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  1. Last 7 days
    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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    1. Treatment of superficial vein reflux (see Varicose Veins, above) has been shown to decrease the recurrence rate of venous ulcers. Where there is substantial obstruction of the femoral or popliteal deep venous system, superficial varicosities supply the venous return and should not be removed.

      Failure of venous insufficiency ulcerations to heal is most often due to inconsistent use of first-line treatment methods. Ongoing control of edema is essential to prevent recurrent ulceration; the use of compression stockings following ulcer healing is critical, with recurrence rates 2–20 times higher if compression stockings are not used

      Duplex ultrasound evaluation should assess blood flow direction, venous reflux, and venous obstruction, and include examination of the deep venous system, great saphenous vein (GSV), small saphenous vein (SSV) and its thigh extension (Giacomini vein), accessory saphenous veins, and perforating veins. Venography is recommended primarily in patients with post-thrombotic disease, especially when intervention is planned, as it provides greater anatomic detail than duplex ultrasonograph The examination also identifies patterns of disease that have treatment implications. Axial reflux is defined as uninterrupted retrograde flow from groin to calf and can occur in either superficial or deep systems. [4] Junctional reflux is limited to the saphenofemoral or saphenopopliteal junction, while segmental reflux occurs in a portion of a truncal vein. [4] Understanding whether reflux originates from superficial junctions versus deep venous incompetence fundamentally changes treatment planning, as superficial disease is amenable to ablation while deep disease typically requires conservative management Management of secondary varicose veins from post-thrombotic syndrome (PTS) is fundamentally different and more challenging. Compression therapy, lifestyle modifications, and symptom management form the cornerstone of PTS treatment. [4-8] Elastic compression stockings (20-30 mm Hg), leg elevation, weight loss, and exercise constitute the primary therapeutic approach Endovascular interventions for PTS—including percutaneous transluminal venoplasty and stenting—are reserved for select patients with significant iliofemoral obstruction who have failed conservative management. [7] These procedures require careful patient selection and standardized criteria. The role of superficial venous ablation in PTS patients with concomitant superficial reflux remains controversial and should be approached cautiously, as the underlying deep venous pathology may limit benefit

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  2. Feb 2025
    1. Life is a war and only the strongest warriors will survive. Compassion with the weak is a luxury, which neither Fascists nor Libertarians can afford.

      for - quote - Life is a war and only the strongest warriors survive. Compassion with the weak is a luxury, which neither Fascists nor Libertarians can afford. - article - Guido Palazzo

      comment - This is a self-fulfilling prophecy that models one aspect of life - the fact that living beings must compete for resources with other living beings to survive - It ignores the other side, the cooperative and altruistic side - It ignores the intertwingledness of self and other - the individual / collective gestalts - It ignores the fundamental altruism of the mother in assuring their own survival in the world - the mOTHER, the Most significant OTHER

  3. Jan 2025
    1. to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us?

      for - quote - to make significant, to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us? - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke

      quote - to make significant, to reflect upon, to celebrate and enact Religio is to fundamentally enhance our agency, the disclosure of the world and our connectedness to it. And what else could be more valuable to us? What else could be more valuable to us? - John Vervaeke - (see below) - And we do this, I would argue, - for the very good reason that - to make significant, - to reflect upon, - to celebrate and enact Religio - is to fundamentally - enhance our agency, - the disclosure of the world and our connectedness to it. - And what else could be more valuable to us? What else could be more valuable to us?

  4. Dec 2024
    1. To put it bluntly, Web3 and the crypto economy is still largely an ‘exit’ play for financial and coding elites, practicing the arbitrage of nation-states, but without much connections to local communities and resilient production; Similarly, local communities engaged in relocalized and regenerative production are not in sync with the mutual coordination capacities developed in the crypto/web3 context.

      for - quote - silos - web 3 and crypto silo - localization silo - desiloing can bring about significant empowerment to people everywhere - from Substack article - The Cosmo-Local Plan for our Next Civilization - Michel Bauwens - 2024, Dec 20 - adjacency - desilo web 3 / Blockchain and localisation - educate cud events such as - Tipping Point Festival - from Substack article - The Cosmo-Local Plan for our Next Civilization - Michel Bauwens - 2024, Dec 20

      quote - silos - web 3 and crypto silo - localization silo - desiloing can bring about significant empowerment to people everywhere - (see quote below) - To put it bluntly, Web3 and the crypto economy is still largely an ‘exit’ play for financial and coding elites, - practicing the arbitrage of nation-states, - but without much connections to local communities and resilient production; - Similarly, local communities engaged in relocalized and regenerative production - are not in sync with the mutual coordination capacities developed in the crypto/web3 context.

      // - We need to create opportunities such as events and workshops to bring these two spheres into dialogue - Tipping Point Festival, as a cosmolocal event can do this by - holding locally organized events hosted by - local community activists at their community level, and - in larger urban centers, at ward and district level - thec internet can be used to facilitate the emergence of trans-national alliances

  5. Nov 2024
    1. it isn't just about alleviating their own personal suffering it's also about alleviating Universal suffering so this is where the the bodh satra or the Christ or those kinds of archetypes about being concerned about the whole

      for - example - individual's evolutionary learning journey - new self revisiting old self and gaining new insight - universal compassion of Buddhism and the individual / collective gestalt - adjacency - the universal compassion of the bodhisattva - Deep humanity idea of the individual / collective gestalt - the Deep Humanity Common Human Denominators (CHD) as pointing to the self / other fundamental identity - Freud, Winnicott, Kline's idea of the self formed by relationship with the other, in particular the mOTHER (Deep Humanity), the Most significant OTHER

      adjacency - between - the universal compassion of the bodhisattva - Deep humanity idea of the individual / collective gestalt - the Deep Humanity Common Human Denominators (CHD) as pointing to the self / other fundamental identity - Freud, Winnicott, Kline's idea of the self formed by relationship with the other, in particular the mOTHER (Deep Humanity), the Most significant OTHER - adjacency relationship - When I heard John Churchill explain the second turning, - the Mahayana approach, - I was already familiar with it from my many decades of Buddhist teaching but with - those teachings in the rear view mirror of my life and - developing an open source, non-denominational spirituality (Deep Humanity) - Hearing these old teachings again, mixed with the new ideas of the individual / collective gestalt - This becomes an example of Indyweb idea of recording our individual evolutionary learning journey and - the present self meeting the old self - When this happens, new adjacencies can often surface - In this case, due to my own situatedness in life, the universal compassion of the bodhisattva can be articulated from a Deep Humanity perspective: - The Freudian, Klinian, Winnicott and Becker perspective of the individual as being constructed out of the early childhood social interactions with the mOTHER, - a Deep Humanity re-interpretation of "mother" to "mOTHER" to mean "the Most significant OTHER" of the newly born neonate. - A deep realization that OUR OWN SELF IDENTITY WAS CONSTRUCTED out of a SOCIAL RELATIONSHIP with mOTHER demonstrates our intertwingled individual/collective and self/other - The Deep Humanity "Common Human Denominators" (CHD) are a way to deeply APPRECIATE those qualities human beings have in common with each other - Later on, Churchill talks about how the sacred is lost in western modernity - A first step in that direction is treating other humans as sacred, then after that, to treat ALL life as sacred - Using tools like the CHD help us to find fundamental similarities while divisive differences might be polarizing and driving us apart - A universal compassion is only possible if we vividly see how we are constructed of the other - Another way to say this is that we see others not from an individual level, but from a species level

  6. Aug 2024
    1. When a work does appear that bears no clearrelationship to a familiar genre, a new genre can sometimes be born

      Genres are not black and white, they can transform over time or with the use of new styles and ideas new genres can be created.

    2. Poems can often also produce a sense of timelessness or of a short period of timeabstracted from ordinary time because they are measured by meter and other sound repetitionsthat have aural effects, unfolding over a particular period of time (as long as the speaker speaks),but no meaning, and because they are short enough to be easily repeatable over and over againand even easily memorized and recited at will.
    3. A particular mode willoften reflect certain assumptions and raise certain kinds of questions about the nature of humanbeings, about the relationships they have with one another, and about the universe they inhabit.

      Important to know about Mode

    4. the basic patterns and components of many ofthe genres used by authors who write in Modern English have remained remarkably stable.

      Important Basic patterns and components of many of the geners have stayed the same throughout the past 500 years or so

    1. The shop was closed. Or you had doubts—The sort that minds like oursDream up incessantly. You thoughtI might not want your flowers

      the speaker accepts his excuses on not following through. This can show that she was immersed in this man and even if he wasn't consistent she still let it go just to be with him.

    2. But for the lovers, their armsRound the griefs of the ages,Who pay no praise or wagesNor heed my craft or art.

      He writes for ordinary lovers who have real experience and just randomly stumble upon his work. He does not want to write for people who are fully immersed in his work because it is beautiful, he wants someone to have lived it.

    3. Tis visible silence, still as the hour-glass

      Even in a moment where he wants time to stand still, time keeps moving. This scares the speaker as he wishes he could just enjoy this moment with her instead of imagining what could happen. Love fades with time.

    4. he fading rose;For in your beauty’s orient deep,These flowers, as in their causes, sleep

      The speaker comparing her beauty to a flower is a reflection of how both flowers and people go through transition rapidly, and with that beauty fades.

    5. Ask me no more where Jove bestows

      "Jove" can be representative of the world within ourselves. Beauty on the outside, like a flower, fades and transitions. However, the beauty within oneself never dies.

  7. Sep 2023
  8. Feb 2023
    1. The results of this investigation revealed significant decreases in long-term scores were present only in our RUN sample

      This is significant because it shows that a specific school had a different outcome. This can now open the question and research to know if this is a general conclusion or if it is just for a specific program.

    2. In terms of each of the individual survey items, taking an experiential philanthropy course, on average, significantly increased a RUN student’s scores on awareness of social needs (awneeds) and awareness of nonprofit organizations (awnpo) by 9.82 and 14.38 scale points, respectively

      This is significant because it shows that this type of learning does have a benefit on the outcome of a student.

    3. indicate that experiential philanthropy does not result in positive long-term effects on any of our outcome variables.

      This is significant because it shows the outcome of the data that was being studied. It is also significant because it shows that this can impact the future of experiential philanthropy

  9. Jan 2023
    1. With safety of her innocence;

      I find that the speaker may be alluding to different ideas in this line. His daughter, who passed at only six months, will be safeguarded of her innocence as she will not experience any form of hatred or danger in the mortal world. Yet, I also believe it applies to the sacrament of baptism which ties to her innocence. Baptism is performed a few weeks after birth for purity in the eyes of God. Therefore, Mary is pure and innocent as she goes to heaven.

  10. Sep 2022
  11. Aug 2022
  12. Jul 2022
    1. Even though human existence in such a bare state may seem inconceivable, it is therenevertheless: every time a baby is born, a new, not yet programmed, prepersonal human is lookinginto somebody’s eyes ([27 ]: p. 133). This undeniable prepersonal presence we already call human leadsus to logically infer that humans do happen to exist prior to their personware [ 20 ,25 ,28 ]. It is thereforeour fundamental point of departure that humans are marvellous, intelligent, living cognitive agents inthemselves that can be said to exist prior to and independently of any particularly determined socialpersona. The point of acknowledging a prior prepersonal platform is not made towards arguing that ahuman can exist without any personware.

      !- for : altricial, feral children, mOTHER as the significant OTHER * The bare state of zero culture, zero social context is what each and every neonate starts with in life * The mOTHER is the most significant OTHER that begins the process of socializing and enculturating the neonate into a social system * Altrciality forces human parent into role of strong socialization * Without culture, the neonate born into the world outside the womb can become a feral child * https://www.zmescience.com/other/feature-post/feral-children/ * The state of human ferality can tell us an enormous amount of the perspective of virtually every modern, encultured person - we have a bias towards a cultural perspective because almost noone has seen from a feral perspective * Language is the gateway into the symbolosphere, where enculturated, modern humans spend a significant portion of their lives immersed in this ubiquitous, constructed, symbolic reality

  13. Apr 2022
  14. Feb 2022
  15. Jan 2022
    1. heaven’s gifts being heaven’s due,

      The writer of the poem includes many religious elements throughout the poem and references heaven quite a lot. This belief in the after-life, where they think the passed youth has been gifted, most likely provides solace to the mourning.

  16. Nov 2021
    1. In this report, we investigated performance of the omnibus test using simulated data. The hierarchical procedure is a widely used approach for comparing multiple (more than two) groups.[1] The omnibus test is intended to preserve type I errors by eliminating unnecessary post-hoc analyses under the null of no group difference. However, our simulation study shows that the hierarchical approach is not guaranteed to work all the time. The omnibus and post-hoc tests are not always in agreement. As our goal of comparing multiple groups is to find groups that have different means, a significant omnibus test gives a false alarm, if none of the post-hoc tests are significant. But, most important, we may also miss opportunities to detect group differences, if we have a non-significant omnibus test, since some or all post-hoc tests may still be significant in this case.Although we focus on the classic ANOVA model in this report, the same considerations and conclusions also apply to more complex models for comparing multiple groups, such as longitudinal data models [2]. Since for most models, post-hoc tests with significant levels adjusted to account for multiple testing do not have exactly the same type I error as the omnibus test as in the case of ANOVA, it is more difficult to evaluate performance of the hierarchical procedure. For example, the Bonferroni correction is generally conservative.Given our findings, it seems important to always perform pairwise group comparisons, regardless of the significance status of the omnibus test and report findings based on such group comparisons.

      Post hoc not significant when omnibus test is significant.

  17. Sep 2021
  18. Jul 2021
  19. May 2021
  20. Mar 2021

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  21. Feb 2021
  22. Dec 2020
  23. Nov 2020
    1. Today that 37 year old white man with 13 years of police forcing

      I feel as though this detail of being a white male who has served in the police force is a negative connotation. Even in this situation he is seen shooting down a ten year old. I think the speaker is trying to prove something by giving the detailed information about the person.

  24. Jun 2020
  25. May 2020
  26. Apr 2020
  27. Apr 2017
  28. Mar 2015
    1. Now, we are discussing ideal objects here: addressability implies different levels of abstraction (character, word, phrase, line, etc) which are stipulative or nominal: such levels are not material properties of texts or Pythagorean ideals; they are, rather, conventions.

      Might be useful in thinking about what an “edition” is—must it include all items most editions currently include, or are those conventions or manifestations of values, and not necessary values themselves?

  29. Feb 2014
    1. b. Identify legally relevant facts, t hat is, those facts that tend to prove or disprove an issue before the court. The relevant facts tell what happened before the parties enter ed the judicial system. c. Identify procedurally significant facts. You should set out (1) the cause of action (C/A) (the law the plaintiff claimed was broken), (2) relief the plaintiff requested, (3) defenses, if any, the defendant raised.