600 Matching Annotations
  1. Jun 2025
  2. Oct 2024
  3. Sep 2024
    1. Tests performed: Haemostatic tests ristocetin-induced platelet aggregation plasma VWF antigen VWF risocetin cofactor VWF FVIII-binding capacity VWF multimers and FVIII activity DDAVP test Concentration timecourses

      sequencing from genomic DNA performed and reported in 2011

      cDNA analysis

      Real-time-PCR analysis

      long PCR

      Ellman assay (quantifying sulfhydryls)

      Dynamic light scattering measurements

      circular dichroism

      ADAMTS13 proteolysis assay

      ADAMTS13-VWF binding assay

  4. Aug 2024
    1. amazon prime castle rock which is based on the work of stephen king

      for - comparison - Amazon Prime - Castle Rock - Stephen King - compared to - Michael Levin caterpillar to butterfly metamorphosis - adjacency - universal - vs localized consciousness - empathy - Michael Levin - caterpillar to butterfly

      adjacency - between - Stephen King movie "castle rock" - universal consciousness - localized, individual consckousness - empathy - adjacency relationship - Bernardo compares the Stephen King movie series "Castle Rock" with ghostly beings taking over the identify of an existing physical body. - Universal consciousness is in all of us - but we strongly identify with the localized consciousness - In Michael Levin's caterpillar to butterfly process, - the living being has memories of a caterpillar but what happens when it becomes a butterfly? Those memories don't confer any meaning to the butterfly - But beneath both the butterfly and the caterpillar, the universal consciousness is at the ground layer - When we experience others as ourselves, because we have the same universal consciouness, - then we can truly enact empathy as an expression of recognition

    1. Freedom of Expression and Challenges Posed by Artificial Intelligence

      The first section concentrates on the building a conceptual framework which is based on the relationship between freedom of expression and democracy and the way in which the Internet and social media enhance the exercise of freedom of expression.

      The second section examines the challenges to freedom of expression in relation to the promotion of gender equality on social media which are imposed by AI content curation and moderation.

      In the final section, the two-tiered approach, i.e., policies and law, is proposed to deal with the problem.

    1. It illustrates, in a strikingmanner, the ontological dualism that can, without a doubt, beconsidered the basic assumption of Lacanian psychoanalysis.°This ontological dualism is related to the fact that Lacan thinksof language and the body as originally external to each other.

      This presents something about language and the body being external to one another? The duality and the contrast between language and bodily expression?

    1. Which implies thatmuch of the novel is about what is left unsaid than what is said; forexample, in “Monet’s Berm” Oliver says “Don’t ever say you didn’tknow” and Elio admits “His words made no sense. But I knew exactlywhat they meant” (Aciman 150).

      Implying that much of the communication was obvious even when words were not shared ?

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    1. This passage conflates Elio’s desire with the physical body. By connecting ejaculation with therevealing of his secret, Elio grounds his desire in the physical action of his body. With thismetaphor linking speaking and masturbating, he attempts to convince himself that the confessionhas been completed, resulting in a physical act.

      The only notable quote i think would support my argument. The passage of words to physical truth coming out of his body in his semen. This links the confession of the verbal to the truthful (and permanent) confession of the physical.

    1. ’d commit the ultimateindignity, and with this indignity show him that the shame was all his, notmine, that I had come with truth and human kindness in my heart and that Iwas leaving it on his sheets now to remind him how he’d said no to a youngman’s plea for fellowship.

      "Truth" is embedded in his semen that he will lay on the sheets after lots of fuddling trials by making excuses. In the end it is all his sexuality that will confess all truth and human kindness

    2. When I looked at my dessert plate and saw the chocolate cakespeckled with raspberry juice, it seemed to me that someone was pouringmore and more red sauce than usual, and that the sauce seemed to becoming from the ceiling above my head until it suddenly hit me that it wasstreaming from my nose. I gasped, and quickly crumpled my napkin andbrought it to my nose, holding my head as far back as I could.

      A obvious sign he likes it, and it was not through verbal fuddling that he communicated this, but through his body's involuntary reaction that he cannot plan nor control.

    3. wanted his tongue inmy mouth and mine in his—because all we had become, after all theseweeks and all the strife and all the fits and starts that ushered a chill drafteach time, was just two wet tongues flailing away in each other’s mouths

      All the misunderstandings lead to simply the physicality and exchange of identity of two wet tongues, while words deceived them all

    4. Now, in the silence of the moment, I stared back, not to defy him,or to show I wasn’t shy any longer, but to surrender, to tell him this is who Iam, this is who you are, this is what I want, there is nothing but truthbetween us now, and where there’s truth there are no barriers,

      Silence and yet at the same time communication

    5. “What things that matter?”Was he being disingenuous?“You know what things. By now you of all people should know.”Silence.“Why are you telling me all this?”“Because I thought you should know.”“Because you thought I should know.” He repeated my words slowly,trying to take in their full meaning, all the while sorting them out,

      No explicit conversation here, just fuddling, yet the meaning is conveyed perfectly and they share it with a kiss.

  5. Jul 2024
    1. and I never waited long enough to knowwhether I was even wanted there; look away because I was too scared to stareanyone back; look away because I didn’t want to give anything away

      Proof that this physical moment of eye contact "gives things away" rather than words

    2. Oliver’s response “hated it?” turns Elio’sstatement into a question, just as Echo turns Narcissus’ question into a statement: dixerat “ecquisadest?” et “adest!” responderat Echo (“He had said, ‘Is anyone here?’ and ‘She is here!’ Echohad responded,” Ov. Met. 6.379)

      Does this show how meaning in words can be twisted into several other variations, and therefore how speaking can be of deception, while bodily expression is most honest of the identity? And then how do we connect bodily continuity/expression to identity holding contradictions?

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    1. "Scholars teach in Universities and claim that they’re smart and cunning Tell them find a cure when we sneeze and that’s when their nose start running" the academic community and university is designed for very purpose of maintaining the “status quo”/ethics of research and the system/preventing progressive ideas from being explored until you can be trusted to know what the “truth” is apparently is to be known by those who came before you. Whoever says that in university your freedom/capacity of thought/speech/action is not limited is blind. Certain ideas are more preferable “healthy” to the system than others, and if you promote and engage with the more agreeable concepts you’ll get through your degree/get accepted by academic community easily. once again, scholars are still in the "problem, reaction and solution" paradigm, rather than focusing on preventions than cures. We've got a long way to go in the evolution of consciousness. PATIENCE.

      True freedom of expression (a need for the soul as expressed by Simone Weil) must be given in academia as well; to write about that which you want to write about... Regardless of "social acceptance". A degree should be about objective knowledge and quality of knowledge, not the content of said knowledge.

    1. I would have blushed, and blushed because I had blushed, fuddledwith words and ultimately broken down—and then where would I be? Whatwould he say?Better break down now, I thought, than live another day juggling all ofmy implausible resolutions to try again later

      Shows that true identity is most transparent (Cor cordium; heart of hearts) through the expression of the body. The body never lies. The blushing and the fuddling would have given it all, and therefore is the basis of bodily continuity

  6. May 2024
    1. I asked, “Must we?” This was theclosest I would ever come to saying, Stay. Just stay with me. Let your handtravel wherever it wishes, take my suit off, take me, I won’t make a noise,won’t tell a soul, I’m hard and you know it, and if you won’t, I’ll take thathand of yours and slip it into my suit now and let you put as many fingersas you want inside me

      Later in the novel it shows that he does pick up on this. This shows support of body language, the deception of words and yet the honesty of bodily expression. True identity comes through in skin.

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  7. Mar 2024
    1. 大家都會「呼攏」「呼攏」的說。但其實正確的寫法是「糊弄」!①應付、敷衍。如:「對於這次事件的報告,他只想要糊弄過關,所以始終交代不清。」②將就、隨便。如:「這吃力不討好的工作,你就糊弄做吧!」③欺騙、愚弄。如:「他說的話不可信,全都是糊弄人的。」

      蛤?爲何我多年來以爲是「呼攏」,認爲是中國的用法,也許是方言,不疑有他?

      「糊弄」倒是很好理解。

  8. Feb 2024
  9. Nov 2023
  10. Oct 2023
  11. Jul 2023
    1. Spirit is movement and needs to move. Even at rest, the spirit has a sort of underlying kinetic potential about it. If spirit doesn’t get expressed, it can translate into agitation, anxiety, lethargy, despondency, or any number of unpleasant emotional experiences. And, it’s through release in the form of expression that we ease the pain.

      Inspiration needs to be expressed (not only passive consumption and annotating) - what about capturing your thoughts and synthesising them with readings to create something for yourself (expressing/creating privately)

  12. May 2023
  13. Feb 2023
    1. Although these vectors were safe, many gene therapy programs failed in the clinic because of poor transduction.

      i.e., these were not good expression vectors because they did not effectively transfer transgenetic material to the host.

  14. Jan 2023
  15. Dec 2022
    1. Diagram of immunoprecipitation (IP) using either pre-immobilized or free antibodies.

      Immunoprecipitation is a technique for the isolation of protein or a complex (protein-protein interactions) Sample is combined with a specific antibody for the epitope of interest. The antibody-protein complex is removed and analysed.

      1. Molecules from biological sample (lysed) +incubated with antibodies (free or mounted onto support (like agarose bead, magnetic bead))
      2. protein A or G coupled beads added.
      3. Centrifuged
      4. Results in Beads with protein A/G bound to antibody-POI complex.
      5. Well separated in this way, differentially based on sedimentation coefficient.

      Co-immunoprecipitation (can isolate one type of protein in its complex)

      Isolate POI(s) Good with low conc. of POI Protein interactions Unknown proteins Determine if protein is actually being expressed in a given tissue.

      Western blot is carried out to analyse the output.

      Vary salt and detergent levels to preserve or destroy protein interactions.

  16. Nov 2022
    1. Second, reading, if it is active, is thinking, and thinking tendsto express itself in words, spoken or written. The person whosays he knows what he thinks but cannot express it usually doesnot know what he thinks.

      Active reading is thinking, and thinking requires expression which can come in many forms including both spoken and written ones.


      I like that he acknowledges that expression (and thus thinking) can be done in both oral or written forms.

  17. Jul 2022
  18. Jun 2022
    1. not all of us are going to have super 00:37:28 high need for self-expression you know most of us are probably like me i'm more of a people pleaser than i would even want to be

      conformity and self-expression are not mutually exclusive. We can have qualities of both. We are a self who was taught since before birth to be interpersonal. Hence we are human INTERbeings from before birth. Conformity and individuality coexist.

  19. May 2022

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  20. Apr 2022
  21. Mar 2022
  22. Dec 2021
  23. Sep 2021
    1. What was ROLI Ltd.?ROLI Ltd. was known as a leading innovator in electronic musical instruments for professionals such as the Seaboard, Seaboard RISE, and BLOCKS — and a pioneer of MIDI Polyphonic Expression (MPE). As part of the 2021 restructure, Luminary will continue to manufacture ROLI’s professional and hobbyist instruments, with a relaunch of the iconic Seaboard, slated for 2022.

      Sad day for MPE advocates. Sure, we knew this was coming. And we have plenty of support from other vendors. Yet those efforts by then-ROLI are erased by this #pianocentric pivot.

  24. Jul 2021
    1. HMGB1, which was demonstrated to be crucial for viral entry

      Indeed, a recent paper has shown that an inihibitor of HMGB1, glycyrrhizin, can simultaneously stop virus replication and suppress proinflammatory mediators. This evidence provides a potential new therapeutic option for COVID-19 patients (DOI: 10.1016/j.cyto.2021.155496).

  25. Jun 2021
  26. May 2021

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  27. Jan 2021
  28. Dec 2020
    1. RecommandationsRendre l’enfant acteur de ses droitsRecommandation 1Le Défenseur des droits recommande à l’ensemble des établissements scolaires (publics, privés sous contrat et hors contrat), ainsi qu’aux autorités chargées d’en exercer la tutelle, de s’assurer que l’enfant soit mis en mesure de s’exprimer sur les faits qui lui sont reprochés avant toute décision de sanction à son encontre, conformément à l’article 12 de la Convention internationale des droits de l’enfant et l’article 6 de la Convention européenne de sauvegarde des droits de l’homme.

      article 12 à mettre au règlement intérieur ?

  29. Nov 2020
    1. The success of JSX has proved that the second curly is unnecessary. Moreover, a lot of people — particularly those who have been exposed to React — have a visceral negative reaction to double curlies, many of them assuming that it brings with it all the limitations of crusty old languages like Mustache and Handlebars, where you can't use arbitrary JavaScript in expressions.
  30. Oct 2020
    1. It looks like you accidentally passed resolve() (immediately invoking the function) directly to setTimeout rather than passing a function to invoke it. So it was being resolved immediately instead of after a 1000 ms delay as intended.

      I guess this is the "immediately invoked function" problem.

      Not to be confused with: immediately invoked function expression. (Since it is a regular named function and not a function expression.)

  31. Sep 2020
    1. genetic devices have been designed for suppressing leaky basal expression levels through the engineering of super‐repressors (Ruegg et al, 2018), exploitation of antisense RNAs (O'Connor & Timmis, 1987), or physical decoupling of regulatory elements along with conditional proteolysis
  32. Aug 2020
    1. Corbett, K. S., Edwards, D. K., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., Dinnon, K. H., Elbashir, S. M., Shaw, C. A., Woods, A., Fritch, E. J., Martinez, D. R., Bock, K. W., Minai, M., Nagata, B. M., … Graham, B. S. (2020). SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature, 1–8. https://doi.org/10.1038/s41586-020-2622-0

    1. Martino, C., Kellman, B. P., Sandoval, D. R., Clausen, T. M., Marotz, C. A., Song, S. J., Wandro, S., Zaramela, L. S., Benítez, R. A. S., Zhu, Q., Armingol, E., Vázquez-Baeza, Y., McDonald, D., Sorrentino, J. T., Taylor, B., Belda-Ferre, P., Liang, C., Zhang, Y., Schifanella, L., … Knight, R. (2020). Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity. BioRxiv, 2020.08.17.238444. https://doi.org/10.1101/2020.08.17.238444

    1. > (square: (x: y: square x + square y) 3 7) (x: x*x)58

      This can be written up in many other forms, plus the possibility of currying deserves to be pointed out:

      $ nix repl
      nix-repl> (sq: (x: y: sq y + sq x) 2 7) (x: x*x)
      53
      
      nix-repl> (sq: (x: y: sq y + sq x)) (x: x*x)     
      «lambda @ (string):1:11»
      
      nix-repl> (sq: (x: y: sq y + sq x)) (x: x*x) 2
      «lambda @ (string):1:14»
      
      nix-repl> (sq: (x: y: sq y + sq x)) (x: x*x) 2 7
      53
      
      nix-repl> (sq: x: y: sq y + sq x) (x: x*x) 2 7   
      53
      
  33. Jul 2020
    1. En effet, n’est-il pas paradoxal que d’une part, la corporéité sous-tend de larges pans de la Recherche, alors que d’autre part le narrateur reste dans une totale indétermination : est absente du récit toute description objective ou physique du héros, nous ignorons son nom exact, la nature de ses interactions avec Albertine, le détail de ses séjours successifs dans des maisons de santé ?

      La phrase est un peu longue et sa structure un peu complexe à la lecture : peut-être en faire deux phrases ?

    2. La Nouvelle Vague désigne, comme on le sait, un courant cinématographique que l’on peut situer de façon sommaire à la période qui s’étend de 1956 à la fin des années 1960

      je mettrai cette information en note

    1. Partant du phénomène physique du comportement des vagues qui présentent différents modèles de diffraction – par exemple les formes qui apparaissent lorsque nous jetons une pierre dans un volume aqueux – et qui résultent de la réaction des vagues en rencontrant un obstacle (2007, 28)

      c'est une phrase nominale ?

    2. Que l’on pense à Swann

      c'est une structure de formulation qui se retrouve beaucoup (peut-être de manière un peu trop répétitive) dans ce chapitre, et très peu dans les chapitres précédents

    3. Bergson écrit : « Un homme, qui courait dans la rue, trébuche et tombe : les passants rient. On ne rirait pas de lui, je pense, si l’on pouvait supposer que la fantaisie lui est venue tout à coup de s’asseoir par terre. On rit de ce qu’il s’est assis involontairement. Ce n’est donc pas son changement, c’est la maladresse. Une pierre était peut-être sur le chemin. Il aurait fallu changer d’allure ou tourner l’obstacle. Mais par manque de souplesse, par distraction ou obstination du corps, par un effet de raideur ou de vitesse acquise, les muscles ont continué d’accomplir le même mouvement quand les circonstances demandaient autre chose » (2007, 7).↩

      peut-être introduire par un commentaire

    4. « Et au moment où je voulais me lever – nous apprend le narrateur en se réveillant dans une chambre d’hôtel à Doncières –, j’en éprouvais délicieusement l’incapacité ; je me sentais attaché à un sol invisible et profond par les articulations, que la fatigue me rendait sensibles, de radicelles musculeuses et nourricières » (II, 390).

      Peut-être introduire ou inclure cett citation dans une phrase ou la mettre en retrait

    5.  L’espace intercorporel qui se fait jour existe en deçà des paramètres usuels qui nous permettent de saisir l’expérience humaine (langage, lois sociales), elle en efface les signifiants.

      je ne ne comprends pas bien la succession des sujets ici

    6. en se fondant sur les observations de l’entomologiste.

      Si je comprends bien, il déplace en quelque sorte un discours/lexique (entomologiste) vers un nouvel objet. Peut-être reformuler la phrase pour que ce soit plus évident

    7. Autrement dit, si cette technique n’avait pas existé, le narrateur n’aurait pas pu exprimer la même chose

      Peut-être est-ce juste une question d'expression, parce que je saisis bien l'idée du paragraphe, mais cette phrase résonne à la lecture selon l'adage "avec des si, on mettrait Paris en bouteille"

    8. Si la voix inépuisable qui résonne à travers la Recherche s’adresse directement au lectorat, on peut être sensible à ce qu’elle recèle

      La construction "si...., alors ..." implique souvent une contradiction sousentendue, ici je ne la vois pas. Peut-être choisir une construction plus causale ?

    1. Corbett, K. S., Edwards, D., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., Dinnon, K. H., Elbashir, S. M., Shaw, C. A., Woods, A., Fritch, E. J., Martinez, D. R., Bock, K. W., Minai, M., Nagata, B. M., … Graham, B. S. (2020). SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness. BioRxiv, 2020.06.11.145920. https://doi.org/10.1101/2020.06.11.145920

  34. Jun 2020
    1. Recommandation 13Chaque enfant doit pouvoir s’exprimer sur toute question intéressant son environnement quotidien, participer à son évaluation et réfléchir à son amélioration. Les initiatives visant à encourager l’expression et la participation de l’enfant doivent être encouragées. Le Défenseur des droits recommande la mise en place, par chaque institution, d’un dispositif de recueil de la parole et de l’opinion des enfants, que ce soit dans un cadre individuel ou collectif.
    1. il y a « entre ma conscience et mon corps tel que je le vis, entre ce corps phénoménal et celui d’autrui tel que je le vois du dehors, il existe une relation interne qui fait apparaître autrui comme l’achèvement du système » (Merleau-Ponty 2008, 410).

      le "il y a" fait répétition avec le "l existe" de la citation

    2. Ainsi, nous pouvons être touchés par un regard qui exprime de la tristesse, de l’empathie, ou de la crainte.

      peut-être qu'à ce stade de ta démontration cett phrase fait trop simple, ou semble trop se fonder sur une manière de dire, je la déplacerai au paragraphe suivant

    3. N’est-ce pas ce que suggère Merleau-Ponty, lorsqu’il évoque « l’intermonde où se croisent nos regards et se recoupent nos perceptions » (2011, 72) ?

      je ne suis pas sûre de l'effet rhétorique de la question, peut-être laisser la phrase à l'affirmative

    1. « Les 2 000 enfants que nous avons largement consultés cette année sur leur perceptionde leurs droits et des progrès à faire, nous l’ont confirmé : quel que soit le contexte, ils témoignent trop souvent d’un manque de considération de leur personne, de leurs avis et de leurs rêvespar les adultes qui les entourent. Commençons par leur faire une juste place, c’est la conditionpour mieux lutter contre la violence qu’ils subissent. »
    1. Dans la dichotomie qui s’établit entre l’aplatissement et la fragmentation de l’expérience (l’appréhension cinématographique du voyage en automobile) d’une part, et son intensification (« quand notre imagination nous portait du lieu où nous vivions jusqu’au cœur d’un lieu désiré »).

      est-ce volontairement ici une phrase nominale ?