44 Matching Annotations
  1. Sep 2024
  2. Jul 2024
  3. Aug 2022
  4. Apr 2022
  5. Mar 2022
  6. Dec 2021
  7. Oct 2021
    1. Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., Loney, C., Herder, V., Allan, J., Jarmson, I., Cameron-Ruiz, N., Varjak, M., Pinto, R. M., Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D. G., Swingler, S., Greenwood, E. J. D., … Wilson, S. J. (n.d.). A prenylated dsRNA sensor protects against severe COVID-19. Science, 0(0), eabj3624. https://doi.org/10.1126/science.abj3624

  8. May 2021
  9. Apr 2021
  10. Mar 2021
  11. Jan 2021
    1. The finding is the latest in a series of discoveries, over the past several years, pointing to the possibility that DNA and its close chemical cousin RNA arose together as products of similar chemical reactions, and that the first self-replicating molecules—the first life forms on Earth—were mixes of the two.

      early molecules

  12. Dec 2020
    1. Transfection commonly refers to the introduction of nucleic acids into eukaryotic cells, or more specifically, into animal cells. Classically, the term transfection was used to denote the uptake of viral nucleic acid from a prokaryote‑infecting virus or bacteriophage, resulting in an infection and the production of mature virus particles. However, the term has acquired its present meaning to include any artificial introduction of foreign nucleic acid into a cell.

      Artificially introducing RNA into cells by means other than a virus or bacteriophage.

  13. Nov 2020
  14. Oct 2020
  15. Sep 2020
  16. Aug 2020
  17. Jul 2020
    1. Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S. P., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fonter-Garfias, C., Shi, P.-Y., Tuereci, O., Tompkins, K. R., Walsh, E. E., … Jansen, K. U. (2020). Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. MedRxiv, 2020.06.30.20142570. https://doi.org/10.1101/2020.06.30.20142570

    1. That does not mean that there is infectious virus present. (This distinction has confused a great number of reports about the persistence of the virus on surfaces as well). We still don’t know how long infected patients (symptomatic and asymptomatic) are shedding infectious virus – those are far harder data points to obtain than just detecting viral RNA.
  18. May 2020
  19. Apr 2020
  20. Oct 2019
  21. Oct 2018
  22. Sep 2018
  23. Jun 2018
  24. Mar 2018
  25. Feb 2018
  26. Nov 2017
  27. Oct 2017
  28. Nov 2016