for - key insight - leverage point of the 99% - our numbers - from Substack article - The Cosmo-Local Plan for our Next Civilization - Michel Bauwens - 2024, Dec 20 - key insight - 2 levels of individual / collective gestalt - from Substack article - The Cosmo-Local Plan for our Next Civilization - Michel Bauwens - 2024, Dec 20

key insight - 2 levels of individual / collective gestalt - first is from individual to local organization - second is from local organization to trans-national alliances

key insight - leverage point of the 99% - our numbers - The trans-national companies power is in their capital - The trans-national alliances leverage point is our large numbers of people - Through our strength in numbers, we can mobilize trans-alliance resources such as human innovation resources, which most local actors are lacking in

Disease: N/A, variant present in F12 gene

Patient: 36 yo, Female, Saudi descent

Variant:F12 NC_000005.9:g.176,830,269 G>A; p.Gly506Asp Homozygous mutation, exon 12 Located in peptidase S1 domain of F12

Family:

Consanguineous family history (parents first-degree cousins)

No family history of bleeding or thrombosis

Phenotypes:

Significantly high activated partial thromboplastin time

No history of bleeding during deliveries or tooth extractions

No history of thrombosis or skin manifestations

On no medications, physical examination unremarkable

Factor assays and VWF tests within normal ranges except Factor XII (Severely deficient)

variant is proposed to be deleterious but there is insufficient evidence to support this claim.

for - developmental journey - human inner transformation - planetary training technology - integrating the best of the east and the west - John Churchill - developmental journey - healing the foundations affects the higher levels of human inner transformation - John Churchill

developmental journey - human inner transformation - planetary training technology - integrating the best of the east and the west - integrating - developmental healing with - attachment to the meditation practice - resulting in: - meditating down instead of - meditating up - Opening up the lower attachment system - by building a powerful field of safety and attunement - dissolves the higher blocks

The whole of the planet must be an UNDIVIDED WHOLENESS A whole cannot be at different levels

for - quote - levels of wisdom - humanity is in middle school - John Churchill

Sounds like you're doing what Mortimer J. Adler and Charles van Doren would call "inspectional reading" and outlining the space of your topic. This is both fine and expected. You have to start somewhere. You're scaffolding some basic information in a new space and that's worthwhile. You're learning the basics.

Eventually you may come back and do a more analytical read and/or cross reference your first sources with other sources in a syntopical read. It's at these later two levels of reading where doing zettelkasten work is much more profitable, particularly for discerning differences, creating new insights, and expanding knowledge.

If you want to think of it this way, what would a kindergartner's zettelkasten contain? a high school senior? a Ph.D. researcher? 30 year seasoned academic researcher? Are the levels of knowledge all the same? Is the kindergartner material really useful to the high school senior? Probably not at all, it's very basic. As a result, putting in hundreds of atomic notes as you're scaffolding your early learning can be counter-productive. Read some things, highlight them, annotate them. You'll have lots of fleeting notes, but most of them will seem stupidly basic after a month or two. What you really want as main notes are the truly interesting advanced stuff. When you're entering a new area, certainly index ideas, but don't stress about capturing absolutely everything until you have a better understanding of what's going on. Then bring your zettelkasten in to leverage yourself up to the next level.

• Adler, Mortimer J. “How to Mark a Book.” Saturday Review of Literature, July 6, 1940. https://www.unz.com/print/SaturdayRev-1940jul06-00011/
• Adler, Mortimer J., and Charles Van Doren. How to Read a Book: The Classical Guide to Intelligent Reading. Revised and Updated edition. 1940. Reprint, Touchstone, 2011.

reply to u/jack_hanson_c at https://old.reddit.com/r/Zettelkasten/comments/1g9dv9b/is_scoping_the_subject_a_counterzettelkasten/

for - adjacency - multi scale competency architecture - communication between levels - intrinsic to natural flows of life

for - climate crisis - 5 deg C could reproduce similar levels of catastrophes as those in early earth history

for - statistics - progress trap - comparative levels of poverty

statistics - progress trap - comparative levels of poverty - modern civilization has - a huge middle class - a small elite class - a huge impoverished class - The absolute number of people living on less than 2 dollars a day is less than the entire population of humans only 100 years ago

for - personal health - metabolic disease - insulin resistance caused by mitochondria dysfunction - interview - Dr. Robert Lustig - health - dangers of sugar in our diet

summary - Robert Lustig is a researcher and major proponent for educating the dangers of sugar as the root cause of the majority of preventable western disease - He explains how sugar and carbs are a major variable and root cause of a majority of these diseases - It is useful to look at these bodily dysfunctions from the perspective of Michael Levin, in which all these diseases of the body are problems with lower levels of the multi-scale competency architecture - https://jonudell.info/h/facet/?max=100&expanded=true&user=stopresetgo&exactTagSearch=true&any=michael+levin%2C+multi-scale+competency+architecture

for - health - heart - need to identify those with high LDL but ARE metabolically healthy

health - heart - high LDL AND metabolically healthy - against medical norms, there may be NO NEED TO LOWER THEIR LDL levels - and in fact, trying to do so may lead to harm

The navigation bar at the top of this webpage has clear contrast between the background and the foreground. This ensures that individuals experiencing limited vision will be able to navigate the website and tell the difference between the background and the foreground.

Characteristics

Characteristics

Characteristics

Characteristics

• Title
  • Three levels of the symbolosphere
• Authors
  • Mark Burgin and John H. Schumann

• Abstract

  • This paper attempts to understand the coexistence of the
    • material and
    • non-material
  • aspects of our lives.
  • By synthesizing ideas about
    • structures,
    • physical entities,
    • mental phenomena, and
    • symbolic relations,
  • we argue that
    • the nonmaterial can emerge from the material, and
    • then the nonmaterial may mediate the production of material entities.
  • Finally, this cycle is applied to notions of creativity and invention.

• Comment

  • the authors are situated in materialism that explains non-materialism as an epi-phenomena

One) Successful men realize that the most important decision in their life is the woman they choose, because outside of work, this is what they'll be spending most time on. The woman must understand the man's grand ambition, and support them with it. (Cf. Flow & The Intellectual Life as well). Women should be chosen on personality, not looks. Looks fade (attraction as well), personality "stays".

Two) Everyone deserves an opinion but not everyone deserves a say. Charlie Munger sums this up right: "I don't ever allow myself to have [express] an opinion about anything that I don't know the opponent side's argument better than they do." Or Marcus Aurelius, who says: "The opinion of ten thousand men is of no value if none of them know anything about the subject." In short: Only state your opinion when you can back it up!; knowledge and experience. The same goes for judging opinion (and advice) from others.

Three) Successful people buy assets when the money is enough. Assets > Luxury. (See also: Rich Dad, Poor Dad, Robert Kiyosaki). Only buy glamor and other "interests" once your assets are there to secure your financial success.

Four) Be pragmatic. Do what's practical, not what is "sexy". Notice inefficiencies and solve them. The entrepreneurial mindset.

Five) The morning sets the tone for the rest of the days. Time is subjective, waking up early doesn't matter as much as waking up later. It depends on the person. Someone who wakes up at 10am can be as successful as someone who wakes up at 6am. Instead, what defines success, is a highly effective morning routine.

Six) The less you talk, the more you listen. Talking less means less mistakes. In addition, the less you talk, the more people will listen when you do speak. It puts extra weight on your message. Listening means analysis and learning.

Seven) Pick the right opportunity at the right time. Pick the right vehicle. Do the right things in the right order! The advice "don't do what someone says, do what they do" is bullshit, as you can't do what someone is able to do after ten years of experience.

Eight) Discipline > Motivation. Motivation, like Dr. Sung says, fluctuates and is multifactorial dependent... When you are lead by motivation you will not be as productive. Don't rely on chance. Rely on what is stable.

Nine) Once a good career has been made, buy A1 assets and hold on to them to secure a financially successful future.

Ten) Just because you won, you are not a winner. Being a winner is a continuous process, it means always learning and reflecting as well as introspecting. Don't overvalue individual wins but do celebrate them when appropriate.

Eleven) Build good relationships with the banks early on. At times you need loans to fund certain ventures, when having a good relation with them, this will be significantly easier. Understand finance as early as possible. Read finance books.

Twelve) Keep the circle small. Acquintances can be many, but real close relationships should be kept small. Choose your friends wisely. "You become the average of the five people you spend most time with." Privacy is important. Only tell the most deep secrets to the Inner Circle, to avoid overcomplication.

Thirteen) Assume that everything is your fault. Responsibility. It leads to learning. It requires reflection and introspection. It leads to Dr. Benjamin Hardy's statement: "Nothing happens to you, everything happens for you."

Fourteen) Work like new money, but act like your old money. Combine the hunger of the new with the wisdom of the old.

Fifteen) Assume that you can't change the world, but slightly influence it. It prevents disappointments and gives a right mindset. Do everything (that has your ambition) with an insane drive. Aim to hit the stars. To become the best of the best.

Sixteen) Private victories lead to public victories. The solid maxim is the following: "The bigger the public victory, the more private victories went into it." Work in private. Social media doesn't need to known the struggle. Let your results talk for you. This is also why you should never compare yourself to others, but rather to your own past self.

Seventeen) After extreme experience, the most complicated task will look elegant and effortless. Unconscious competence.

There is no consensus on the idea of levevls of science, hwo many numbers of levels and what constitutes the lowest levels etc. But big data, data exploreation and eScience demanded computer oarsability. That requires organizing knowledge and types of entities in unambigious hierarchies (of levels!) for comnputer based reasoning.

levels -> becamse granularity levels different hierarchies based on levels -> granular perspectives criteria of identifying and demarcating levels -> granularity framework

Review coordinated by Life Science Editors Foundation

Reviewed by: Dr. Angela Andersen

Potential Conflicts of Interest: None

Background: * mRNAs in polarized cells often have a distinct spatial localization patterns that enable localized protein production * In non-polarized cells, mRNAs encoding membrane and secretory proteins are predominantly translated on the endoplasmic reticulum (ER), some mRNAs are enriched on the mitochondrial surface, some mRNAs are bound to the RNA-binding protein (RBP) TIS11B at the surface of the rough ER in "TIS granules". * The translation of specific mRNAs in TIS granules allows assembly of protein complexes that cannot be established when the mRNAs are translated on the ER but outside of TIS granules (physiological relevance). * The canonical rough ER (CRER) is distinct from the TIS granule ER (TGER), and both are distinct from the cytosol.

Questions: * Do mRNAs that encode non-membrane proteins differentially localize to the ER or the cytosol? (in steady state) * Does the amount of protein synthesis differ depending on the subcytoplasmic location of an mRNA?

Summary: * A third of mRNAs that encode non-membrane proteins have a biased localization to TGER or CRER, indicating that the ER membrane is a general site of translation for both membrane and non-membrane proteins. * 52% of mRNAs that encode non-membrane proteins have a biased mRNA transcript localization pattern towards a single cytoplasmic compartment. the TGER, CRER or cytosol. * The localization at the TGER or CRER was largely controlled by a combinatorial code of AU-RBPs at the 3'UTR. TIS11B promotes mRNA localization to TGER and TIA1/L1 to CRER. * LARP4B bound to the 3'UTR promotes cytosolic localization. * The location of translation has an independent effect on protein levels independent of the RBPs/3'UTR: redirecting cytosolic mRNAs to the rough ER membrane increased their steady-state protein levels by two-fold, indicating that the ER environment promotes protein expression. * Compartment-enriched mRNAs differed in their mRNA production and degradation rates, as well as functional classes and levels of their encoded proteins. Therefore the cytoplasm is partitioned into different functional and regulatory compartments that are not enclosed by membranes. * low-abundance proteins are translated in the TGER region. mRNAs encoding zinc finger proteins and transcription factors were substantially enriched at the TGER. These gene classes are usually expressed at lower levels than others.. This localization may regulate protein complex assembly (membrane proteins that are translated in the TGER domain establish protein complexes that cannot be formed when the proteins are translated on the CRER). The TGER may ensure that low-abundance mRNAs are effectively translated into low-abundance proteins. * mRNAs that are the most stable and encode the most highly expressed proteins are enriched on the CRER and include helicases, cytoskeleton-bound proteins, and chromatin regulators, overturning the idea that most non-membrane protein-encoding mRNAs are translated in the cytosol. * mRNAs overrepresented in the cytosol had the highest production and degradation rates and were enriched in proteins involved in mRNA processing and translation factors, whose abundance levels require tight control.

Advance: Evidence for functional compartmentalization of non-membrane mRNA protein expression in the cytosol vs ER. In steady state, general localization of mRNAs to the ER promotes high protein levels.

Significance: Engineered 3'UTR sequences could potentially boost protein expression by localizing mRNAs to the ER in experimental settings, for vaccines etc.

Remaining questions/points: * How does the rough ER stimulate protein expression? * Does the mRNA localization affect complex formation and/or function of non-membrane proteins? * Does this occur in cells other than HEK293T? * Is this regulated?

!-- priorities : 3 levels - Short term (next few years) - medium term (next 5 to 10 years) - long term ( next 50 years)

https://dictionary.apa.org/elaboration

The practice of repeating items as a means of attempting to place them into short-term memory is called maintenance rehearsal. Examples of this practice include repeating a new acquaintance's name or perhaps their phone number multiple times as a means of helping to remember it either for the short term or potentially the long term.

Research on the levels-of processing model of memory indicates that maintenance rehearsal is not as effective at promoting long term memory as methods like elaborative rehearsal.

How to Control Blood Glucose Levels

5.4 Navigate levels effectively.

Vega-Oliveros, D. A., Grande, H. L. C., Iannelli, F., & Vazquez, F. (2021). Bi-layer voter model: Modeling intolerant/tolerant positions and bots in opinion dynamics. The European Physical Journal Special Topics, 230(14–15), 2875–2886. https://doi.org/10.1140/epjs/s11734-021-00151-8

Elisabeth Mahase. (2021, July 26). At least 6 weeks between Pfizer vaccine doses = higher neutralising antibody levels (than a 3-4 wk interval) For those with the delta variant, antibody levels were 2.3-fold higher with the longer interval Preprint from @pitchstudy @bmjlatest https://t.co/E3yOTqNgpa [Tweet]. @emahase. https://twitter.com/emahase_/status/1419604658344112130

Britt, Robert Roy. ‘10 Signs the Pandemic Is About to Get Much Worse’. Medium, 19 October 2020. https://elemental.medium.com/10-signs-the-pandemic-is-about-to-get-much-worse-cf261bf3885d.

ReconfigBehSci. (2021, February 12). RT @NatureNews: The science behind how and when to give vaccines doses. Https://t.co/S75TXESOG9 [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1360489348223893505

Thompson, B., Baker, N., & Ledford, H. (2021). Coronapod: Is mixing COVID vaccines a good idea? Nature. https://doi.org/10.1038/d41586-021-00390-8

Contrast with: https://hyp.is/U_7sXhGREeumDJvbgTImjQ/github.com/sveltejs/svelte/pull/4601

From the linked article

Full ownership of a book only comes when you have made it a part of yourself, and the best way to make yourself a part of it— which comes to the same thing— is by writing in it.

Really love that quote - the idea of [[marginalia]] is to write in the margins, take notes as you read - to ask questions and answer them, and context around the highlights.

In turn, [[make the book your own]]

[[analytical reading]] is one of the [[four levels of reading]] - the goal is to get to know a particular text very well.

sub-type of [[inspectional reading]] - reading the table of contents, skimming pages, looking for the hooks - how does this relate to [[proximity principle]] and [[scanning patterns]] - but getting a sense enough to know "is this book worth adding to the collection" for deeper reading

I think this is where I've been able to use #ADHD to it's advantages at times is with [[inspectional reading]] - being able to skim a large amount of content and get a sense of what I want to dig into later on or not.

Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. M., Thouvenel, C., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L. P., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. MedRxiv, 2020.08.11.20171843. https://doi.org/10.1101/2020.08.11.20171843

Pollán, M., Pérez-Gómez, B., Pastor-Barriuso, R., Oteo, J., Hernán, M. A., Pérez-Olmeda, M., Sanmartín, J. L., Fernández-García, A., Cruz, I., Larrea, N. F. de, Molina, M., Rodríguez-Cabrera, F., Martín, M., Merino-Amador, P., Paniagua, J. L., Muñoz-Montalvo, J. F., Blanco, F., Yotti, R., Blanco, F., … Villa, A. V. de la. (2020). Prevalence of SARS-CoV-2 in Spain (ENE-COVID): A nationwide, population-based seroepidemiological study. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31483-5

Fontanet, A., Grant, R., Tondeur, L., Madec, Y., Grzelak, L., Cailleau, I., Ungeheuer, M.-N., Renaudat, C., Pellerin, S. F., Kuhmel, L., Staropoli, I., Anna, F., Charneau, P., Demeret, C., Bruel, T., Schwartz, O., & Hoen, B. (2020). SARS-CoV-2 infection in primary schools in northern France: A retrospective cohort study in an area of high transmission. MedRxiv, 2020.06.25.20140178. https://doi.org/10.1101/2020.06.25.20140178

Fontanet, A., Tondeur, L., Madec, Y., Grant, R., Besombes, C., Jolly, N., Pellerin, S. F., Ungeheuer, M.-N., Cailleau, I., Kuhmel, L., Temmam, S., Huon, C., Chen, K.-Y., Crescenzo, B., Munier, S., Demeret, C., Grzelak, L., Staropoli, I., Bruel, T., … Hoen, B. (2020). Cluster of COVID-19 in northern France: A retrospective closed cohort study. MedRxiv, 2020.04.18.20071134. https://doi.org/10.1101/2020.04.18.20071134

Liu, T., Wu, S., Tao, H., Zeng, G., Zhou, F., Guo, F., & Wang, X. (2020). Prevalence of IgG antibodies to SARS-CoV-2 in Wuhan—Implications for the ability to produce long-lasting protective antibodies against SARS-CoV-2. MedRxiv, 2020.06.13.20130252. https://doi.org/10.1101/2020.06.13.20130252

Long, Q.-X., Tang, X.-J., Shi, Q.-L., Li, Q., Deng, H.-J., Yuan, J., Hu, J.-L., Xu, W., Zhang, Y., Lv, F.-J., Su, K., Zhang, F., Gong, J., Wu, B., Liu, X.-M., Li, J.-J., Qiu, J.-F., Chen, J., & Huang, A.-L. (2020). Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine, 1–5. https://doi.org/10.1038/s41591-020-0965-6

It is impossible to provide a specific costing method, but only general methods. How is design dependent? What is the benefit level of? and the range means the limit of the "Single-payer" system?

Jack Phillips and ROI. This page describes the Phillips Return on Investment model. The model as presented here is an alternative to Kirkpatrick's model. There's a bulleted list of the components of the model as well as a nice graphic that briefly describes the levels. There is an explanation about how to apply the model, though I think more information would be needed for real world practice. Rating 4/5

This is one of many discussions of Kirkpatrick's four levels of evaluation. More of the page is taken up with decoration and graphics than needs to be the case but this page is included in this list because it offers a printable guide and because the hierarchy of the four levels is clearly shown. The text itself is printed in black on a white background and it is presented as a bulleted list (the bullets are not organized as well as they could be). Nonetheless it is a usable presentation of this model. rating 3/5

Federalism has the capability of being both bad and good. It just depends who you ask. On one side the advantages of fedaralism is it creates more effectiveness and makes the government stable. On the other hand federalism is risky it gets expensive, lead to a complex tax system and is slow in responses to crisis.

Engineering focus, but a very detailed rubric of how to rank different personnel levels. Could maybe be generalized/adapted for other fields.