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  1. Last 7 days
    1. Claude Opus 4.7 is measurably better than Opus 4.6 for Bolt's longer-running app-building work, up to 10% better in the best cases, without the regressions we've come to expect from very agentic models.

      在长时间应用构建中实现10%的提升且没有常见回归问题,这表明AI在持续任务执行上的稳定性取得了重大突破,'pushes the ceiling on what our users can ship in a single session'暗示了AI对软件开发范式的根本性改变。

    1. The age of abundant AI is over, & it will remain so for years.

      这一断言标志着对AI发展范式的根本性认知转变。从'无限计算'到'资源受限'的转变将迫使整个行业重新思考技术发展路径,可能加速对更高效算法、模型压缩和边缘计算的需求,同时也可能引发对计算资源分配和获取公平性的社会讨论。

    1. In a single run, most models—including earlier versions of GLM—give up quickly: they produce a basic skeleton with a static taskbar and one or two placeholder windows, then declare the task complete.

      令人惊讶的是:即使是先进的AI模型在构建复杂Linux桌面环境时也会很快放弃,只创建基本框架就宣布任务完成。这揭示了当前AI系统在需要持续改进和长期规划的任务上的局限性,而GLM-5.1通过8小时的迭代实现了完整桌面环境的构建。

  2. Apr 2026
    1. AMI Labs is not building a product for immediate deployment. This is a fundamental research effort, likely measured in years before commercial applications emerge.

      在当今AI创业公司追求快速变现的环境中,作者认为AMI Labs正在进行的是基础研究,而非产品开发。这与大多数AI初创公司的商业模式背道而驰,暗示真正的AI突破需要长期投入而非短期商业考量。

    1. Urgent treatment for neoplasm consists of (1) cautious use of intravenous diuretics and (2) mediastinal irradiation, starting within 24 hours, with a treatment plan designed to give a high daily dose of radiation but a short total course of therapy to rapidly shrink the local tumor. Intensive radiation therapy combined with chemotherapy will palliate the process in up to 90% of patients. In patients with a subacute presentation, radiation therapy alone usually suffices. Chemotherapy is added if lymphoma or small-cell carcinoma is diagnosed

      endovascular stenting emerging as first-line therapy for rapid symptom relief, while definitive treatment targets the underlying cause

      Glucocorticoids (dexamethasone 4 mg every 6 hours) are commonly prescribed but lack robust supporting data; they may be more beneficial in lymphoma or thymoma and as prophylaxis against radiation-induced edema. [2-4] Importantly, SVC syndrome is no longer considered a medical emergency except in rare cases with life-threatening cerebral edema, laryngeal edema, or altered mental status. When thrombosis is present, catheter-directed thrombolysis or aspiration thrombectomy should be performed within 2-5 days of symptom onset before thrombus organization occurs. [3] The role of long-term anticoagulation after stenting remains unclear, though it is standard when significant thrombosis is present The American College of Chest Physicians recommends obtaining histologic diagnosis before treatment in suspected lung cancer cases, as stenting does not interfere with tissue diagnosis. [2] For small cell lung cancer (SCLC), chemotherapy alone is recommended as first-line treatment given rapid response rates. [2] For non-small cell lung cancer (NSCLC), radiation therapy and/or stent insertion are recommended, with response rates of 59% for chemotherapy and 63% for radiation therapy. [2] Patients with chemotherapy- or radiation-refractory disease should receive vascular stents For device-related thrombosis (catheters, pacemakers), catheter removal should be considered in conjunction with anticoagulation. [4] Endovascular therapy is first-line for device-related obstruction, while surgical bypass may be preferred for mediastinal fibrosis. [7] Both approaches show good mid-term patency, though secondary interventions are common (approximately 27-28%

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  3. Dec 2025
  4. Sep 2024
    1. I enjoyed this podcast but got the feeling they see PKM as a kind of grueling Fordist production line. The process in your book seems a lot less like a grind and a lot more like fun!

      Zettelkasten is a method for creating "slow productivity" against a sea of information overload

      Some of the framing goes back to using the card index as a means of overcoming the eternal problem of "information overload" [see A. Blair, Yale University Press, 2010]. I ran into an example the other day in David Blight's DeVane Lectures at Yale in which he simultaneously shrugged at the problem while talking about (perhaps unknown to him) the actual remedy: https://boffosocko.com/2024/09/16/paul-conkins-zettelkasten-advice/

      It's also seen in Luhmann claiming he only worked on things he found easy/fun. The secret is that while you're doing this, your zettelkasten is functioning as a pawl against the ratchet of ideas so that as you proceed, you don't lose your place in your train of thought (folgezettel) even if it's months since you thought of something last. This allows you to always be building something of interest to you even (especially) if the pace is slow and you don't know where you're going as you proceed. It's definitely a form of advanced productivity, but not in the sort of "give-me-results-right-now" way that most have come to expect in a post-Industrial Revolution world. This distinction is what is usually lost on those coming from a productivity first perspective and causes friction because it's not the sort of productivity they've come to expect.


      In reply to writingslowly and Bob Doto at https://discord.com/channels/992400632390615070/992400632776507447/1285175583877103749<br /> Conversation/context not for direct attribution

  5. Jun 2024
  6. Jan 2024
  7. Dec 2023
  8. Nov 2023
  9. Jun 2023
  10. May 2023
    1. Should the W3C be disbanded, then any Web site will be granted the right to make a copy (at a different URI) of all public persistent resources so long as they are not modified and are preserved in their entirety and made available free of charge, and provided the same persistence policy is applied to these "historical mirrors." In such event, the original https://www.w3.org web site will be handed over for management to another organization only if that organization pledges to this policy or one considered more persistent.
  11. Mar 2023
  12. Nov 2022
    1. Schemas are chunks of multiple individual units of memory that are linked into a system ofunderstanding

      How do Bransford, Brown, & Cocking (2000) define schemas? (Metiri Group, Cisco Sytems, 2008) As chunks of multiple individual units of memory that are linked into a system of understanding

      What term is defined by Bransford, Brown, & Cocking (2000) to be "chunks of multiple individual units of memory that are linked into a system of understanding"? (Metiri Group, Cisco Sytems, 2008) Schemas.

  13. Sep 2022
    1. maintenance rehearsal repeating items over and over to maintain them in short-term memory, as in repeating a telephone number until it has been dialed (see rehearsal). According to the levels-of-processing model of memory, maintenance rehearsal does not effectively promote long-term retention because it involves little elaboration of the information to be remembered. Also called rote rehearsal. See also phonological loop.

      The practice of repeating items as a means of attempting to place them into short-term memory is called maintenance rehearsal. Examples of this practice include repeating a new acquaintance's name or perhaps their phone number multiple times as a means of helping to remember it either for the short term or potentially the long term.

      Research on the levels-of processing model of memory indicates that maintenance rehearsal is not as effective at promoting long term memory as methods like elaborative rehearsal.

  14. Aug 2022
    1. Dowdy, D. (2021, September 21). On the J&J booster news, keep in mind: 1. Median follow-up since 2nd dose was just 36 days, 2. Efficacy vs moderate COVID was 75% globally, and 3. Total number of cases in the US was 15. Please don’t take this to mean that a 2nd dose provides long-term increase in protection. Https://t.co/RnqDNBmwuD [Tweet]. @davidwdowdy. https://twitter.com/davidwdowdy/status/1440323242942554122

  15. Apr 2022
  16. Mar 2022
    1. The Future is Vast: Longtermism’s perspective on humanity’s past, present, and futureIf we manage to avoid a large catastrophe, we are living at the early beginnings of human historyby Max RoserMarch 15, 2022The point of this text is not to predict how many people will ever live. What I learned from writing this post is that our future is potentially very, very big. This is what I try to convey here.If we keep each other safe – and protect ourselves from the risks that nature and we ourselves pose – we are only at the beginning of human history.
    1. Evaluations of the platform show that users who follow the avatar inmaking a gesture achieve more lasting learning than those who simply hear theword. Gesturing students also learn more than those who observe the gesture butdon’t enact it themselves.

      Manuela Macedonia's research indicates that online learners who enact specific gestures as they learn words learn better and have longer retention versus simply hearing words. Students who mimic these gestures also learn better than those who only see the gestures and don't use them themselves.

      How might this sort of teacher/avatar gesturing be integrated into online methods? How would students be encouraged to follow along?

      Could these be integrated into different background settings as well to take advantage of visual memory?

      Anecdotally, I remember some Welsh phrases from having watched Aran Jones interact with his cat outside on video or his lip syncing in the empty spaces requiring student responses. Watching the teachers lips while learning can be highly helpful as well.

    2. In one study, subjects who had watched a videotapedspeech were 33 percent more likely to recall a point from the talk if it wasaccompanied by a gesture. This effect, detected immediately after the subjectsviewed the recording, grew even more pronounced with the passage of time:thirty minutes after watching the speech, subjects were more than 50 percentmore likely to remember the gesture-accompanied points.

      People are more likely to remember points from talks that are accompanied by gestures. This effect apparently increases with time.

      What does the effect of time have on increased lengths? Does it continue to increase and then decrease at some point? Anecdotally I often recall quotes and instances from movies based on movements that I make.

      What effects, if any, are seen in studies of mirror-neurons and those with impairment of them? What memory effects might be seen with those on the autism spectrum who don't have strong mirror-neuron responses? If this is impaired, what might account for their improved memories for some types of material? Which types of material do they have improved memories for?

      Is the same true of drawing points from a speech using the ideas of sketchnotes? Is drawing an extension of gestural improvement of memory?

    1. Psychologists call this mechanism activeinhibition (cf. MacLeod, 2007

      Active inhibition is the filter that prevents our minds from being constantly flooded with memories and allows us to focus. It acts as a barrier between our long term memories and our immediate present.

      Is the filter behind active inhibition really active or is it passive? What is the actual physiological mechanism?

  17. Feb 2022
    1. APPG on Coronavirus. (2022, January 18). 🗣Dr.Claire Steves continued: “Looking in the national core studies, from cohort studies across the UK we’ve looked at 10 different longitudinal studies. Our best estimates are that about 5% of middle aged people are experiencing long term.. 27/ #APPGCoronavirus #LongCovid [Tweet]. @AppgCoronavirus. https://twitter.com/AppgCoronavirus/status/1483453895061999618

  18. Jan 2022
    1. Routen, A., O’Mahoney, L., Ayoubkhani, D., Banerjee, A., Brightling, C., Calvert, M., Chaturvedi, N., Diamond, I., Eggo, R., Elliott, P., Evans, R. A., Haroon, S., Herret, E., O’Hara, M. E., Shafran, R., Stanborough, J., Stephenson, T., Sterne, J., Ward, H., & Khunti, K. (2022). Understanding and tracking the impact of long COVID in the United Kingdom. Nature Medicine, 28(1), 11–15. https://doi.org/10.1038/s41591-021-01591-4

    1. Technological solutions to social problems seem quicker, cheaper, and simpler to implement than larger social changes.

      Tech solutionism can often seem useful because it appears to be cheaper, simpler, and easier to implement than making more difficult choices and larger, necessary social changes.

      One needs to always ask what is the real underlying problem? What other methods are there for potential solutions? What are the knock-on effects of these potential solutions. Is the particular solution really just a quick fix or bandaid? Once implemented how will one measure the effects and adjust after-the-fact?

  19. Nov 2021
    1. Drexel emphasizesthe difficulty of image-based arts of memory and how short-lived are theirresults: “Great labor places so many images of things in this treasury ofmemory; but no amount of labor has managed to preserve them there forlong without excerpts” (A, p. 3). Instead, for Drexel excerpting is the onlysure way to retain material for the long term. Drexel insists too that, farfrom detracting from memory, note taking is the best aid to memory.

      Jeremias Drexel is certainly a writer who complains about the work of the ars memoria, particularly for long term memory and supplants it with writing/note taking.

  20. Oct 2021
  21. Sep 2021
  22. Aug 2021
  23. Jul 2021
    1. Dr. Jeff Benyacar on Twitter: “@AlexBerenson ‘Even if a link between myocarditis and the vaccine holds up, the condition is usually mild, requiring treatment only with anti-inflammatory drugs, whereas COVID-19 infection can also cause serious disease and long-term side effects, even in young people.’ https://t.co/3VQprF7bIz” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/jbenyacar/status/1399851524487106562?s=12

  24. Jun 2021
    1. "While it takes time to make these changes now, it's a one-time engineering cost that will have lasting impacts, both internally and externally," Sorenson said in an email. "We're in this for the long game, and we know inclusive language is just as much about how we code and what we build as it is about person-to-person interactions."
    1. Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., Blyuss, O., El-Taravi, Y., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Mazankova, L., Miroshina, A., Chistyakova, E., Samitova, E., Borzakova, S., Bondarenko, E., … Sechenov StopCOVID Research Team. (2021). Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study [Preprint]. Pediatrics. https://doi.org/10.1101/2021.04.26.21256110

  25. May 2021
    1. After 10 minutes, the word lists were collected and students were asked to write down as many of the list items as they could recall within five minutes.

      Were students asked or told if they'd be tested with this on long-term memory?

      Personally, I'd have used a simple major system method to memorize such a list for short term memory, but would have used other techniques for long term memory.

    1. “Monetising what we see as sacred knowledge, our way of being – driving, walking – is sacred knowledge and the only people who should have any purview over that is our community. … What if we look at what the data could do for our community and how to achieve that? … We are gathering our data because we love our people, we want a better future for the next generations. What if all data was gathered for those reasons? What would it look like?”

      A great quote and framing from Abigail Echo-Hawk.

      This reliance on going to community elders (primarily because they have more knowledge and wisdom) is similar to designing for the commons and working backward. Elders in many indigenous cultures represent the the commons.

      This isn't to say that we shouldn't continue to innovate and explore the evolutionary space for better answers, but going slow and fixing things is far more likely to be helpful than moving fast and breaking things as has been the mode for the last fifteen years. Who's watching the long horizon in these scenarios?

      This quote and set up deserves some additional thought into the ideas and power structures described by Lynne Kelly in Knowledge and Power in Prehistoric Societies Orality, Memory and the Transmission of Culture

    2. There’s a way of thinking about data – and about how we use the linked technologies to connect, communicate and organise – that grows out of the seven generations view KSR talks about in TMFTF. It’s something that serves us, and which never stops being of us. It’s not an asset so much as a gift, but not all gifts can be given or received by all people. Once you start thinking of it this way, you can never go back.

      Not delineated directly here, but the idea of a seven generations view sounds intriguing.

    1. There’s this thing I simply call “365”. With each new year (or sometimes at the end of a notebook, when I feel like it), I make a 2-page spread mind map of things that kept me busy. It’s more or less an analog tag cloud and it’s extremely rewarding to make. You get to browse through previous journals, look at things you’ve written down and actually managed to pull of, and take note of that in one or two words. That creates a thick cloud full of the things that defined you for the last year. It’s actually quite incredible to look at. When I’m done doing that, I try to underline the words that meant more to me than others. Applying the retrospective principles from software development on your own personal life and writing down what made you glad, mad or sad actually helps you do something about that.

      This is an example of spaced repetition being done as retrospective and hiding some of the value of making the important things stand out and reviewing them for better long term retention.

    1. Dr. Tom Frieden. (2021, April 30). Globally, the end of the pandemic isn’t near. More than a million lives depend on improving our response quickly. Don’t be blinded by the light at the end of the tunnel. There isn’t enough vaccine and the virus is gathering strength & speed. Global cooperation is crucial. 1/ [Tweet]. @DrTomFrieden. https://twitter.com/DrTomFrieden/status/1388172436999376899

  26. Apr 2021
  27. Mar 2021
    1. With all this “monetization” happening around Trailblazer, we will also make sure that all free and paid parts of the project grow adult and maintan an LTS - or long-term support - status. Those are good news to all you users out there having been scared to use gems of this project, not knowing whether or not they’re being maintained, breaking code in the future or making your developers addicted to and then cutting off the supply chain. Trailblazer 2.1 onwards is LTS, and the last 1 ½ years of collaboration have proven that.
  28. Feb 2021
  29. Jan 2021
  30. Oct 2020
  31. Sep 2020
  32. Aug 2020
    1. Hogan, A. B., Jewell, B. L., Sherrard-Smith, E., Vesga, J. F., Watson, O. J., Whittaker, C., Hamlet, A., Smith, J. A., Winskill, P., Verity, R., Baguelin, M., Lees, J. A., Whittles, L. K., Ainslie, K. E. C., Bhatt, S., Boonyasiri, A., Brazeau, N. F., Cattarino, L., Cooper, L. V., … Hallett, T. B. (2020). Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: A modelling study. The Lancet Global Health, 0(0). https://doi.org/10.1016/S2214-109X(20)30288-6

    1. Salahudeen, A. A., Choi, S. S., Rustagi, A., Zhu, J., O, S. M. de la, Flynn, R. A., Margalef-Català, M., Santos, A. J. M., Ju, J., Batish, A., Unen, V. van, Usui, T., Zheng, G. X. Y., Edwards, C. E., Wagar, L. E., Luca, V., Anchang, B., Nagendran, M., Nguyen, K., … Kuo, C. J. (2020). Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures. BioRxiv, 2020.07.27.212076. https://doi.org/10.1101/2020.07.27.212076

  33. Jul 2020
    1. Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M., Coles, J. P., Manji, H., Al-Shahi Salman, R., Menon, D. K., Nicholson, T. R., Benjamin, L. A., Carson, A., Smith, C., Turner, M. R., … Plant, G. (2020). Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. The Lancet Psychiatry. https://doi.org/10.1016/S2215-0366(20)30287-X

  34. Jun 2020
  35. May 2020
  36. Oct 2017