67 Matching Annotations
  1. Feb 2024
    1. If an activity is both meaningful and engaging, you’re golden, and if it’s neither you’ve got a one-way ticket to dullsville.

      for - boredom - factors - boredom - quote

      quote - boredom - ( see below)

      • If an activity is both meaningful and engaging, you’re golden,
      • and if it’s neither you’ve got a one-way ticket to dullsville.
    2. both factors—a dearth of meaning and a breakdown in attention—play independent and roughly equal roles in boring us.

      for - boredom - factors

    1. Thecalamity of the unexpected surrender, the “bleeding borders” re-drawn in the postwar settlement at Versailles, and the overwhelm-ing chaos of the inflation in the early 1920s were collective experi-ences that made the suffering of the nation more comprehensible.During the Weimar years, the people’s community denoted the be-leaguered condition Germans shared, while expressing the politicalunity necessary for national renewal.
    2. heNazis responded to an intense desire for order in Germany in 1933.Fears of Communist revolutionaries mingled with more generalanxieties about crime and delinquency.
    3. Socialists around the worldhad celebrated May Day as a festival of labor since the 1880s; butin Germany they had failed to get the official recognition the Nazisnow offered. So strong were the hopes for national unity that theGerman Free Trade Unions welcomed the Nazi gesture and encour-aged members to participate in the celebrations.
    4. The state of permanent emer-gency declared by the National Socialists helps explain the tremen-dous efforts that they and their followers made to reconstruct thecollective body and the satisfaction they took in images of unityand solidarity. It also helps explain the violent exclusions they ac-cepted as part of the rebuilding process.
    5. . It was the experience of conversion, which left peoplelike Dürkefälden and Ebermayer isolated, that was new and pro-vided the Third Reich with legitimacy and energy.
    6. “he doesn’t want to take part in any waragain,” Karl reported; “he has had enough.”
    7. the prospect of a new war, a topic Germanfamilies discussed frequently in the years after 1933
    8. The strong presence of the police,who tended to sympathize with the National Socialists, restrictedthe mobility of opponents, while Nazi toughs broke into SocialDemocratic or trade union offices and Nazi officials banned so-cialist newspapers.
    9. the “August Days” of 1914, when thou-sands of Germans rallied in the streets to support the national causein time of war, revealed extraordinary emotional investment in thepromise of national unity.
    10. The enduring popularity of the Nazis rested on the idea of theVolksgemeinschaft, or people’s community.

      volksgemeinschaft - people's community

    11. Germans converted to National Socialism out of fear and for thesake of appearances. Indeed, each diary refers to concentrationcamps, arrests, and other violence. Moreover, pressure to conformto Nazi expectations persisted, a fact that Karl’s father tried topoint out. Like Friedrich Kassler, Germans also converted becausethey were persuaded finally that Nazism represented a “new direc-tion,” which offered opportunities and to which citizens simply hadto adapt. In addition, there were countless people who mistrustedthe Nazis, misunderstood their racial precepts, and resented theirhostility to the churches, but nonetheless endorsed the “nationalrevolution” of January 1933 and the political reconciliation it ap-peared to achieve. In some ways, Erich Ebermayer falls into thiscategory. Finally, Germans converted because they were genuinelyattracted to the social and political vision of National Socialism andparticularly to the promise of the people’s community.

      reasons for german conformity - fear of nazi retaliation - maintaining appearances with other germans - pressure to conform - new opportunities in nazi society - disliked nazis but liked german unity - in search of national community - agreed w nazis socially and politically

    1. for - Biden vote - Gen z factors - adjacency - 2024 U.S. elections - Trump vs Biden - Gen Z is an important demographic

      adjacency - between - 2024 U.S. elections - Trump vs Biden - Gen Z is an important demographic - adjacency statement - Gen Z can play a critical role in the 2024 U.S. elections. - Pro - they care about environment - Con - not many of them may bother voting - Challenge - reaching them with the right message

  2. Jan 2024
  3. Jul 2023
    1. four mitigating factors that make power appear to corrupt when something else is actually going on.
      • four mitigating factors that make power appear to corrupt when something else is actually going on.
        • dirty hands
          • people in power often are faced with no good alternatives and your hands will appear dirty, even when you choose the lesser of the evils
        • the idea of learning
          • authoritarian leaders are new to the job in the beginning and they have to learn to be good at being bad. Their leadership may appear to get worse but they are just learning how to be more effectively ruthless - on-the-job training
        • the problem of opportunity
          • a scaling effect. A leader of a country has far more people they can harm with his/her decision than a janitor.
        • the problem of scrutiny
          • people in power get more scrutiny
          • if you are not in power, you could be committing a crime but never get caught because you are not scrutinized to the same degree - think Donald Trump
  4. Jun 2023
    1. Refinements themselves present a significant hurdle to adoption by virtue of their limitations and overall introduction of conceptual complexity. So it’s a tough sell to recommend this for anything outside of personal projects or places with incredibly strong esoteric Ruby knowledge (like, say, hidden away within Rails).
  5. Feb 2023
    1. Review coordinated by Life Science Editors

      Reviewed by: Dr. Helen Pickersgill, Life Science Editors

      Potential Conflicts of Interest: None

      Impact Point: Transcription factors may mediate the release of specific genes in extracellular vesicles that could be taken up by other cells and directly influence their behaviour.

      Background: Extracellular vesicles (EVs) are nanoscale, membrane-bound vesicles containing proteins, nucleic acids and lipids that are released by most cell types. Originally thought of as a cell waste disposal mechanism, they have since been rebranded as a means of intercellular communication, both short and long range, (like a cellular postal service), and can, for example, modify gene expression and function in recipient cells via the transfer of specific RNAs (DOI: 10.1038/s41580-020-0251-y). One interesting function for EVs was the recent discovery that antigen presenting cells (APCs) could donate telomeres via EVs to recipient T cells and rescue them from senescence (DOI: 10.1038/s41556-022-00991-z).

      Given EVs contain a wide variety of cargos derived from the secreting cells, which have been extensively profiled (e.g., DOI: 10.1016/j.cell.2020.07.009) they are particularly interesting as sources of biomarkers for diagnosing diseases such as cancer (e.g., DOI: 10.1038/s12276-019-0219-1). We might also be able to use them as stable delivery mechanisms for controlling cell behaviour or targeting therapeutics/diagnostics.

      We know quite a bit about how RNAs and proteins are selected for secretion by EVs (mediated by the autophagy protein LC3: e.g., DOIs: 10.1080/15548627.2020.1756557; 10.1038/s41556-019-0450-y). But little is known about DNA. DNA presents a particular challenge as it is packed up into the nucleus. This is also particularly important to understand in the context of horizontal gene transfer, i.e., passing functional genes between cells.

      Main question: How does a cell ‘select’ specific DNA cargo from the nucleus and enable it to be released by EVs?

      The advance: They discover that a transcription factor (FOXM1) plays a central role in mediating DNA release in EVs.

      Results: • FOXM1 and LC3 (autophagy protein) colocalize and interact in cultured cells (coIP endogenous and exogenous, EMSA, immunostaining and identify an FOXM1-binding domain mutant). • FOXM1, LC3 and DNA colocalise in the cytoplasm in cultured cells, which increases upon starvation-induced autophagy (immunofluorescence). • FOXM1 and LC3 are found in EVs released from cultured cells (Western blot). • 15,544 DNA identified in EVs released from cultured cells (evDNA sequencing), of which 25 overlapped with DNA loci binding FOXM1 (ChIP). • FOXM1-bound nuclear DNA is transported to the cytoplasm upon induction of autophagy and is released in EVs in cultured cells (knock-in tagged chromatin with CRISPR-cas9, IF and PCR). This is dependent on FOXM1 (knock-out in cultured cells).

      Significance: Transcription factors display strong DNA binding specificity and so are ideal candidates for directing specific genes into EVs for potential transfer to recipient cells.

      Remaining questions/points: Care needs to be taken with regard to purification of EVs. Are the FOXM1-DNAs in the EVs functional in recipient cells? Is the DNA being actively ‘selected’ for an intercellular signalling purpose or is this just random degradation? Is it all FOXM1 bound DNA that has the potential to be trafficked to EVs or just a subset? Do other transcription factors have the same function or is it specific to this protein/family? Does this mechanism occur in other contexts (e.g., in vivo, under disease conditions).

  6. Apr 2022
    1. ReconfigBehSci. (2021, February 1). @MaartenvSmeden @richarddmorey 2/2 Having conducted experiments on lay understanding of arguments from ignorance, in my experience, people intuitively understand probabilistic impact of factors, such as quality of search, that moderate strength. Rather than build on that, we work against it with slogan! [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1356228495714746370

  7. Jan 2022
    1. Multiple factors appear to increase the risk of PGD, including depression, anxiety disorders, current substance use/abuse, multiple losses, particularly stressful circumstances surrounding the death, lack of social supports, uncertainty about the death, and the unavailability of usual mourning rituals.

      depression, anxiety disorders, current substance use/abuse, multiple losses, particularly stressful circumstances surrounding the death, lack of social supports, uncertainty about the death, the unavailability of usual mourning rituals

  8. Aug 2021
  9. Jun 2021
    1. We should think about the number of simultaneous connections (peak and average) and the message rate/payload size. I think, the threshold to start thinking about AnyCable (instead of just Action Cable) is somewhere between 500 and 1000 connections on average or 5k-10k during peak hours.
      • number of simultaneous connections (peak and average)

      • the message rate/payload size.

    1. Rather than write new tooling we decided to take advantage of tooling we had in place for our unit tests. Our unit tests already used FactoryBot, a test data generation library, for building up test datasets for a variety of test scenarios. Plus, we had already built up a nice suite of helpers that we coud re-use. By using tools and libraries already a part of the backend technology’s ecosystem we were able to spend less time building additional tooling. We had less code to maintain because of this and more time to work on solving our customer’s pain points.
    2. The problem domain and the data involved in this project was complicated enough. We decided that not having to worry about unknowns with the frontend end-to-end testing stack helped mitigate risk. This isn’t to say you should always going with the tool you know, but in this instance we felt it was the right choice.
    3. This particular project team came in with a lot of experience using testing tools like RSpec and Capybara. This included integrating with additional tools like Selenium WebDriver, Chrome and Chromedriver, data generation libraries like FactoryBot, and task runners like Rake. We had less experience doing end-to-end testing with Protractor even though it too uses Selenium WebDriver (a tool we’re very comfortable with).
    4. There are times to stretch individually and as a team, but there are also times to take advantage of what you already know.
    1. Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., Blyuss, O., El-Taravi, Y., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Mazankova, L., Miroshina, A., Chistyakova, E., Samitova, E., Borzakova, S., Bondarenko, E., … Sechenov StopCOVID Research Team. (2021). Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study [Preprint]. Pediatrics. https://doi.org/10.1101/2021.04.26.21256110

  10. May 2021
  11. Apr 2021
  12. Mar 2021
  13. Feb 2021
  14. Jan 2021
  15. Dec 2020
  16. Nov 2020
    1. It is very important that "production ready" UI libraries are available because otherwise the use of Svelte cannot be argued. A key point would be to make it easy possible that people can contribute
  17. Oct 2020
    1. Developmental benzo[a]pyrene (B[a]P) exposure impacts larval behavior and impairs adult learning in zebrafish

      A truly enjoyable read about specific environmental factors and their effect on learning in adult zebra fish. Although the study was done on fish, it is known that this particular contaminant effects humans as well in many ways, including in intelligence. The fact that this contaminant was found to effect learning and memory in adult fish reminds us to consider multiple aspects when constructing educational environments. Physical location and learning environment can greatly impact adult learning outcomes and is rarely talked about in adult learning theory papers. 10/10 for interest, 1/10 for relevance to this class.

  18. Sep 2020
    1. Muge Cevik {@mugecevik} (2020) Over the last 6 months, we've learned a lot about how SARS-CoV-2 spreadsMicrobe What does the evidence so far tell us about SARS-CoV-2 transmission dynamics, high-risk activities and environments? Thread. Twitter. Retrieved from: https://twitter.com/mugecevik/status/1308080065830363138

  19. Aug 2020
  20. Jul 2020
  21. Jun 2020
  22. Apr 2020
    1. Disappointingly, a recent meta-analysis failed to demonstrate any value for autologous platelet-rich plasma in the treatment of chronic wounds
    2. This approach allows treatment with patient-specific factors at an apparently physiologic ratio of growth factor concentrations.
    3. Autologous growth factors are harvested from the patient’s own platelets, yielding an unpredictable combination and concentration of factors, which are then applied to the wound.
    4. Fibroblasts stimulated by growth factors can produce type I collagen and glycosaminoglycans (e.g., chondroitin sulfates), which adhere to the wound surface to permit epithelial cell migration, as well as adhesive ligands (e.g., the matrix protein fibronectin), which promote cell adhesion.
  23. Oct 2019
    1. The first is the way the natural scientific community operates.

      First Factor encouraging professional environmentalists in their denial of social collapse in the near term

    2. Especially in situations of shared powerlessness, it can be perceived as safer to hide one's views and do nothing if it goes against the status quo.
  24. Jan 2019
  25. Nov 2018
    1. Instructional Design Strategies for Intensive Online Courses: An Objectivist-Constructivist Blended Approach

      This was an excellent article Chen (2007) in defining and laying out how a blended learning approach of objectivist and constructivist instructional strategies work well in online instruction and the use of an actual online course as a study example.

      RATING: 4/5 (rating based upon a score system 1 to 5, 1= lowest 5=highest in terms of content, veracity, easiness of use etc.)

    1. Distance Education Trends: Integrating new technologies to foster student interaction and collaboration

      This article explores the interaction of student based learner-centered used of technology tools such as wikis, blogs and podcasts as new and emerging technology tools. With distance learning programs becoming more and more popular, software applications such as Writeboard, InstaCol and Imeem may become less of the software of choice. The article looks closely at the influence of technology and outcomes.

      RATING: 4/5 (rating based upon a score system 1 to 5, 1= lowest 5=highest in terms of content, veracity, easiness of use etc.)

    1. Factors Influencing Teachers' Integration of ICT in Teaching and Learning

      ICT is enhancing communication in the digital learning environment. In this article the integration of ICT is explored and reveals how both teachers and students are able to better utilize their digital options 24/7 more effectively and efficiently. In addition, a gap has been identified in being showing how to best use ICT in the learning environment and included are in-depth studies of its’ use. The article identifies factors influencing teachers’ decision to integrate ICT in teaching.

      RATING: 4/5 (rating based upon a score system 1 to 5, 1= lowest 5=highest in terms of content, veracity, easiness of use etc.)

  26. Nov 2017
    1. A visual exploration of the link between statin use and the risk of Diabetes in a subpopulation of patients with subclinical hypothyroidism.

      This is an interactive graph created with Biovista Vizit; nodes and links can be further explored to view supporting bibliography and molecular mechanism of action.

  27. Jul 2017