105 Matching Annotations
  1. Last 7 days
  2. Jun 2022
  3. May 2022
  4. Apr 2022
    1. Humans’ tendency to“overimitate”—to reproduce even the gratuitous elements of another’s behavior—may operate on a copy now, understand later basis. After all, there might begood reasons for such steps that the novice does not yet grasp, especially sinceso many human tools and practices are “cognitively opaque”: not self-explanatory on their face. Even if there doesn’t turn out to be a functionalrationale for the actions taken, imitating the customs of one’s culture is a smartmove for a highly social species like our own.

      Is this responsible for some of the "group think" seen in the Republican party and the political right? Imitation of bad or counter-intuitive actions outweights scientifically proven better actions? Examples: anti-vaxxers and coronavirus no-masker behaviors? (Some of this may also be about or even entangled with George Lakoff's (?) tribal identity theories relating to "people like me".

      Explore this area more deeply.

      Another contributing factor for this effect may be the small-town effect as most Republican party members are in the countryside (as opposed to the larger cities which tend to be more Democratic). City dwellers are more likely to be more insular in their interpersonal relations whereas country dwellers may have more social ties to other people and groups and therefor make them more tribal in their social interrelationships. Can I find data to back up this claim?

      How does link to the thesis put forward by Joseph Henrich in The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous? Does Henrich have data about city dwellers to back up my claim above?

      What does this tension have to do with the increasing (and potentially evolutionary) propensity of humans to live in ever-increasingly larger and more dense cities versus maintaining their smaller historic numbers prior to the pre-agricultural timeperiod?

      What are the biological effects on human evolution as a result of these cultural pressures? Certainly our cultural evolution is effecting our biological evolution?

      What about the effects of communication media on our cultural and biological evolution? Memes, orality versus literacy, film, radio, television, etc.? Can we tease out these effects within the socio-politico-cultural sphere on the greater span of humanity? Can we find breaks, signs, or symptoms at the border of mass agriculture?


      total aside, though related to evolution: link hypercycles to evolution spirals?

  5. Mar 2022
  6. Feb 2022
  7. Jan 2022
  8. Dec 2021
  9. Nov 2021
    1. It remains unclear whether the reduction in the neutralization sensitivity of the N501Y.V2 strain to vaccine-induced antibodies is enough to seriously reduce vaccine efficacy. First, mRNA vaccines also induce virus-specific helper T cells and cytotoxic T cells, both of which might be involved in protection against challenge. Also, the mRNA vaccines, in particular, induce such a strong NAb response that there could be enough “spare capacity” to deal with reductions in the sensitivity of the variant to NAbs. In other words, N501Y.V2 (and the related virus from Brazil) may be less sensitive to NAbs, but not to an extent that will cause widespread vaccine failure.

      Variants that show reduced sensitivity to NAbs don't necessarily mean mRNA vaccine failure

      New variants may emerge that show reduced sensitivity to NAbs.

      This may not result in vaccine failure because:

      1. The mRNA vaccines induce such a strong NAb response, there will be enough spare capacity to deal with the virus.
      2. The mRNA vaccines also induce other virus specific protection such as helper T cells and cytotoxic T cells, which may not be affected by the reduction in NAb sensitivity.
    1. Readministration of influenza vaccine has become an annual event for much of the population, in response to both waning immunity and the appearance of variants, termed antigenic drift, necessitating updated vaccines. Even when there is no substantial drift, revaccination is recommended because of waning immunity. But antigenic drift is a constant issue and is monitored globally, with vaccine composition updated globally twice a year on the basis of recommendations from a World Health Organization consultation.

      Influenza vaccines need to be updated yearly to counter (1) waning immunity and (2) antigenic drift.

      Antigenic drift is monitored globally and the WHO makes recommendations for the updates.

    2. Thus, the value of influenza vaccines, now given to as many as 70% of people in some age groups, lies not in eliminating outbreaks but in reducing them and preventing severe complications.

      The goal of influenza vaccines is to prevent severe complications and to reduce outbreaks — not to prevent them.

      As many as 70% of some age groups get influenza vaccines.

    3. Vaccine effectiveness against laboratory-confirmed symptomatic infection is never higher than 50 to 60%, and in some years it is much lower.

      Vaccine effectiveness for influenza vaccines for symptomatic infection is never higher than 50-60% and some years it is much slower.

    4. The effect on asymptomatic infections was a welcome surprise, because it has been thought that most vaccines for respiratory illnesses, including influenza, are “leaky” — that is, they allow some degree of asymptomatic infection and are better at preventing symptomatic infection.

      Most vaccines for respiratory illnesses are leaky.

      The efficacy the mRNA vaccines showed in preventing asymptomatic transmission was therefore a welcome surprise.

  10. Oct 2021
  11. Sep 2021
    1. Published clinical data on the safety of mRNA-LNP vaccines are scarce, in comparison with siRNA, and are limited to local administration (ID and IM).

      Safety of mRNA vaccines.

    2. Although LNPs are promising delivery systems, safety issues need to be addressed to enable proper clinical development of LNP-formulated mRNA vaccines. LNPs’ potential toxicity could be complex and might manifest in systemic effects due to innate immune activation (induction of pro-inflammatory cytokine production), and/or in local, cellular toxicity due to accumulation of lipids in tissues (Hassett et al. 2019; Semple et al. 2010; Sabnis et al. 2018). Toxicity could potentially be abrogated, or reduced, by the administration of prophylactic anti-inflammatory steroids or other molecules and/or using biodegradable lipids (Hassett et al. 2019; Abrams et al. 2010; Tabernero et al. 2013; Tao et al. 2011). LNPs can also activate the complement system and might potentially elicit a hypersensitivity reaction known as complement activation-related pseudoallergy (CARPA) (Dezsi et al. 2014; Mohamed et al. 2019; Szebeni 2005, 2014), which can be alleviated using different strategies such as steroid and anti-allergic premedication (i.e., dexamethasone, acetaminophen, and antihistaminic drugs) or the use of low infusion rates during intravenous administration (Mohamed et al. 2019; Szebeni et al. 2018). Alternatively, co-delivery of regulatory cytokines (i.e., IL-10) using LNPs might be a viable strategy to reduce potential LNP-associated adverse events.

      Safety of mRNA Liquid Nanoparticles

  12. Jul 2021
  13. Jun 2021
    1. "Fertility Regulating Vaccines," World Health Organization, 1993.

      Title: Fertility Regulating Vaccines

      Subtitle: "Report of a meeting between women's health advocates and scientists to review the current status of the development of fertility regulating vaccines."

      Event: Geneva, Switzerland 17-18 August, 1992

      Publisher: World Health Organization

  14. May 2021
  15. Apr 2021
    1. Maryland offers a microcosm of the issues states face as they rush to open enough vaccination sites to meet President Biden’s goal of making every adult eligible for Covid-19 shots by May 1. It has encountered nearly all the geographic, demographic and human behavioral challenges that come with a public health task of this scale.

      Hi Ben

  16. Mar 2021
  17. Feb 2021
  18. Dec 2020
  19. Sep 2020
  20. Aug 2020
  21. Jul 2020
    1. The vaccine uses messenger RNA (mRNA), which are cells used to build proteins -- in this case, the proteins that are needed to build the coronavirus' spike protein, which the virus uses to attach itself to and infect human cells. Once the immune system learns to recognize this target -- thanks to the vaccine -- it can mount a response faster than if it encountered the virus for the first time due to an infection.

      This explanation is garbled and misstated. Genetic material is stored in DNA in the nucleus of the cell. Messenger RNA (mRNA) molecules carry the information stored within the DNA to the rest of the cell. Both DNA and RNA are a type of molecule called a "nucleic acid." Once outside the nucleus, the information in the messenger RNA can then be read, or "translated," to create proteins, such as the spike protein used by SARS-CoV-2. These proteins in turn carry out a wide variety of tasks that allow cells to function. This process is known as the "Central Dogma of Molecular Biology".

  22. May 2019
    1. To Gorski's statement, Stickland tweeted, "Look, another guy in a white coat who thinks he’s a better parent than everyone else! #shocking #notreally Why do you want to run my life and own my kids?"
  23. Apr 2018
  24. Mar 2018
    1. says the flu vaccine is laced with cancer-causing ingredients.

      It isn't. </a>


      This statement has been analyzed by a member of the International Fact Checking Network. This annotation is provided by Hypothesis as a public service.

  25. Jun 2017
  26. Mar 2017
    1. SHOWS

      In the original article, it was said that vaccines directly cause brain disorders, which is not what the study found. The study said that there was a time-oriented association (not even a coorelation) between the amount of certain diagnosed brain disorders and antecendant vaccines. The study never makes the claim of causation, though the phrasing of the title (out of onctext, that is) is common for clickbait articles such as this. While not completely made up, the original research as a completely different tone than what is being presented by this article. In addition, the original artice discuses limitation that are completely thrown out by this article: they mention that doctors diagnose disorders differently than other doctors, which is something readers/sharers of the article ought to be aware of.

      Though I found the original research, the message of this article has completely distorted Yale's findings. The study was writen from a HINDSIGHT perspective. Meaning, they mentioned vaccines are received more often by those who have any of the aforementioned disorders. For exaple, they say, "The principal findings of this study are as follows: (i) children with OCD, AN, anxiety disorder, and tic disorder were more likely to have received influenza vaccine during the preceding 1-year period". The entire study was merely showing (seemingly unintentionaly so) that those who have mental disorders are more likely to hae received vaccinations in the past several years. Not even close to stating that they are directly caused by vaccines. The article doesn't mention this, but one reason may be socioeconomic status, IE the wealthy have better doctors who diagnose, and they can afford more vaccines for their cildren. The article has completely distorted the findings and ignored the mentioned limitations of the article.

      Citations: Webber, P. (2017, February 10). BREAKING: Yale Study SHOWS Vaccines Cause Brain Disorders - RFK Jr. Retrieved March 30, 2017, from http://newamericannews.com/yale-study-shows-vaccines-cause-brain-disorders-rfk-jr/#

      Leslie, D. L., Kobre, R. A., Richmand, B. J., Guloksuz, S. A., & Leckman, J. F. (2017, January 04). Temporal Association of Certain Neuropsychiatric Disorders Following Vaccination of Children and Adolescents: A Pilot Case–Control Study. Retrieved March 30, 2017, from http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00003/full

    1. Caregivers completed the Achenbach Child Behavior Checklist (CBCL),11 a well-validated questionnaire designed to measure behavioral and emotional functioning in preschoolers (1.5 to 5 years old) in research and clinical settings

      Interesting, this is related to something else I know about.

  27. Aug 2016
    1. Credibull score = 0.99 / 10

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    1. Credibull score = 2.87 / 10

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  28. Jan 2015
    1. These include death, sudden infant death syndrome, auto-immune disorders, inflammatory bowel disease, allergies, asthma, ADHD, autism, Guillian-Barré Syndrome and other neurological damage.

      A lot of generic accusations, what about sources?