392 Matching Annotations
  1. Apr 2020
    1. Newton, P. N., Bond, K. C., Adeyeye, M., Antignac, M., Ashenef, A., Awab, G. R., Babar, Z.-U.-D., Bannenberg, W. J., Bond, K. C., Bower, J., Breman, J., Brock, A., Caillet, C., Coyne, P., Day, N., Deats, M., Douidy, K., Doyle, K., Dujardin, C., … Zaman, M. (2020). COVID-19 and risks to the supply and quality of tests, drugs, and vaccines. The Lancet Global Health, S2214109X20301364. https://doi.org/10.1016/S2214-109X(20)30136-4

    1. Abdulla, A., Wang, B., Qian, F., Kee, T., Blasiak, A., Ong, Y. H., Hooi, L., Parekh, F., Soriano, R., Olinger, G. G., Keppo, J., Hardesty, C. L., Chow, E. K., Ho, D., & Ding, X. (n.d.). Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention. Advanced Therapeutics, n/a(n/a), 2000034. https://doi.org/10.1002/adtp.202000034

  2. Mar 2020
    1. Cancer - a symbolic drama between mother and child Bahne-Bahnson (1982) notes that people suffering from cancer experience in a psychosomatic way old emotional deficits that have never been consciously addressed. He suggests that cancer patients have been deprived of being innocent children, and that many of them had to look after and emotionally support their parents. These people missed out on much of the essential emotional nurturing that would have allowed them to develop a strong sense of self.
  3. Jan 2020
  4. Dec 2019
    1. blood circulate

      The early modern English physician William Harvey (1578-1627) made several valuable contributions to the medical sciences, including the circulation of blood in the human body. In De Motu Cordis (1628), Harvey sets down his landmark experiments; in these, Harvey used ligatures to stem blood flow to better understand how the heart works to pump blood throughout the human body. This knowledge will be critical for Victor's creation of the Creature.

    2. physiology

      By 1818 physiology had become a controversial branch of medicine at the center of the dispute between vitalism, the idea that a divine spark energized animal life, and materialism, the argument that chemical processes alone give rise to life. Mary Shelley was well aware of the dispute since the Shelleys' family doctor, William Lawrence, was vigorously taking up the materialist argument in works like An Introduction to Comparative Anatomy and Physiology (1816). For a full view of this controversy as it relates to the novel, see Marilyn Butler, "Frankenstein and Radical Science" [1993] reprinted in J. Paul Hunter, Frankenstein, Norton Critical Edition, second ed. (New York: Norton, 2012): 404-416.

  5. Nov 2019
    1. Considerable obstacles remain, however, before the genetic therapy can be tested on human heart attack patients. Most of the treated pigs died after the treatment because the microRNA-199 continued to be expressed in an uncontrolled way.

      My imagination is running wild, but not in a good way. 😞

  6. Oct 2019
  7. Sep 2019
  8. Aug 2019
    1. heTaw-Rouzecameinthismorningtoaskmeforalittlephysio.Itold[him]Iwouldgivehimsomesalts.Wehadverylittleofthat.Hesaidhehadbeensickagoodmanydays.Igave.himsome.Iwenttohislodgethisafternoon,themedecinehadoppor—atedwe

      the Taw-Rouze (Native Doctor?) asks Mrs. Ely for salt because he has been sick

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  9. Jul 2019
    1. Two years ago, when he moved from Boston to London, he had to register with a general practitioner. The doctor’s office gave him a form to sign saying that his medical data would be shared with other hospitals he might go to, and with a system that might distribute his information to universities, private companies and other government departments.The form added that the although the data are anonymized, “there are those who believe a person can be identified through this information.”“That was really scary,” Dr. de Montjoye said. “We are at a point where we know a risk exists and count on people saying they don’t care about privacy. It’s insane.”
  10. Jun 2019

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  11. May 2019
  12. Apr 2019
    1. Balm of Mecca[edit] Forskal found the plant occurring between Mecca and Medina. He considered it to be the genuine balsam-plant and named it Amyris opobalsamum Forsk. (together with two other varieties, A. kataf Forsk. and A. kafal Forsk.).[4] Its Arabic name is abusham or basham, which is identical with the Hebrew bosem or beshem.[6] Bruce found the plant occurring in Abyssinia.[3] In the 19th century it was discovered in the East Indies also.[4] Linnaeus distinguished two varieties: Amyris gileadensis L. (= Amyris opobalsamum Forsk.), and Amyris opobalsamum L., the variant found by Belon in a garden near Cairo, brought there from Arabia Felix. More recent naturalists (Lindley, Wight and Walker) have included the species Amyris gileadensis L. in the genus Protium.[4] Botanists enumerate sixteen balsamic plants of this genus, each exhibiting some peculiarity.[6] There is little reason to doubt that the plants of the Jericho balsam gardens were stocked with Amyris gileadensis L., or Amyris opobalsamum, which was found by Bruce in Abyssinia, the fragrant resin of which is known in commerce as the "balsam of Mecca".[3] According to De Sacy, the true balm of Gilead (or Jericho) has long been lost, and there is only "balm of Mecca".[6] Newer designations of the balsam plant are Commiphora gileadensis (L.) Christ., Balsamodendron meccansis Gled. and Commiphora opobalsamum.
  13. Feb 2019
    1. Cure of those El'ils

      A medicinal model of education. "Hi, I'm Thomas Sheridan. All these dumbasses are hopelessly lost because they don't speak correctly. They'll never do anything good, or see what good is, because bad speech runs rampant. The only hope is to heal them by teaching them to speak well. That is, like me."

  14. Jan 2019
  15. Nov 2018
    1. The hospitalist movement mirrors the health care trend toward ever-increasing specialization. However, hospitalists are fundamentally generalist physicians who provide and coordinate inpatient care, often aided by myriad subspecialists. How can a generalist be a specialist? Specialties in medicine are traditionally defined by organ (eg, cardiology), disease (oncology), population (pediatrics), or procedure/technology (surgery or radiology). The hospitalist, on the other hand, is a "site-defined generalist specialist" (similar to emergency medicine physicians or critical care specialists), caring for patients with a wide array of organ derangements, illnesses, and ages within a specific location.45 Accordingly, the hospitalist should not be seen as a retreat from generalism and its emphasis on coordination and integration9,77 but rather as an affirmation of these values and as a surrogate for the primary care physician in the hospital. The competing pressures resulting from the distance between office and hospital as well as the requirement of around-the-clock availability make the hospital-based generalist a logical evolution. Hospital medicine has already satisfied many of the requirements of a specialty. A large and enthusiastic group of practitioners identify themselves not according to their training background but as hospitalists. The NAIP is almost certainly the fastest growing physician society in the United States. The field hosts several successful meetings each year and has its own clinical textbook.78 To establish themselves as members of a recognized medical specialty, hospitalists must identify a core skill set or body of knowledge and obtain the approval of credentialing organizations. Advocates of specialty status for hospitalists should be encouraged by the history of 2 other site-defined inpatient specialties: emergency medicine and critical care medicine. Like these relatively young fields, it seems probable that hospitalists will ultimately define a unique set of skills and competencies that will distinguish their field. The identification of practice-training mismatches (Table 2) represents an important first step. Credentialing organizations deliver the final stamp of approval on new specialties by creating a board certification or added qualification. Most new fields quickly agitate for such status, their motivation both practical and visceral. However, for unique reasons, few hospitalists are pressing this point. Many physicians—hospitalists and nonhospitalists—worry that if a credentialing body (such as the American Boards of Internal Medicine or Pediatrics) created a hospital medicine credential, health maintenance organizations might require that physicians possess this credential to care for inpatients. This would be unacceptable to many primary care physicians, who would be excluded from the hospital despite their desire and competence to continue practicing there. For this reason, we expect neither NAIP nor the relevant boards to promote separate credentials in the near future. Nevertheless, as evolutionary forces lead to specialized training, some formal specialty designation may emerge.79
    1. Hospitalists were seen as people to lead the charge for safety because they were already taking care of patients, already focused on reducing LOS and improving care delivery—and never to be underestimated, they were omnipresent, Dr. Gandhi says of her experience with hospitalists around 2000 at Brigham and Women’s Hospital in Boston. “At least where I was, hospitalists truly were leaders in the quality and safety space, and it was just a really good fit for the kind of mindset and personality of a hospitalist because they’re very much … integrators of care across hospitals,” she says. “They interface with so many different areas of the hospital and then try to make all of that work better.”

      role of hospitalists in safety and quality

    2. “When the IOM report came out, it gave us a focus and a language that we didn’t have before,” says Dr. Wachter, who served as president of SHM’s Board of Directors and to this day lectures at SHM annual meetings. “But I think the general sensibility that hospitalists are about improving quality and safety and patients’ experience and efficiency—I think that was baked in from the start.”
    3. “The role of the hospitalist often is to take recommendations from a lot of different specialties and come up with the best plan for the patient,” says Tejal Gandhi, MD, MPH, CPPS, president and CEO of the National Patient Safety Foundation. “They’re the true patient advocate who is getting the cardiologist’s opinion, the rheumatologist’s opinion, and the surgeon’s opinion, and they come up with the best plan for the patient.”
    4. Two major complaints emerged early on, Dr. Gorman says. Number one was the notion that hospitalists were enablers, allowing PCPs to shirk their long-established duty of shepherding their patients’ care through the walls of their local hospital. Number two, ironically, was the opposite: PCPs who didn’t want to cede control of their patients also moonlit taking ED calls that could generate patients for their own practice.
    5. The model Dr. Wachter settled on—internal medicine physicians who practice solely in the hospital—wasn’t entirely novel. He recalled an American College of Physicians (ACP) presentation at 7 a.m. on a Sunday in 1995, the sort of session most conventioneers choose sleep over. Also, some doctors nationwide, in Minnesota and Arizona, for instance, were hospital-based as healthcare maintenance organizations (HMOs) struggled to make care more efficient and less costly to provide.
    1. Others are implementing bedside ultra-sonography for procedures and diagnosis, pioneering methods of making rounds more patient- and family-centric, implementing unit-based leadership teams, or applying process-improvement ap-proaches such as the Toyota Pro-duction System to inpatient care.
    2. mentation of quality- and systems-related initiatives. Hospitalists have been slow to pursue sub-stantial inquiry into discovery re-lated to the common inpatient diseases they see or to lead multi-center trials of new diagnostic or therapeutic approaches. This defi-ciency limits hospitalists’ credibil-ity in academia and the advance-ment of the field.

      Finally, the few academic hospitalist groups that have developed substantial research programs generally emphasize the implementation of quality- and systems-related initiatives.

    3. Many hospitalists have added value as local leaders in quality improvement, safety, and innova-tion, but some have functioned more as shift workers. For exam-ple, many community hospital-ists have a 7-days-on, 7-days-off schedule that focuses mainly on high-volume clinical work and sends an unspoken but clear mes-sage that, at the end of an inten-sive clinical “on” stint, one is “off ” and uninvolved. Our impression is that hospitalist programs pro-vide more value when hospital-ists’ inpatient assignments (clini-cal “systole”) are complemented by a systems-oriented “diastole,” dur-ing which clinical activity is limit-ed but they contribute to key in-stitutional programs. Productive diastole is more likely when hos-pitalists have strong leadership, a robust professional-development curriculum, and a mutual hospi-tal–hospitalist commitment to adding value during specified and structured nonclinical time.

      The hospitalists patient is the hospital

    1. So many medical publications appear worldwide every day that it is no longer possible for an individual medical professional to keep up with the latest state of knowledge. In order to offer support and to encourage new medical research, EBM provides a toolbox of different methods. These tools can be divided into three categories:The first category includes methods that serve to create reliable new knowledge: Someone who would like to compare the advantages and disadvantages of different drugs, for example, will find suitable types of studies here.The second category involves methods that help to summarize the existing knowledge on a subject: They serve to find and select the previously published studies that are best able to answer a particular question. There are now networks of researchers that specialize in looking for the latest research findings and summarizing them to provide easily accessible information.The third category covers methods for presenting information to medical professionals and laypeople in a way that helps them to find, understand and make use of it.The main aim is always to find out what kind of care is most suitable for a particular patient – and how to incorporate their individual preferences and circumstances into the treatment decision.
    2. An evidence-based approach also includes informing patients about the pros and cons of medical options so that they can actively be part of the decision.So making a treatment decision in accordance with EBM means basing it on the best available knowledge from clinical research and medical practice. A number of factors play an important role in the decision. As well as the type and severity of the health problem, these include the person's general life situation, personal values and opinions.
    3. This is the purpose of evidence-based medicine (EBM): to provide healthcare professionals, patients and those close to them with up-to-date and scientifically proven information on the various medical options that are available to them. It can help to find out what sorts of advantages or disadvantages a treatment or test has, when people might benefit from it and whether it might also be harmful.EBM uses special methods that it has developed to find the highest quality evidence for the benefits of a specific medical intervention. This evidence can be found in conclusive scientific studies. EBM also plays a part in making sure that the research that is done can help patients to answer the most important questions. This means that studies look into both the benefits of a treatment as well as how it affects quality of life, for example.
    1. “It’s about embracing the inscrutable nature of human interactions,” says Chang. Evidence-based medicine was a massive improvement over intuition-based medicine, he says, but it only covers traditionally quantifiable data, or those things that are easy to measure. But we’re now quantifying information that was considered qualitative a generation ago.

      Biggest challenges to redesigning the health care system in a way that would work better for patients and improve health

    1. The concept of patient-centered care extends to the treatments and therapies clinicians provide. Not only are care plans customized, but medications are often customized as well. A patient’s individual genetics, metabolism, biomarkers, immune system, and other “signatures” can now be harnessed in many disease states — especially cancer — to create personalized medications and therapies, as well as companion diagnostics that help clinicians better predict the best drug for each patient.

      Patient-centered care via personalized medicine

    2. Strict visiting hours and visitor restrictions are a thing of the past in a patient-centered care model. Patients are given the authority to identify who can visit and when. Family members (as defined by the patient and not limited to blood relations) are invited to visit during rounding and shift changes so they can be part of the care team, participating in discussions and care decisions. When not in the room with the patient, they are kept informed of their loved one’s progress through direct and timely updates. A patient-centered care hospital’s infrastructure encourages family collaboration through a home-like environment that not only meets the needs of the patient, but also meets the needs of family members. For example, maternity wards are being redesigned with family-friendly postpartum rooms that can accommodate the mom, new baby, and family members, who are encouraged to spend up to 24 hours a day together in the room to foster family bonding.

      Patient-centered care in the hospital

    1. Poor health literacy is a silent and ubiquitous health care issue, and the field of neurosurgery is particularly prone to the consequent adverse effects. Failure to address low health literacy has several detrimental health and economic consequences, and numerous policies have been initiated to address these. Better facilitating patient understanding of neurosurgical disease, treatment options, and care surrounding the operative period may have a positive impact on the health care economy and ultimately achieve improved outcomes for patients.

      Certain disciplines are particularly prone to consequent adverse effects of poor health literacy.

  16. Oct 2018
  17. Sep 2018
  18. Jul 2018
    1. Maintained by the Agency for Healthcare Research and Quality [AHRQ], part of the Department of Health and Human Services, the database is known as the National Guideline Clearinghouse [NGC], and it’s scheduled to “go dark,” in the words of an official there, on July 16.

      ...

      Guideline.gov was our go-to source, and there is nothing else like it in the world,” King said, referring to the URL at which the database is hosted, which the agency says receives about 200,000 visitors per month. “It is a singular resource,” King added.

      ...

      The vetting role played by the NGC is a critical one, says Roy Poses, with the Patient-Centered Outcomes Research Institute.

      “Many guidelines are actually written mainly for commercial purposes or public relations purposes,” said Poses, and can be subtly shaped to promote a given course of treatment.

  19. Jun 2018
  20. ktakahata.github.io ktakahata.github.io
    1. successive crops Of defedations oft will spot the skin: These thou, with turpentine and guaiac pods, Reduc’d by coction to a wholesome draught, Total remove, and give the blood its balm
  21. ktakahata.github.io ktakahata.github.io
    1. Fell, winged insects, which the visual ray Scarcely discerns, their sable feet and hands Oft penetrate; and, in the flesh nest, Myriads of young produce; which soon destroy [260] The parts they breed in; if assiduous care, With art, extract not the prolific foe.
  22. ktakahata.github.io ktakahata.github.io
    1. Yet, if due skill, And proper circumspection are employed, [250] It may be won its volumes to wind round A leaden cylinder: But, O, beware, No rashness practise; else ‘twill surely snap, And suddenly, retreating, dire produce An annual lameness to the tortured Moor.
  23. ktakahata.github.io ktakahata.github.io
  24. May 2018
  25. Mar 2018
  26. Dec 2017
  27. Nov 2017
    1. New York is one of 29 states (plus the District of Columbia) that have legalized medical marijuana––a trend that 94 percent of Americans support, according to an August Quinnipiac poll. But on December 8, all of that could begin to change.

      Congress has until that day to decide whether to include the Rohrabacher-Farr Act (also known as Rohrabacher-Blumenauer) in a bill that will fund the government through the next fiscal year. Right now, that law, made up of just 85 words, blocks the Department of Justice from using any money to prosecute medical marijuana in states where it's legal.

      . . .

      “I believe it would be unwise for Congress to restrict the discretion of the Department to fund particular prosecutions, particularly in the midst of an historic drug epidemic and potentially long-term uptick in violent crime," Sessions wrote in his letter.

    1. By him the elements of medical science may be taught, with a history & explanations of all it’s successive theories from Hippocrates to the present day: and anatomy may be fully treated.

      From being in a Medicine and Culture class, I have come to discuss the many nuisances of what a doctor's education and life is like. We have discussed repeatedly and in great depth of the need for doctors to obtain a comprehensive education, both among different medical fields but also not just limited to the math and sciences. Philosophy, morality, history, humanities, among other subjects can all have a positive effect on the quality of a doctor and his performance and happiness. It prevents the idea of medicalization in which doctors are taught to be like robots and reminds them that they are first and foremost caretakers meant to heal people physically but also mentally and emotionally.

    1. Donohue syndrome and Rabson-Mendenhall syndrome usually have homozygous or compound heterozygous mutations in the IR gene, and patients with these diseases have severe insulin resistance together with various symptoms, such as growth retardation, occasional hypoglycemia from infancy, intrauterine growth retardation, and low birth weight [3–6]

      This is interesting!

  28. Oct 2017
    1. SoifIhadtochoosebetweenlibtheo,oranyology,Iwouldgowithscienceaslongasservicetothepoorwentalongwithit.ButIdon’thavetomakethatchoice,doI?”

      Medicine and faith are often viewed as contradictory but they do not have to be reconciled or mutually exclusive in order to treat patients effectively.

  29. Apr 2017
    1. The Administration could also exercise its regulatory authority—most potently, to direct the Centers for Medicare and Medicaid Services (CMS) to allow reimbursement for molecular profiling of cancers

      Perhaps the most important measure to keep precision medicine initiate alive. Surge in risk and treatment response prediction in genomic assays is of little value without practical means of affordable molecular profiling of a patient's tumor or more importantly, pre-diagnosis genomic screen.

    1. As Martha Stoddard Holmes suggests, nineteenth-century thinkers were among the first to see disability as a cause of individual suffering, which has the problematic consequence of minimizing “the importance of the material circumstances that surround all disabilities” while maximizing “the importance of personal agency while minimizing the need for social change” (Fictions of Affliction 28-9).

      This part of the article stands out to me for a number of reasons. First, the idea that people with physical and mental disabilities prior to the nineteenth century suffered in a difference sense compared to what they deal with now. Prior to this point, this introduction points out the stereotypes that people with disabilities had in the eighteenth century. Though this is something that is still socially dealt with now, we've taken further measures to help people who deal with specific setbacks that emphasis the overall point on maximizing "the importance of personal agency," and minimizing social change. Overall, this article interests me because it allows me to think deeper about how disabilities have always existed, though they've been handles in a variety of different ways as well as reflect it to how it's handled regarding circumstances we've learned including the role of the doctor and what they can do to help and the resources we had access to then versus now.

  30. Mar 2017
    1. Small, portable medical devices can offer patient's newfound mobility. Engineers at the University of Pittsburgh developed an artificial lung that can be carried in a patient’s backpack. Trials have so far shown that the device works on sheep and could offer relief and mobility for people who suffer from lung failure.

      This is incredible!

  31. Feb 2017
    1. And, like most foreign-born physicians, Tauseef came on a J1 visa. That meant after training he had two options: return to Pakistan or work for three years in an area the U.S. government has identified as having a provider shortage.

      There is a huge demand in rural areas for doctors.

  32. Jan 2017
    1. Pathology

      Definitions of pathology

      • "The science of the causes and effects of [diseases]."
      • "The science of the causes and effects of [disorders of structure or function of biological organisms]."
      • "The science of the causes and effects of [perturbations to sustainable function] of biological organisms."
      • "The science of the causes and effects of perturbations to sustainable function of biological [ecosystems]."
      • "The science of the causes and effects of perturbations to sustainable function of biological ecosystems, [with some emphasis on human beings]."
    1. “What is disease?” is a contentious question among philosophers of medicine.  These philosophers distinguish among four different notions of disease.
      • Ontological
      • Desviación de la fisiología normal
      • Mecanismo desadaptativo (biología evolucionista)
      • Genética (ausencia o no expresión de un gen)
  33. Oct 2016
    1. Shu Lam, a 25-year-old PhD student at the University of Melbourne in Australia, has developed a star-shaped polymer that can kill six different superbug strains without antibiotics, simply by ripping apart their cell walls.

      ...

      Before we get too carried away, it's still very early days. So far, Lam has only tested her star-shaped polymers on six strains of drug-resistant bacteria in the lab, and on one superbug in live mice.

      http://www.nature.com/articles/nmicrobiol2016162

  34. Jun 2016
  35. Apr 2016
    1. First of all, people aren’t uniformly good at splitting pills. Dose deviation is common among pill-splitters and that’s an issue for drugs that need to be maintained in a narrow range. Worse, many pills are in extended release formulations that break down when split. Splitting a time-released pill in half can cause an overdose. The list goes on: cutting all your pills in half before you need them could cause them to become ineffective, people often forget to cut them and take a double dose, etc.
  36. Jan 2016
  37. Dec 2015
    1. The idea was to pinpoint the doctors prescribing the most pain medication and target them for the company’s marketing onslaught. That the databases couldn’t distinguish between doctors who were prescribing more pain meds because they were seeing more patients with chronic pain or were simply looser with their signatures didn’t matter to Purdue.
  38. May 2015
  39. Oct 2013
    1. For as the medicines which men apply to the bodies of their fellow-men are of no avail except God gives them virtue (who can heal without their aid, though they cannot without His), and yet they are applied; and if it be done from a sense of duty, it is esteemed a work of mercy or benevolence; so the aids of teaching, applied through the instrumentality of man, are of advantage to the soul only when God works to make them of advantage, who could give the gospel to man even without the help or agency of men

      All things, even rhetoric and medicine, have effect only through the divine

  40. Sep 2013
    1. Its possible abuse is no argument against its proper use on the side of truth and justice.

      Much like medicine, science, and any other art, rhetoric can be misused, but then do we consider all things that can be used for bad purposes bad in themselves?