http://www.rachelwu.com/Wu_2019.pdf

proposes ...adaptation is relevant for all age groups because the environment is dynamic, suggesting that learning what to learn is a problem relevant across the lifespan

reviews new research demonstrating the importance and ways of learning what to learn across the lifespan, from objects to real-world skills 2018/2019pub

Saul Justin Newman's 2018 paper criticising some papers wrt longevity and aging. Says the results can be generated by having a few randomly distributed age-misreporting errors. Barbi et al's models turn out to be sensitive to that. Barbi posit their data means there's an evolutionary dimension to their aging data, whereas Newman says it's just faulty data that causes the effect. Won an 2024 Ig Nobel for this topic.

https://doi.org/10.1371/journal.pbio.3000048

Longevity data from the UN says researcher is highly suspect, given where they report highest rate of centenarians. Those reaching are often, poor, lacking in administrative systems, or even without government. Says data is fully untrustworthy from the start.

certainly been that way through the ages, no reason it shouldn't be like that now.

Relying on documentation for age measurement is highly problematic. Yet it determines a lot in terms of pension rates, insurance and health care cost planning.

Researcher proposes developing a way to measure human age independent of documentation. (what would that be? telomeres? x-rays (like they do to determine where refugees are rightfully claiming to be underage?))

High registered age caused more likely by bad admin and fraud pressures. Worst places in terms of aging, and listing the lowest number of 90 yr olds in the UK have the highest of 100yr olds.

Researcher says Eurostat data in 1990 https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Mortality_and_life_expectancy_statistics#Life_expectancy_at_age_65 (note that link does not seem to give that data) list EU blue zones actually quite low. Sardinia 51st, Ikaria (Greece) 109th. Research estimates 72% of Greek old age cases are untrue or fraudulent.

Japanese so-called blue zone Okinawa actually has a very bad health and dito eating/drinking habits.

Supposedly centenarians in Japan turn out to be mostly unregistered deaths.

https://web.archive.org/web/20240915125021/https://theconversation.com/the-data-on-extreme-human-ageing-is-rotten-from-the-inside-out-ig-nobel-winner-saul-justin-newman-239023

Saul Justin Newman won an Ig Nobel for finding most claims about people living over 105 are wrong / faulty.

Blue zones wrt human aging are actually bad data zones. Either because actual birthdata is missing (war, bad administrative quality) or pension fraud is rife.

Jumped out at me as I just yday saw snippets of a docu about increasing personal longevity which visited Sardinia, one of the blue zones.

DOI: 10.18632/aging.104165

Resource: SCR_00645

Curator: @anisehay

SciCrunch record: RRID:SCR_00645

What is this?

DOI: 10.18632/aging.103843

Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)

Curator: @bandrow

SciCrunch record: RRID:SCR_006457

What is this?

DOI: 10.18632/aging.204251

Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)

Curator: @mpairish

SciCrunch record: RRID:SCR_006457

What is this?

DOI: 10.18632/aging.204472

Resource: (BDSC Cat# 64349,RRID:BDSC_64349)

Curator: @mpairish

SciCrunch record: RRID:BDSC_64349

What is this?

DOI: 10.18632/aging.204593

Resource: (BDSC Cat# 2376,RRID:BDSC_2376)

Curator: @mpairish

SciCrunch record: RRID:BDSC_2376

What is this?

DOI: 10.18632/aging.104196

Resource: (BDSC Cat# 5905,RRID:BDSC_5905)

Curator: @olekpark

SciCrunch record: RRID:BDSC_5905

What is this?

DOI: 10.18632/aging.102387

Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)

Curator: @bandrow

SciCrunch record: RRID:SCR_006457

What is this?

DOI: 10.18632/aging.205518

Resource: (BDSC Cat# 76592,RRID:BDSC_76592)

Curator: @olekpark

SciCrunch record: RRID:BDSC_76592

What is this?

DOI: 10.18632/aging.102650

Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)

Curator: @olekpark

SciCrunch record: RRID:SCR_006457

What is this?

DOI: 10.18632/aging.204422

Resource: (BDSC Cat# 33388,RRID:BDSC_33388)

Curator: @DavidDeutsch

SciCrunch record: RRID:BDSC_33388

What is this?

DOI: 10.18632/aging.204422

Resource: (BDSC Cat# 6357,RRID:BDSC_6357)

Curator: @DavidDeutsch

SciCrunch record: RRID:BDSC_6357

What is this?

DOI: 10.18632/aging.204422

Resource: (BDSC Cat# 3605,RRID:BDSC_3605)

Curator: @DavidDeutsch

SciCrunch record: RRID:BDSC_3605

What is this?

DOI: 10.18632/aging.204422

Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)

Curator: @DavidDeutsch

SciCrunch record: RRID:SCR_006457

What is this?

for - health advice - aging well - Denis Noble

health advice - aging well - ll if you want to age well do something! - It can be - dancing - music - swimming - whatever but do something - That's the first bit of advice to those who want to make sure that they stay on top

DOI: 10.18632/aging.205234

Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)

Curator: @maulamb

SciCrunch record: RRID:SCR_006457

What is this?

for - CAR T cells - anti aging - eliminate senescent cells in mice. - quote - anti aging - CAR T cells

quote - (see below)

• If we give it to aged mice, they rejuvenate.
• If we give it to young mice, they age slower.
• No other therapy right now can do this,
• author: Amor Vegas

for - CAR T cells - research - anti aging - adjacency - CAR T cells - Michael Levin - Cold Spring Harbor Lab - Corina Amor Vegas - senescent cells - fountain of youth

• Mary Harrington makes a good point
  • about the dystopian possibility if major biological hurdles are removed,
    • such as human aging
    • witness the trend of cryogenic freezing of bodies
      • which only the elites can afford
  • pervasive inequality skews the utopian vision towards market realities
    • the rich currently have access to the latest biomedical technologies that can extend / enhance life and human wellbeing
    • the vast majority, the poor don't have access to it
    • why would this change if transhumanism produces a cure for aging?
    • such a technology would enable elites to outlive the rest of us even longer!

Review coordinated by Life Science Editors.

Reviewed by: Dr. Angela Andersen, Life Science Editors

Potential Conflicts of Interest: None

Background: The ability to reproduce decreases with age in many animals - including humans and worms. Oocytes age earlier than other tissues, and their decline in quality contributes to reduced reproduction. Diminished mitochondria number/activity in human oocytes correlates with age-related decline.

Question: Does mitochondrial dysfunction cause (or just correlate with) reduced egg quality?

Summary: The authors compared the proteomes of mitochondria isolated from young worms, old worms and daf-2 mutant worms (c. elegans) (insulin/igf-1 receptor mutant) that have longer lifespans & longer reproductive lifespan. * Mitochondria from young & mutant worms had high levels of BCAT-1 (branched chain aminotransferase). * RNAi of bcat-1 reduced the longevity, reproductive longevity & egg quality of daf2 mutants, and increased mitochondrial activity/mtROS. * Similar effects of bcat-1 kd in wt worms, but interestingly the effects on reproductive longevity were more severe in wt than daf2 mutants (from a quick look), but there was no effect on lifespan in wt animals. * Overexpressing bcat-1 in wt extended reproduction & egg quality but not lifespan. * Treating animals with vitamin B1 (a cofactor downstream of BCAT1 in BCAA metabolism) delayed reproductive aging, slightly extended lifespan, improved oocyte quality, reduced mtROS in aged worms..

Advance: BCAT-1 levels/BCAA metabolism correlate with mitochondrial quality & reproductive longevity. Vit B1, which promotes BCAA metabolism, can extended reproductive longevity.

Significance: More/strong evidence that dysfunctional mitochondria cause a decline oocyte quality, reduce reproductive longevity. If vitamin B1 supplements are a safe way to delay age-related decline of eggs in female mammals (humans) that would be amazing. .

Ang asks:

• is this effectively dietary restriction of BCAA? Would that be a better (albeit perhaps more difficult to sustain) approach?

• How does this relate to some recent papers pointing out that mitochondria in eggs are special (e.g. Cheng et al. Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment, Science 2022; Rodriguez-Nuevo et al., Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I, Nature 2022) and a role for BCAA in longevity (e.g. Richardson et al., Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice, Nature Aging 2021).

• How does low BCAA metabolism lead to mitochondrial dysfunction/oocyte aging? Is it related to accumulation of amino acids in the cytosol and toxicity to mitochondria? (e.g. Hughes et al., Cysteine toxicity drives age-related mitochondrial decline by altering iron homeostasis, Cell 2020).

• Overall these data support the idea that oocytes are particularly vulnerable to conditions that drive aging, and conserved aging mechanisms in the soma and germline as well as across species.

!- grateful list : low stress - stress increases cortisol which can age you

!- Uric acid : aging impacts - high uric acid levels accelerate aging - bad for cancer and heart disease - https://www.drperlmutter.com/books/drop-acid/

!- beer : aging impacts - beer raises Uric acid levels in body and will accelerate aging

!- red wine : health benefits - one glass a day cuts cardiovascular bad cholesterol and raises good cholesterol (HDL)

!- New health / aging metrics test : DNA Methylation / Horvath Test

!- smoking : aging impacts - 10 years off your life

!- David Sinclair ; aging researcher interview - aging effects of smoking

Seaman, K. L., Christensen, A. P., Senn, K., Cooper, J., & Cassidy, B. S. (2022). Age Differences in the Social Associative Learning of Trust Information. PsyArXiv. https://doi.org/10.31234/osf.io/b38rd

I agree with Minha's assessment of the project. Her research question is phrased perfectly for the overall topic of these combined videos. I can't stop, and I think I won't stop thinking about what it truly means for me to age. Each voice represents a background that provides a resource for both the voice owner and the audience to answer this question. Aging for me means being more cautious with words and actions. I consciously do this because I see everyone around me go through this process and talk about it. Aging for me means looking at my grandparents and and thinking what I will do and what I will look like when I reach their age. I thought about this question a few times when I was much younger, then there was a long period of me not worrying about it at all, and in college, the question came back to me at higher rate of frequencies. I often ask myself if my future kids/grandkids (if I ever have them) would care about me and life after death was something that seems to be in my head for the longest time. Aging for me means carrying new responsibilities. I know that there are things that was acceptable when I was one year younger and became inapplicable for me the year after, and vice versa. "What it means to age?" is repeatedly asked throughout the video, motivating us to give it a try and craft our own response. This research question has well summarized for the bigger and better understanding of the purpose that these 'storytellers' and collaborators embed in this project. Same with taylortots, I may revisit this project from time to time with newer perspectives about the definition of growing old. Thank you for the insightful post!

Kourtesis, Panagiotis, Graham Wilson, and Mario Parra Rodrigues. ‘Factors Influencing Acceptance of Technology across Age: Amid the COVID-19 Pandemic’. PsyArXiv, 4 February 2022. https://doi.org/10.31234/osf.io/tsrk4.

https://people.com/tv/main-characters-in-satc-revival-and-just-like-that-are-same-age-as-the-golden-girls/

A noted difference in how adults learn: older adults take longer and learn less in training than younger adults.

The number of adults working past the traditional age of retirement is growing. Engaging adults in continuing education is becoming more important.

Implying that the old man may as well have been dead already. What is the difference between death and a "stupefied doze"? From the perspective of a child, there is little discernible distinction. The permanence of death does not quite carry weight to those who have not been affected by it yet, and seems like a mere natural extension of this "stupefied" state.

My grandma used to grow these in our backyard, and I grew up anticipating their bloom, only to see them shrivel up and brown a couple weeks later...for the plant to stay alive, they must be vigorously pruned and cut back regularly...so this choice of flowers, I think, is pretty apt for the themes of youth/entering society/the fear of age.

Lange, Ann-Marie G de, Tobias Kaufmann, Daniel S Quintana, Adriano Winterton, Lars T. Westlye, and Klaus P. Ebmeier. ‘Risk Factors Associated with Loneliness, Social Isolation, and Neuroticism in the UK Biobank Cohort’. Preprint. PsyArXiv, 21 September 2020. https://doi.org/10.31234/osf.io/q8kjv.

Mitchell, O. S. (2020). Building Better Retirement Systems in the Wake of the Global Pandemic (Working Paper No. 27261; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27261

Friedson, A. I., McNichols, D., Sabia, J. J., & Dave, D. (2020). Did California’s Shelter-in-Place Order Work? Early Coronavirus-Related Public Health Effects (Working Paper No. 26992; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w26992

Dave, D. M., Friedson, A. I., Matsuzawa, K., & Sabia, J. J. (2020). When Do Shelter-in-Place Orders Fight COVID-19 Best? Policy Heterogeneity Across States and Adoption Time (Working Paper No. 27091; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27091

here it may be useful to look towards current research on aging of ASD individuals for compensating development in adulthood.

Essential to fully grok. Chart out. Link to other regulatory systems

So, this entire pathway, or segment, is dependent on mitochondria

Dementia is indeed a burden

in humans.

War is not only difficult on the physical aspect of an individual; it is just as difficult on the emotional and mental capacity of a human. It is factual that WWI culminated an astronomical amount of casualties, destruction, and disablement. This reference to being “drunk” may help guide us into the notion that soldiers are not able to differentiate between fantasy and reality under the duress of mentioned “fatigue.” We can understand that the state of "drunk" alters your reality and can have dangerous repercussions; in this sense, the loss of one's mind or life. In the prior lines we have loss of physical functionalities of the human body with words such as “limped on,” “lame,” and “blind,” which coincides with the premature aging or physical deterioration of the soldiers.

With the introduction and evolution of chemical weapons used in this war (WWI); human bodies were no match for the damage these weapons were designed to inflict. Leading into the imagery of soldiers physically deteriorating when using phrases such as "bent double," "coughing like hags," and "men marched asleep;" would not lead one to believe that war is “sweet and fitting” in any capacity. With the use of the word “beggars” our minds may envision the effects of poverty and desperation which war seems to produce, and in this sense, we are given language expressing the overwhelming misery and accelerated age progression with the use of “old.” These descriptions challenge the assumptions the mind tends to gravitate towards when picturing what it means to "die for ones country."

Billionaires want to live forever.

So, in Ant Man, there is the same thing with Michael Douglas. I totally think it will be a common thing. Not just for flashbacks but for actors who want to play the role "younger."

Things are dying in the wasteland and no longer glorious.

Or independence, getting to my earlier point.