Df(2L)exel7027
DOI: 10.1261/rna.065417.117
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @maulamb
SciCrunch record: RRID:SCR_006457
Df(2L)exel7027
DOI: 10.1261/rna.065417.117
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @maulamb
SciCrunch record: RRID:SCR_006457
gmr-GAL4
DOI: 10.1261/rna.062703.117
Resource: Bloomington Drosophila Stock Center (RRID:SCR_006457)
Curator: @maulamb
SciCrunch record: RRID:SCR_006457
Bloomington stock center #1522
DOI: 10.1261/rna.064691.117
Resource: RRID:BDSC_1522
Curator: @maulamb
SciCrunch record: RRID:BDSC_1522
54594
DOI: 10.1261/rna.079192.122
Resource: (BDSC Cat# 54594,RRID:BDSC_54594)
Curator: @mpairish
SciCrunch record: RRID:BDSC_54594
55172
DOI: 10.1261/rna.077446.120
Resource: BDSC_55172
Curator: @olekpark
SciCrunch record: RRID:BDSC_55172
Yale researchers develop RNA-based therapy that clears SARS-CoV-2 from mice. (n.d.). EurekAlert! Retrieved January 9, 2022, from https://www.eurekalert.org/news-releases/934454
The Guardian. ‘We Can Prevail over Omicron. We Just Need to Use the Tools We Have’, 1 December 2021, sec. Opinion. https://www.theguardian.com/commentisfree/2021/dec/01/we-can-prevail-over-omicron-use-tools-we-have.
narid:https://www.oxfordjournals.org/nar/database/summary/1223
narCategory:RNA sequence databases
Chertow, Daniel, Sydney Stein, Sabrina Ramelli, Alison Grazioli, Joon-Yong Chung, Manmeet Singh, Claude Kwe Yinda, et al. ‘SARS-CoV-2 Infection and Persistence throughout the Human Body and Brain’, 28 December 2021. https://doi.org/10.21203/rs.3.rs-1139035/v1.
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., Loney, C., Herder, V., Allan, J., Jarmson, I., Cameron-Ruiz, N., Varjak, M., Pinto, R. M., Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D. G., Swingler, S., Greenwood, E. J. D., … Wilson, S. J. (n.d.). A prenylated dsRNA sensor protects against severe COVID-19. Science, 0(0), eabj3624. https://doi.org/10.1126/science.abj3624
Study finds no increased risk of COVID-19 vaccination in pregnancy. (n.d.). Retrieved October 4, 2021, from https://www.gavi.org/vaccineswork/study-finds-no-increased-risk-covid-19-vaccination-pregnancy
García-Fiñana, M., & Buchan, I. E. (2021). Rapid antigen testing in COVID-19 responses. Science, 372(6542), 571–572. https://doi.org/10.1126/science.abi6680
Kolata, G. (2021, April 8). Kati Kariko Helped Shield the World From the Coronavirus. The New York Times. https://www.nytimes.com/2021/04/08/health/coronavirus-mrna-kariko.html
Isaacson, Walter. ‘Opinion | I Was Part of a Trial for Pfizer’s Covid-19 Vaccine. It’s a Miracle for Genetic Medicine.’ Washington Post. Accessed 6 March 2021. https://www.washingtonpost.com/opinions/i-took-the-pfizer-covid-19-vaccine-its-a-miracle-for-genetic-medicine/2020/11/09/77e652d0-22bf-11eb-952e-0c475972cfc0_story.html.
Dolgin, E. (2021). How COVID unlocked the power of RNA vaccines. Nature, 589(7841), 189–191. https://doi.org/10.1038/d41586-021-00019-wq
The "RNA World" hypothesis posits that the first replicators were RNA-based, and that DNA arose only later as a product of RNA life forms.
RNA -} DNA
The finding is the latest in a series of discoveries, over the past several years, pointing to the possibility that DNA and its close chemical cousin RNA arose together as products of similar chemical reactions, and that the first self-replicating molecules—the first life forms on Earth—were mixes of the two.
early molecules
Transfection commonly refers to the introduction of nucleic acids into eukaryotic cells, or more specifically, into animal cells. Classically, the term transfection was used to denote the uptake of viral nucleic acid from a prokaryote‑infecting virus or bacteriophage, resulting in an infection and the production of mature virus particles. However, the term has acquired its present meaning to include any artificial introduction of foreign nucleic acid into a cell.
Artificially introducing RNA into cells by means other than a virus or bacteriophage.
ribonucleases
A type of nuclease that catalyzes a degradation for the RNA into smaller parts.
reading fram
The reading frame is the way of dividing each sequence of nucleotides in the DNA or RNA molecule into a set of consecutive, non-overlapping triplets.
Kaplan, Edward H, Dennis Wang, Mike Wang, Amyn A Malik, Alessandro Zulli, and Jordan H Peccia. ‘Aligning SARS-CoV-2 Indicators via an Epidemic Model: Application to Hospital Admissions and RNA Detection in Sewage Sludge’. Preprint. Infectious Diseases (except HIV/AIDS), 29 June 2020. https://doi.org/10.1101/2020.06.27.20141739.
Hupf, J., Mustroph, J., Hanses, F., Evert, K., Maier, L. S., & Jungbauer, C. G. (2020). RNA-expression of adrenomedullin is increased in patients with severe COVID-19. Critical Care, 24(1), 527. https://doi.org/10.1186/s13054-020-03246-1
Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., Amit, I., Liu, L., Zhang, S., & Zhang, Z. (2020). The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. MedRxiv, 2020.08.15.20175638. https://doi.org/10.1101/2020.08.15.20175638
Sun, F., Wang, X., Tan, S., Dan, Y., Lu, Y., Zhang, J., Xu, J., Tan, Z., Xiang, X., Zhou, Y., He, W., Wan, X., Zhang, W., Chen, Y., Tan, W., & Deng, G. (2020). SARS-CoV-2 Quasispecies provides insight into its genetic dynamics during infection. BioRxiv, 2020.08.20.258376. https://doi.org/10.1101/2020.08.20.258376
Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., Amit, I., Liu, L., Zhang, S., & Zhang, Z. (2020). The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. MedRxiv, 2020.08.15.20175638. https://doi.org/10.1101/2020.08.15.20175638
Peter English #FBPE on Twitter. (n.d.). Twitter. Retrieved August 24, 2020, from https://twitter.com/petermbenglish/status/1296730819420196864
Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S. P., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fonter-Garfias, C., Shi, P.-Y., Tuereci, O., Tompkins, K. R., Walsh, E. E., … Jansen, K. U. (2020). Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. MedRxiv, 2020.06.30.20142570. https://doi.org/10.1101/2020.06.30.20142570
That does not mean that there is infectious virus present. (This distinction has confused a great number of reports about the persistence of the virus on surfaces as well). We still don’t know how long infected patients (symptomatic and asymptomatic) are shedding infectious virus – those are far harder data points to obtain than just detecting viral RNA.
Varmus, H. (2020, May 9). The World Doesn’t Yet Know Enough to Beat the Coronavirus. The Atlantic. https://www.theatlantic.com/ideas/archive/2020/05/lack-testing-holding-science-back/611422/
Wölfel, R., Corman, V.M., Guggemos, W. et al. Virological assessment of hospitalized patients with COVID-2019. Nature (2020). https://doi.org/10.1038/s41586-020-2196-x
We have demonstrated that small RNAs can tightly repress their target genes when their synthesis rate is smaller than some threshold, but have little or no effect when the synthesis rate is much larger than that threshold
a threshold-linear response with a tunable threshold, a robust noise resistance characteristic, and a built-in capability for hierarchical cross-talk.
In particular, small RNAs are shown to establish a threshold for the expression of their target, providing safety mechanism against random fluctuations and transient signals. The threshold level is set by the transcription rate of the small RNA and can thus be modulated dynamically to reflect changing environmental conditions.
Motif models for RNA-binding proteins
A Large-Scale Binding and Functional Map of Human RNA Binding Proteins
Influenza Viruses and mRNA Splicing: Doing More with Less
Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs
Queuosine metabolite necessary for DNMT2-induced tRNA modification; salvaged from bacteria of microbiome
A compendium of RNA-binding motifs for decoding gene regulation
Direct Competition between hnRNP C and U2AF65 Protects the Transcriptome from the Exonization of Alu Elements
De Novo Prediction of PTBP1 Binding and Splicing Targets Reveals Unexpected Features of Its RNA Recognition and Function
RNA splicing in particular
This is a historical project on origins of a contested discovery
Salmon provides fast and bias-aware quantification of transcript expression
Two new molecular catalysts of water oxidation have been synthesized by a team of brilliant scientists from the U.S. Department of Energy’s Brookhaven National Laboratory. These new molecular catalysts – complexes of ruthenium which are surrounded by the binding molecules, and they contain phosphonate groups.