- Apr 2022
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www.nature.com www.nature.com
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Tao, K., Tzou, P. L., Nouhin, J., Gupta, R. K., de Oliveira, T., Kosakovsky Pond, S. L., Fera, D., & Shafer, R. W. (2021). The biological and clinical significance of emerging SARS-CoV-2 variants. Nature Reviews Genetics, 1–17. https://doi.org/10.1038/s41576-021-00408-x
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Wallis, C. (n.d.). COVID Has Pushed Medical Research into Remote Trials, Benefiting Patients and Scientists. Scientific American. https://doi.org/10.1038/scientificamerican0521-24
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twitter.com twitter.com
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The Lancet. (2021, April 16). Quantity > quality? The magnitude of #COVID19 research of questionable methodological quality reveals an urgent need to optimise clinical trial research—But how? A new @LancetGH Series discusses challenges and solutions. Read https://t.co/z4SluR3yuh 1/5 https://t.co/94RRVT0qhF [Tweet]. @TheLancet. https://twitter.com/TheLancet/status/1383027527233515520
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EMA. (2020, October 27). COVID-19 vaccines: Development, evaluation, approval and monitoring [Text]. European Medicines Agency. https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/vaccines-covid-19/covid-19-vaccines-development-evaluation-approval-monitoring
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- Feb 2022
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psyarxiv.com psyarxiv.com
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Inasaridze, K. (2022). COVID-19-related symptoms’ assessment tool. PsyArXiv. https://doi.org/10.31234/osf.io/wf8rv
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jamanetwork.com jamanetwork.com
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Heesakkers, H., van der Hoeven, J. G., Corsten, S., Janssen, I., Ewalds, E., Simons, K. S., Westerhof, B., Rettig, T. C. D., Jacobs, C., van Santen, S., Slooter, A. J. C., van der Woude, M. C. E., van den Boogaard, M., & Zegers, M. (2022). Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19. JAMA, 327(6), 559–565. https://doi.org/10.1001/jama.2022.0040
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twitter.com twitter.com
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Prof. Akiko Iwasaki. (2022, January 27). Vaccines that reduce infection & disease are needed to combat the pandemic. Here, @tianyangmao @BenIsraelow et al. Describe our new mucosal booster strategy, Prime and Spike, to induce such immunity via nasal delivery of unadjuvanted spike vaccine 🧵 (1/) https://biorxiv.org/content/10.1101/2022.01.24.477597v1 https://t.co/bcB5MFph9F [Tweet]. @VirusesImmunity. https://twitter.com/VirusesImmunity/status/1486510697332842498
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Devlin, H., & correspondent, H. D. S. (2022, February 3). Novavax Covid vaccine approved for use in over-18s in UK. The Guardian. https://www.theguardian.com/society/2022/feb/03/novavax-covid-vaccine-approved-for-use-in-over-18s-in-uk
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twitter.com twitter.com
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Deepti Gurdasani. (2022, January 29). Going to say this again because it’s important. Case-control studies to determine prevalence of long COVID are completely flawed science, but are often presented as being scientifically robust. This is not how we can define clinical syndromes or their prevalence! A thread. [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487366920508694529
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- Dec 2021
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medicalxpress.com medicalxpress.com
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Convalescent plasma not efficacious in hospitalized COVID-19 patients. (n.d.). Retrieved December 17, 2021, from https://medicalxpress.com/news/2021-12-convalescent-plasma-efficacious-hospitalized-covid-.html
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www.medrxiv.org www.medrxiv.org
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Simon, M. A., Luginbuhl, R. D., & Parker, R. (2021). Reduced Incidence of Long-COVID Symptoms Related to Administration of COVID-19 Vaccines Both Before COVID-19 Diagnosis and Up to 12 Weeks After (p. 2021.11.17.21263608). https://doi.org/10.1101/2021.11.17.21263608
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www.nature.com www.nature.com
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Heitmann, J. S., Bilich, T., Tandler, C., Nelde, A., Maringer, Y., Marconato, M., Reusch, J., Jäger, S., Denk, M., Richter, M., Anton, L., Weber, L. M., Roerden, M., Bauer, J., Rieth, J., Wacker, M., Hörber, S., Peter, A., Meisner, C., … Walz, J. S. (2021). A COVID-19 peptide vaccine for the induction of SARS-CoV-2 T cell immunity. Nature, 1–9. https://doi.org/10.1038/s41586-021-04232-5
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www.theguardian.com www.theguardian.com
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Devlin, H., & Kollewe, J. (2021, November 26). BioNTech says it could tweak Covid vaccine in 100 days if needed. The Guardian. https://www.theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed
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- BioNTech
- transmissibility
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theguardian.com/society/2021/nov/26/biontech-says-it-could-tweak-covid-vaccine-in-100-days-if-needed -
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jamanetwork.com jamanetwork.com
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Jabagi, M. J., Botton, J., Bertrand, M., Weill, A., Farrington, P., Zureik, M., & Dray-Spira, R. (2021). Myocardial Infarction, Stroke, and Pulmonary Embolism After BNT162b2 mRNA COVID-19 Vaccine in People Aged 75 Years or Older. JAMA. https://doi.org/10.1001/jama.2021.21699
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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COVID-19 vaccine surveillance report—Week 47. (n.d.). 46.
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- data
- lang:en
- clinical trials
- vaccine efficacy
- UK
- safety profile
- delta
- COVID-19
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- UKHSA
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URL
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- Nov 2021
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www.science.org www.science.org
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Couzin-Frankel, J. (2021). Antiviral pills could change pandemic’s course. Science, 374(6569), 799–800. https://doi.org/10.1126/science.acx9605
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Walter, E. B., Talaat, K. R., Sabharwal, C., Gurtman, A., Lockhart, S., Paulsen, G. C., Barnett, E. D., Muñoz, F. M., Maldonado, Y., Pahud, B. A., Domachowske, J. B., Simões, E. A. F., Sarwar, U. N., Kitchin, N., Cunliffe, L., Rojo, P., Kuchar, E., Rämet, M., Munjal, I., … Gruber, W. C. (2021). Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. New England Journal of Medicine, NEJMoa2116298. https://doi.org/10.1056/NEJMoa2116298
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- Oct 2021
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Abbas-Hanif, A., Modi, N., Smith, S. K., & Majeed, A. (2021). Covid-19 treatments and vaccines must be evaluated in pregnancy. BMJ, n2377. https://doi.org/10.1136/bmj.n2377
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Mateus, J., Dan, J. M., Zhang, Z., Rydyznski Moderbacher, C., Lammers, M., Goodwin, B., Sette, A., Crotty, S., & Weiskopf, D. (n.d.). Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells. Science, 0(0), eabj9853. https://doi.org/10.1126/science.abj9853
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Flu and Covid jabs safe to be given at same time, study finds | Vaccines and immunisation | The Guardian. (n.d.). Retrieved October 1, 2021, from https://www.theguardian.com/society/2021/sep/30/flu-covid-jabs-safe-same-time-study?CMP=Share_iOSApp_Other
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- Jun 2021
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Lipsitch, M., & Kahn, R. (2021). Interpreting vaccine efficacy trial results for infection and transmission. Vaccine, 39(30), 4082–4088. https://doi.org/10.1016/j.vaccine.2021.06.011
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40 Iowa infectious disease doctors recommend COVID-19 vaccines. (n.d.). Retrieved June 28, 2021, from https://eu.desmoinesregister.com/story/opinion/columnists/iowa-view/2021/06/27/iowa-infectious-disease-doctors-recommend-covid-19-vaccines/7777363002/
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Duarte-Salles, T., & Prieto-Alhambra, D. (2021). Heterologous vaccine regimens against COVID-19. The Lancet, S0140673621014422. https://doi.org/10.1016/S0140-6736(21)01442-2
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Borobia, A. M., Carcas, A. J., Pérez-Olmeda, M., Castaño, L., Bertran, M. J., García-Pérez, J., Campins, M., Portolés, A., González-Pérez, M., García Morales, M. T., Arana-Arri, E., Aldea, M., Díez-Fuertes, F., Fuentes, I., Ascaso, A., Lora, D., Imaz-Ayo, N., Barón-Mira, L. E., Agustí, A., … Torvisco, J. M. (2021). Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): A multicentre, open-label, randomised, controlled, phase 2 trial. The Lancet, S0140673621014203. https://doi.org/10.1016/S0140-6736(21)01420-3
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Thompson, M. G., Burgess, J. L., Naleway, A. L., Tyner, H. L., Yoon, S. K., Meece, J., Olsho, L. E. W., Caban-Martinez, A. J., Fowlkes, A., Lutrick, K., Kuntz, J. L., Dunnigan, K., Odean, M. J., Hegmann, K. T., Stefanski, E., Edwards, L. J., Schaefer-Solle, N., Grant, L., Ellingson, K., … Gaglani, M. (2021). Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers—Eight U.S. Locations, December 2020–March 2021. MMWR. Morbidity and Mortality Weekly Report, 70(13), 495–500. https://doi.org/10.15585/mmwr.mm7013e3
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
- May 2021
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Park, J. J. H., Ford, N., Xavier, D., Ashorn, P., Grais, R. F., Bhutta, Z. A., Goossens, H., Thorlund, K., Socias, M. E., & Mills, E. J. (2021). Randomised trials at the level of the individual. The Lancet Global Health, 9(5), e691–e700. https://doi.org/10.1016/S2214-109X(20)30540-4
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Dron, L., Taljaard, M., Cheung, Y. B., Grais, R., Ford, N., Thorlund, K., Jahan, F., Nakimuli-Mpungu, E., Xavier, D., Bhutta, Z. A., Park, J. J. H., & Mills, E. J. (2021). The role and challenges of cluster randomised trials for global health. The Lancet Global Health, 9(5), e701–e710. https://doi.org/10.1016/S2214-109X(20)30541-6
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Park, J. J. H., Mogg, R., Smith, G. E., Nakimuli-Mpungu, E., Jehan, F., Rayner, C. R., Condo, J., Decloedt, E. H., Nachega, J. B., Reis, G., & Mills, E. J. (2021). How COVID-19 has fundamentally changed clinical research in global health. The Lancet Global Health, 9(5), e711–e720. https://doi.org/10.1016/S2214-109X(20)30542-8
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Park, J. J. H., Grais, R. F., Taljaard, M., Nakimuli-Mpungu, E., Jehan, F., Nachega, J. B., Ford, N., Xavier, D., Kengne, A. P., Ashorn, P., Socias, M. E., Bhutta, Z. A., & Mills, E. J. (2021). Urgently seeking efficiency and sustainability of clinical trials in global health. The Lancet Global Health, 9(5), e681–e690. https://doi.org/10.1016/S2214-109X(20)30539-8
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- Mar 2021
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Iversen, P. L., & Bavari, S. (2021). Is there space for a three-dose vaccine to fight the spread of SARS-CoV-2? The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00149-3
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A Few People Developed a Rare Blood Disorder, Immune Thrombocytopenia, After Getting a COVID Vaccine | Health.com. (n.d.). Retrieved March 17, 2021, from https://www.health.com/condition/infectious-diseases/coronavirus/rare-blood-disorder-covid-vaccine-thrombocytopenia
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Nature Editorial. (2020, October 23). The race to make COVID antibody therapies cheaper and more potent. Nature. https://www.nature.com/articles/d41586-020-02965-3?utm_source=twt_nnc&utm_medium=social&utm_campaign=naturenews&sf239165668=1&error=cookies_not_supported&code=2b2dd7c6-d01f-4057-8389-3be656a7ba58
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Vasconcelos. M. K., Epalza. C., Renk. H., Tagarro. A., Bielicki. J. A., (2020). Harmonisation preserves research resources. The Lancet Infectious Diseases. Retrieved from: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30585-5/fulltext
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- Dec 2020
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Ledford, H., Cyranoski, D., & Noorden, R. V. (2020). The UK has approved a COVID vaccine—Here’s what scientists now want to know. Nature, 588(7837), 205–206. https://doi.org/10.1038/d41586-020-03441-8
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Ledford, H. (2020). Oxford COVID-vaccine paper highlights lingering unknowns about results. Nature. https://doi.org/10.1038/d41586-020-03504-w
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Long-term effects of Covid include damage to heart, liver, kidneys. (2020, September 29). ITV News. https://www.itv.com/news/2020-09-29/long-covid-long-term-effects-of-coronavirus-include-damage-to-heart-liver-kidneys-oxford-study-reveals
Tags
- long-term impact
- heart
- lang:en
- liver
- recovery
- COVID-19
- is:news
- kidney
- symptom
- clinical outcome
- medicine
- organ damage
- research
Annotators
URL
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- Sep 2020
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www.nature.com www.nature.com
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magazine, D. C., Smriti Mallapaty,Nature. (n.d.). Coronavirus Vaccine U.K. Trial Restarts, But Scientists Question Lack of Transparency. Scientific American. Retrieved September 16, 2020, from https://www.scientificamerican.com/article/coronavirus-vaccine-u-k-trial-restarts-but-scientists-question-lack-of-transparency/
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Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Izcovich, A., Kum, E., Pardo-Hernandez, H., Rochwerg, B., Lamontagne, F., Han, M. A., Liu, Q., Agarwal, A., Agoritsas, T., Chu, D. K., Couban, R., Darzi, A., Devji, T., Fang, B., Fang, C., … Brignardello-Petersen, R. (2020). Drug treatments for covid-19: Living systematic review and network meta-analysis. BMJ, 370. https://doi.org/10.1136/bmj.m2980
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Ponchner, D. (n.d.). Costa Rica Readies Horse Antibodies for Trials as an Inexpensive COVID-19 Therapy. Scientific American. Retrieved September 8, 2020, from https://www.scientificamerican.com/article/costa-rica-readies-horse-antibodies-for-trials-as-an-inexpensive-covid-19-therapy/
Tags
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ccforum.biomedcentral.com ccforum.biomedcentral.com
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Hupf, J., Mustroph, J., Hanses, F., Evert, K., Maier, L. S., & Jungbauer, C. G. (2020). RNA-expression of adrenomedullin is increased in patients with severe COVID-19. Critical Care, 24(1), 527. https://doi.org/10.1186/s13054-020-03246-1
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- Aug 2020
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Lancet, T. (2020). Research and higher education in the time of COVID-19. The Lancet, 396(10251), 583. https://doi.org/10.1016/S0140-6736(20)31818-3
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Monforte, A. d’Arminio, Tavelli, A., Bai, F., Marchetti, G., & Cozzi-Lepri, A. (2020). Effectiveness of hydroxychloroquine in COVID-19 disease: A done and dusted deal? International Journal of Infectious Diseases, 99, 75–76. https://doi.org/10.1016/j.ijid.2020.07.056
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Mather, N. (2020). How we accelerated clinical trials in the age of coronavirus. Nature, 584(7821), 326–326. https://doi.org/10.1038/d41586-020-02416-z
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CNN, J. G., Naomi Thomas, Dana Vigue and Jacqueline Howard. (n.d.). Oxford’s Covid-19 vaccine appears safe and induces immune response, early results suggest. CNN. Retrieved August 2, 2020, from https://www.cnn.com/2020/07/20/health/oxford-covid-19-vaccine-results-cansino-pfizer-study/index.html
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Herper, M. (2020, July 1). Covid-19 vaccine from Pfizer and BioNTech shows positive results. CNBC. https://www.cnbc.com/2020/07/01/coronavirus-vaccine-from-pfizer-and-biontech-shows-positive-results-report-says.html
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Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S. P., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fonter-Garfias, C., Shi, P.-Y., Tuereci, O., Tompkins, K. R., Walsh, E. E., … Jansen, K. U. (2020). Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. MedRxiv, 2020.06.30.20142570. https://doi.org/10.1101/2020.06.30.20142570
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In the academic setting especially, a premium will beplaced on clinical quality improvement, the develop-ment of practice guidelines, and outcomes research,not only to provide the physician with a creative out-let and a potential source of funding during thenonclinical months but also to give the academiccenter a practical research-and-development arm
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A research method for n=1
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