CaseNotHPOs: Not reported

CaseNotHPOFreeText: Not reported

GenotypingMethod: PCR and direct sequencing of ABCA4

PreviouslyPublished: Yes

Variant: NM_000350.2:c.2588G>C (p.Gly863Ala) NM_000350.2:c.161G>A (p.Cys54Tyr)

ClinVar: Not reported

CAID: Not reported

SupplementalData: Segregation and sequencing data (Figures 1, 4)

This variant is found in homozygosity in family MD-0084 in a previous publication (PMID: 23755871)

This variant was not evaluated.

This variant was not evaluated.

PMID: 31456290

Gene: ABCA4

HGNCID: HGNC:34

SupplementalData: as applicable Table S2. Variant found in cohort of 2,420 families including 3,413 individuals with inherited retinal diseases in Israel. Likely, this is the same family reported in PMID 29706639.

Total number of families: 1; phenotype/s: CRD; NM_000350.2:c.4895dup, p.(Asn1632Lysfs*14)

Case#: Family F23 Patient P26, 42yo

DiseaseAssertion: MD-C

FamilyInfo: family f23

CasePresentingHPOs:

CaseHPOFreeText:

CaseNotHPOs:

CaseNotHPOFreeText:

GenotypingMethod: capture-based next-generation sequencing (NGS) testing

PreviouslyPublished: n/a

Variant: c.4555del(;)6119G>A genotype b (a patient harboring a severe/null variant and a missense or in-frame insertion/deletion variant)

CAID: CA232815

SupplementalData: table s2

Knowledge Mapper 60%くらいまでやってみたけど、

1位　法医学考古学 2位　政治社会学 3位　犯罪学

私本来の知識というより 翻訳かけられた回答が漢字多めかどうか、知らなくてもなんとなくで回答できるジャンルが把握できただけのように感じた

(その言葉を知っているのではなくその言葉を構成する単語の意味からなんとなくその言葉の意味やニュアンスを予測して答えてる)

No distinction for regions, different interventions within HAP, and vulnerable populations. Also just uses annual data. No realtime, quick feedback.

In Capitalist cultures people are taught to feel prideful over having more opportunities in life than others that lead to more success. Pride is blind, arrogant, self assurance. It is engineered in our Idol culture here in America where rappers are paid to dumb down their lyrics and glamorize wealth and success at other's expense marketed as "personal accomplishments".

In Communist cultures they engineer a social stigma against the flaunting of wealth. People feel embarrassed over their own ego surrounding wealth when it comes at the expense of their friends and family.

The proper response to success and accomplishing something should be gratefulness, self awareness, and consideration for those who provided support and those who are less fortunate. And hopefully a desire to lift your friends up to your level.

I think every writer gets to this point eventually. How long it takes to get to this point is different for each individual.

I overthink a lot like this through out my daily life. I always over worry about everything and then things turn out fine and I get on myself about why I panicked the whole time only to start the process again the very next day. This is my life.

The M.R. key on a typewriter stands for "More Room" as defined by William Clark's daughter. <br /> via https://www.facebook.com/groups/27453296880990639/posts/28305005765819742