8,812 Matching Annotations
  1. Nov 2023
    1. Trends in the application of deep learning networks in medical image analysis: Evolution between 2012 and 2020

      Tendencias en la aplicación de redes de aprendizaje profundo en el análisis de imágenes médicas: Evolución entre 2012 y 2020

    1. Drug repurposing for COVID-19 via knowledge graph completion

      Reutilización de medicamentos para COVID-19 mediante la finalización del gráfico de conocimiento

  2. Oct 2023
    1. Thank you. Steve, for raising the alarm on this catastrophe! One minor comment. It should be QC'ed, not QA'ed. Quality control is done first. Quality Assurance (QA) comes after QC. QA is basically checking the calculations and the test results in the batch records. I worked in QC and QA for big pharma for decades. I tried to warn people in early 2021 that there's no way the quality control testing could be done at warp speed. Nobody listened to me despite my decades of experience in big pharma!

      "warp speed" sounds fancy, plus "its an emergency, we have no time"...

      it really was just an intelligence test, a global-scale exploit of trust in authorities. (and lets be honest, stupid people deserve to die.)

      problem is, they (elites, military, industry) seem to go for actual forced vaccinations, which would be an escalation from psychological warfare to actual warfare against the 95% "useless eaters".

      personally, i would prefer if they would globally legalize serial murder and assault rifles, then "we the people" would solve the overpopulation. (because: serial murder is the only alternative to mass murder.) but they are scared that we would also kill the wrong people (their servants because they are evil or stupid). (anyone crying about depopulation should suggest better solutions. denying overpopulation is just another failed intelligence test.)

  3. Sep 2023
    1. He says that ultimately, about 50% of participants who were screened to be part of the control group couldn’t be included because of continuing symptoms.

      Honestly, this should be the headline. A full 50% of people who volunteered to be in the control were actually still suffering symptoms! Half! Of a self-selected group!

    1. food intake and vasoconstriction

      Is this why eating is causing instant sleepiness? Non-digestive vessels vasoconstrict and shut off too much cerebral blood flow, then nerves instantly have reduced firing/waste and CO2 build up/diminished mitochondria output/oxidative buildup/ &or then resultant inflammatory triggering cytokine increase?

      Vessel endothelial enormous surface area, manipulator of blood flow vasoconstrictor system, and cytokine producer/influencer, and high vulnerability sensitivity to viral infection/corruption...and then it's role or adjacent system and the immediate available Google research on COVID affecting> the vascular elastin system and corrupted elevated production of destructive elastases resulting in reduced vascular compliance then resulting too narrow "pulse pressure" band essentially creating arteriosclerosis.

      Also, make sure to be thinking of the entire vascular system not as one system, but subsided by dynamic changing gated sections and inspect signaling creating changing locations and amounts of high/low pressure zones. Also, keep in mind 3 things about BP: 1, when taken with a cuff it is only measuring a reading at the elbow. 2, is a reading from the artery and not giving any direct data from vein part of the system. 3, BP is not the same as blood flow. So I conceive that you could read a good BP, but actual flow could be completely inadequate.

      Remember analogy, vascular system is just like car AC system, or any pressurized hydraulic system, or even actually electric circuits. Meaning that there is a high pressure side, the load component(s), and a low pressure side. Also remember veins act as the reservoir tank, and when they constrict it is injecting more blood into the system to, if functioning correctly, allow higher performance and meet increase load demand. It also, therefore has less direct effect on whole system BP vs artery constriction because it's downstream of the load. Arterial constriction conversely has immediate direct effect on systolic BP as it is essentially putting a wall directly downstream of the heart. Therefore, regardless if diastolic pressure is zero or high, when the heart contacts, the pressure shoots straight up.

      A working theory component: my pulmonary vein is inappropriately constricting too much. That causes high back up pressure at alveoli. Exercise then induces veinous reservoir injection and increased blood volume into the "working system" further increasing pressure. Possibly arterious had already been fully dilated at rest in order to compensate and then when exercise happens, it can't be dilated further to increase blood flow throughout and BP increases further all behind the pulmonary vein "dam". However it doesn't present as right side heart failure like might initially be guessed (with leg and belly edema) because the right side heart is not failing...yet. So it contains any further backflow and the alveoli are the weakest point and taking the most abuse and pressure is relieved as pulmonary edema. And therefore what may be present is if we look for it, we'll find that actual blood throughput output exiting the heart is too low. And this can exist with a normal ejection fraction because the heart is functioning correctly and pumping the right percentage of what is a low starting volume. And also this can support why right ventricle is showing first signs of enlarging because it's being overpressured and stretching out (enlarging). And this can support why normal BP readings are measured at the arm because it can completely handle the abnormally low blood volume being received in the downstream location it's at. And then therefore this further supports why BP is normal but HR is riding the high limit at rest and then instantly jumps on exertion AND why dizziness happens because the artery system was already maxed out dilation at rest and for any amount of exertion, increasing HR because of the immediate too fast rise in tissue hypoxia due to too low blood supply the brain keeps driving up HR to meet demand. Total result upon exercise: supply continues to more and more not meet demand, HR rises faster and faster to try to inadequately compensate, physically become weaker especially after high output anaerobic every supply deleted in 1-3 minutes and there is no aerobic capacity cavalry with it's O2 rushing in to take over and that's when I fall off the cliff> HR spikes even faster, chest pain immediately jumps, lung edema turns on full tilt as the HR spikes and the resulting pressure is forced to "spray out of the gaskets (alveoli), and brain blood O2 supply immediately becomes super inadequate and the dizziness and need to fall over is the instant result effect. And since dysfuntioning cerebral vasoconstriction is likely the cause or highly involved in migraines, this also supports why the headaches come. ... And perhaps this explaining the rest pain and how it increases with dex and exertion because blood flow o2 becomes inadequate. Then causing lactic acid waste and CO2 buildup... (ie pain). And then it, like all body tissues being deprived necessary blood flow trigger cytokine inflammation response. ... And then, fuck it, maybe this IS chronic fatigue syndrome, and IS long covid explaining PEM, explaining why every symptom imaginable in any combination permutation is being shown, is explaining the observed elevated varing soups of cytokinesis, explaining all variety of tissue damage depending on any person's unique amount of total hit and their particular systems vulnerabilities and ultimately how far down they went on the increasing spiralling cascading systems failure towards total shutdown, and explains why measures at addressing the variety of manifestations are all somewhat helpful, but inadequate and varing efficacy from patient to patient because they are all too downstream of the root cause trunk of the symptom tree where the need to relieve vascular over constriction is the root or next to the root of the symptom tree that is common to all patients. If this were all to be accurate, then the seed would be what caused the break in vasoconstrictor system and repairing/killing it, or perhaps it's a PC bootstrap phenomenon where the simple uncomplex virus was just enough bios code to place innocuous wrenches in any of machines of the systems and then those malfunctioning systems took over control in their new malfunctioning patterns and became the new bosses that are infact the disease, you become your disease, and the initial virus seed has long been killed/departed (they're the ultimate down the road end game that is the totally corrupted bcdhhs that will then exist now as a new monstrous organism slowly lingering and depleting itself and eventually all resources at which point it will have finally killed itself after it destroyed the once thriving self sustaining world it lived in. COVID then is the teenage abusive bf or mean drunk father from their past, that put in motion what would become decades and generations of monsters, years and years after they had been long since gone). And maybe this explains the phasing leaving and returning it symptoms. Because when enough if the symptoms start to be reset/repaired, that starts spiraling the spread of the shutdown of the corruption back to health, but if the spiral up isn't strong enough to overcome the consequential reactive spiral down response, the monster returns and the rebellion is quashed. And so explains why the overall, in every system, stronger less vulnerabilities less armor chinks youth are able to quash with ease the spiral down with their incumbent exceptional spiral up response. .... And aside, this explains why dysautonomia has become a top suspect. And explains why POTS has become almost synonymous with long COVID and CFS.

  4. Jul 2023
    1. But since Covid-19, I’ve watched people around me – friends, family and perfect strangers my own age whose stories are told in obituaries – drop dead from this contagion. A sharp sense of existential dread has taken up residence in my psyche. That vague inevitability that I assumed would happen in the distant future smashed me over the head like an anvil in an old cartoon. I could easily die sooner than later. My mortality was, for the first time, in center focus.
      • due to death of so many young people, covid has shifted mortality salience into center focus for many young people
  5. Jun 2023
    1. D-dimer levels (a fibrin degradation product used to determine the activation of the coagulation cascade), are enhanced in acute COVID-19 cases (Zhou F. et al., 2020; Berger et al., 2020). Different reports have found a correlation between the increase of D-dimer levels and COVID-19 severity with an about 7-fold increase in critically ill patients, associated with an increased mortality risk (Zhou F. et al., 2020; Yao Y. et al., 2020)
  6. May 2023
  7. Apr 2023
    1. those who got the updated booster had one-tenth the risk of being hospitalized compared with those who are unvaccinated

      Basically 65-79 higher seniors are in high risk of being sent to the hospital rather than other people who aren't even vaccines The booster is much more stronger to seniors.

    1. Ga-eun: So many conditions in life are rapidly changing, making even adults feel confused. I hardly dare to im-agine how much fear and anxiety this might cause among children. What about children having to bear all fam-ily problems by themselves? It makes me feel terribly sad. If it was like now, Hana could not even have gone out-side, she would have felt even more lonesome.

      Covid quarantines could change how people understand the film due to feelings during lockdowns.

  8. Feb 2023
  9. Jan 2023
    1. Selain itu, isolat virus RaTG13 memiliki nilai kekerabatan 96,1%. Virus ini ditemukan di Yunnan, Cina. Sedangkan isolat virus yang berasal dari tenggiling mempunyai nilai kekerabatan sekitar 91%. Adanya nilai kekerabatan yang tinggi ini dimungkinkan akibat dari evolusi yang telah terjadi dari nenek moyang yang sama.

      Untuk diperhatikan, artikel yang dikutip dengan judul "Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak" sudah di erratum 3 tahun yang lalu (https://pubmed.ncbi.nlm.nih.gov/32315626/)

      Sehingga masuk dalam jangkauan diskusi PubPeer dengan komentar sebagai berikut:

      Readers should become aware of a preprint (DOI: 10.1101/2020.05.07.077016) entitled "The SARS-CoV-2-like virus found in captive pangolins from Guangdong should be better sequenced" that provides critics to the quality of the sequence runs used in Liu et al. 2019 and also in this paper, to infer the genome sequence of Pangolin-CoV.

      This preprint states, in particular, that "I found the genome assemblies of GD/P virus of poor quality, having high levels of missing data. Additionally, unexpected reads in the Illumina sequencing data were identified. The GD/P2S dataset contains reads that are identical to SARS-CoV-2, suggesting either the coexistence of two SARS-CoV-2-like viruses in the same pangolin or contamination by the human virus".

      Penting bagi penulis untuk menambahkan informasi kebaharuan dan status riset dan temuan terbaru dari artikel yang dikutip. Semoga menjadi koreksi.


    1. I asked why she thought that was happening, and she said, “Covid”. The lack of socialization, especially at such a key time in life, had made this incoming class the first one that lacked basic manners and social skills.

      Covid has heavily impacted our social/communication skills

  10. Dec 2022
    1. forced on the population

      at least in the US, no one is being forced to get a vaccine. Not only that, but there's no evidence anyone's even considered it: https://www.snopes.com/fact-check/forced-vaccines-covid-19/

      Maybe they're talking about another population?

    1. We analyzed URLs cited in Twitter messages before and after the temporary interruption of the vaccine development on September 9, 2020 to investigate the presence of low credibility and malicious information. We show that the halt of the AstraZeneca clinical trials prompted tweets that cast doubt, fear and vaccine opposition. We discovered a strong presence of URLs from low credibility or malicious websites, as classified by independent fact-checking organizations or identified by web hosting infrastructure features. Moreover, we identified what appears to be coordinated operations to artificially promote some of these URLs hosted on malicious websites.
    1. We found that misinformation-exposure scores are significantly positively related to language toxicity (Fig. 3a; b = 0.129, 95% CI = [0.098, 0.159], SE = 0.015, t (4121) = 8.323, p < 0.001; b = 0.319, 95% CI = [0.274, 0.365], SE = 0.023, t (4106) = 13.747, p < 0.001 when controlling for estimated ideology) and expressions of moral outrage (Fig. 3b; b = 0.107, 95% CI = [0.076, 0.137], SE = 0.015, t (4143) = 14.243, p < 0.001; b = 0.329, 95% CI = [0.283,0.374], SE = 0.023, t (4128) = 14.243, p < 0.001 when controlling for estimated ideology). See Supplementary Tables 1, 2 for full regression tables and Supplementary Tables 3–6 for the robustness of our results.
    1. Exposure to elite misinformation is associated with sharing news from lower-quality outlets and with conservative estimated ideology.

      Shown is the relationship between users’ misinformation-exposure scores and (a) the quality of the news outlets they shared content from, as rated by professional fact-checkers21, (b) the quality of the news outlets they shared content from, as rated by layperson crowds21, and (c) estimated political ideology, based on the ideology of the accounts they follow10. Small dots in the background show individual observations; large dots show the average value across bins of size 0.1, with size of dots proportional to the number of observations in each bin.

    1. We find that, during the pandemic, no-vax communities became more central in the country-specificdebates and their cross-border connections strengthened, revealing a global Twitter anti-vaccinationnetwork. U.S. users are central in this network, while Russian users also become net exporters ofmisinformation during vaccination roll-out. Interestingly, we find that Twitter’s content moderationefforts, and in particular the suspension of users following the January 6th U.S. Capitol attack, had aworldwide impact in reducing misinformation spread about vaccines. These findings may help publichealth institutions and social media platforms to mitigate the spread of health-related, low-credibleinformation by revealing vulnerable online communities
    1. we found that social bots played a bridge role in diffusion in the apparent directional topic like “Wuhan Lab”. Previous research also found that social bots play some intermediary roles between elites and everyday users regarding information flow [43]. In addition, verified Twitter accounts continue to be very influential and receive more retweets, whereas social bots retweet more tweets from other users. Studies have found that verified media accounts remain more central to disseminating information during controversial political events [75]. However, occasionally, even the verified accounts—including those of well-known public figures and elected officials—sent misleading tweets. This inspired us to investigate the validity of tweets from verified accounts in subsequent research. It is also essential to rely solely on science and evidence-based conclusions and avoid opinion-based narratives in a time of geopolitical conflict marked by hidden agendas, disinformation, and manipulation [76].
    1. Engagement of religious leaders, for example, has been documented as an important approach to improve vaccine acceptance16,57. Key to the preparation of a COVID-19 vaccine is, therefore, the early and frequent engagement of religious and community-leaders58, and for health authorities to work collaboratively with multiple societal stakeholders to avoid the feeling that they are only acting on behalf of government authorities59.
    2. Similar rates of vaccine hesitance (26% and 25%) and resistance (9% and 6%) were evident in the Irish and UK samples, with only 65% of the Irish population and 69% of the UK population fully willing to accept a COVID-19 vaccine. These findings align with other estimates across seven European nations where 26% of adults indicated hesitance or resistance to a COVID-19 vaccine7 and in the United States where 33% of the population indicated hesitance or resistance34. Rates of resistance to a COVID-19 vaccine also parallel those found for other types of vaccines. For example, in the United States 9% regarded the MMR vaccine as unsafe in a survey of over 1000 adults35, while 7% of respondents across the world said they “strongly disagree” or “somewhat disagree” with the statement ‘Vaccines are safe’36. Thus, upwards of approximately 10% of study populations appear to be opposed to vaccinations in whatever form they take. Importantly, however, the findings from the current study and those from around Europe and the United States may not be consistent with or reflective of vaccine acceptance, hesitancy, or resistance in non-Western countries or regions.
  11. Nov 2022
    1. Our kids have lost so much—family members, connections to friends and teachers, emotional well-being, and for many, financial stability at home. And, of course, they’ve lost some of their academic progress. The pressure to measure—and remediate—this “learning loss” is intense; many advocates for educational equity are rightly focused on getting students back on track. But I am concerned about how this growing narrative of loss will affect our students, emotionally and academically. Research shows a direct connection between a student’s mindset and academic success.
    1. “Our kids have lost so much—family members, connections to friends and teachers, emotional well-being, and for many, financial stability at home,” the article begins, sifting through a now-familiar inventory of devastation, before turning to a problem of a different order. “And of course, they’ve lost some of their academic progress.”
    1. These labor actions underscored the frustrations of teachers, who have had to navigate not only the pandemic but also political harangues about their curricula, as well as insufficient pay and other long-standing issues tied to their actual work as educators. Teachers were already leaving the profession, but stress induced by the pandemic accelerated the pace.
    1. We’re dedicated to providing the highest standards of safety to protect you and your family during your visit to Founders Family Medicine. We screen all patients for COVID-19 symptoms. We also require masks and social distancing at our clinic.

      We’re dedicated to providing the highest standards of safety to protect you and your family during your visit to Founders Family Medicine. We screen all patients for COVID-19 symptoms. We also require masks and social distancing at our clinic.

  12. Oct 2022
    1. Many now find Japanese society’s prevalence for mask wearing and the numerous vestiges of preventative measures (social distancing in some restaurants, compulsory temperature checks and hand sanitizer upon entering facilities with cramped quarters, just to name a few) all an overcautious holdover from another time.

      lol at westerners thinking wearing masks is overly cautious

    1. A study across the population of Scotland researched the affects of covid by comparing those with a positive PCR test with a control group that did not have covid. Vaccinations were shown to decrease symptoms. There are concerns about long-term effects as the virus becomes endemic.

  13. Sep 2022
    1. The North American Division has put together a series of links to offer guidance about vaccines from national and international health organizations, the General Conference, and healthcare experts — with the COVID-19 vaccine highlighted in particular.
  14. Aug 2022
    1. The socioeconomic disruption associated with COVID-19 represents a highly unusual alteration of the human interaction with the Earth System. This alteration is likely to generate a series of responses, illuminating the processes connecting energy, emissions, air quality and climate, as well as globalization, food security, poverty and biodiversity

      La perturbación socioeconómica asociada a COVID-19 representa una alteración muy inusual de la interacción humana con el Sistema Tierra. Es probable que esta alteración genere una serie de respuestas que iluminen los procesos que conectan la energía, las emisiones, la calidad del aire y el clima, así como la globalización, la seguridad alimentaria, la pobreza y la biodiversidad.

    1. Lucas, C., Vogels, C. B. F., Yildirim, I., Rothman, J. E., Lu, P., Monteiro, V., Gelhausen, J. R., Campbell, M., Silva, J., Tabachikova, A., Peña-Hernandez, M. A., Muenker, M. C., Breban, M. I., Fauver, J. R., Mohanty, S., Huang, J., Shaw, A. C., Ko, A. I., Omer, S. B., … Iwasaki, A. (2021). Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity. Nature, 1–9. https://doi.org/10.1038/s41586-021-04085-y

    1. Gilbert, P. B., Montefiori, D. C., McDermott, A., Fong, Y., Benkeser, D. C., Deng, W., Zhou, H., Houchens, C. R., Martins, K., Jayashankar, L., Castellino, F., Flach, B., Lin, B. C., O’Connell, S., McDanal, C., Eaton, A., Sarzotti-Kelsoe, M., Lu, Y., Yu, C., … Teams, U. S. G. (USG)/CoVPN B. (2021). Immune Correlates Analysis of the mRNA-1273 COVID-19 Vaccine Efficacy Trial. MedRxiv, 2021.08.09.21261290. https://doi.org/10.1101/2021.08.09.21261290

    1. Munro, A. P. S., Janani, L., Cornelius, V., Aley, P. K., Babbage, G., Baxter, D., Bula, M., Cathie, K., Chatterjee, K., Dodd, K., Enever, Y., Gokani, K., Goodman, A. L., Green, C. A., Harndahl, L., Haughney, J., Hicks, A., van der Klaauw, A. A., Kwok, J., … Appleby, K. (2021). Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): A blinded, multicentre, randomised, controlled, phase 2 trial. The Lancet, S0140673621027173. https://doi.org/10.1016/S0140-6736(21)02717-3 s

    1. Chadeau-Hyam, M., Wang, H., Eales, O., Haw, D., Bodinier, B., Whitaker, M., Walters, C. E., Ainslie, K. E. C., Atchison, C., Fronterre, C., Diggle, P. J., Page, A. J., Trotter, A. J., Ashby, D., Barclay, W., Taylor, G., Cooke, G., Ward, H., Darzi, A., … Elliott, P. (2022). SARS-CoV-2 infection and vaccine effectiveness in England (REACT-1): A series of cross-sectional random community surveys. The Lancet Respiratory Medicine, 0(0). https://doi.org/10.1016/S2213-2600(21)00542-7

    1. Kustin, T., Harel, N., Finkel, U., Perchik, S., Harari, S., Tahor, M., Caspi, I., Levy, R., Leschinsky, M., Dror, S. K., Bergerzon, G., Gadban, H., Gadban, F., Eliassian, E., Shimron, O., Saleh, L., Ben-Zvi, H., Amichay, D., Ben-Dor, A., … Stern, A. (2021). Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals. MedRxiv, 2021.04.06.21254882. https://doi.org/10.1101/2021.04.06.21254882

    1. Sadoff, J., Gars, M. L., Cardenas, V., Shukarev, G., Vaissiere, N., Heerwegh, D., Truyers, C., Groot, A. M. de, Scheper, G., Hendriks, J., Ruiz-Guinazu, J., Struyf, F., Hoof, J. V., Douoguih, M., & Schuitemaker, H. (2021). Durability of antibody responses elicited by a single dose of Ad26.COV2.S and substantial increase following late boosting (p. 2021.08.25.21262569). https://doi.org/10.1101/2021.08.25.21262569

    1. Pozzetto, B., Legros, V., Djebali, S., Barateau, V., Guibert, N., Villard, M., Peyrot, L., Allatif, O., Fassier, J.-B., Massardier-Pilonchéry, A., Brengel-Pesce, K., Yaugel-Novoa, M., Denolly, S., Boson, B., Bourlet, T., Bal, A., Valette, M., Andrieu, T., Lina, B., … Trouillet-Assant, S. (2021). Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination. Nature, 1–9. https://doi.org/10.1038/s41586-021-04120-y

  15. khub.net