616 Matching Annotations
  1. Nov 2023
    1. Hitzebedingte Todesfälle bei über 65-Jährigen haben seit den 90ern um 85% zugenommen. Senior:innen sind – wie kleine Kinder – zweimal soviel Hitzewellen-Tagen ausgesetzt wie 1986-2005. Extreme Hitze führte 2022 zu Produktivitätsverlusten von ca. 863 Milliarden USD. Alle Indikatoren für öffentliche Gesundheit haben sich in den letzten 9 Jahren verschlechtert. – Die NYT stellt den 2023 Report des Lancet Countdown ausführlich dar. https://www.nytimes.com/2023/11/14/climate/climate-change-health-effects-lancet.html

      Mehr zum Rreport: https://hypothes.is/search?q=tag%3A%222023%20report%20of%20the%20Lancet%20Countdown%20on%20health%20and%20climate%20change%22

    1. Vor der Apec-Konferenz haben China und die USA "statements of cooperation" veröffentlicht, die als positive Signale für eine Zusammenarbeit beim Klimaschutz gewertet werden, auch wenn China nicht auf Investitionen in Kohlekraftwerke verzichtet. Beide Seiten wollen die Kapazität bei Erneuerbaren bis 2030 global verdreifachen. Erstmals ist China bereits, Reduktionsziele für alle Treibhausgase festzulegen. https://www.nytimes.com/2023/11/14/climate/us-china-climate-agreement.html

      Sunnylands Statement on Enhancing Cooperation to Address the Climate Crisis: https://www.state.gov/sunnylands-statement-on-enhancing-cooperation-to-address-the-climate-crisis/

    1. Auf den Öl- und Gasfeldern der Vereinigten Arabischen Emirate, darunter vielen, die der staatlichen Gesellschaft Adnoc gehören, wurde in den vergangenen 20 Jahren in großem Umfang routinemäßig Gas abgefackelt, was zu hohen Methanemissionen führt. Die Emirate hatten sich verpflichtet, das Abfackeln schnell zu reduzieren. Die dieser Selbstverpflichtung krass widersprechende Praxis gilt bei NGO als weiterer Beleg dafür, dass Selbstverpflichtungen der Fossilindustrie nicht getraut werden kann. https://www.theguardian.com/environment/2023/nov/17/cop28-host-uae-breaking-its-own-ban-on-routine-gas-flaring-data-showsactor

    1. Ausführlicher Kommentar zu den 2,4 Billionen (Tausend Milliarden, im Artikel falsch übersetzt) Dollar, die laut dem COP27-Bericht von 2022 erforderlich sind, um Klimaschutz und -Anpassung in den Ländern des globalen Südens (außer China) zu finanzieren. Der auf Konsens ausgerichtete COP-Prozess sei außerstande, die nötigen Entscheidungen zu treffen. Der Betrag entspricht grob den aktuellen weltweiten Militärausgaben. https://www.repubblica.it/commenti/2023/11/19/news/cambiamenti_climatici_spesa_annua-420689085/?ref=RHRT-BG-I279994148-P4-S3-T1

    1. Der Emissions Gap Report 2023 des UN-Umweltprogramms (Titel: Broken Rekord) zeigt, dass sich die Welt nach wie vor auf eine Erhitzung um 2,5-2,9° zubewegt. Die Wahrscheinlichkeit dafür, dass das 1,5°-Ziel noch erreicht wird, liegt bei höchstens 14%. Der Treibhausgasausstoß erreichte einen historischen Rekord; er war 2022 1,2% höher als 2021. https://www.derstandard.at/story/3000000195965/welt-steuert-auf-drei-grad-erhitzung-zu-methan

      Bericht: https://www.unep.org/resources/emissions-gap-report-2023

    1. Das deutsche Bundesverfassungsgericht hat untersagt, dass 60 Milliarden Euro, die ursprünglich für Corona-Hilfen vorgesehen waren aber nicht abgerufen worden, für Klimaschutz- und andere Projekte benutzt werden. Die im deutschen Grundgesetz festgelegte Schuldenbremse dürfe so nicht umgangen werden. Damit ist die deutsche Bundesregierung zu einer Neu-Festlegung ihrer Klimapolitik gezwungen, die zu erheblichen Konflikten zwischen den Ampelparteien führen dürfte.https://www.derstandard.de/story/3000000195316/gericht-stoppt-finanztrick-der-deutschen-ampel

    1. https://en.wikipedia.org/wiki/Boots_theory

      “The Sam Vimes "Boots" Theory of Economic Injustice runs thus:<br /> At the time of Men at Arms, Samuel Vimes earned thirty-eight dollars a month as a Captain of the Watch, plus allowances. A really good pair of leather boots, the sort that would last years and years, cost fifty dollars. This was beyond his pocket and the most he could hope for was an affordable pair of boots costing ten dollars, which might with luck last a year or so before he would need to resort to makeshift cardboard insoles so as to prolong the moment of shelling out another ten dollars.<br /> Therefore over a period of ten years, he might have paid out a hundred dollars on boots, twice as much as the man who could afford fifty dollars up front ten years before. And he would still have wet feet.<br /> Without any special rancour, Vimes stretched this theory to explain why Sybil Ramkin lived twice as comfortably as he did by spending about half as much every month.”<br /> ― Terry Pratchett, Men at Arms (1993)

    1. Ein neuer kanadischer Satellit wird es zum ersten Mal möglich machen die CO2 Emissionen einzelner Quellen z.b von Fabriken oder Kohlekraftwerken, zu messen. Bei methan ist das bereits vorher möglich gewesen. Man erwartet, dass die Messungen - wie zuvor bei Methan - auch bei CO2 ergeben dass die Emissionen höher sind als bisher angenommen https://www.reuters.com/business/environment/new-satellite-will-detect-share-co2-data-individual-facilities-2023-11-11/

    1. Der Critical Raw Materials Actt wird von Industrie-Lobbies benutzt, um Einschränkungen beim Zugang zu Rohmaterialien abzubauen, und zwar auch dann, wenn es nicht um die Energieversorgung geht. IT-, Rüstungs- und Raumfahrtindustrie versuchen von der Krisensituation bei den neuen Energien zu profitieren. Die Libéation berichtet über einen neuen Report von Lobbying-Warchdogs. Die Liste der kritischen Rohmaterialien wurde bereits von 15 auf 34 Stoffe erweitert. https://www.liberation.fr/international/europe/ue-le-critical-raw-materials-act-un-open-bar-pour-lindustrie-miniere-20231112_HZUR6376QJCZVBM5IGIUR6V2QE/

    1. In Delhi wurden die Schulen ein weiteres Mal wegen der akuten Luftverschmutzung geschlossen. Hauptursache ist Kohleverbrennung. Der Grenzwert für die besonders gefährlichen PM 2,5-Partikel wurde um das 35fache überschritten. In den vergangenen 7 Jahren stiegen in Indien die Emissionen pro Einwohner um 29%. 2020 starben ca 1,67 Millionen Menschen in Indien durch Luftverschmutzung. https://www.liberation.fr/environnement/pollution/inde-delhi-suffoque-encore-et-toujours-sous-la-pollution-les-ecoles-ferment-pour-deux-jours-20231103_WQ22QAO745BQ5GOGW7JPNB4SXY/

    1. In dem sogenannten Trilog-Verfahren haben sich Vertreter:innen des europäischen Parlaments und der europäischen Kommission auf eine endgültige Version des Nature Restoration Laws geeinigt, durch die bis 2030 20% der Land- und Wasserflächen der-unter Schutz gestellt bzw. wiederhergestellt werden sollen. Vor allem aufgrund des Einflusses der europäischen Volkspartei wurde die von der Kommission vorgelegte Version des Gesetzes stark verwässert. https://www.theguardian.com/environment/2023/nov/10/eu-strikes-landmark-deal-nature-restoration-law

    1. In der Repubblica stellt Jaime d'Alessandro fest, dass Italien dabei ist, den Kampf um ein neues Energiesystem und damit auch eine Erneuerung der Wirtschaft zu verlieren. Seit den 90ern befinde sich das Land im Stillstand. D'Alessandro beruft sich auf Studien zur besonderen Betroffenheit des Mittelmeerraums von der globalen Erhitzung und zur schon bald bevorstehenden Eisfreiheit der Arktis. https://www.repubblica.it/green-and-blue/2023/11/01/news/decarbonizzazione_greenblue_novembre-418935623/

      Studie zur eisfreien Arktis: https://www.nature.com/articles/s41467-023-38511-8

      Studie zur Erhitzung in Europa: doi:10.2760/93257

    1. Ein Viertel der Weltbevölkerung war in den vergangenen 12 Monaten von extremen Hitzewellen betroffen. Die NGO Climate Central berichtet im Detail darüber, welche Regionen welchem Ausmaß zusätzlicher Erwärmung ausgesetzt war, und hat dazu den "Climate Shift Index" entwickelt. In den letzten 12 Monaten fielen in Rom 44, in Mailand 64 Tage in die höchste Stufe 5 dieses Index.

      https://www.repubblica.it/green-and-blue/2023/11/09/news/temperature_terra_record_12_mesi-419936099/?ref=RHLF-BG-I419929632-P12-S2-T1

    1. Die europäischen Produzenten von Windturbinen machen enorme Verluste. Die Hauptgründe sind Kostensteigerungen und logistische Probleme. Hinzu kommen Investitionen für neue, stärkere Modelle und chinesische Konkurrenz. Ein zusätzliches Risiko könnte die Förderung der US-Turbinen-Industrie durch die Biden-Administration darstellen. Die europäischen Produzenten erwarten mehr Unterstützung durch die Regierungen, um Kompetenzen in Europa zu halten.

    1. Der dänische Konzern Ørsted hat zwei große Offshore-Windenergie-Projekte in den USA gestoppt. Ørsted ist der weltweit größte Entwickler von Windenergie-Anlage. Ursache sind Kostensteigerungen. Die Windenergiebranche befindet sich gerade insgesamt in einer Krise, wobe in China sehr schnell zusätzliche Produktionskapazitäten aufgebaut werden. https://taz.de/Erneuerbare-Energien-in-der-Krise/!5967100/

    1. RWE hat seine Klage gegen den niederländischen Staat bei einem Weltbank-Schiedsgericht zurückgezogen. RWE hatte unter Berufung auf den Energiecharta-Vertrag gegen das Verbot der Nutzung von Kohle zur Stromproduktion ab 2030 geklagt. Ausschlaggebend war ein Urteil des Bundesgerichtshofs. Die NGO Powershift soricht von einem "riesigen Erfolg für die Klimabewegung". https://taz.de/RWE-gegen-Niederlande/!5967101/

    1. https://en.wikipedia.org/wiki/Presentism_(historical_analysis)

      relationship with context collapse

      Presentism bias enters biblical and religious studies when, by way of context collapse, readers apply texts written thousands of years ago and applicable to one context to their own current context without any appreciation for the intervening changes. Many modern Christians (especially Protestants) show these patterns. There is an interesting irony here because Protestantism began as the Catholic church was reading too much into the Bible to create practices like indulgences.)

    1. Malm, Andreas. How to Blow Up a Pipeline. Verso Books, 2021. https://www.versobooks.com/products/2649-how-to-blow-up-a-pipeline.

      Aram Zucker-Scharff indicated that this was one of his favorite books on the climate crisis and has interesting consequences for both individual and group action. He said it might make an interesting pairing with Palo Alto (@Malcolm2023).

      It came up as we were talking about the ideas of climate crisis in the overlap of The Monkey Wrench Gang.

      Might also be interesting with respect to @Hoffer2002 [1951].

    1. How to Apply the SAMR Model with Ruben Puentedura, 2016. https://www.youtube.com/watch?v=ZQTx2UQQvbU.

      https://www.youtube.com/watch?v=ZQTx2UQQvbU

      Enhancement:<br /> - Substitution: Tech acts as a direct tool substitute with no functional improvement - Augmentation: Tech acts as a direct tool substitute with functional improvement

      Transformation - Modification: Tech allows for significant task redesign - Redefinition: Tech allows for the creation of new tasks, previously inconceivable

    1. As an ex-Viv (w/ Siri team) eng, let me help ease everyone's future trauma as well with the Fundamentals of Assisted Intelligence.<br><br>Make no mistake, OpenAI is building a new kind of computer, beyond just an LLM for a middleware / frontend. Key parts they'll need to pull it off:… https://t.co/uIbMChqRF9

      — Rob Phillips 🤖🦾 (@iwasrobbed) October 29, 2023
      <script async src="https://platform.twitter.com/widgets.js" charset="utf-8"></script>
  2. Oct 2023
    1. ExxonMobil übernimmt den fossilen Energiekkonzern Pioneer für 59,6 Milliarden Dollar. Es handelt sich um die größte Konzernübernahme dieses Jahres. Damit verschafft sich Exxon einem besseren Zugang zu den Schieferöl-Ressourcen des Permian Basin in Texas und New Mexico. Exxon hält unter Darren Woods an einer ölorientierten Strategie fest. 2022 hatte der Konzern 56 Milliarden Dollar Gewinn gemacht. https://www.derstandard.at/story/3000000190710/us-oelriese-exxon-uebernimmt-pioneer-fuer-595-milliarden-dollar

    1. https://en.wikipedia.org/wiki/Shmita

      During shmita, the land is left to lie fallow and all agricultural activity, including plowing, planting, pruning and harvesting, is forbidden by halakha (Jewish law).

      The sabbath year (shmita; Hebrew: שמיטה, literally "release"), also called the sabbatical year or shǝvi'it (שביעית‎, literally "seventh"), or "Sabbath of The Land", is the seventh year of the seven-year agricultural cycle mandated by the Torah in the Land of Israel and is observed in Judaism.

    1. Mit drastischen Repressionsmaßnahmen versuchte die Polizei, Proteste gegen die Internationale Automobilausstellung IAAA in München zu unterdrücken. Verdächtig wirkende Personen wurden in der Stadt festgehalten und durchsucht, während der Automobiliindustrie große Flächen als „open spaces“ zur Veerfügung gestellt wurden. Dennoch erregten Proteste und Aktionen große öffentliche Aufmerksamkeit. https://taz.de/Protest-gegen-Automobilausstellung-IAA/!5956556/

  3. Sep 2023
  4. May 2023
    1. I think the best example one can give of this basic difference of the use of terms is “the right to work.” The Soviet Union insists that this is a basic right which it alone can guarantee because it alone provides full employment by the government. But the right to work in the Soviet Union means the assignment of workers to do whatever task is given to them by the government without an opportunity for the people to participate in the decision that the government should do this. A society in which everyone works is not necessarily a free society and may indeed be a slave society; on the other hand, a society in which there is widespread economic insecurity can turn freedom into a barren and vapid right for millions of people.

      Roosevelt gives a specific example here in contrasting definitions of terms held by the soviet union and the United States. She proceeds to critique the Soviets understanding of the right to work, noting that it the soviet unions understanding of the right to work does not include individual freedom, because they understand the right to work as being given by the government. Roosevelt points out such control is not freedom, but is akin to a slave society. Interestingly she does not use assertive language when saying this, but only states that a totalitarian society with control of the right to work may be a slave society. It is however interesting that the U.N's declaration of human rights does not initially include social rights, as social rights are something that Roosevelt was very focused on in her career.

    1. I think the best example one can give of this basic difference of the use of terms is “the rightto work.” The Soviet Union insists that this is a basic right which it alone can guaranteebecause it alone provides full employment by the government. But the right to work in theSoviet Union means the assignment of workers to do whatever task is given to them by thegovernment without an opportunity for the people to participate in the decision that thegovernment should do this. A society in which everyone works is not necessarily a free societyand may indeed be a slave society; on the other hand, a society in which there is widespreadeconomic insecurity can turn freedom into a barren and vapid right for millions of people.

      Roosevelt gives a specific example here in contrasting definitions of terms held by the soviet union and the United States. She proceeds to critique the Soviets understanding of the right to work, noting that it the soviet unions understanding of the right to work does not include individual freedom, because they understand the right to work as being given by the government. Roosevelt points out such control is not freedom, but is akin to a slave society. Interestingly she does not use assertive language when saying this, but only states that a totalitarian society with control of the right to work may be a slave society. It is however interesting that the U.N's declaration of human rights does not initially include social rights, as social rights are something that Roosevelt was very focused on in her career.

  5. Apr 2023

    Tags

    Annotators

  6. Mar 2023
    1. Ki gépen száll fölébe, annak térkép e táj, s nem tudja, hol lakott itt Vörösmarty Mihály, annak mit rejt e térkép? gyárat s vad laktanyát, de nékem szöcskét, ökröt, tornyot, szelíd tanyát, az gyárat lát a látcsőn és szántóföldeket, míg én a dolgozót is, ki dolgáért remeg, erdőt, füttyös gyümölcsöst, szöllőt és sírokat, a sírok közt anyókát, ki halkan sírogat, s mi föntről pusztitandó vasút, vagy gyárüzem, az bakterház s a bakter előtte áll s üzen, piros zászló kezében, körötte sok gyerek, s a gyárak udvarában komondor hempereg; és ott a park, a régi szerelmek lábnyoma, a csókok íze számban hol méz, hol áfonya, s az iskolába menvén, a járda peremén, hogy ne feleljek aznap, egy kőre léptem én, ím itt e kő, de föntről e kő se látható, nincs műszer, mellyel mindez jól megmutatható.

      ez a rész egyetlen mondat, képzeletbeli párbeszéd zajlik Radnóti és egy bombázó repülőgép pilótája között. a költő érveket sorakoztat fel, miért ne pusztítsa el hazáját. a szerkesztési elv roppant egyszerű: a pilóta fentről szemláli a tájat; csak egy térképet lát, míg a költő lentről figyeli a tájat, látja az apró életképeket, melyek a térképet élettel töltik meg. a költő ellentétpárokkal dolgozik: háborús célpontok állnak szemben a békés mindennapok képével (vad laktanya - szelíd tanya; gyárat - dolgozót; gyárüzem - gyerek). a pusztítandó célpontok Radnóti számára a hazát jelentik, amelyet ismer és szeret. visszatérnek az első rész képei is: erdő, füttyös gyümölcsös, sírok közt anyóka, bakterház udvarán játszó gyermekek. végül személyes emlékeket idéz fel: szerelmeit, egy apró követ mely szerencsét hozott neki diák korában. egyszóval felidézi a még háború előtti szelíd és békés gyermek- és fiatalkorát. mindez fentről nem látható, de talán átérezhető

  7. Jan 2023
    1. surveillance capitalism, invented by Google in 2001, benefitted from a couple of important historical windfalls. One is that it arose in the era of a neoliberal consensus around the superiority of self-regulating companies and markets. State-imposed regulation was considered a drag on free enterprise. A second historical windfall is that surveillance capitalism was invented in 2001, the year of 9/11. In the days leading up to that tragedy, there were new legislative initiatives being discussed in Congress around privacy, some of which might well have outlawed practices that became routine operations of surveillance capitalism. Just hours after the World Trade Center towers were hit, the conversation in Washington changed from a concern about privacy to a preoccupation with “total information awareness.” In this new environment, the intelligence agencies and other powerful forces in Washington and other Western governments were more disposed to incubate and nurture the surveillance capabilities coming out of the commercial sector.

      !- summary : surveillance capitalism incentives - popularity of neoliberal norm of minimizing government regulation - 9/11 accelerated popularity of a global surveillance state

  8. Dec 2022
  9. Nov 2022
    1. I came to this page looking for a way to disable news stories in Windows 11 Widgets. I attempted one of the solutions (Disable Interests From Widgets To Turn Off News Feeds) but News recommendations still appeared.

      Since I mainly wanted the Widget enabled for a calendar view, I decided against using Widgets altogether and settled for using the calendar in the notifications bar.

      Another alternative I considered was to have 4 static Widgets pinned to obscure any news articles in the feed. However, unless one uses the insider Windows 11 build 25211 or later, Widget display will pop up from mouse hovering.

    1. anditails · 1 yr. agoDell Pro Support Engineer (3rd party)You don't need Support Assist on Windows 11. Enable the "Optional Updates" and it'll do all the drivers through Windows Update.It's fast, too. Far quicker than Support Assist!

      Someone recommending to avoid using Dell SupportAssist on Windows 11. I came across this because I was trying to see if there was a way to update SA in order to ensure the driver iqvw64e.sys was removed. Related to the problem here. Uninstalling SupportAssist resolved the aforementioned problem since recursive file search through C drive failed to find driver iqvw64e.sys

      Based on other comments in this thread, seems like it's best to let Windows Update handle the drivers. Will no longer use Dell SA and will utilize "Optional Updates" to handle drivers

      Currently, the only perceived benefit from SA is automating support tickets submissions if product is under warranty. Last IT support experience with Dell was positive (they did the best they could), but they didn't know much about sys admin stuff on Windows (weren't very helpful in resolving issue without losing all files and installed software).

    1. The correct answer here is to uninstall the intel network driver completely because it is not supported anymore. Support Information for Intel® PROSet and Intel® Advanced...Let Kernel isolation on. saying home users should not care about safety is just a stupid way of thinking. installing bad drivers is a way to spread malware with ease. This should be the "marked solution" to this thread.And I would also add a link to the Intel® Driver & Support Assistant (Intel® DSA) to easily install the latest official driver. Thank you BjornVermeulen for pointing out the support info from Intel.

      I came here looking for a way to resolve an error "A driver cannot load on this device" for the driver "iqvw64e.sys". This error popped up after I enabled "memory integrity" in Windows 11.

      Note that "some malware camouflages itself as iqvw64e.sys" source.

      This driver is associated with Intel network connections software, and gets removed by uninstalling the software per this reddit comment in r/sysadmin. This error is probably because Intel won't support Intel PROSet & Intel Advanced Network Services on Windows 11. The driver is likely a holdover from my Windows 10 OS before I upgraded it to Windows 11. The driver is probably unneeded since other Intel drivers are available .

      The accepted answer in this Microsoft Q&A forum seems silly (just disable memory integrity), so I kept reading and found the highlighted response which quoted a more sensible answer (get rid of bad drivers). Later in the replies, someone asks what's the most efficient way to remove the driver and someone else states

      I found the solution to this problem. After digging for the source of this file, I came across this article. File.net description of iqvw64e.sys. According to the article, this driver can be removed by uninstalling "Intel(R) Network Connections". Sure enough, I went to Control Panel, uninstalled the recommended app, rebooted, and voila! No more error. As for the value of that application, I have no idea. I am however happy to be rid of this error.

      This didn't work for my case since "Intel(R) Network Connections" wasn't installed. Couldn't find iqvw64e.sys in the expected location of C:\Windows\System32\drivers. May have been removed after memory integrity enabled?

      Presently looks like non-issue and can disregard warning in the future

  10. Aug 2022
    1. Benjy Renton. (2021, November 16). New data update: Drawing from 23 states reporting data, 5.3% of kids ages 5-11 in these states have received their first dose. Vermont leads these states so far in vaccination rates for this age group—17%. The CDC will begin to report data for this group late this week. Https://t.co/LMJXl6lo6Z [Tweet]. @bhrenton. https://twitter.com/bhrenton/status/1460638150322180098

  11. Mar 2022
    1. Ce programme nommé « I can word it too », disponible en hébreu et arabe, a été spécialement créé pour cette étude. Il reproduit les activités quotidiennes (jouer à des jeux, prendre les repas, faire sa toilette…) et demande à l’enfant ce à quoi il veut jouer, en lui présentant un choix de jeux sur l’écran

      ==>il s’agirait d’une déclinaison sur écran des outils et méthodes de communication améliorée et alternative (CAA), comme le PECS ou le Makaton. déjà existants, IDEOPICTO ou le langage conceptuel SACCADE

    2. L’imitation et l’influence du jeu interactif sont bien mises en évidence dans une étude de Orit Hetzroni et Juman Tannous, de la Faculté des Sciences de l’éducation de l’Université de Haifa (Israël)

      ==>l’échantillon de l’étude est est extrêmement limité, l’étude n’est pas répliqué et elle ne permet pas de retirer de résultats concluants

  12. Jan 2022
  13. Dec 2021
  14. Nov 2021
  15. Sep 2021
  16. Jul 2021
  17. Jun 2021
    1. The European Union has strong programs to invest in scientific research. Researchers Abraham García and Pierre Mohnen demonstrate that firms who received support from the Austrian government actually increased their research intensity and had more sales. Governments can support scientific research and technical training that helps to create and spread new technologies. Governments can also provide a legal environment that protects the ability of inventors to profit from their inventions.

      From OS

  18. May 2021
  19. Apr 2021
  20. Mar 2021
    1. Muse

      Reminded of Chapter 11 in The Odyssey:

      I am likely going to retire this year and I find resonance in this as it appears that I will be accepting a "voluntary" buyout at the end of this fiscal year. My long sea journey, 25 years worth in teaching, will be officially over. Hence...the appeal to propitiate the gods, to let all the pain go, to ask forgiveness of the implacable Poseidon.

    1. Results for individual PALB2 variants were normalized relative to WT-PALB2 and the p.Tyr551ter (p.Y551X) truncating variant on a 1:5 scale with the fold change in GFP-positive cells for WT set at 5.0 and fold change GFP-positive cells for p.Y551X set at 1.0. The p.L24S (c.71T>C), p.L35P (c.104T>C), p.I944N (c.2831T>A), and p.L1070P (c.3209T>C) variants and all protein-truncating frame-shift and deletion variants tested were deficient in HDR activity, with normalized fold change <2.0 (approximately 40% activity) (Fig. 1a).

      AssayResult: 4.9

      AssayResultAssertion: Normal

      StandardErrorMean: 0.27

    1. Most Suspected Brugada Syndrome Variants Had (Partial) Loss of Function

      AssayResult: 101

      AssayResultAssertion: Normal

      ReplicateCount: 41

      StandardErrorMean: 8.9

      Comment: This variant had normal function (75-125% of wildtype peak current, <1% late current, no large perturbations to other parameters). These in vitro features are consistent with non-disease causing variants. (Personal communication: A. Glazer)

  21. Feb 2021
    1. He was so deeply offended and concerned by the notion that somehow it was America’s fault that a group of radical, violent Islamist terrorists killed nearly 3,000 Americans that it opened his eyes to the indoctrination that was happening in his classes.

      This seems to be true revisionist history. No one I've come across took a "blame America first" approach. Gingrich and Miller would be incredibly hard pressed to come up with contemporaneous statements that back up this proposition.