Over the past 25 years the pace of progress in neuroscience research has been extraordinary, with advances in both understanding and technology. We might expect that this would stimulate improved understanding and treatment of mental health problems, yet in general this has not been the case. In fact, our standard treatment approaches have barely changed in decades, and still fail many people suffering from mental distress.

legal uncertainty interferes with the productive reuse of research data.

We often speak of refereeing as something that has been a stable and unchanging part of science ever since the age of Isaac Newton, but peer review’s story is both shorter and more complex than we often assume. It is also littered with criticism. As early as 1845, the scientific referee was described as “full of envy, hatred, malice, and all uncharitableness.”33. A. Csiszar, Nature 532, 306 (2016). https://doi.org/10.1038/532306a Complaints about reviewer uselessness and bias, in other words, are hardly new.

o staunch a flood of “veritable sewage thrown into the pure stream of science,” as physiologist and Member of Parliament Michael Foster put it

had sent you our manuscript for publication and had not authorized you to show it to specialists before it is printed. I see no reason to address the—in any case erroneous—comments of your anonymous expert. On the basis of this incident I prefer to publish the paper elsewhere.

I hate the narrative of the Semantic Web because the focus has been on the wrong set of things for a long time. That community, who I have been consciously distancing myself from for a few years now, is schizophrenic in its direction. Precious time is spent in groups discussing how we can query all this Big Data that is sure to be published via RDF instead of figuring out a way of making it easy to publish that data on the Web by leveraging common practices in use today. Too much time is spent assuming a future that’s not going to unfold in the way that we expect it to. That’s not to say that TURTLE, SPARQL, and Quad stores don’t have their place, but I always struggle to point to a typical startup that has decided to base their product line on that technology (versus ones that choose MongoDB and JSON on a regular basis). I like JSON-LD because it’s based on technology that most web developers use today. It helps people solve interesting distributed problems without buying into any grand vision. It helps you get to the “adjacent possible” instead of having to wait for a mirage to solidify.

“Academics are incentivised to produce research that caters to these demands,” said the biologist and Nobel laureate Sydney Brenner in a 2014 interview, calling the system “corrupt.”

“bizarre” “triple-pay” system,

‘Umar Mukhtar who refused to kill Italian POW’s declaring to his men, “They are not our teachers.”

`Umar himself, may Allah be pleased with him, used to whip his foot at night and say to himself: "Tell me, what have you done today?!"

Until now, maintaining the availability of scientific contributions has been decentralized, mature and effective, utilizing methods developed over centuries to archive the books and journals in which they were communicated.

Common to all these is the idea of building infrastructure based on rich metadata for the resources in the research environment, that support their optimal re-use.

“By essentially endorsing Duterte’s murderous war on drugs, Trump is now morally complicit in future killings,” said John Sifton, the Asia advocacy director of Human Rights Watch. “Although the traits of his personality likely make it impossible, Trump should be ashamed of himself.”

We should’ve known that dragon blood would have healing properties. Rubeus Hagrid used it on his injuries after being attacked by giants, after all.

Angry as hell

no one country alone can afford to effectively monitor the entire Earth

Progressive values demand empathy for the poor and this often manifests as hatred for the rich.

I’m realizing more and more how desperately this perspective is needed as I watch researchers and advocates, politicians and everyday people judge others from their vantage point without taking a moment to understand why a particular logic might unfold.

The potential of BBD is hindered (similar to that of money) when it accumulates, but does not flow.

It is the unifying space in which genes, neural structure, neural function, body plan, physical constraints and environmental effects converge.

I have time; it is a priority.

”Things can be taught inside of history, not before time, but in time, on time.” (p.222)

Neal and Rick find that in 2010, black men earned about 75 cents for every dollar white men out of prison made.

According to Census data from 2014, there are more young black high school dropouts in prison than have jobs.

Black men are imprisoned at six times the rate of white men.

Cen-sorship became a productive force, re-channeling the censored material symp-tomatically across the text in a nascent, uncrystalized form (Foucault 4–11).

Woody was meant to be a sorry specimen—“a slob in a cowboy hat, bleary of eye and dark of jowl” (Lane 86).15

3Important scholarly work in studies of contemporary censorship has gone to the “stigma of the X rating” (Sandler, Lewis)

As Ju-dith Halberstam has noted, Pixar films are also doing curious cultural work, in their “preoccupation with revolt, change, cooperation, and transforma-tion” (Halberstam 79).

Although on the surface Pixar’s Toy Story (Dir. John Lasseter, 1995) and WALL-E (Dir. Andrew Stanton, 2008) are “innocent” animated film about ob-jects, their value as cinema lies in their ability to complexly address human—and sometimes wholly adult—fears about meaninglessness, apocalypse, and oblivion.

As Ju-dith Halberstam has noted, Pixar films are also doing curious cultural work, in their “preoccupation with revolt, change, cooperation, and transforma-tion” (Halberstam 79)

“The visual and nar-rative incoherence that often arose from the effacement and displacement of sen-sitive subjects encouraged audiences to become active interpreters, obliging them to make their own sense of contra-dictory evidence” (Vasey 127–28).

If “veiling something from sight turns out [as it did] to inspire as signifi-cant an erotic reaction as the unveiled event would have done...If the film screen works like a kind of censoring, elaborating the effect of what it covers, how will you censor that?” (Cavell 83)

making strange,” as Brecht would have it, allows the paren-tal viewer to process these narratives as an “other,” “unintended” audience and thus relieves them of the burden of full-frontal spectatorship (Brecht 93).

“Why prolong the inevi-table? We are all one stitch from here [the shelf] to there [the yard sale].”

:

"Here is the land of opportunity -- money and success," Mr. Guarnizo said. "But social life is also important to Dominicans. They talk a lot, sharing, hanging out with friends. Here they work so hard they have to give a lot of that up. They have to strengthen their culture here to keep going in a society that appears hostile. They love their country. They recreate Dominicanness here."

wenty years ago, her mother started cooking a Dominican stew called sancocho for neighborhood customers.

The Dominicans, redefining the nature of "Hispanic" in a city where the word has long been synonymous with "Puerto Rican,"

All immigrants live suspended between two worlds, the old country and the new. The Dominicans just do so more than most. They may complain incessantly about how bad things are at home -- the incompetent bureaucracy, the daily blackouts, the steep price of everything from plantains to sugar, but they talk just as much of returning. Home is a three-hour flight and a $489 round-trip ticket away.

However, there has been surprisingly little research exploring the actual use of primary healthcare services around the time of hospitalisation, which requires linkage of primary care and hospital data for individuals.

la justice est un profit pour qui ne la possède pas, un mal pour qui la possède

At the heart of the interpretative rift is the question of unknown motivations. Citation is not a transparent activity: the process is not amenable to scrutiny.

A proper (pluralistic) explanation of what citation entails may mean that we accept aspects of both (or all) perspectives. It may, therefore, be counterproductive to think in terms of ‘competing’ theories or perspectives.

the micro- sociological view is that citations do not exist in uacuo, and that a proper comprehension of the citation phenom- enon and its surface manifestations will only be achieved by moving the critical gaze from the formal communi- cation mechanisms (the superstructure) to the social reality (the infrastructure) which supports the primary communications system.

Support for these findings came from Hagstrom (1971), who correlated citation counts with such variables as quality of graduate faculty and grants awarded to departments.

Metaphorically speaking, citations are frozen footprints on the landscape of scholarly achievement; footprints which bear witness to the passage of ideas. From footprints it is possible to deduce direction; from the configuration and depth of the imprints it should be possible to construct a picture of those who have passed by, whilst the distribution and variety furnish clues as to whether the advance was orderly and purposive.

it is mildly ironic that science, founded on traditions of quanti- fication and verification, should be content with an explanation of citation, an activity central to the scientific process, which emits a whiff of the meta- physical.

It is quite conceivable that citation would not have emerged as a serious ‘academic’ issue for sociologists and historians of science had not the commercial develop- ment of citation indexing proved so successful (Garfield, 1979; Hall, 1970; Narin, 1976)*

Anecdotal evidence seems to favour the idea that many authors cite in reflexive fashion, without necess- arily dwelling on the implications of the practice.

You will need forty hours a week to perform teaching and administrative duties, another twenty hours on top of that to conduct respectable research, and still another twenty hours to accomplish really important research.... Make an important discovery, and you are a successful scientist in the true, elitist sense in a profession where elitism is practiced without shame.... Fail to discover, and you are little or nothing.

Vannevar Bush’s beautiful lie makes it easy to believe that scientific imagination gives birth to technological progress, when in reality technology sets the agenda for science, guiding it in its most productive directions and providing continual tests of its validity, progress, and value. Absent their real-world validation through technology, scientific truths would be mere abstractions.

By honest I don't mean that you only tell what's true. But you make clear the entire situation. You make clear all the information that is required for somebody else who is intelligent to make up their mind.Richard Feynman

I don't require you to fall in love with my boy, but I do think you might try and understand him.

And to Eisen, the idea that research is filtered into branded journals before it is published is not a feature but a bug: a wasteful hangover from the days of print.

Scientists are humanand will therefore respond (consciously or unconsciously) to incentives; when per-sonal success (e.g., promotion) is associated with the quality and (critically) thequantityof publications produced, it makes more sense to use finite resources togenerate as many publications as possible (p. 1037, emphasis in original). Sec-ond, researchers may be trying to do their best, but selection processes rewardmisunderstandings and poor methods.

n the Eternal there is no Time, or Space, or Individuality,

The body you perceive has no meaning. The body you have created as a result of fear and guilt has no meaning. That definition has been overlaid upon something that does: The visibility and tangibility of your individuality. And your individuality is the Presence of God expressed and expressing interminably eternally.

All the mutually agreed upon definitions have as their purpose: to protect and maintain the ongoing ignorance of your divinity, by preoccupying you with your independent status and its improvement with the promise that you can become a presence of excellence without a Source.

But the point is, that you are not a body and any successful use you put it to that convinces you that it is foolish to abandon the body as your vantage point, that must be overcome! You must arrive at a place where you’re willing to abandon that, even if it’s only for the sake of experiment, to see whether what I’m saying is true or not.

Thus, the story of DNA, like a Charles Dickens novel, came out in installments. F

“If you change the way you look at things, the things that you look at change.” Max Planck

As science itself becomes a body of data that we can analyze and study, thereare staggeringly large opportunities for improving the accuracy and validity of science, through thescientic study of data analysis

“If I wanted to do it for the compensation, I would be better off using that time to flip burgers or go wash windows.”

I know. The ego suggests that that is a nice escape from dealing with what needs to be dealt with. It says, “Come back. You have a few loose ends to take care of.” But, as I have said before, your income, your abundance, comes from being Centered. I did not say it comes from taking care of loose ends which are perceived from uncenteredness. Now, we are talking about being Centered with a fuller meaning of Centeredness. Centeredness really means at-Homeness. It really means the conscious comprehension of the experience of being at Home, which now our communications are substantiating.

was a platinum fob chain simple and chaste in design, properly proclaiming its value by substance alone and not by meretricious ornamentation--as all good things should do.

It’s easier to be cynical;

Here’s what the Finns, who don’t begin formal reading instruction until around age 7, have to say about preparing preschoolers to read: “The basis for the beginnings of literacy is that children have heard and listened … They have spoken and been spoken to, people have discussed [things] with them … They have asked questions and received answers.”

The world you walk through is the Mind that you Are.

RAJ: Whenever you are faced with a demand to give specific attention to some part of your infinitude and it presents itself as being “problematic,” it is simply the time and place for this aspect of You to be consciously incorporated into and as your conscious experience of being as Yours! You say you don’t want to be bothered, that this is not a good time because of other more pressing demands. But, Paul, your Being unfolds Itself as You according to divine Intelligence, Universal order and priorities. Every problem is your opportunity to be the Christ—that accurate perception of Reality (Your Being) that is not deluded in any way—and for that perception to become irrevocably “incorporated” into and as your Self-awareness. There is no more pressing need than that, because when seen, it becomes apparent that pressing needs are illusions of the partial view. They never existed as anything for you to sweat over and tense yourself up about.

RAJ: I think you can see that unfoldment is really a matter of how quickly or slowly we are willing to let go of limitations, rather than the presence or availability of something to expand into, since Infinity is the Actuality of every moment of conscious experience. This is important to understand, because we often feel that we are held back by the limitation as though it had the ability to influence or deprive us of our Good. Not true! There is never anything holding us!

It is quite accurate that it is not possible for those who believe that they have been born to communicate with those who believe that they have died. These are two different states of the three-dimensional-only frame of reference. It is part of the distortion of that finite view which makes it seem as though some part of one’s infinitude (those who have “passed on”) is not available to him as his conscious experience. There are infinitely more individualizations of Being who are Awake than there are those who are “asleep.” it is ridiculous to believe that communication with them is impossible.

And instead of a nice dish of minnows—they had a roasted grasshopper with lady-bird sauce; which frogs consider a beautiful treat; but I think it must have been nasty!

I looked, and could see a tiny flutter in the doorway, but a quicker signal had made its way from the heart on shore to the heart on the sea.

I got into bed. I said some words to the close and holy darkness, and then I slept.

Darkness is cheap, and Scrooge liked it

Say ‘Merry Christmas!’ Jim, and let’s be happy.

RAJ: I know you feel like you need help, but no one can help you at this point. There is no other One but You, and you had better be sure that you have no other “ones” before You, You Self, God. Your entire Being, in all Its infinitude, is harmonizing with You, loving You, and supporting You because of the Integrity of your Being. No one but You can relinquish consciously your hold on the false sense of self—the misidentification which feels it can’t do it.

RAJ: Don’t add that “but.” Stay with the simple Fact you have just stated. The “but” is the hooker! “All is infinite Mind and Its infinite manifestation.“1 There aren’t any “buts” about it! Being is “neither behind the point of perfection nor advancing towards it. It is at that point and must be understand therefrom.“2 It will never be understood from the standpoint of the three-dimensional frame of awareness (ego). You must stop looking for clues, helpful hints, or reassurances objectively. Being doesn’t need them, and “ego” only needs them in order to hook you. Remember, as you “do battle,” that there is no battle going on at all. It is a process by which you are becoming less slipshod in your self-identification. It seems as though it is an attempt to influence you in the direction of misidentification, but you are at a point where the thrust truly cannot reach you because you are hidden in the Secret Place of the Most High. You have experienced It.

You see, Paul, whether you have misidentified your Self as “ego,” or whether you have correctly identified yourSelf as Fourth-dimensional Man, your Being has effortlessly been being Itself totally, perfectly, and successfully by being rather than “doing.” Anything ego has thought it has done was pure nonsense.

Your focal point must remain at that within Point wherein you are constantly aware of being as Conscious Being, not as the operator of a business, or the promoter of a service. You must let the business and the service be what they will, as the ever-fluid manifestation of that living Being which You Are. Do not let what “occurs” become the repository of yourself. This is because Your Self, being infinite, cannot be confined to any manifestation or visibility which It evolves for Its identification. Yes, in your terms, it would mean a dispassionate, uninvolved experience of what is appearing. You must learn to get your satisfaction from being What You Are as Conscious Being, rather than what you appear to be by virtue of what is done three-dimensionally.

It is always us that is holding onto some comfortable sense of limitation with which we feel some sense of familiarity. The active agent which holds us back is actually our own refusal to let go of the known for the Unknown. This reluctance is entirely due to an adopted belief that we are what we appear to be—finite, separate, an independent “intelligence” that exists “inside” this finite object called a body, a potential victim of an unpredictable environment. Yet, the finiteness, separateness, independence, and unpredictability are entirely inherent in the partial view of the Actual conscious experience of Being which is going on. If it weren’t going on, there couldn’t be a misinterpretation or misidentification!

RAJ: It is because the time has come to stop manipulating the finite view to improve it according to finite concepts. This does not constitute waking up out of the dream or waking up out of the distortions of the partial view. If you succeed in improving the partial view—in “healing it”—you will find no necessity to involve yourself in the labors necessary to Awaken

I can say, “Be patient, everything will be alright,” but that will not help you unless you believe it. No one can truly convince you of the Reality of Your Being. It’s already the Fact of You, and you are having to live this “time” out from that Fact.

PAUL: Raj, I am failing miserably at demonstrating or seeing the omnipresence of my Being in terms of supply. It’s true that from day to day we have what we need, but it’s far from a comfortable way to live. All we’re getting are basics. The larger debts we owe are not being met. RAJ: Paul, I want you to be aware that you are beginning to give up your faith, trust, and belief in the validity of our conversations. This is indicated by the flip-flopping back and forth between knowing they are real and doubting they are real. I point out also that the doubting comes into play when you are challenged by opinions or circumstances. This certainly is a natural response, but it is not the consistent vantage point which you will find necessary if you’re going to be free from being dangled like a yo-yo or blown to and fro on the breeze of chance. PAUL: Well, if you are wanting me to develop some inner strength which will not yield, no matter what I’m confronted with—and if I’m supposed to do this while it’s my family’s lack that I’m faced with—then I don’t think you should be surprised! Theoretically, intellectually, I can grasp its value. But when it comes down to the nitty-gritty of life, it often seems like nonsense. RAJ: I understand, Paul. I want to refer you to what your Supply told you about how to set the Law in motion. I want you to begin doing this on a regular basis. A word to the wise: Be sure of what you are asking for, because you shall surely get it. PAUL: Alright, Raj. I shall forge forward. I will tell you this: It would be much easier if my family’s needs were being better met.

You are afraid that if you let go and stop “doing,” everything will fall apart. This is because you are still caught in the belief that what you have “done” in the past has succeeded in getting you where you are. This is foolishness, and you are beginning to see this. You haven’t gotten anywhere, because Infinity has no place to go. Nevertheless, Infinity—your Being—has unfolded Itself in spite of what you thought you were “doing,” and where you thought you were getting to.

You have been concerned in the last few days that you are not making the connection between what I have been discussing with you and your daily experience. The simple fact is that you have been trying to relate infinite ideas to finite beliefs. There is no connection. There is no connection between Mind and Its manifestation. They are one. It is only from the standpoint of ego—of finite, three-dimensional misperception—that there can seem to be a “connection.” Since ego separates itself from what it sees, it divides things into subject and object, “in here” and “out there,” me and thee, and all the rest of the dualism. This prompts the attempt to manipulate all of these disconnected aspects, so that they will harmonize in such a way as to not destroy the basic illusion of the existence of “ego.” Thus, from the three-dimensional standpoint, it seems obvious that the misidentification of Identity called “ego” must become, do, initiate, manipulate, and achieve. One cannot bring these endeavors into that Place where Self is properly identified and experienced as Conscious Being or Fourth-dimensional Man, since the basic illusion of separateness has no existence there.

If you try to deal with the way things appear, if you pay attention to what the five physical senses are telling you, you will scare yourself shitless.

And better understanding them means we can skillfully stimulate the neural substrates of those states—which, in turn, means we can strengthen them. Because as the famous saying by the Canadian scientist Donald Hebb goes, “Neurons that fire together, wire together.”

But itis not theproper role ofthe University to attempt to shield individuals from ideasand opinionsthey find unwelcome, disagreeable, or even deeply offensive. Although theUniversity greatly values civility, and althoughall members of the University community share in the responsibilityformaintaininga climate of mutual respect, concerns about civility and mutual respect can never be used as a justification for closing off discussion of ideas, however offensive or disagreeable those ideas may be to some members of ourcommunity.

t “education should not be intended to make people comfortable, it is meant to make them thin

omething strange is happening at America’s colleges and universities.

But students should also be taught how to live in a world full of potential offenses.

“The presumption that students need to be protected rather than challenged in a classroom is at once infantilizing and anti-intellectual.”

vindictive protectiveness

Even compassion, the concern we feel for another being’s welfare, has been treated with downright derision. Kant saw it as a weak and misguided sentiment: “Such benevolence is called soft-heartedness and should not occur at all among human beings,” he said of compassion. Many question whether true compassion exists at all—or whether it is inherently motivated by self-interest.

a simpletraining exercise where you practice loving kindness, where you’re just thinking compassionatethoughts towards others and towards yourself over time, actually pretty dramatically increasesyour own personal happiness, suggesting that the Dalai Lama was on to something when hesaidthat compassion is the pathway to happiness.

Darwin made the case that sympathy, or compassion, is our strongest instinct. And I’ll quote,because “sympathy will have been increased through natural selection for those communitieswhich included the greatest number of the most sympathetic members would flourish thebest and raise the greatest number of offspring.”

The act of perspective-taking is summed up by one of the most enduring definitions of empathy that we have, formulated by Adam Smith as “changing places in fancy with the sufferer.”

Percy Shelley says is“the great secret of morals is love; or a going out of your own nature and anidentification of ourselves with the beautiful which exists in thought, action,or person, not our own. A man, to be greatly good, must imagine intensely andcomprehensively; he must put himself in the place of another and of many others;the pains and pleasures of his species must become his own. The great instrument ofmoral good is the imagination.”

Despite data heterogeneity, the large size and detailed nature of the dataset enabled data-driven detection of recovery as a graded, emergent pattern defined within the full multivariate syndromic space

Two centuries ago Leibnitz invented a calculating machine which embodied most of the essential features of recent keyboard devices, but it could not then come into use. The economics of the situation were against it: the labor involved in constructing it, before the days of mass production, exceeded the labor to be saved by its use, since all it could accomplish could be duplicated by sufficient use of pencil and paper. Moreover, it would have been subject to frequent breakdown, so that it could not have been depended upon; for at that time and long after, complexity and unreliability were synonymous.

For the biologists, and particularly for the medical scientists, there can be little indecision, for their war has hardly required them to leave the old paths

“The cat is out of the bag. The content people have no clue. I mean, no clue.” - Bram Cohen

As I did 20 years ago, I still fervently believe that the only way to make software secure, reliable, and fast is to make it small. Fight Features.

Civic education cannot be just a matter of teaching and persuading young people to participate in the existing system; it must acknowledge deep-seated and understandable critiques of politics.

Much like a Unix power user will compose multiple single-purpose tools into a complex piped command, a functional programmer will combine single-purpose function invocations into chains of operations (think Map/Reduce).

But this is the one that I want to get you: If you can bear to hear the truth you ’ve spoken Twisted by knaves to make a trap for fools, What it’s saying is: you say something that you think it’s true, and somebody out there takes what you’ve said and then twists it to trap somebody else who either admires you or doesn’t like you. What is said in the poem I didn’t understand, but being in the software free community I’ve really seen that. We work really hard to find the truth: what’s important, what will work, how can we move forward.

As Park says, "We need both kinds: people who can hack the technology, as well as people who can hack the bureaucracy."

the code is a black box, and what they enjoy is the program

Code is the tool. The program is the product.

The men of Normandy had faith that what they were doing was right, faith that they fought for all humanity, faith that a just God would grant them mercy on this beachhead or on the next. It was the deep knowledge -- and pray God we have not lost it -- that there is a profound, moral difference between the use of force for liberation and the use of force for conquest. You were here to liberate, not to conquer, and so you and those others did not doubt your cause. And you were right not to doubt.

Research publication can both communicate and miscommunicate

Consequently, we are reaching out broadly to the research community, scientific publishers, universities, industry, professional organizations, patient-advocacy groups and other stakeholders to take the steps necessary to reset the self-corrective process of scientific inquiry. Journals should be encouraged to devote more space to research conducted in an exemplary manner that reports negative findings, and should make room for papers that correct earlier work.

Science has long been regarded as 'self-correcting', given that it is founded on the replication of earlier work. Over the long term, that principle remains true. In the shorter term, however, the checks and balances that once ensured scientific fidelity have been hobbled. This has compromised the ability of today's researchers to reproduce others' findings.

“Getting the data is much easier than making it useful,” said Deborah Estrin, a professor of computer science and public health at Cornell University.

Good people are leaving academic science, forced out by a lack of money, inequity in decision making, and hypocrisy in career recognition and advancement. Many are tired of playing a game whose rules change before you even know what the rules are.

by a seriously flawed reviewing system

"The margins of manuscripts often contain medieval and early modern reactions to the text, and these can cast light on what our ancestors thought about what they were reading," Williams explained. "The 'Black Book' was particularly heavily annotated before the end of the 16th century."

Today it’s a famous course, but in those days it was a laughable idea, alarmingly American.

…empowerment of individuals is a key part of what makes open source work, since in the end, innovations tend to come from small groups, not from large, structured efforts.

“Great things are not done by impulse, but by a series of small things brought together.” —Vincent van Gogh

some researchers feel that a dangerous precedent is being set. They argue that publishers wrongly characterize text-mining as an activity that requires extra rights to be granted by licence from a copyright holder, and they feel that computational reading should require no more permission than human reading. “The right to read is the right to mine,” says Ross Mounce of the University of Bath, UK, who is using content-mining to construct maps of species’ evolutionary relationships.

”