Molecular findings:

Severe bleeding phenotype in homozygotes, alleviated bleeding phenotype in heterozygotes.

Difficult to classify based on the phenotype and plasma levels.

p.M771V variant shows elevated proVWF to mature VWF ratio, reduced levels of cleaved VWFpp.

p.M771V has potential to negatively influence VWFpp cleavage to contribute to decreased VWF processing in endothelial cells.

Other variants near p.M771 locus reported to disrupt the cleavage by furin. (Variants are at R763 and R760 respectively).

Other researchers have come across the p.M771 variant and reported it as well.

functional studies performed in cord blood derived ECFCs through adenine base editing and overexpressed in HEK293 cells.

Utilized Immunocytochemistry staining and confocal analysis

ELISA to test for secreted VWF in ECFCs

Multimer assay and densitometry graphs to view VWF multimer patterns

Western blotting to view proteolytic processing of VWF and VWFpp

Genomic sequencing to verify mutations.

Authors here used SpCas9-mediated base editing to mimic patient variant if primary ECFCs are not available or are difficult to culture to assist in improved characterization in a true endothelial background.

The Pen Tool in Photoshop is a game-changer for eCommerce brands. Learn how to master it with our easy-to-follow guide.

🔗 https://pathedits.com/blogs/tips/how-use-pen-tool-photoshop-beginner-tutorial

CapCut剪映又多了一票

Auto Caption: especially if CapCut 剪映 jianying, jian ying (made by ByteDance, think TikTok) also offers Chinese caption, I'm sold!

Can't wait to find out

Right on! Going with the text only is asking for trouble. The waveform is still irreplaceable; the words are a guide.

To some extent, Luhmann felt that his books wrote themselves. He spent an inordinate amount of time writing out notes and filing them into his zettelkasten. The writing portion consisted primarily of typing out the manuscript and after writing it, he usually didn't revise it.

Link to https://hypothes.is/a/LG--lGpmEe6yvy8lp7nfPw

Descript

All-in-one video & podcast editing, easy as a doc.

Alan Levine has been using this to do podcast editing and it allows for snipping out and replacing audio segments.

Keith Taylor is Moving to Web3

In recent years, I've been searching for an inclusive platform on which to develop new Internet content. Because I want to form supportive, learning communities. Where I can continue to help people with problems that I've found solutions for. But in a way that encourages others to pass on what they learn.

I was inspired by giffgaff customer support. Which puts frontline support in the hands of fellow customers. Allowing giffgaff to provide cost-effective personal support. While allowing committed customers to earn some spare cash. Ingeniously, giffgaff pays that cash twice a year. Meaning that customers can easily receive £200 in November and in May - nicely timed for winter and summer holiday seasons. Importantly, that £200 is easily achieved in a few enjoyable minutes most days. But it's also easy to put more effort in and earn significantly more.

So for years, I tried to find or create a platform that I could use in similar ways. To provide helpful, inclusive customer support for my websites. That together, we could expand to replace first line support in most industries. Luckily, I found it.

Unfortunately, Web3 is quite new. And its decentralized nature means that current participants are pioneers. So if you are the type of person who needs "the answer" from "the owners", you need to wait a year or three. But do you like to be at the cutting edge, making your own choices, and enjoy the benefits of early adoption? If yes, please accept my invitation to join Keith Taylor Web3.

In future, I'll bring you step-by-step details. With onboarding and ongoing Web3 support.

https://www.youtube.com/watch?v=aaHEgPk0tNM

Rowan Williams quote - not who I thought he was

• Read
• Write (collect)
• Reflect

Important caveat here....

Annotation and AI Starter Assignments<br /> by Jeremy Dean

• students as fact-checkers
• students as content experts
• students as editors

There was an effort made to emphasize the facts. It should help people looking for the best clipping path service provider or product photo editing studio and those who are already in the business or getting ready to start.

When does using an artificial intelligence-based writing tool make the writer an editor of the computer's output rather than the writer themself?

https://www.youtube.com/watch?v=NPqjgN-pNDw

When did the switch in commonplace book framing did the idea of "second brain" hit? (This may be the first time I've seen it personally. Does it appear in other places?) Sift through r/commonplace books to see if there are mentions there.

By keeping one's commonplace in an analog form, it forces a greater level of intentionality because it's harder to excerpt material by hand. Doing this requires greater work than arbitrarily excerpting almost everything digitally. Manual provides a higher bar of value and edits out the lower value material.

This is the most intriguing aspect of the article.

I've not seen this explicitly laid out as advice before though in most contexts people's note taking spaces have historically been divorced from their writing spaces for publication because slips and notes are usually kept physically separate from the working spaces or finished parts, but Richard Carter specifically separates the digital spaces in which he takes his notes and then uses them for creating end products. While he could both take notes in Obsidian, his tool of choice for notes, as well as write his finished pieces there, he actively changes contexts to use a different digital app to compose his notes into final pieces.

What affordances does this context shift provide? <br /> - blank slate may encourage reworking and expansion of original notes - is there a blank slate effect and what would it entail? - potentially moves the piece into a longer format space or tool which provides additional writing, formatting or other affordances (which? there don't seem to be any in this case aside from a potential "distraction free mode" which may tend to force one to focus only on the piece at hand rather than the thousands of other pieces (notes) hiding within the app)

What affordances does this remove?<br /> - He's forced to repeat himself (cut & paste / DRY violation)

Is it easier or harder (from a time/effort perspective) to provide citations with such a workflow? Carter does indicate that for him:

Having links to original sources in my outline makes the compilation of references for the chapter far easier than it used to be.

https://www.npr.org/sections/health-shots/2023/01/18/1139783203/what-makes-songs-swing-physicists-unravel-jazz-mystery

Spaces in both language, text, and music help to create the texture of what is being communicated (and/or not).

Link to Edward Tufte's latest book in section entitled "Spacing enhances complex meaning, encourages slow, thoughtful reading":

<small><cite class='h-cite via'>ᔥ <span class='p-author h-card'>KevinMarks</span> in #meta 2023-01-19 (<time class='dt-published'>01/19/2023 11:32:19</time>)</cite></small>

Link to Indigenous astronomy example of negative spaces (like the Great Emu)

—Brian W. Kernighan, 1974 “UNIX for Beginners” [PDF] as Bell Labs Technical Memorandum 74-1273-18 on 29 October 1974.

For easier editing and reuse of sentences, or even portions of lines of text, one can (and should) write sentences or sentence fragments on their own lines in digital contexts.

This way future edits or the ability to more easily cut and paste will far easier in addition to keeping your version control files simpler and easier to read and visually track your changes. (That is in many version control systems, instead of a change appearing to affect an entire paragraph, it will only show on the single line that was changed thereby making the change easier to see.)

This particular affordance may be a particularly useful one for note takers who expect to regularly reuse their notes in other contexts. Many forms of software (including Tex, LaTeX, and even markdown) will autowrap newlines so that a sentence broken up into clauses on multiple lines will properly wrap back into a proper looking single line when printed. Take care that in many Markdown versions adding two spaces at the end of a line will automatically create a newline in your text.

Fascinating to think that Damion Searls edited this edition of Thoreau's journals almost as if they were his (Searls') own commonplace book of Thoreau's journals themselves.

Very meta!

https://riverside.fm/magic-editor

Jerry Michalski mentioned using this recording/editing tool as a means of having something that looked "different" than the traditional Zoom, Meet, etc. products.

I love this! It is similar to Prezi or VoiceThread.

Do you also support collaborative editing (public or with invited collaborators)? If yes, a high-resolution world map could be used for collaborative pinning of local events, meetups, news, videos, and so on, such as radio.garden or YouTube Geofind.

Changing the order in which you do things. —Brian Eno, Oblique Strategies

This sounds like the sort of shift Walter Murch made in his sound editing by doing his first cut completely without sound. If you can't tell the story visually without sound the whole thing will fall apart. But you can use the sound, music, etc. to supplement, gild, and improve a picture.

https://web.archive.org/web/20161201164608/http://www.theparisreview.org/interviews/6286/adam-phillips-the-art-of-nonfiction-no-7-adam-phillips

Another example to link to: https://hypothes.is/a/yEFMHoCkEeyl34fItJe__w

Film making is like note taking

Incidentally, one should note that the video is made up of snippets over time and then edited together at some later date. Specifically, these snippets are much like regularly taken notes which can then be later used (and even re-used--some could easily appear in other videos) to put together some larger project, namely this compilation video of his process. Pointing out this parallel between note taking and movie/videomaking, makes the note taking process much more easily seen, specifically for students. Note taking is usually a quite and solo endeavor done alone, which makes it much harder to show and demonstrate. And when it is demonstrated or modeled, it's usually dreadfully boring and uninteresting to watch compared to seeing it put together and edited as a finished piece. Edits in a film are visually obvious while the edits in written text, even when done poorly, are invisible.

Over simplification

What's a better way to format this?

Repetitive

What is the point of this? Is it clearly reflected?

Remove

https://screencast-o-matic.com/

Recommended by Greg McVerry

http://johannadaniel.fr/isidoreganesh/2015/06/archives-roland-barthes/

Hypothes.is & 📒ShrewdNotes Web Page Annotation

I'm blogging about how I'm using Hypothes.is as a starting point for documentation about 📒ShrewdNotes Web Page Annotation. Because I'm learning how to organize efficient workflows with 📒ShrewdNotes. Then I can be certain that my documentation is accurate for when I get more people involved.

So these are practical notes that guide me. In order to become reference material for anonymous learners, followers, subscribers, and members. Also, these notes can become a framework for Hypothes.is-style 📒ShrewdNotes that I can adapt for Sciwheel and other annotation services.

Hypothes.is Groups and Tags

I use Hypothes.is Groups as follows: * Public Group for Anonymous Learners. * 🗃ShrewdSubjects Groups. * My Private Group.

Public Group for Anonymous Learners

I make most of my Hypothes.is 📒ShrewdNotes in public. Mainly on my own websites. But increasingly whenever I find anything useful or interesting. Especially where I find good content relating to one of my 🗃ShrewdSubjects. So anyone can follow my Public 📒ShrewdNotes.

To recognize 🗃ShrewdSubjects, I use Hypothes.is Tags. Currently, these are Food, Gout, and Learning. Where Learning includes any topic not covered by the other subjects. In this way, as I recognize new subjects, I will separate them from Shrewd Learning.

Note that Public annotations for my subject tags include notes from all Hypothes.is users. So, tags are a great way to collect notes by everyone who is interested in a topic. Also, you can mix and match User, Group, and Tag searches. As well as using free-format search.

Additionally, I've started using Hypothes.is Tags to help me organize my workflows. Currently, I use 4, but I may extend this as I incorporate annotation into my daily life. My current 4 tags are: * New - denotes new content that I'm preparing. * Change - denotes changes I plan to make. * editing - means that I've saved the note that I'm currently working on. Or that I've forgotten to delete my editing tag! I use this to avoid losing text as I'm writing it, as Hypothes.is does not have autosave. Though there are ways round that. * BuildInPublic - read more at #BuildInPublic.

🗃ShrewdSubjects Groups

Though I like to BuildInPublic, I also like to collaborate. Now, collaboration is possible using public annotation. But I'm trying to create services built around teams. So I've created private groups for each 🗃ShrewdSubject.

Currently, joining these private Hypothes.is groups starts by subscribing to one or more newsletters: * Foodary Nexus Newsletter * GoutPal Links Newsletter * Shrewd Learning Newsletter

My Private Web Annotation Group

I try to do most of my content creation in public. Or in teams. So I only currently have one group for private notes. But Hypothes.is allows you to create as many private groups as you need. Which is useful where you want to keep notes separate. However, I recommend using tags unless you are sure you want separate groups of notes.

Halstead, I., Lewis, G., & McKay, R. (2021). Opposition to Novel Biotechnologies: Testing An Omission Bias Account. PsyArXiv. https://doi.org/10.31234/osf.io/4ef7m

Lightroom, Luminar AI, and ON1 Photo RAW were mentioned in the list. These are RAW editors used before Photoshop. The shot is then brought into Photoshop (or another editor) for local modifications. Lightroom and Photoshop are used. Thanks!

Whether I'm doing a design in Photoshop or not, I always find it helpful to have another option for altering my photos, and I've found one that's both easy to use and powerful. In place of Photoshop, Photopea is a great option. This online picture editor is free; however, it offers almost all of Photoshop's features. Take a quick look at the following

Ersetze mit "wie"

Würde ich wegen Dopplung im folgenden Satz hier streichen

Komma fehlt: "modellieren, prägt"

Ersetzen mit "also"

https://every.to/letter

A manifesto about what the Every platform is all about. They're trying to create a new(?) economic model for writers working together.

I'm not really sure how this is dramatically different from prior efforts or if the economic incentives are actually properly aligned here. Many writers without critically looking at the whole may be led here as much by marketing hype as anything else. It almost sounds like they're recreating The Huffington Post, but giving away some of the value up front instead of leaving all the value in one person's hand for a future sale.

Who owns the copyright of the created works? Are editors and proofreaders just work for hire here? What about their interests?

I'm reminded of how Academy Award winning film editor Walter Murch once told me that his first edit of a feature film was always done without any sound at all. If the motions and actions of the actors could communicate as much meaning as possible, then the spoken words would only help to supplement the storytelling.

https://www.kapwing.com/settings/account

Set up using my gmail account.

How to record and edit audio in Ableton Live

Professional photographers who want to save time and benefit from picture editing services can consider my experience with the top image editing business in the United Kingdom that adheres to all current digital photography standards.

I am constantly involved in their service, continually monitoring, counting the beautiful opinions of the clients who continue to evaluate the quality of the final product. So dig my post to find out what services can help you get perfectly edited images!

what an aphorism for our time!

In a version similar to a footnote, a line and a dot were first used much as we use the carot symbol (^) today for editing to indicate the insertion of a missing line.

Facet.ai, an AI-based image editing software

[[John McPhee]] has a passage in Draft No. 4 (The New Yorker, 2013-04-22) which describes some of their editorial process which mirrors some of this sort of work and conversation about writing.

Teaching writing...

having more eyes is better

This is an untested statement and does not take into account the perspectives of those contributing to the publishers' revenue. The Rights Retention Strategy (RRS) relies on the author's accepted manuscript (AAM) and for an AAM to exist and to have the added value from peer-review a Version of Record (VoR) must exist. Libraries recognise this fundamental principle and continue to subscribe to individual journals of merit and support lucrative deals with publishers. From some (not all) librarians' and possibly funders' perspectives these statements could undermine any mutual respect.

just for the sciences? Or do you mean, "For instance, as we're building a course for the sciences,"....

"These exercises and activities are designed to support growth..." then.. "They can be used by groups of any number number of team members working in higher education." Shorter sentences better.

do these need to be capped?

this is a suuuuper long sentence and there are a number of ideas in it. Suggest breaking it down.

let, i think. right?

"can" or "should" work together, yes?

"flow" doesn't seem to be directly counterintuitive to cognitive, uh, whelm. Like, they're not mutually exclusive.

...want to see a student absorb. (we don't so much "learn" information as we take it in.)

...larger university community, and includes the university's library, accessibility..."

Efficiency sounds too exciting to not try!

I'd like to strike a blow for line editing. From Peter Ginna's brilliant What Editors Do:

A line edit dials down to the paragraph/sentence/word level. As we said, it’s usually a much more expensive job than a developmental edit. A line editor will go through the pages of your book with a fine-toothed comb, looking for dialogue that feels awkward, sentences that don’t quite work, repetition, and more. Obviously this happens when the bulk of the work in terms of plot, character, beginnings, middles, and ends is done. It’s not that a line edit can’t address the bigger picture. But in most publishing houses an editor simply won’t do a line edit until the bigger issues are addressed, so as not to have to do the same work twice. It’s smart to stick with that order in self-publishing too. Line edits may or may not come with an editorial letter. But be sure that the fee includes time for you to meet in person or talk on the phone once you’ve had a chance to digest the edits. Often the same person could do both a developmental edit and line edit, if that’s what you decide to pay for, but you will also need a copyeditor. Copyeditors are the grammarians, the fact-checkers, the formatting gurus, the identifiers of repetitive words and phrases. They are the ones who make a book as smooth as a fresh jar of Skippy. The one instance where you might not need a separate copyeditor is if you hire someone to do a line edit who does a copyedit simultaneously. Some people have both skills and can pull this off, though it’s rare.

Chris Chambers & David Mellor with the Center for Open Science - Registered Reports Q&A Video

change video height and width,

So if you want to utilize this new model of photo sharing/chatting app for your app, and want to know how to make an app like Snapchat, you can ready more here.

We have top class designers who is expert on graphics design. We provide clipping path. background remove, image retouching service. We are also expert on eCommerce photo editing.

Because that's always a good idea...

https://en.wikipedia.org/wiki/Jurassic_World

0.1% is still a lot from a theraputic standpoint!

This editor chose to keep the manuscript reading "Beowulf"; the editors of Klaeber 4 emended to "Beow." In their Commentary on line 18f (page 113), they note that "Beow" fits the meter in "Beowulf"'s second appearance at 53, and that traditional genealogies provide the name "Beow." However, I prefer the choice (as does Liuzza in his translation): whether poet or scribe, someone has made the name match that of the poem's protagonist. An earlier hero foreshadows a later.

Here and at 1, "Hwæt.", the edition uses periods instead of commas. Many editions and translations use exclamation points at one or both places, which changes the tone. Eric Weiskott notes that the exclamation point was hundreds of years in the future when the manuscript was written: “Making Beowulf Scream: Exclamation and the Punctuation of Old English Poetry,” Journal of English and Germanic Philology 111.1 (2012), 25–41. DOI: 10.5406/jenglgermphil.111.1.0025

"I have, in the following little volume, collected a few of these, the Love-Songs of a single province merely, which I either took down in each county of Connacht from the lips of the Irish-speaking peasantry - a class which is disappearing with most alarming rapidity - or extracted from MSS, in my own possession, or from some lent to me, made by different scribes during this century, or which I came upon while examining the piles of modern manuscript Gaelic literature that have found their last resting-place on the shelves of the Royal Irish Academy." (iv)

The way Hyde makes reference to sources is casual and non-specific. It would be difficult for a reader to access his sources. Because we have such little insight, it is important to be alert to potential biases in the collecting and editing process.

If we can identify consistencies among the anthologized songs in terms of their depiction of love and lovers, and/or among songs which are excluded from the anthology, we will have reason to regard the very partial disclosure of sources with suspicion.

As I have already noted, part of Hyde’s project is to bring the reader into contact with language which has an ‘unbounded’ power to excite the Irish Muse. Perhaps part of the way he contrives this encounter is to control the kind of subject matter that will appear to the reader as that which occurs most naturally in the Irish language.

We have manually analyzed our customer reviews, in-depth interviews and on-site analytics to understand what are the customers need and how to give that to them.

Not clear what this means?

Uh, this is a very uncomfortable sentence. There are two possibilities, here, regarding the function of this sentence. 1) The Technically True but Terribly Vague: This is a category of opening sentence that is grammatically and intellectually fine, but also very boring. It's a cousin of "since the dawn of time," and I don't let my Rhetoric students use either type of opening line, as they are both lazy rhetoric. However, the second possibility is much more troubling: 2) This also sounds a lot like the extremely racist "black people can be very articulate."

I know we are to the point of just beating the crap out of the editors, now, but come on. This could have been easily avoided.

Who was in charge of this notation??? Was there an audience response? Would it not have been just as effective to start a new paragraph?

Why would the odds be in his favor if there will be more men than women? Sounds more like the deck stacked against him.

This part isn't clear to me; I felt a little confused.

Two questions to help clarify the meaning (briefly) :

1. What sorts of choices?
2. How are they progressing?

If, by adding one or two words (or very short phrases), you can specify those two things (or both in the same shot), I think that would improve the readability for me dramatically.

I would love a source article (or video) linked here, for me to read/watch -- sounds very amusing!!

I felt a little (slightly) uncomfortable reading this -- my brain evaluates it as a bit snarky or know-it-all-ish.

I think I would take it more sincerely, and feel more... deep appreciation, and gratitude & resonance for the message, if the word "hint" were removed (or it were otherwise rephrased or reframed).

While I (as a reader who likes to think of himself as intelligent and well-informed, as I think many of us do) know that recycling isn't the answer..., it's not clear to me whether the writer (and I read, think of, and receive this article as an anonymous / arbitrary speaker; not as you, Aaron, personally) knows & trust that me, his audience, knows this.

So having some sense the person directing their message at me /trusts/ me to some degree is really important for me to feel resonance with, and trust and confidence in, the article.

[this annotation is actually for the above green bar, stating: "The Oil Industry Is Certainly Willing to 'Win Ugly'"]

It was not clear to me that that green bar with text contained a link -- I only discovered it by accident, when I moused-over it, and noticed the cursor changed to a hand. I'm not sure how to make this more apparent -- maybe add "(article here: {URL})" or somesuch?

re: The photo on the right: (Sorry, I couldn't figure out how to highlight the picture, so I'm adding the annotation here.)

I think it would be useful to add a caption (below the photo, in small / italic) describing what the photo is (e.g., "Dr. Frank Mitloehner, on his farm in...")

ouch.

Reading this at the beginning, I felt a bit like I was being hit over the head with a bludgeon (not in a good way).

My reaction: "He's attacking me! Why is he targeting me? I'm even on the same side as him!"

Since I'm assuming (hoping?) your target audience is folks who already are confident that human industrialization has caused climate change...

.... consider moving this caption to after the introductory paragraph (so I, reading this, know that you're not attacking nor targeting me as a reader -- but rather, I think your point is, talking about those other people who are part of the challenge that we (as readers, in this together) are facing).

Does that any sense?

Another possibility:

Consider adding a header before this paragraph, along the lines of: "The Psychology of Climate Change" [optionally add: "in the US / America," if you like]

That will give folks some heads-up as to where the next bit is coming from; prepares the audience a bit.

[see also thoughts in previous annotation on "both"]

I like the first part -- "I welcome you to join me in this exploration."

Reading the latter, it seems to me somewhat prescriptive (what I should do), which I think is less effective (doesn't meet my need for autonomy / self-determination).

One possibility, which (for me) would read very well and nicely, is to eliminate the rest of the sentence altogether (principle of "less is more").

Another possibility: I'm wondering how this can be rephrased or reframed, such that it is truly an unattached invitation, rather than (how it seems to me) a moral recommendation.

Consider removing the underline on "both." I think this may read better (and possibly be more influential) without it -- my sense is that with the underline, I receive it as more prescriptive (what one should do), whereas without, I imagine it would feel less prescriptive & more descriptive (making an observation, not recommending action). .... Side note: Dale Carnegie's research seems to indicate, "Let people think it's their idea" (when choosing an action or decision) is a more effective approach in 'conversion.'

My thoughts: This seems a little out-of-the-blue. Two points: One, the transition for me as a reader was (slightly) abrupt; and two, my inner skeptic says, "Really? You just suddenly woke up one day and realized this?" It begs the question of "How did this occur to you?", and leaves a little to be desired (for me at least). Some context, e.g. hearing friends/community talk about this, learning more, etc., may be of use for the reader here. I'm wondering whether telling a (brief) story or anecdote (maybe 1 to 3 paragraphs?) about how this occurred to you in the first place (or whether you'd thought about it for a while, etc.), may be worthwhile.

The Center for Plain Language is a non-profit organization that promotes clear communication in government and business.

"A communication is in plain language if its wording, structure, and design are so clear that the intended readers can readily find what they need, understand it, and use it."

Plain language checklist<br> https://twitter.com/plain_language

Megan Cossey<br> Tips for fact checking your writing:<br> * Verify every fact, no matter how insignificant.<br> * Find out which sources are regarded the most highly in the field you are writing about.<br> * If you can't verify it, delete it.

• When it involves a person, email them the facts in question, and ask them whether they are correct.
• Don't rely on Wikipedia articles alone, but the references used there may help.
• http://www.census.gov
• CIA World Factbook
• UNDP Human Development Indicators<br> Rankings of countries by various statistics.
• UN maps
• US Securities and Exchange Commission<br> Form 10K, audited annual reports of public companies. Publicly traded companies will also have an annual report to shareholders on their site.
• http://www.forbes.com/largest-private-companies/<br> Forbes does research on private companies.
• http://www.politifact.com/<br> Fact checking of political news.
• http://quoteinvestigator.com/<br> Blog that traces the origins of quotations.
• http://snopes.com<br> Internet rumors, photos, urban legends and such.