- Jul 2020
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In the Set class we already called this - and difference, which it is ok but not really accurate because of the previous explanation, but probably not worthwhile to change it.
Is this saying that the name difference is inaccurate?
Why is it inaccurate? You even called it the "theoretic difference" above.
Is that because "relative complement" would be better? Or because the full phrase "theoretic difference" [https://en.wiktionary.org/wiki/set-theoretic_difference] is required in order for it to be accurate rather than just "difference"?
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inaccurate
How is the use of - for sets inaccurate?
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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(Henry 2004, 243), et l’autre à un livre d’Anne Henry
il est étrange de citer à la suite deux fois Henry
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(Körper) des sciences et du corps-sujet (Leib)
est-ce qu'il ne faudrait pas inclure les déterminant dans les traductions ?
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, le philosophe
cette expression un peu générale l'est peut-être trop
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demande à
nous demande de ?
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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Flash dont l’activité est déclenchée
C'est une drôle de comparaison dans la mesure ou le Flash est aujourd'hui obsolète et que les contenus dans ce format sont irrécupérable faute d'avoir les clefs de déchiffrement. Est-ce le même cas pour Proust ?
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son regard laborieux en coup de sonde
je ne suis pas sûre de bien comprendre l'expression
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prisonnière
il me semble que dans les chapitres précédents, le terme était avec une majuscule
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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La prisonnière.
majuscule ?
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tant soit peu réussie
je ne suis pas sûre de ce que cette précision apporte.
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œuvre littérature
littéraire ?
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steadicam
en italique ?
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filmées au m
quel est le référent ici ?
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selon l’expression de Wittgenstein.
est ce qu'il existe une référence précise ?
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l’-être-présent-au-corps.
faut-il conserver le tiret entre l'apostrophe et être ?
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Qu’on imagine à présent la pulpe d’un fruit dont nous apprécions la saveur.
est-ce une référence à un extrait plus précis ?
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Nouvelle Vague
à vérifier mais il me semble que dans le premier chapitre, Nouvelle Vague est écrit sans majuscule à vague.
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ant, le point marquant la transgression d’un silence initial.
devient le point marquant ? On ne sait pas si cette portion se réfère au corps ou au moment.
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À la vérité, cette opposition nous éloigne de la dimension opaque du langage qui se trouve au cœur de l’écriture de Proust.
peut-être expliciter ici, ce que tu comptes en faire, si le traiter pourquoi, sinon pourquoi également.
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considère semble
semble le considérer ?
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textuellement :
je ne comprends pas bien l'usage de cet adverbe ici
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Mais il nous faut maintenant revenir au problème de l’expression qui marque l’éternel commencement, l’univers en perpétuelle création.
Je ne suis pas sûre de saisir l'idée ici
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So why isn't there an easy way to remove an element from such an array in a way that respects both the order and number (count) of each element? Why do all methods for removing elements from an array assume that you always want to remove all matching elements from the receiver, with no option to do otherwise?
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Annotators
URL
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developer.mozilla.org developer.mozilla.org
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JavaScript functions are themselves objects — like everything else in JavaScript — and you can add or change properties on them
how can we add or change properties on a function?
edit: see below section (Custom objects)
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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, Francisco J
pas de point à J ?
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Quantique »
tu ne mets pas "Article "..."" ?
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chercheur.e.s
il ne me semble que l'écriture inclusive soit présentes partout...
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, c’est à l’écrivain qu’il revient de restituer la complexité de l’expérience intérieure.
je ne suis pas sûre de la rhétorique de cette phrase
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(Francisco J 1996, 71).↩
J. ?
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(Francisco J 1996, 113
J. ?
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Partant du phénomène physique du comportement des vagues qui présentent différents modèles de diffraction – par exemple les formes qui apparaissent lorsque nous jetons une pierre dans un volume aqueux – et qui résultent de la réaction des vagues en rencontrant un obstacle (2007, 28)
c'est une phrase nominale ?
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décèdera des suites d’un accident à cheval
C'est une hypothèse totalement parce que je ne connais pas bien le passage (si passage il y a) de l'accident de cheval, mais est-ce qu'il y aurait peut-être une piste ou un élément d'analyse à trouver dans cet objet du cheval (objet sexuel chez Freud) qui est à la fois un ancien corps "technique" de voyager ?
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Corps en mouvement : Le cas Saint-Loup
je me demande pourquoi tu édites certaine parties comme des listes (ici certainement avec un *) plutôt que de mettre un titre de niveau 4
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nser »[No
espace manquand, enlever le point dans les crochets, mais surtout pourquoi le souligner ?
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l’illustre le rendez-vous manqué avec Gilberte
donner la référence ?
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Ces expériences lancinantes sont
à quoi cela se réfère ? si c'est à la citation de la note, mieux vaut intégrer la citation en retrait dans le texte
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[corporelle]
pourquoi des crochets ?
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« it is after all, the story of a ‘nervous Narrator’ who struggles against negative hereditary factors in his family (personified in the semi-invalid aunt Léonie), and who suffers from a chronic lack of drive that makes him prefer salon time to productive time alone
Il me semblait que dans les chapitres précédents les citations en anglais été traduites
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dimension originaire de silence
je ne suis pas sûre de bien comprendre ici le rapport au silence
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The disruption and constriction of one’s habitual world thus correlates with a new relation to one’s body. In pain, the body or a certain part of the body emerges as an alien presence » (Leder 1990, 76).
peut-être proposer une traduction en note ?
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L’espace intercorporel qui se fait jour existe en deçà des paramètres usuels qui nous permettent de saisir l’expérience humaine (langage, lois sociales), elle en efface les signifiants.
je ne ne comprends pas bien la succession des sujets ici
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Autrement dit, si cette technique n’avait pas existé, le narrateur n’aurait pas pu exprimer la même chose
Peut-être est-ce juste une question d'expression, parce que je saisis bien l'idée du paragraphe, mais cette phrase résonne à la lecture selon l'adage "avec des si, on mettrait Paris en bouteille"
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Si la voix inépuisable qui résonne à travers la Recherche s’adresse directement au lectorat, on peut être sensible à ce qu’elle recèle
La construction "si...., alors ..." implique souvent une contradiction sousentendue, ici je ne la vois pas. Peut-être choisir une construction plus causale ?
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- Jun 2020
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wangjohn.github.io wangjohn.github.io
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In this case, we notice that comment.post and post should belong to the same database object. But, is Rails smart enough to know that the comment should be removed from both of the associations? Or are comment.post and post different representations of the same database row?
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Local file Local file
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bits.csb.pitt.edu bits.csb.pitt.edu
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but subsequent trials failed to show any acti
cellular activity is not promising
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URL
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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essais.
majuscule ?
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Vocabulaire de.
?
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Cité d’après « L’œuvre d’art à l’époque de sa reproduction mécanisée », in Zeitschrift für Sozialforschung 5, 1936, p. 43 Benjamin (2010).↩
je ne comprends pas très bien le lien entre la note et le texte
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(Cité d’après Benjamin 2010, 123)
pourquoi le "cité d'après" ?
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laborieuses Proust
virgule + pourquoi laborieuse ?
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espace médian entre un rire et le voile du regard.
c'est à peu prè la même construction poétie ue plus haut, y-a-t-il un passage en particulier qui l'encourage ?
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l’information centrale est bien « la vague éclaboussante » qui s’est imprimée à la manière d’un pli dans la conscience d’Elstir
je ne suis pas sûre de bien saisi l'idée dans le deuxième temps de cette phrase.
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Le toucher. Odorat et ouïe.
pourquoi séparer les sens par un point ?
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n tant qu’étoffe indivise qui entre-tisse, en même temps que notre corps, les choses, les animaux, les autres
j'ai de la difficulté à comprendre la structure de cet insert, une erreur quelque part ?
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qui est au monde.
la formulation me semble un peu compliquée à comprendre, je m'interroge surtout sur le "qui"
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15721.courses.cs.cmu.edu 15721.courses.cs.cmu.edu
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With this second scheme, the DBMS stores the physical addressof versions in the index entries. This approach is only applicablefor append-only storage, since the DBMS stores the versions in thesame table and therefore all of the indexes can point to them. Whenupdating any tuple in a table, the DBMS inserts the newly createdversion into all the secondary indexes. In this manner, the DBMScan search for a tuple from a secondary index without comparingthe secondary key with all of the indexed versions. Several MVCCDBMSs, including MemSQL and Hekaton, employ this scheme
Physical Pointers: 只对Append-only storage有用
问题:“since the DBMS stores the versions in the same table and therefore all of the indexes can point to the”这句话怎么理解
Likewise, using physical pointers is better for read-intensive workloads because an index entry points to the exact version. But it is slower for update operations because this scheme requires theDBMS to insert an entry into every secondary index for each new version, which makes update operations slower
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multi-versioning does notbring any benefits to phantom prevention
How to prevent Phantom in MVCC?
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Thebasic idea of MVCC is that the DBMS maintains multiple physicalversions of each logical object in the database to allow operations onthe same object to proceed in parallel.
How to make sure different physical copies are in sync?
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when there are a large numberof threads running in parallel, the synchronization overhead canoutweigh the benefits of multi-versioning
如何保证延展性
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web.hypothes.is web.hypothes.is
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Annotating in Sections
What exactly do they mean by annotating? Is it note taking, or a conversation?
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URL
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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de matière physico-chimiques
si c'est bien les connexions qui sont physico-chimiques je placerai ce terme avant "de matière"
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Entfremdung en allemand
pourquoi cette précision ?
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résulte l’impuissance
résulte de ?
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dépayement
dépaysement ?
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Ce n’est là qu’une des dénominations de couleur mythique que nous trouvons
Je ne comprends pas le lien entre le texte et la note.
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un fond d’altérité sous-tendant le commerce d’un étant avec le monde
Je trouve cette formule un peu trop complexe, on a du mal à voir ce que tu veux dire ... sous-entendu une relation avec autrui ?
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Dans la dichotomie qui s’établit entre l’aplatissement et la fragmentation de l’expérience (l’appréhension cinématographique du voyage en automobile) d’une part, et son intensification (« quand notre imagination nous portait du lieu où nous vivions jusqu’au cœur d’un lieu désiré »).
est-ce volontairement ici une phrase nominale ?
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à la du Côté de chez Swann
il manque un élément je crois + j'ajouterai une virgule après Swann
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incarnée
je ne suis pas sûre du sens ici : corporelle ? ou tout simplement reçue ?
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simple:
espace + peut être que simple est condescendant ?
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Prous),
Proust ?
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sa lecture du monde
le référent n'est pas clair : la lecture du stéréoscope ? la représentation alors plutôt ?
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(dé)limitent.
Pourquoi cette précision avec parenthèse ?
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Or pourquoi recourir à l’image du stéréoscope pour expliquer la profondeur de l’image perçue?
peut-être faut-il mieux exprimer l'apparente incohérence dans l'association : image intime / dispositif extérieur ?
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clarté de cette description
clarté dans quel sens ?
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On peut alors se demander pour quelle raison Proust recourt à la vision artificielle du stéréoscope.
est ce qu'il y a un fait étonnant à ce qu'il le fasse ?
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dont affectent
dont ils ?
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Des premières p
Dans les ? ou Dès ?
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est racontée
le référent n'est pas clair ici, est-ce bien le récit ?
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à la croisée de la vie intérieure et des désordres situés au-delà des limites corporelles
c'est une belle formule mais peut-être un peu trop forte dans le style, peut-être l'alléger un peu pour que l'idée soit plus évidente à la lecture ?
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caractère stérile
pourquoi stérile ?
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s qu’elles éme
problème de référent ici : ils émergent ?
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Pour rassurante qu’elle paraisse,
rassurante parce que calculable ?
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Lalande, Poirier, et Philosophie
le troisième auteur s'appelle vraiment Philosophie ?
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sont
dont ?
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e, ;
C'est peut-être ici une retranscription juste mais je m'étonne de la succession des deux ponctuations virgule et point virgule
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cadd cadd
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UT-34 induced the regression of enzalutamide-resistant tumors at doses when the AR is degraded
What dose?
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T-34 caused the degradation of the full-length AR, but not the tau-5-deleted AR
tau-5 locates between AF-1 and DBD, deletion of this region may cause significant protein structure change, such change may result in different AR degradation profile which is irrelavant with UT-34
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URL
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ulausannebusiness.eu.qualtrics.com ulausannebusiness.eu.qualtrics.com
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SARS-CoV-2 Study. (n.d.). Retrieved June 17, 2020, from https://ulausannebusiness.eu.qualtrics.com/jfe/form/SV_0rgUXxwC5wIiuRD
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stylo.ecrituresnumeriques.ca stylo.ecrituresnumeriques.ca
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s 19e et 20e
pourquoi pas des chiffres romains comme précédemment ?
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inst-fs-iad-prod.inscloudgate.net inst-fs-iad-prod.inscloudgate.net
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engaged in art history
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unix.stackexchange.com unix.stackexchange.com
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It would be better if you asked a new question. In the worst case scenario, it would be marked as a duplicate (which still means you would probably get some sort of resolution).
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stackoverflow.com stackoverflow.com
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Sure, all these other answers show ways to not do what the OP asked, but that really screws up the rest of us who searched for the OP's question.
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Local file Local file
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chloroform extracts of ten marine sponges werescreened for their antimicrobial activit
chloroform extracts were directly used without further separation for antimicrobial activity test. How to separate the active indigrient then?
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more than5000 different compounds have been isolated fromabout 500 species of sponges
will this reference provide a list of extracts of marine sponges
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Since then well over 14,000 dif-ferent natural products from marine organismshave been described
will this reference provide a list of extracts of marine sponges
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cfmsurvey.org cfmsurvey.org
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COVID-19 and UK Public Finances | The CFM-CEPR Surveys. (n.d.). Retrieved June 8, 2020, from https://cfmsurvey.org/surveys/covid-19-and-uk-public-finances
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blogs.bmj.com blogs.bmj.com
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Sebastian Walsh: We are asking the wrong questions about easing lockdown. (2020, June 2). The BMJ. https://blogs.bmj.com/bmj/2020/06/02/sebastian-walsh-we-are-asking-the-wrong-questions-about-easing-lockdown/
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files.zotero.net files.zotero.net
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tunnel splitting
What exactly is tunnel splitting? The essay mentions this various times without clearly explaining what it is, and whenever I search it up online multiple things are said about it.
From what I could understand, quantum spin tunnel splitting makes it so that the magnetization of a system can "switch between states with opposite magnetization that are separated by an energy barrier much larger than thermal energy". But what exactly happens during tunnel splitting? And why are there different ones mentioned in the article? [magnetization tunneling, zero-field tunnel splitting, ground-state tunnel splitting]
I also understand that this phenomenon "defies classical physics" because of magnetization switching. How is that possible?
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URL
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- May 2020
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github.com github.com
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Deepset-ai/haystack. (2020). [Python]. deepset. https://github.com/deepset-ai/haystack (Original work published 2019)
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en.wikipedia.org en.wikipedia.org
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Related concepts in other fields are: In natural language, the coordinating conjunction "and". In programming languages, the short-circuit and control structure. In set theory, intersection. In predicate logic, universal quantification.
Strictly speaking, are these examples of dualities (https://en.wikipedia.org/wiki/Duality_(mathematics))? Or can I only, at strongest, say they are analogous (a looser coonection)?
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docs.basex.org docs.basex.org
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The context item
What does "context item" here means?
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URL
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stackoverflow.com stackoverflow.com
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ssh-add <(echo "$PRIVATE_KEY")
Does this have any advantage over simply saving that key to a key file under ~/.ssh?
Like they do on https://stackoverflow.com/a/61944004/47185:
mv "$DEPLOY_KEY_PRIVATE" ~/.ssh/id_rsa
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stackoverflow.com stackoverflow.com
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deployer-token
Where does
deployer-token
come from? Is this a placeholder or a well-known hard-coded value specific to __ (GitLab? my.company.com?)? Where is it documented?
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www.investopedia.com www.investopedia.com
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machines tend to be designed for the lowest possible risk and the least casualties
why is this a problem?
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stackoverflow.com stackoverflow.com
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1. Disabling concrete extension update. That's what I wanted! You can do this by editing the extensions manifest json-file on Windows: C:\Users\<USERNAME>\AppData\Local\Google\Chrome\User Data\Default\Extensions\<EXTENSION-ID>\<VERSION>\manifest.json (find out the extensions ID by enabling developer mode in the extension settings page) on Ubuntu for Chromium: ${HOME}/.config/chromium/Default/Preferences In this file set "update_url" property to something invalid like "https://localhost" for example. For now according to given url updating of that extension is simply impossible.
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developer.mozilla.org developer.mozilla.org
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infinite time
Say what? Hows is this demonstrated by the example?
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gitlab.com gitlab.com
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shouldn't a MR be treated as an unit of work, independent from master?
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stackoverflow.com stackoverflow.com
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If you update your pages and push to github, people revisiting the pages who have already got cached copies will not get the new pages without actually cleaning their browser cache. How can a script running in a page determine that it is stale and force an update?
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www.chromestatus.com www.chromestatus.com
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Mojofication, Onion Souping, and the Network Service.
What is Mojofication?
What is Onion Souping?
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www.iubenda.com www.iubenda.com
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The consent provided by the user is saved in some cookies within the host page’s domain. By verifying the presence or the absence of these cookies you can determine whether the user has given their consent or not.
But how do you check if they've given consent to a specific category??
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www.iubenda.com www.iubenda.com
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Make it clear that signing up is optional. Consent must be “freely given”; you may not coerce users into joining your mailing list or make it appear as if joining the list is mandatory. For this reason, you must make it clear that signing up is optional. This is especially relevant in cases where you offer free white-papers (or e-books) for download. While the user’s email address is required for the delivery of the service, signing up for your newsletter is not. In such a case, you must not make it appear as if signing-up to the newsletter list mandatory and must make it clear that it is optional.
Question (answer below)
Are they saying that it's not allowed to make signing up for a mailing list a precondition/requirement for anything? This was surprising to me.
So if you have a newsletter sign-up page that sends a digital bonus gift (like an e-book) to new subscribers, are required to completely change/repurpose your "newsletter sign-up page" into a "download e-book page" (that has an optional checkbox to also sign up for the newsletter, if you want)? That seems dumb to me, since it requires completely reversing the purpose of the page — which was, in my mind, primarily about signing up for the newsletter, with a bonus (an essentially optional one) thrown in for those who do so. Are you required to either repurpose it like that or remove the free bonus offer that would be sent to new subscribers?
The irony of this is that it requires websites that have a newsletter sign-up page like that to change it into a "newsletter sign-up page" where the newsletter sign-up part is optional. Which make you look kind of stupid, making a page that claims to be one thing but doesn't necessarily do what it says it's for.
Does this mean, in effect, that you may not lawfully provide any sort of incentive or reward for signing up for something (like a mailing list)? As long as it's very clear that some action is required before delivery of some thing, I don't see why this sort of thing should not be permitted? Would this fall under contract law? And as such, wouldn't such a contract be allowed and valid? Are mailing lists a special class of [service] that has special requirements like this? Or is it part of a broader category to which this requirement applies more generally?
Why is requiring the user to provide an email address before they can download a digital reward allowed but not requiring signing up to a mailing list? Why isn't it required that even the email address be optional to provide? (To answer my own question, probably because it's allowed to allow a user to request a specific thing to be sent via email, and an email address is required in order to fulfill that request. But...) It seems that the website could just provide a direct link to download it via HTTP/FTP/etc. as an option for users that chose not to provide an email address. (But should they be required to provide that option anytime they / just because they provide the option to have the same thing delivered via email?)
Answer
Looks like my question was answered below:
Explicit Form (where the purpose of the sign-up mechanism is unequivocal). So for example, in a scenario where your site has a pop-up window that invites users to sign up to your newsletter using a clear phrase such as: “Subscribe to our newsletter for access to discount vouchers and product updates!“, the affirmative action that the user performs by typing in their email address would be considered valid consent.
So the case I described, where it is made very clear that the incentive that is offered is conditional on subscribing, is listed as an exception to the general rule. That's good; it should be allowed.
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ambermd.org ambermd.org
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Ideally you should really test these parameters (by comparing to ab initio calculations for example) to ensure they are reasonable
How to compare?
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C, N, O, S, P, H, F, Cl, Br and I
GAFF only supports 10 elements?
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Annotators
URL
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nwalsh.com nwalsh.com
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Regular Expression Functions There are three regular-expression functions that operate on strings: matches() tests if a regular expression matches a string. replace() uses regular expressions to replace portions of a string. tokenize() returns a sequence of strings formed by breaking a supplied input string at any separator that matches a given regular expression. Example:
Test question: how many are there regular-expression functions in XSLT?
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What’s the difference between xsl:value-of, xsl:copy-of, and xsl:sequence? xsl:value-of always creates a text node. xsl:copy-of always creates a copy. xsl:sequence returns the nodes selected, subject possibly to atomization. Sequences can be extended with xsl:sequence.
What’s the difference between xsl:value-of, xsl:copy-of, and xsl:sequence?
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<xsl:variable name="date" select="xs:date('2003-11-20')"/>
How to declare the date in the variable in XSLT 2?
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Types XSLT 2.0 allows you to declare: The type of variables. The return type of templates. The type of sequences (constructed with xsl:sequence) The return type of (user-declared) functions. Both the type and required type of parameters.
What are the types that one can declare in XSLT 2?
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www.ibm.com www.ibm.com
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<xsl:sequence select="1 to 16"/>
How to create a sequence with range.
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<xsl:for-each select="1 to 32"> <!-- Do something useful here --></xsl:for-each>
How to create a loop in XSLT?
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The new as attribute defines the data type of the variable, and the asterisk (xs:integer*) means that the sequence contains zero or more integers
How is the @as attribute? Which values can it have?
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One of the major new concepts in XPath 2.0 and XSLT 2.0 is that everything is a sequence.
What is one of the major concepts in XPath 2.0 and XSLT 2.0?
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unix.stackexchange.com unix.stackexchange.com
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www.sciencedirect.com www.sciencedirect.com
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MONN contains a pairwise interaction prediction module, which can capture the non-covalent interactions between atoms of a compound and residues of a protein with extra supervision from the labels extracted from available high-quality 3D compound-protein complex structures
does that mean MONN can predict binding site
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- Apr 2020
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pubs.acs.org pubs.acs.org
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available
commercialized?
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URL
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www.examtopics.com www.examtopics.com
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A company runs a memory-intensive analytics application using on-demand Amazon EC2 C5 compute optimized instance. The application is used continuously and application demand doubles during working hours. The application currently scales based on CPU usage. When scaling in occurs, a lifecycle hook is used because the instance requires 4 minutes to clean the application state before terminating.Because users reported poor performance during working hours, scheduled scaling actions were implemented so additional instances would be added during working hours. The Solutions Architect has been asked to reduce the cost of the application.Which solution is MOST cost-effective?
should be A here, cause C5 is 40% cheaper than R5
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Local file Local file
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pubs.acs.org pubs.acs.org
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Mixed the plate thoroughly and incubated for one hour at room temperature. Then 5 μL development solution was added to each well and the plate was incubated for 1h at room temperature;
the compound and kinase are incubated together for at least 2 hours. And 2 hours is enough for covalent adduct to form. if compound can form covalent adduct with FGFR1, why FGFR1 inhibition IC50 is so poor?
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medium.com medium.com
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What is a Function Expression?A JavaScript function can also be defined using an expression.A function expression can be stored in a variable:var x = function (a, b) {return a * b};After a function expression has been stored in a variable, the variable can be used as a function. Functions stored in variables do not need function names. They are always invoked (called) using the variable name.
Test question: What is function expression?
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codeburst.io codeburst.io
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Writing an async function is quite simple. You just need to add the async keyword prior to function:
Test question: What is the syntax of async function?
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codeburst.io codeburst.io
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Our Promise can have one of three states:
Testing question: what are the states of a promise?
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javascript.info javascript.info
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Using objects as keys is one of most notable and important Map features.
Test question: What is one of the most notable and important Map features?
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Map is a collection of keyed data items, just like an Object. But the main difference is that Map allows keys of any type.
Test question: What is the difference between Map and Object in JavaScript?
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javascript.info javascript.infoFetch1
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he basic syntax is: let promise = fetch(url, [options])
Test question: What s the basic syntax of fetch(); ?
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Webpack is a most have to compile a complete JavaScript project.
Test question: how do you pack the web extension?
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linter
Test question: What is a linter?
Answer (Wikipedia): lint, or a linter, is a tool that analyzes source code to flag programming errors, bugs, stylistic errors, and suspicious constructs.[1] The term originates from a Unix utility that examined C language source code.[2]
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This tool accepts both a configuration file and line parameters.
Test question: How can you configure web-ext?
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levelup.gitconnected.com levelup.gitconnected.com
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Here are the possible ways to make an API call:XMLHttpRequestfetchAxiosjQuery
Test question: What are 4 ways to make an api call?
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Local file Local file
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A poised fragment library enables rapid syntheticexpansion yielding thefirst reported inhibitors ofPHIP(2), an atypical bromodomain
what is the library? compound in the library can be expanded quickly by synthesis why they designed it this way? they did not find convincing hits from solution screen. They use crystallography as primary screening tech what assay they used for the screening? AlphaScreen competition assay as function assay
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web.hypothes.is web.hypothes.is
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Most pages aren’t very dynamic, and therefore won’t have any orphans. In these cases, the orphans tab will not appear.
Question: What about to use archive.org when the page is dramatically changed?
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www.w3schools.com www.w3schools.com
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document.addEventListener(event, function, useCapture)
Test question: What is the syntax of element.addEventListener() ?
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developer.mozilla.org developer.mozilla.org
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It should be 48x48 pixels.
Test question: What is the recommendes size of the icon for the firefox extension?
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www.tutorialspoint.com www.tutorialspoint.com
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It is an unordered set of name/value pairs.
Test question: What is an object in JSON?
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www.tutorialspoint.com www.tutorialspoint.com
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Square brackets hold arrays and values are separated by ,(comma).
Test question: What are square brackets used for?
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JSON syntax is basically considered as a subset of JavaScript syntax;
Test question: What is JSON syntax part of?
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name/value pairs.
Test question: How is the data in json represented?
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developer.mozilla.org developer.mozilla.org
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Extensions for Firefox are built using the WebExtensions APIs, a cross-browser system for developing extensions.
Testing question: How compatible are extensions among Web Browsers?
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developer.mozilla.org developer.mozilla.org
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The most interesting key here is content_scripts, which tells Firefox to load a script into
Testing question: What part of "manifest.json" tells firefox where is the script to load?
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description is optional, but recommended: it's displayed in the Add-ons Manager. icons is optional, but recommended: it allows you to specify an icon for the extension, that will be shown in the Add-ons Manager.
Testing question: What are the optional parts of manifest.json?
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The first three keys: manifest_version, name, and version, are mandatory and contain basic metadata for the extension.
Question: What are the mandatory part of manifest.json?
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developer.mozilla.org developer.mozilla.orgeval()1
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Never use eval()! eval() is a dangerous function, which executes the code it's passed with the privileges of the caller.
Testing question: Should you ever use eval()?
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developer.mozilla.org developer.mozilla.orgPopups2
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The popup is specified as an HTML file, which can include CSS and JavaScript files, as a normal web page does.
Testing question: Of which files the popup consists of?
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Popups resize automatically to fit their content.
Testing question: How is the popup resized?
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developer.mozilla.org developer.mozilla.org
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There are two ways to specify a browser action: with or without a popup
Question: What are the ways in which the browser action can work?
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The only mandatory key is default_icon
Question: What is the only mandatory key in the firefox "browser action" in the manifest.json file?
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Specifying the browser action
Question: Where do you define the browser action? Answer: In the manifest.json.
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ommonly referred to as a browser action, this user interface option is a button added to the browser toolbar. Users click the button to interact with your extension.
Question: What is a "browser action"?
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extensionworkshop.com extensionworkshop.com
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An extension is a simple collection of files that modify the browser’s appearance and behavior.
Question: What is an extension?
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content.aws.training content.aws.training
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Your client’s CloudWatch Logs configuration receives logs and data from on-premises monitoring systems and agents installed in operating systems. A new team wants to use CloudWatch to also monitor Amazon EC2 instance performance and state changes of EC2 instances, such as instance creation, instance power-off, and instance termination. This solution should also be able to notify the team of any state changes for troubleshooting.
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Chrome first sends an encrypted, 3-byte hash of your username to Google, where it is compared to Google's list of compromised usernames. If there's a match, your local computer is sent a database of every potentially matching username and password in the bad credentials list
Why do they only send password matches if username also matches?? A password should be deemed compromised and never used again if the password is found in a breach/paste anywhere, even if in connection with a different username/email.
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www.troyhunt.com www.troyhunt.com
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Over the years, many people have said "well, the data is public anyway by virtue of it having been breached, what's the problem if you now store the password in your system?" Here's the philosophical problem I have with that:
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docs.syncthing.net docs.syncthing.net
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Override Changes
is this like a danger button?
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Changes are still received so the folder may become “out of sync”, but no changes will be applied.
Bit confusing, when the previous line says changes will be ignored.
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Local file Local file
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Local file Local file
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Local file Local file
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We did not use the YAP peptides containing residues in interface1 because it has been shown that interface 1 is dispensable forYAP binding
this is strange, as the YAP interface 1 segment is a beta strand, which forms multiple Hbond with TEAD. So how could it be dispensable for TEAD binding?
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YAP peptide
what is the sequence of the peptide? it might be the peptide 1 in Fig 1D, which shows the strongest binding to TEAD, ~ 200 nM. Peptide 1 contains just the alpha helix and omega loop, so it is possible that the FA binding will affect the beta strand part which is missing in peptide 1
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The central pocket of TEADs has an excellent druggabilityscore
what is the score? calculated by which software the author probably used Schrodinger Sitemap, although they did not mention. but they used Schrodinger to calculated the strain energy and prepare the protein structure
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- Mar 2020
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www.iubenda.com www.iubenda.com
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What data is being collected? How is that data being collected?
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For which specific purposes are the data collected? Analytics? Email Marketing?
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What is the Legal basis for the collection?
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www.iubenda.com www.iubenda.com
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Using our privacy policy software implies having a third party integrate into your site. This post explains what kind of data is and is not tracked by iubenda.
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accessmedicine.mhmedical.com accessmedicine.mhmedical.com
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In the absence of insulin, the entry of glucose into skeletal, cardiac, and smooth muscle and other tissues is decreased (Figure 24–8). Glucose uptake by the liver is also reduced, but the effect is indirect. Intestinal absorption of glucose is unaffected, as is its reabsorption from the urine by the cells of the proximal tubules of the kidneys. Glucose uptake by most of the brain and the red blood cells is also normal.
Q: Is this because it's not an issue with taking in glucose, it's an issue with letting go of all the glucose you have saved up?
It's like the difference between generational wealth and binge/purge wealth. On a metabolic level. Oof.
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In the tissues in which insulin increases the number of GLUTs in cell membranes, the rate of phosphorylation of the glucose, once it has entered the cells, is regulated by other hormones. Growth hormone and cortisol both inhibit phosphorylation in certain tissues. Transport is normally so rapid that it is not a rate-limiting step in glucose metabolism. However, it is rate-limiting in B cells.
Q: Why would you want to inhibit phosphorylating glucose, trapping it in the cell, when you are stressed out (cortisol)? Why would you want to inhibit it during growth and repair (growth hormone)?
Are they trying to divert glucose to other tissues, selectively inhibiting glucose from being trapped in non-essential tissues?
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accessmedicine.mhmedical.com accessmedicine.mhmedical.com
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Increased ketone uptake
Q: Why would you take up ketones. Is this just the opposite of when you send out ketones during a glucagon state?
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Increased K+ uptake
Q: Why though. What do you need K for?
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www.portainer.io www.portainer.io
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You'll just need to access the port 9000 of the Docker engine where portainer is running using your browser.
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www.adrianjock.com www.adrianjock.com
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So if they choose to play the video, do they get some other prompt to accept cookies from YouTube BEFORE the video will play?
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www.ics.uci.edu www.ics.uci.edu
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identification of resources; manipulation of resources through representations; self-descriptive messages; and, hypermedia as the engine of application state
Where can I read more about these constraints?
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developers.google.com developers.google.com
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select an origin
It's interesting that under my site's origin it lists cookies for other domains. Are these considered 3rd-party cookies or 1st-party cookies written by a 3rd-party script? How is it allowed to set them on my site? Presumably because I loaded a script from their origin.
Loading scripts from other origins allows them to set cookies on which domains? Only their origin? And which cookies can they read?
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www.newadvent.org www.newadvent.org
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is a statement not made by us only; although it may seem a sufficiently marvellous and incredible assertion to those who have a reputation as philosophers among Greeks and Barbarians, by some of whom, however, an idea of His existence seems to have been entertained, in their acknowledging that all things were created by the word or reason of God.
I am not sure I understand perfectly what was said here, however, if what I believe it is being said is right I think this is a very interesting sentence. Son of God is a statement made by us, which is sufficient by itself but also by greek philosophers? As a reinforcement of this statement?
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- Feb 2020
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www.newadvent.org www.newadvent.org
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But to us, who distinguish God from matter, and teach that matter is one thing and God another, and that they are separated by a wide interval (for that the Deity is uncreated and eternal, to be beheld by the understanding and reason alone, while matter is created and perishable),
I would like to look at other texts to see how this compares because, while most writers agree that God is not physical, if they are including Jesus in their definition of God it becomes more complicated because of the Incarnation. I wonder why in this section the author doesn't reference the physical nature of God in the form of Jesus. If the idea of the incarnation was still in dispute at this point, maybe Athenagoras shared beliefs with Docetism?? Or maybe he is just discussing the immaterial God for the sake of supporting his argument that Christians acknowledge on God. What would he make of the father, son, and holy spirit? I will look for more on this further in the text.
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- Jan 2020
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www.c3l.uni-oldenburg.de www.c3l.uni-oldenburg.de
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continuous rather than a discrete variable, a relative rather thanan absolute term
try and understand this better. Ask about it in the synchronous meeting?
???
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stackoverflow.com stackoverflow.com
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This illustrates a pretty common challenge with joins: you want them to be used for some of the query but not for other of it.
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kids.kiddle.co kids.kiddle.co
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Mining can include extraction of metals and minerals, like coal, diamond, gold, silver, platinum, copper, tin and iron. Mining can also include other things like oil and natural gas.
How do you mine gas?
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