269 Matching Annotations
  1. Last 7 days
    1. we are certainly special I mean 00:02:57 no other animal rich the moon or know how to build atom bombs so we are definitely quite different from chimpanzees and elephants and and all the rest of the animals but we are still 00:03:09 animals you know many of our most basic emotions much of our society is still run on Stone Age code
      • for: stone age code, similar to - Ronald Wright - computer metaphor, evolutionary psychology - examples, evolutionary paradox of modernity, evolution - last mile link, major evolutionary transition - full spectrum in modern humans, example - MET - full spectrum embedded in modern humans

      • comment

      • insights

        • evolutionary paradox of modernity
          • modern humans , like all the living species we share the world with, are the last mile link of the evolution of life we've made it to the present, so all species of the present are, in an evolutionary sense, winners of their respective evolutionary game
          • this means that all our present behaviors contain the full spectrum of the evolutionary history of 4 billion years of life
          • the modern human embodies all major evolutionary transitions of the past
          • so our behavior, at all levels of our being is a complex and heterogenous mixture of evolutionary adaptations from different time periods of the 4 billion years that life has taken to evolve.
          • Some behaviors may have originated billions of years ago, and others hundred thousand years ago.
      • Examples: humans embody full spectrum of METs in our evolutionary past

        • fight and flight response
          • early hominids on African Savannah hundreds of thousands to millions of years ago when hominids were predated upon by wild predators
        • cancer
          • normative intercell communication breaks down and reverts to individual cell behavior from billions of years ago
            • see Michael Levin's research on how to make metastatic cancer cells return to normative collective, cooperative behavior
        • children afraid to sleep in the dark
          • evolutionary adaptation against dangerous animals that might have hid in the dark - dangerous insiects, snakes, etc, which in the past may have resulted in human fatalities
        • obesity
          • hunter gatherer hominid attraction to rich sources of fruit. Eating as much of it as we can and maybe harvesting as much as we can and carrying that with us.
            • like squirrels storing away for the winter.
  2. Oct 2023
    1. The Chicago Sun-Times' wandering Newshen Glenna Syse spent 39 minutes with Author James Thurber, left with the conviction that he is "the funniest man alive." In an epigrammatic mood, Thurber ranged free and easy over—by count—39 subjects. Glenna's sampling included a Thurberism on age: "I'm 65 and I guess that puts me in with the geriatrics. But if there were 15 months in every year, I'd only be 48.* That's the trouble with us. We number everything. Take women, for example. I think they deserve to have more than twelve years between the ages of 28 and 40." On the forthcoming election: "It's accusation time in Normalcy. And in spite of the nominations, my mother is voting for Lindbergh." On martinis: "One is all right, two is too many, three is not enough."

      Syse, Glenna. “People, Aug. 15, 1960.” Time, August 15, 1960. https://content.time.com/time/subscriber/article/0,33009,939759,00.html.

  3. Sep 2023
    1. whales and dolphins have had culture passed down vocally for 34 million years humans have only been speaking vocally impacted on culture for like 200 000 years tops 00:17:16 like and that which is oldest correlates with that which is wisest
      • for: quote, quote - age of whale and dolphin languages

      • quote

        • whales and dolphins have had culture passed down vocally for 34 million years
        • humans have only been speaking vocally impacted on culture for like 200 000 years tops and
        • that which is oldest correlates with that which is wisest
      • author - Aza Raskin
      • date: 2023
    1. "Surrendering" by Ocean Vuong

      1. He moved into United State when he was age of five. He first came to United State when he started kindergarten. Seven of them live in the apartment one bedroom and bathroom to share the whole. He learned ABC song and alphabet. He knows the ABC that he forgot the letter is M comes before N.

      2. He went to the library since he was on the recess. He was in the library hiding from the bully. The bully just came in the library doing the slight frame and soft voice in front of the kid where he sit. He left the library, he walked to the middle of the schoolyard started calling him the pansy and fairy. He knows the American flag that he recognize on the microphone against the backdrop.

  4. Aug 2023
      • for: human life expectancy, life expectancy, life expectancy myth, life expectancy at birth, life expectancy - ancestors
      • title: The life expectancy myth, and why many ancient humans lived long healthy lives
      • comment
      • new insight
        • life expectancy at birth skews our understanding of how the health and longevity of adults. -There is a false claim and belief that due to modern technologies, modern humans have lived far longer than our ancestors in the distant past.
        • In fact, child mortality rates play a major role in calculating life expectancy and this is what differs modernity from our ancestors.
        • Our distant ancestors did live to their 70s and 80s
  5. Jul 2023
  6. Jun 2023
  7. May 2023
    1. this era began in the mid-20th century before you and I were born with a biomedical Innovation
      • Mary Harrington suggests that

        • a starting point for the transhuman age
        • was marked by
        • the introduction of the birth control pill
      • comment

        • while that may mark the first time a technology has radically reshaped human physiology in such a direct way,
          • the spirit of transhumanism is inherent in our nature as innovating cognitive beings
          • in fact, I find the term "transhuman" self-contradictory and problematic
            • as our very nature as innovative beings means we are constantly reinventing and transcending our old behaviors
  8. Jan 2023
    1. one reason the Golden Age of Piracy remains the stuff oflegend is that pirates of that age were so skilled at manipulatinglegends; they deployed wonder-stories—whether of terrifyingviolence or inspiring ideals—as something very much like weaponsof war, even if the war in question was the desperate and ultimatelydoomed struggle of a motley band of outlaws against the entireemerging structure of world authority at the time.
    1. during Iron Age I, in the 12th–11thcenturies BCE, Ekron, which is located very near the Sorek Valley, was thedominant Philistine center, and the biblical tradition accordingly places thenarrative concerning the Philistines in that valley.
    2. duringIron Age IIA, the 10th–9th centuries BCE, Gath in the Elah Valley becamethe dominant Philistine center and the biblical tradition recounting theborder disputes between the Philistines and the Israelites accordingly shiftsfrom the Sorek Valley to the Elah Valley.
    3. Traditions connected to the Elah Valley are preserved in the books ofSamuel and Chronicles, which relate to Iron Age IIA.
  9. Dec 2022
  10. www.janeausten.pludhlab.org www.janeausten.pludhlab.org
    1. playfully

      Is Emma flirting or is this a younger sister teasing an older brother?

      The age gap and the family relationship both can make this a little icky - though people talk about it less than Marianne and Colonel Brandon in Sense and Sensibility

  11. Sep 2022
    1. most intriguing to me was the discovery which even today some 00:23:13 archaeologists deny but the evidence is actually overwhelming that oceans were no barriers to erectus they sailed across oceans so this is a quote from a 00:23:24 very good book on Paleolithic Stone Age seafarers Paleolithic books our ancestors have often been painted as unintelligent brutes however this simply is not the case evidence suggests that at least homo erectus and perhaps even 00:23:37 pre erectus hominids were early seafarers based on this evidence it seems that our early ancestors were successful seafarers biological studies suggest that considerable numbers of founder populations so when we find 00:23:50 evidence of erectus tools on an island there had to have been 2250 erectus arrived they're more or less the same time it's not just that one erectus got there we also know and I'll go into this 00:24:03 that they didn't just wash ashore it would have been almost impossible some archaeologists suggest that they got there by tsunamis but when I talked to friends of mine who are earth scientists they say that's not how 00:24:17 tsunamis work you know the tsunamis are pushing water to land and it is possible that afterwards some things flow out but most of the energy is towards the land and it is true that a few animals have 00:24:30 made it but we don't find regular systematic colonization by humans waiting to ride tsunamis most people don't try to do that

      !- homo erectus : was a seafarer

  12. Aug 2022
    1. Politique documentaire Ensemble des objectifs et processus pilotant la gestion de l’information, incluant la politique d’acquisition, la politique de conservation et la politique de médiation des collections. La politique documentaire est une partie intégrante et essentielle du projet d'établissement, permettant de répondre aux missions de la structure et aux attentes des usagers.
  13. Jul 2022
    1. The first trap was hunting, the main way of life for about two million years in Palaeolithic times. As Stone Age people perfected the art of hunting, they began to kill the game more quickly than it could breed. They lived high for a while, then starved.

      Anthropology and Archelogy findings support the idea that humans began laying progress traps as early as two million years ago. Our great success at socialization and communication that harnessed the power of collaboration resulted in wiping out entire species upon which we depended. Short term success leading to long term failure is a central pattern of progress traps.

      Anthropology and Archelogy findings support the idea that humans began laying progress traps as early as two million years ago. Our great success at socialization and communication that harnessed the power of collaboration resulted in wiping out entire species upon which we depended. Short term success leading to long term failure is a central pattern of progress traps.

      A remarkable paper from Tel Aviv researchers studying early hunters in the Southern Levant as early as 1.5 million years ago revealed that our ancestors in this part of the world were poor resource managers and over many generations, continually hunted large game to extinction, forcing descendants to hunt progressively smaller game.

      Annotation of the 2021 source paper is here: https://hyp.is/go?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS0277379121005230&group=world Annotation of a science news interview with the researchers here: https://hyp.is/go?url=https%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F2021%2F12%2F211221102708.htm&group=world

      The researchers even surmise that the extinction of game animals by around 10,000 B.C. is what gave rise to agriculture itself!

  14. Jun 2022
  15. May 2022
    1. According to the “Korean age” system, a person turns one the day they are born and they then become a year older on New Year’s Day, irrespective of the date on which they were born.   This traditional method of determining age was used in a number of east Asian nations in the past, including China and Japan, and is believed to stem from the concept that time inside the mother’s womb counts as the first year of a child’s life.
    1. DICER1 syndrome encompasses a variety of benign and malignant manifestations including multinodular goitre

      Gene: DICER1 PMCID: PMC8451242 PMID: 34552563 Pathogenic Inheritance Pattern: Autosomal Dominant MultipleDiseaseEntities Disease Entity: DICER1 syndrome, multinodular goitre, cystic nephroma, anaplastic renal sarcoma, Wilms tumour, differentiated thyroid carcinoma, gynandroblastoma, ciliary body medulloepithelioma, embryonal rhabdomyosarcoma, pineoblastoma, pituitary blastoma, kidney cyst, pulmonary cyst, Sertoli-Leydig Cell Tumor. Mutation: Germline MultipleGeneVariants Variant & Clinvar IDs: c.3452_3453del (485534), c.316del (no ClinVar ID), c.171_172insAC (no ClinVar ID), c.3434del (no ClinVar ID), c.988C>T (933007), c.5388dup (no ClinVar ID) Zygosity: None provided. Case: At time of operation, the goitre patients living in Denmark were ages 21, 12, 21, 8, 14, and 16. Four underwent total thyroidectomies, and two underwent partial thyroidectomies. The patient originally aged 21 previously had a kidney cyst at age 14 and a pulmonary cyst at an unknown age. The patient aged 14 at time of partial thyroidectomy later manifested a Sertoli-Leydig Cell Tumor at age 15. All six patients were female. CasePresentingHPO: None provided. CasePreviousTesting: thyroidectomy gnomAD: ENSG00000100697.10, https://gnomad.broadinstitute.org/gene/ENSG00000100697 Mutation Type: Frameshift, Nonsense

  16. Apr 2022
    1. Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646

    1. Dr Greg Kelly. (2021, July 2). As a pediatrician I’m going on record saying that allowing kids to be freely infected with a novel disease that has unknown long term consequences is the worst idea of 2021 despite being a pretty crowded field so far #COVID19 [Tweet]. @drgregkelly. https://twitter.com/drgregkelly/status/1411083905034117120

    1. Dr Duncan Robertson [@Dr_D_Robertson]. (2021, October 29). ONS Covid survey. 2% of the population +ve. “The percentage of people testing positive for COVID-19 increased for all age groups, except for those in school Year 12 to those aged 34 years, where the trend was uncertain in the week ending 22 October 2021” https://ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/29october2021 https://t.co/1n9KVq6wDT [Tweet]. Twitter. https://twitter.com/Dr_D_Robertson/status/1454050450106376192

    1. Marc Lipsitch. (2021, July 20). At the risk of boiling down too much and certainly losing some detail, one way to summarize this wonderful thread is that when we think about vaccine effectiveness, we should think of 4 key variables: 1 which vaccine, 2 age of the person, 3 how long after vax, 4 vs what outcome. [Tweet]. @mlipsitch. https://twitter.com/mlipsitch/status/1417595538632060931

    1. Prof. Christina Pagel 🇺🇦. (2022, March 8). What could be causing it? Likely combo of: 1—Dominant BA.2 causing more infections (we await ONS!) 2—Reduction in masks, self-isolation & testing enabling more infections 3—Waning boosters in older people esp I worry that we will be stuck at high levels for long time. 2/2 https://t.co/xZ2SLFNVkS [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1501250081693048838

  17. Mar 2022
  18. Feb 2022
    1. Alastair Grant. (2022, February 16). Samples likely to be BA.2 (SGT positive in TaqPath data) now make up 34% of COVID cases in England. The proportion has roughly doubled in a week. That represents a growth in absolute numbers of BA.2, even if overall infections are falling at the same rate as reported cases https://t.co/LNr5baChby [Tweet]. @AlastairGrant4. https://twitter.com/AlastairGrant4/status/1493880986660225024

    1. F. Perry Wilson, MD MSCE. (2022, February 4). If you, like me, are “skipping ahead” during the ACIP meeting re: Moderna vaccine—This slide really drives home the benefit / risk paradigm among the group at highest risk of myocarditis (men 18-35). 2 million shots = 1903 avoided hospitalizations, and 68 myocarditis cases. Https://t.co/3nzWXGXyD1 [Tweet]. @fperrywilson. https://twitter.com/fperrywilson/status/1489649379979972609

  19. Jan 2022
    1. Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2021). Risk of myocarditis following sequential COVID-19 vaccinations by age and sex (p. 2021.12.23.21268276). medRxiv. https://doi.org/10.1101/2021.12.23.21268276

    1. Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932

  20. Dec 2021
  21. Nov 2021
  22. Oct 2021
  23. Sep 2021
    1. from the analog age to the digital age

      So what is the exact definition of digital age? When can we say that we live in a digital age?

    1. John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936

    1. Liu, W., Russell, R. M., Bibollet-Ruche, F., Skelly, A. N., Sherrill-Mix, S., Freeman, D. A., Stoltz, R., Lindemuth, E., Lee, F.-H., Sterrett, S., Bar, K. J., Erdmann, N., Gouma, S., Hensley, S. E., Ketas, T., Cupo, A., Cruz Portillo, V. M., Moore, J. P., Bieniasz, P. D., … Hahn, B. H. (2021). Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerging Infectious Diseases, 27(9), 2454–2458. https://doi.org/10.3201/eid2709.211042

  24. Aug 2021
    1. (((Howard Forman))). (2021, July 26). ‘Among those aged 60-plus, early vaccinators are twice as likely to get infected. For those aged 40-59 early vaccinators are 2.1 times more vulnerable, and among under 39s they are 1.6 more likely to catch the coronavirus.’ https://timesofisrael.com/hmo-those-who-inoculated-early-twice-as-likely-to-catch-covid-as-later-adopters/ [Tweet]. @thehowie. https://twitter.com/thehowie/status/1419647827458789383

  25. Jul 2021