Jury in Sean ‘Diddy’ Combs Trial Reaches Verdict on All Counts but Racketeering Conspiracy by [[Julia Jacobs]], [[Ben Sisario]]
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- Jul 2025
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www.nytimes.com www.nytimes.com
- Oct 2023
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And we found this greatpsychology term—“psychogenic fugue”—describing an event wherethe mind tricks itself to escape some horror. So, in a way, LostHighway is about that. And also the fact that nothing can stay hiddenforever.
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- Mar 2023
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library.scholarcy.com library.scholarcy.com
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ts with pressure sores are more likely to die, but this seems to be related to
wow
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- Feb 2023
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www.reddit.com www.reddit.com
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One can find utility in asking questions of their own note box, but why not also leverage the utility of a broader audience asking questions of it as well?!
One of the values of social media is that it can allow you to practice or rehearse the potential value of ideas and potentially getting useful feedback on individual ideas which you may be aggregating into larger works.
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- Sep 2022
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stratechery.com stratechery.com
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In short, the questions about Google’s behavior are not about free speech; they do, though, touch on other Amendments in the Bill of Rights. For example: The Fourth Amendment bars “unreasonable searches and seizures”; while you can make the case that search warrants were justified once the photos in question were discovered, said photos were only discovered because Mark’s photo library was indiscriminately searched in the first place. The Fifth Amendment says no person shall be deprived of life, liberty, or property, without due process of law; Mark lost all of his data, email account, phone number, and everything else Google touched forever with no due process at all. The Sixth Amendment is about the rights to a trial; Mark was not accused of any crime in the real world, but when it came to his digital life Google was, as I noted, “judge, jury, and executioner” (the Seventh Amendment is, relatedly, about the right to a jury trial for all controversies exceeding $20).
Ben Thompson argues that questions about Google's behavior towards a false positive case of CSAM does not pertain to free speech or to the First Amendment. But it does pertain to other Amendments in the Bill of Rights.
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docdrop.org docdrop.orgUntitled4
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‘Someithasevntacrossthesea,Someit.hascausedto die injail,”‘Andsomeuponthegollows
argues that the cause of the murder was "drink", and that nothing good may come from it.
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en searching Carey they found upon him,‘Mr. Sieenson’s pocket-Knife
shows events from the trial, and provides more information on the reasoning why Pickett and Carey were charged.
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d be saw blood upon their clothes
as the son sees blood on Pickett and Carey's clothes, he ran to the police station, leading to the two men being charged with the murder of Stevenson.
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O’ then what news was for his som,
the act of the neighbor telling the son is important. the son is then the character who saw Pickett and Carey with blood on their clothes, and accused them of the murder of his father.
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- Aug 2022
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www.pbs.org www.pbs.org
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- Jun 2022
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The old cookbook said: " Take enough butter." I say: "Do nottake too many notes." Both recommendations are hard to inter-pret except by trial and error.
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Epidemiology 101 for Journalists. (n.d.). Epidemiology, Biostatistics and Occupational Health. Retrieved 23 February 2021, from https://www.mcgill.ca/epi-biostat-occh/epidemiology-101-journalists
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- Apr 2021
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twitter.com twitter.com
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Seth Trueger. (2021, April 16). *far lower than expectations that’s < 1 in 10k, which is way better than 95% https://t.co/mxQ84MFKc2 [Tweet]. @MDaware. https://twitter.com/MDaware/status/1383065988204220419
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www.theguardian.com www.theguardian.com
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the Guardian. ‘Pfizer Vaccine Has 91% Efficacy for up to Six Months, Trial Shows’, 1 April 2021. http://www.theguardian.com/world/2021/apr/01/pfizer-vaccine-has-91-efficacy-for-up-to-six-months-trial-shows.
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- Mar 2021
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blogs.bmj.com blogs.bmj.com
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Covid-19 vaccine wars: Developing the AstraZeneca vaccine was a triumph, but then things went wrong. (2021, March 26). The BMJ. https://blogs.bmj.com/bmj/2021/03/26/vaccine-wars-developing-the-astrazeneca-vaccine-was-a-triumph-but-then-things-went-wrong/
Tags
- vaccination
- news
- efficacy
- is:blog
- trial
- vaccine
- AstraZeneca
- problem
- effective
- communication
- UK
- COVID-19
- lang:en
- headline
Annotators
URL
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www.thelancet.com www.thelancet.com
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Iversen, P. L., & Bavari, S. (2021). Is there space for a three-dose vaccine to fight the spread of SARS-CoV-2? The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00149-3
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Moutsiakis, D. L., & Chin, P. N. (2007). Why blacks do not take part in HIV vaccine trials. Journal of the National Medical Association, 99(3), 254–257.
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www.thelancet.com www.thelancet.com
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Clinical trials of disease stages in COVID 19: Complicated and often misinterpreted—The Lancet Global Health. (n.d.). Retrieved August 24, 2020, from https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30365-X/fulltext
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www.forbes.com www.forbes.com
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Salzberg, S. (n.d.). I Was Wrong: We Can’t Skip Phase 3 Vaccine Trials. Forbes. Retrieved August 5, 2020, from https://www.forbes.com/sites/stevensalzberg/2020/08/03/i-was-wrong-we-cant-skip-phase-3-vaccine-trials/
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science.sciencemag.org science.sciencemag.org
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Thorp, H. H. (2020). Underpromise, overdeliver. Science, 367(6485), 1405–1405. https://doi.org/10.1126/science.abb8492
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www.reuters.com www.reuters.com
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Coronavirus vaccine safe in early trial, hydroxychloroquine may increase death risk. (2020, May 23). Reuters. https://www.reuters.com/article/us-health-coronavirus-science-idUSKBN22Y2OD
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Lang, T. (2020). Plug COVID-19 research gaps in detection, prevention and care. Nature, 583(7816), 333–333. https://doi.org/10.1038/d41586-020-02004-1
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Rosendaal, F. R. (2020). Review of: “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Gautret et al 2010, DOI:10.1016/j.ijantimicag.2020.105949. International Journal of Antimicrobial Agents, 106063. https://doi.org/10.1016/j.ijantimicag.2020.106063
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www.sciencedirect.com www.sciencedirect.com
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Harvey, H., Reissland, N., & Mason, J. (2015). Parental reminder, recall and educational interventions to improve early childhood immunisation uptake: A systematic review and meta-analysis. Vaccine, 33(25), 2862–2880. https://doi.org/10.1016/j.vaccine.2015.04.085
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twitter.com twitter.com
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A Marm Kilpatrick. (2021, February 9). Vaccine efficacy in blocking infection & transmission (I think) We can now estimate the (minimum) reduction in transmission from the Moderna vaccine. Thread tl;dr Moderna vaccine blocks >90% (87-93%) of infections & 91% (89-94%) of transmission. *Critiques welcome! Https://t.co/GjQIo3v4oe [Tweet]. @DiseaseEcology. https://twitter.com/DiseaseEcology/status/1359213735424872450
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Local file Local file
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Smith, P. (2021). Interim recommendations for use of the AZD1222 (ChAdOx1-S (recombinant)) vaccine against COVID-19 developed by Oxford University and AstraZeneca. WHO.
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www.thelancet.com www.thelancet.com
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Vijayasingham, L., Bischof, E., & Wolfe, J. (2021). Sex-disaggregated data in COVID-19 vaccine trials. The Lancet, 397(10278), 966–967. https://doi.org/10.1016/S0140-6736(21)00384-6
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www.washingtonpost.com www.washingtonpost.com
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Isaacson, Walter. ‘Opinion | I Was Part of a Trial for Pfizer’s Covid-19 Vaccine. It’s a Miracle for Genetic Medicine.’ Washington Post. Accessed 6 March 2021. https://www.washingtonpost.com/opinions/i-took-the-pfizer-covid-19-vaccine-its-a-miracle-for-genetic-medicine/2020/11/09/77e652d0-22bf-11eb-952e-0c475972cfc0_story.html.
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www.frontiersin.org www.frontiersin.org
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Abdelhafiz, Ahmed Samir, Samar Abd ElHafeez, Mohammad Adnan Khalil, Manal Shahrouri, Bandar Alosaim, Raneem O. Salem, Mohamed Alorabi, Fatma Abdelgawad, and Mamoun Ahram. ‘Factors Influencing Participation in COVID-19 Clinical Trials: A Multi-National Study’. Frontiers in Medicine 8 (2021). https://doi.org/10.3389/fmed.2021.608959.
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www.rand.org www.rand.org
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Helmus, Todd C., James V. Marrone, Marek N. Posard, and Danielle Schlang. ‘Russian Propaganda Hits Its Mark: Experimentally Testing the Impact of Russian Propaganda and Counter-Interventions’, 15 October 2020. https://www.rand.org/pubs/research_reports/RRA704-3.html.
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www-nature-com.ezp.lib.cam.ac.uk www-nature-com.ezp.lib.cam.ac.uk
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Nature Editorial. (2020, October 23). The race to make COVID antibody therapies cheaper and more potent. Nature. https://www.nature.com/articles/d41586-020-02965-3?utm_source=twt_nnc&utm_medium=social&utm_campaign=naturenews&sf239165668=1&error=cookies_not_supported&code=2b2dd7c6-d01f-4057-8389-3be656a7ba58
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www.sciencedirect.com www.sciencedirect.com
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Yufika, A., Wagner, A. L., Nawawi, Y., Wahyuniati, N., Anwar, S., Yusri, F., Haryanti, N., Wijayanti, N. P., Rizal, R., Fitriani, D., Maulida, N. F., Syahriza, M., Ikram, I., Fandoko, T. P., Syahadah, M., Asrizal, F. W., Aletta, A., Haryanto, S., Jamil, K. F., … Harapan, H. (2020). Parents’ hesitancy towards vaccination in Indonesia: A cross-sectional study in Indonesia. Vaccine, 38(11), 2592–2599. https://doi.org/10.1016/j.vaccine.2020.01.072
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academic.oup.com academic.oup.com
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Meng Z , Wang T , Li C et al. PREPRINT: An experimental trial of recombinant human interferon alpha nasal drops to prevent coronavirus disease 2019 in medical staff in an epidemic area. medRxiv 2020:2020.04.11.20061473. doi:10.1101/2020.04.11.20061473.
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academic.oup.com academic.oup.com
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Meng Z , Wang T , Li C et al. PREPRINT: An experimental trial of recombinant human interferon alpha nasal drops to prevent coronavirus disease 2019 in medical staff in an epidemic area. medRxiv 2020:2020.04.11.20061473.
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www.wired.com www.wired.com
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The Strange and Twisted Tale of Hydroxychloroquine. (n.d.). Wired. Retrieved 1 March 2021, from https://www.wired.com/story/hydroxychloroquine-covid-19-strange-twisted-tale/
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www.bmj.com www.bmj.com
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Abbasi, K. (2020). The curious case of the Danish mask study. BMJ, 371, m4586. https://doi.org/10.1136/bmj.m4586
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- Feb 2021
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twitter.com twitter.com
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Dr Ellie Murray. (2020, December 3). Some really great resources & discussions in this thread. The tl;dr is (1) yes, the vaccine trials included some people who had previously had COVID; and (2) in general vaccination plans will include those who have previously been sick/infected. Thanks all! [Tweet]. @EpiEllie. https://twitter.com/EpiEllie/status/1334545373126389766
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twitter.com twitter.com
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Carl T. Bergstrom. (2020, December 5). I don’t have a background in medical ethics but this makes me uncomfortable unless it was very clearly explained to study participants at enrollment, and to some degree even then. H/t @RMCarpiano https://t.co/WUE1mXgjJG https://t.co/yLXkxIa5O8 [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1335152266840424449
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twitter.com twitter.com
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ReconfigBehSci. (2020, December 6). RT @statsepi: Lol ok. Https://t.co/eCPpU3Linv [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1335894181248643073
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www.theguardian.com www.theguardian.com
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the Guardian. ‘Air New Zealand to Trial Covid Vaccine Passport on Sydney Flights’, 23 February 2021. http://www.theguardian.com/world/2021/feb/23/air-new-zealand-to-trial-covid-vaccine-passport-on-sydney-flights.
Tags
- app
- New Zealand
- digital
- WHO
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- is:news
- medical
- flights
- vaccine passport
- COVID-19
- verification
- Auckland
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- Air New Zealand
- travel
- Australia
- Sydney
- lang:en
Annotators
URL
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www.cdc.gov www.cdc.gov
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Gee, Julianne. ‘First Month of COVID-19 Vaccine Safety Monitoring — United States, December 14, 2020–January 13, 2021’. MMWR. Morbidity and Mortality Weekly Report 70 (2021). https://doi.org/10.15585/mmwr.mm7008e3.
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Report of 8% vaccine efficacy for elderly debunked by German government. (14:24:16+00:00). Full Fact. https://fullfact.org/health/german-astrazeneca-8-percent-handelsblatt/
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www.nature.com www.nature.com
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Loomba, S., de Figueiredo, A., Piatek, S. J., de Graaf, K., & Larson, H. J. (2021). Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA. Nature Human Behaviour, 1–12. https://doi.org/10.1038/s41562-021-01056-1
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www.nihr.ac.uk www.nihr.ac.uk
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Novavax COVID-19 vaccine 89.3% effective. (n.d.). Retrieved 1 February 2021, from https://www.nihr.ac.uk/news/novavax-covid-19-vaccine-893-effective/26720
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- Jan 2021
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pediatrics.aappublications.org pediatrics.aappublications.org
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Brewer, N. T., Hall, M. E., Malo, T. L., Gilkey, M. B., Quinn, B., & Lathren, C. (2017). Announcements Versus Conversations to Improve HPV Vaccination Coverage: A Randomized Trial. Pediatrics, 139(1). https://doi.org/10.1542/peds.2016-1764
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wp.techtarget.itmedia.co.jp wp.techtarget.itmedia.co.jp
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それを実践しているのが、全国に200店舗以上の大型スーパーマーケット「TRIAL」を展開するトライアルホールディングスだ
TRIALはいつも先進技術に積極的に取り込んでいる
Tags
Annotators
URL
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www.news-medical.net www.news-medical.net
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Analysis supports phase 3 trials of Johnson & Johnson’s COVID-19 vaccine. (2021, January 17). News-Medical.Net. https://www.news-medical.net/news/20210117/Analysis-supports-phase-3-trials-of-Johnson-Johnsons-COVID-19-vaccine.aspx
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www.nejm.org www.nejm.org
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Sadoff, J., Le Gars, M., Shukarev, G., Heerwegh, D., Truyers, C., de Groot, A. M., Stoop, J., Tete, S., Van Damme, W., Leroux-Roels, I., Berghmans, P.-J., Kimmel, M., Van Damme, P., de Hoon, J., Smith, W., Stephenson, K. E., De Rosa, S. C., Cohen, K. W., McElrath, M. J., … Schuitemaker, H. (2021). Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMoa2034201
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COVID-19 Seminars—Emerging Pathogens Institute—University of Florida. (n.d.). Retrieved January 13, 2021, from https://epi.ufl.edu/covid-19-seminars/
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twitter.com twitter.com
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ReconfigBehSci on Twitter: “RT @DrJV75: Some great vaccine myth busting summary images to share https://t.co/MeSjC89eu4” / Twitter. (n.d.). Retrieved January 13, 2021, from https://twitter.com/SciBeh/status/1335893630951755778
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www.theatlantic.com www.theatlantic.com
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Zhang, S. (2020, May 24). We Don’t Even Have a COVID-19 Vaccine, and Yet the Conspiracies Are Here. The Atlantic. https://www.theatlantic.com/science/archive/2020/05/covid-19-vaccine-skeptics-conspiracies/611998/
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www.theatlantic.com www.theatlantic.com
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Zhang, S. (2020, September 28). Vaccine Chaos Is Looming. The Atlantic. https://www.theatlantic.com/health/archive/2020/09/covid-19-most-complicated-vaccine-campaign-ever/616521/
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www.theatlantic.com www.theatlantic.com
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Zhang, S. (2020, December 1). The Long Haul of Vaccine Results Is Just Beginning. The Atlantic. https://www.theatlantic.com/health/archive/2020/12/vaccine-trials-can-still-surprise-us/617247/
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- Dec 2020
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www.nature.com www.nature.com
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Cyranoski, D. (2020). Arab nations first to approve Chinese COVID vaccine—Despite lack of public data. Nature, 588(7839), 548–548. https://doi.org/10.1038/d41586-020-03563-z
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www.nature.com www.nature.com
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Ledford, H., Cyranoski, D., & Noorden, R. V. (2020). The UK has approved a COVID vaccine—Here’s what scientists now want to know. Nature, 588(7837), 205–206. https://doi.org/10.1038/d41586-020-03441-8
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www.theguardian.com www.theguardian.com
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Grover, N. (2020, December 7). WHO looks at giving Covid-19 to healthy people to speed up vaccine trials. The Guardian. https://www.theguardian.com/world/2020/dec/07/who-looks-at-giving-covid-to-healthy-people-to-speed-up-vaccine-trials
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www.nature.com www.nature.com
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Ledford, H. (2020). Oxford COVID-vaccine paper highlights lingering unknowns about results. Nature. https://doi.org/10.1038/d41586-020-03504-w
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www.thelancet.com www.thelancet.com
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Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Collins, A. M., Colin-Jones, R., Cutland, C. L., Darton, T. C., Dheda, K., Duncan, C. J. A., … Zuidewind, P. (2020). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)32661-1
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- Nov 2020
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www.sciencemag.org www.sciencemag.org
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CohenNov. 16, J., 2020, & Am, 7:00. (2020, November 16). ‘Just beautiful’: Another COVID-19 vaccine, from newcomer Moderna, succeeds in large-scale trial. Science | AAAS. https://www.sciencemag.org/news/2020/11/just-beautiful-another-covid-19-vaccine-newcomer-moderna-succeeds-large-scale-trial
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scroll.in scroll.in
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“Let’s say a trial is listed and I have to cross examine a witness,” he said. “Now, what is the guarantee that the witness would be willing to go all the way to the court in such a time?” If witnesses do not appear, then the matter would merely be adjourned.
access to justice
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- Oct 2020
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www.npr.org www.npr.org
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Aubrey, A. (2020). Will Kids Get A COVID-19 Vaccine? Pfizer To Expand Trial To Ages 12 And Up. NPR. https://www.npr.org/sections/health-shots/2020/10/13/923248377/will-kids-get-a-covid-19-vaccine-pfizer-to-expand-trial-to-ages-12-and-up?t=1602805163253
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- Sep 2020
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www.nature.com www.nature.com
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magazine, D. C., Smriti Mallapaty,Nature. (n.d.). Coronavirus Vaccine U.K. Trial Restarts, But Scientists Question Lack of Transparency. Scientific American. Retrieved September 16, 2020, from https://www.scientificamerican.com/article/coronavirus-vaccine-u-k-trial-restarts-but-scientists-question-lack-of-transparency/
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www.bmj.com www.bmj.com
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Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Izcovich, A., Kum, E., Pardo-Hernandez, H., Rochwerg, B., Lamontagne, F., Han, M. A., Liu, Q., Agarwal, A., Agoritsas, T., Chu, D. K., Couban, R., Darzi, A., Devji, T., Fang, B., Fang, C., … Brignardello-Petersen, R. (2020). Drug treatments for covid-19: Living systematic review and network meta-analysis. BMJ, 370. https://doi.org/10.1136/bmj.m2980
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jamanetwork.com jamanetwork.com
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Kouzy, R., Jaoude, J. A., Garcia, C. J. G., Alam, M. B. E., Taniguchi, C. M., & Ludmir, E. B. (2020). Characteristics of the Multiplicity of Randomized Clinical Trials for Coronavirus Disease 2019 Launched During the Pandemic. JAMA Network Open, 3(7), e2015100–e2015100. https://doi.org/10.1001/jamanetworkopen.2020.15100
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www.youtube.com www.youtube.com
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JNOLive | Multiplicity of Randomized Clinical Trials for Coronavirus Disease 2019. (2020, July 14). https://www.youtube.com/watch?v=H-MWPqgLUvA&feature=youtu.be
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www.scientificamerican.com www.scientificamerican.com
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Ponchner, D. (n.d.). Costa Rica Readies Horse Antibodies for Trials as an Inexpensive COVID-19 Therapy. Scientific American. Retrieved September 8, 2020, from https://www.scientificamerican.com/article/costa-rica-readies-horse-antibodies-for-trials-as-an-inexpensive-covid-19-therapy/
Tags
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- Costa Rica
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www.nytimes.com www.nytimes.com
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Emanuel, E. J., & Offit, P. A. (2020, June 8). Opinion | Could Trump Turn a Vaccine Into a Campaign Stunt? The New York Times. https://www.nytimes.com/2020/06/08/opinion/trump-coronavirus-vaccine.html
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www.thelancet.com www.thelancet.com
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Rheumatology, T. L. (2020). COVID-19: A time to reflect. The Lancet Rheumatology, 2(6), e309. https://doi.org/10.1016/S2665-9913(20)30102-8
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- Aug 2020
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www.siliconrepublic.com www.siliconrepublic.com
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Gorey, C. (2020, June 29). RCSI team to start trial for promising Covid-19 therapy for severe infections. Silicon Republic. https://www.siliconrepublic.com/innovation/rcsi-trial-covid-19-therapy-alpha-1-antitrypsin
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twitter.com twitter.com
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Dr Nisreen Alwan 🌻 on Twitter: “There’s no randomised trial evidence for social distancing, hand washing or even testing & contact tracing on #COVID19 so why is it being demanded for masks? I’m for it in all enclosed public spaces (if you can). We need to smile a tiny bit wider though so it shows from our eyes. https://t.co/3J3FToWeud” / Twitter. (n.d.). Twitter. Retrieved July 16, 2020, from https://twitter.com/Dr2NisreenAlwan/status/1281961332963770368
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www.thelancet.com www.thelancet.com
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Zhu, F.-C., Guan, X.-H., Li, Y.-H., Huang, J.-Y., Jiang, T., Hou, L.-H., Li, J.-X., Yang, B.-F., Wang, L., Wang, W.-J., Wu, S.-P., Wang, Z., Wu, X.-H., Xu, J.-J., Zhang, Z., Jia, S.-Y., Wang, B.-S., Hu, Y., Liu, J.-J., … Chen, W. (2020). Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: A randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31605-6
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pubs.acs.org pubs.acs.org
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Shan, B., Broza, Y. Y., Li, W., Wang, Y., Wu, S., Liu, Z., Wang, J., Gui, S., Wang, L., Zhang, Z., Liu, W., Zhou, S., Jin, W., Zhang, Q., Hu, D., Lin, L., Zhang, Q., Li, W., Wang, J., … Haick, H. (2020). Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath. ACS Nano. https://doi.org/10.1021/acsnano.0c05657
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www.medrxiv.org www.medrxiv.org
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Mohana, A., Suliman, T., Mahmoud, N., Hassanein, M., Alfaifi, A., Alenazi, E., Radwan, N., Alkhalifah, N., Elkady, E., Almohaizeie, A., AboGazalah, F., AbdulKareem, K., AlGhofaili, F., Jokhdar, H., & Alrabiah, F. (2020). Hydroxychloroquine Safety Outcome within Approved Therapeutic Protocol for COVID-19 Outpatients in Saudi Arabia. MedRxiv, 2020.08.16.20175752. https://doi.org/10.1101/2020.08.16.20175752
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www.youtube.com www.youtube.com
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Science Facebook Live: Understanding SARS-CoV-2 structure informs vaccine design, clinical trials. (2020, March 20). https://www.youtube.com/watch?v=nOzEx3OpKe8
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www.ijidonline.com www.ijidonline.com
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Monforte, A. d’Arminio, Tavelli, A., Bai, F., Marchetti, G., & Cozzi-Lepri, A. (2020). Effectiveness of hydroxychloroquine in COVID-19 disease: A done and dusted deal? International Journal of Infectious Diseases, 99, 75–76. https://doi.org/10.1016/j.ijid.2020.07.056
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Mather, N. (2020). How we accelerated clinical trials in the age of coronavirus. Nature, 584(7821), 326–326. https://doi.org/10.1038/d41586-020-02416-z
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www.nber.org www.nber.org
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Lo, A. W., Siah, K. W., & Wong, C. H. (2020). Estimating Probabilities of Success of Vaccine and Other Anti-Infective Therapeutic Development Programs (Working Paper No. 27176; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27176
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www.nber.org www.nber.org
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Chaudhuri, S., Lo, A. W., Xiao, D., & Xu, Q. (2020). Bayesian Adaptive Clinical Trials for Anti‐Infective Therapeutics during Epidemic Outbreaks (Working Paper No. 27175; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27175
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CNN, A. V., Holly Yan and Christina Maxouris. (n.d.). FDA won’t ‘cut corners’ to approve a Covid-19 vaccine, commissioner says. CNN. Retrieved 12 August 2020, from https://www.cnn.com/2020/08/10/health/us-coronavirus-monday/index.html
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jamanetwork.com jamanetwork.com
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Khan MS, Fonarow GC, Friede T, et al. Application of the Reverse Fragility Index to Statistically Nonsignificant Randomized Clinical Trial Results. JAMA Netw Open. 2020;3(8):e2012469. doi:10.1001/jamanetworkopen.2020.12469
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www.nber.org www.nber.org
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Manski, C. F., & Tetenov, A. (2020). Statistical Decision Properties of Imprecise Trials Assessing COVID-19 Drugs (Working Paper No. 27293; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27293
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www.nber.org www.nber.org
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Kominers, S. D., Pathak, P. A., Sönmez, T., & Ünver, M. U. (2020). Paying It Backward and Forward: Expanding Access to Convalescent Plasma Therapy Through Market Design (Working Paper No. 27143; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27143
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www.medrxiv.org www.medrxiv.org
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Horby, P., Mafham, M., Linsell, L., Bell, J. L., Staplin, N., Emberson, J. R., Wiselka, M., Ustianowski, A., Elmahi, E., Prudon, B., Whitehouse, A., Felton, T., Williams, J., Faccenda, J., Underwood, J., Baillie, J. K., Chappell, L., Faust, S. N., Jaki, T., … Landray, M. J. (2020). Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a multi-centre, randomized, controlled trial. MedRxiv, 2020.07.15.20151852. https://doi.org/10.1101/2020.07.15.20151852
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www.cnn.com www.cnn.com
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CNN, J. G., Naomi Thomas, Dana Vigue and Jacqueline Howard. (n.d.). Oxford’s Covid-19 vaccine appears safe and induces immune response, early results suggest. CNN. Retrieved August 2, 2020, from https://www.cnn.com/2020/07/20/health/oxford-covid-19-vaccine-results-cansino-pfizer-study/index.html
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- Jul 2020
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www.newscientist.com www.newscientist.com
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Vaughan, A. (n.d.). Which covid-19 treatments work and how close are we to getting more? New Scientist. Retrieved 31 July 2020, from https://www.newscientist.com/article/2250176-which-covid-19-treatments-work-and-how-close-are-we-to-getting-more/
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Sehgal, D. (2020). Analysis of Vaccines to tackle COVID-19 with Patent Review [Preprint]. SocArXiv. https://doi.org/10.31235/osf.io/q96wj
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www.statnews.com www.statnews.com
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Herper, M. (2020, July 1). Covid-19 vaccine from Pfizer and BioNTech shows positive results. CNBC. https://www.cnbc.com/2020/07/01/coronavirus-vaccine-from-pfizer-and-biontech-shows-positive-results-report-says.html
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www.medrxiv.org www.medrxiv.org
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Mulligan, M. J., Lyke, K. E., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S. P., Neuzil, K., Raabe, V., Bailey, R., Swanson, K. A., Li, P., Koury, K., Kalina, W., Cooper, D., Fonter-Garfias, C., Shi, P.-Y., Tuereci, O., Tompkins, K. R., Walsh, E. E., … Jansen, K. U. (2020). Phase 1/2 Study to Describe the Safety and Immunogenicity of a COVID-19 RNA Vaccine Candidate (BNT162b1) in Adults 18 to 55 Years of Age: Interim Report. MedRxiv, 2020.06.30.20142570. https://doi.org/10.1101/2020.06.30.20142570
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www.nationalgeographic.com www.nationalgeographic.com
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A COVID-19 vaccine has passed its first human trial. But is it the frontrunner? (2020, May 29). Science. https://www.nationalgeographic.com/science/2020/05/coronavirus-vaccine-passes-first-human-trial-but-is-it-frontrunner-cvd/
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Richards, A. D. (2020). Ethical Guidelines for Deliberately Infecting Volunteers with COVID-19 [Preprint]. SocArXiv. https://doi.org/10.31235/osf.io/jb7gq
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www.sciencedirect.com www.sciencedirect.com
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Ecker, U. K. H., Butler, L. H., Cook, J., Hurlstone, M. J., Kurz, T., & Lewandowsky, S. (2020). Using the COVID-19 economic crisis to frame climate change as a secondary issue reduces mitigation support. Journal of Environmental Psychology, 101464. https://doi.org/10.1016/j.jenvp.2020.101464
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science.sciencemag.org science.sciencemag.org
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Haushofer, J., & Metcalf, C. J. E. (2020). Which interventions work best in a pandemic? Science. https://doi.org/10.1126/science.abb6144
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www.nytimes.com www.nytimes.com
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Jena, A. B., & Worsham, C. M. (2020, June 30). What Coronavirus Researchers Can Learn From Economists. The New York Times. https://www.nytimes.com/2020/06/30/upshot/coronavirus-economists-dexamethasone.html
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www.clinicalmicrobiologyandinfection.com www.clinicalmicrobiologyandinfection.com
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Meyer, B., Torriani, G., Yerly, S., Mazza, L., Calame, A., Arm-Vernez, I., Zimmer, G., Agoritsas, T., Stirnemann, J., Spechbach, H., Guessous, I., Stringhini, S., Pugin, J., Roux-Lombard, P., Fontao, L., Siegrist, C.-A., Eckerle, I., Vuilleumier, N., & Kaiser, L. (2020). Validation of a commercially available SARS-CoV-2 serological immunoassay. Clinical Microbiology and Infection, 0(0). https://doi.org/10.1016/j.cmi.2020.06.024
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www.biorxiv.org www.biorxiv.org
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Corbett, K. S., Edwards, D., Leist, S. R., Abiona, O. M., Boyoglu-Barnum, S., Gillespie, R. A., Himansu, S., Schäfer, A., Ziwawo, C. T., DiPiazza, A. T., Dinnon, K. H., Elbashir, S. M., Shaw, C. A., Woods, A., Fritch, E. J., Martinez, D. R., Bock, K. W., Minai, M., Nagata, B. M., … Graham, B. S. (2020). SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness. BioRxiv, 2020.06.11.145920. https://doi.org/10.1101/2020.06.11.145920
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Zhou, Q., Chen, V., Shannon, C. P., Wei, X.-S., Xiang, X., Wang, X., Wang, Z.-H., Tebbutt, S. J., Kollmann, T. R., & Fish, E. N. (2020). Interferon-α2b Treatment for COVID-19. Frontiers in Immunology, 11. https://doi.org/10.3389/fimmu.2020.01061
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Chen, L., Zhang, Z., Fu, J., Feng, Z., Zhang, S.-Z., Han, Q.-Y., Zhang, X., Xiao, X., Chen, H.-M., Liu, L.-L., Chen, X.-L., Lan, Y.-P., Zhong, D.-J., Hu, L., Wang, J.-H., Yu, X.-H., She, D.-Y., Zhu, Y.-H., & Yin, Z.-Y. (2020). Efficacy and safety of chloroquine or hydroxychloroquine in moderate type of COVID-19: A prospective open-label randomized controlled study. MedRxiv, 2020.06.19.20136093. https://doi.org/10.1101/2020.06.19.20136093
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Sbidian, E., Josse, J., Lemaitre, G., Mayer, I., Bernaux, M., Gramfort, A., Lapidus, N., Paris, N., Neuraz, A., Lerner, I., Garcelon, N., Rance, B., Grisel, O., Moreau, T., Bellamine, A., Wolkenstein, P., Varoquaux, G., Caumes, E., Lavielle, M., … Audureau, E. (2020). Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: A cohort study of 4,642 in-patients in France. MedRxiv, 2020.06.16.20132597. https://doi.org/10.1101/2020.06.16.20132597
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Boseley, Sarah, and Melissa Davey. ‘Covid-19: Lancet Retracts Paper That Halted Hydroxychloroquine Trials’. The Guardian, 4 June 2020, sec. World news. https://www.theguardian.com/world/2020/jun/04/covid-19-lancet-retracts-paper-that-halted-hydroxychloroquine-trials.
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Bail, C. A. (2016). Combining natural language processing and network analysis to examine how advocacy organizations stimulate conversation on social media. Proceedings of the National Academy of Sciences, 113(42), 11823–11828. https://doi.org/10.1073/pnas.1607151113
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Kurzweil, R. (2020 May 19). AI-Powered Biotech Can Help Deploy a Vaccine In Record Time. Wired. https://www.wired.com/story/opinion-ai-powered-biotech-can-help-deploy-a-vaccine-in-record-time/
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www.wired.com www.wired.com
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The First Shot: Inside the Covid Vaccine Fast Track. (n.d.). Wired. Retrieved May 30, 2020, from https://www.wired.com/story/moderna-covid-19-vaccine-trials/
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UKCDR - COVID-19 Research Project Tracker
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Wagenmakers, E., & Gronau, Q. F. (2020, April 27). Efficacy of Hydroxychloroquine in Patients with COVID-19 (Chen et al., 2020): Moderate Evidence for a Treatment Effect on Pneumonia. Retrieved from psyarxiv.com/7nk8z
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- Apr 2020
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Mullard, A. (2020). Flooded by the torrent: The COVID-19 drug pipeline. The Lancet, 395(10232), 1245–1246. https://doi.org/10.1016/S0140-6736(20)30894-1
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academic.oup.com academic.oup.com
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REE decreased approximately 15% when TSH increased between 0.1 and 10 mU/L.
The individual change in REE to a given change in dose varied radically. The dose change was only 50 mcg, which seemed to change TSH about half what they've calculated for 15% REE change. That is to say, it looks like a 50 mcg dose reduction will only raise TSH from 1.0 to 5.0, not to 10.0. This is my personal guesstimate, and will need to be properly calculated from other studies. My point is merely that 50 mcg will not cause the full 15% REE increase. Additionally, the response to 50 mcg may depend on initial TSH.
It looks like TSH changes that remained hyperthyroid (i.e. bellow 1.0) had little effect on REE. This might be because the body is maintaining thyroid status, or that REE is more like an on/off switch. However, this only covers relatively small changes in thyroxine dose.
It is unclear how supraphysiological doses effect REE. It seems likely that the ten times greater dose (500 mcg) used for depression would significantly increase REE.
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- Mar 2020
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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The mean percentage removal of stains for test group was significantly higher than control group.
Note that this was a two week study. It's hard to guess whether greater benefit would occur over longer periods.
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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The addition of supraphysiologic doses of L-T4 (300 mcg per day) to an otherwise stable medication regimen of standard treatments resulted in a significant decline in depression scores during the 6-week, double-blind treatment phase. At endpoint (week 6), the mean HamD score showed a group difference of 3.7 points in favor of L-T4. Such difference is generally considered to be clinically meaningful in a short-term treatment trial for major depression. NICE used a 3.0-point difference in HamD change scores as a criterion of clinical significance.27
This is consistent with the open label data. The dose is also similar. Combining this placebo-controlled trial with the three open-label supraphysiological thyroxine studies that I've seen, that is sufficient for me to conclude efficacy. Namely, combining with Pfeiffer et al (350 mcg), Rudas et al (235 mcg) and Bauer et al (482 mcg)
I would like to see if this study mentions nonresponders. Those three other studies found roughly a 50% response rate. Thus, the effect size in responders may be twice as significant.
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- Feb 2020
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www.reuters.com www.reuters.com
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From 2010 to 2016, Facebook Ireland paid Facebook U.S. more than $14 billion in royalties and cost-sharing payments
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the Internal Revenue Service tries to convince a judge the world’s largest social media company owes more than $9 billion
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- Jan 2020
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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The authors demonstrated an inverse correlation between TSH and REE with a change of 15% for a TSH ranging from 0.1 to 10 μIU/mL. Of interest, free T4 remained within the normal range in all of the study volunteers. Nonetheless, the changes in REE with different LT4 doses were demonstrated in every patient [46].
Thus, a 15% expected increase would be reasonable for a euthyroid subject such as myself. However, since T3 reduces weight compared to T4, it is possible the weight loss indicates greater energy expenditure.
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academic.oup.com academic.oup.com
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22.3 per cent (−10.7; 95% CI, −15.6 to −5.7) in the diet group
Interesting that the diet group worked better. I'd like to see if it's statistically significantly better than the drug group. It's also worth asking whether sodium was the only important dietary change, or if avoiding sodium caused many other dietary improvements.
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Sleepiness and neck circumference were significantly reduced only in the diet group (p = .007 and p < .001 for the time × group interactions, respectively).
Fascinating. Neck circumference suggests that sodium intake may indeed be the significant dietary factor. The recommended diet wasn't even very restricted in sodium.
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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CONCLUSION: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD.
Is there anything it can't do? I have noted, however, that larger doses cause nausea for me. That is, 3 or more grams on an empty stomach. I just vomited after taking 7.5 grams before my meal, but I have not yet established the causal link. It is the largest amount I've ever taken at one time. I suspect that it may have contributed significantly, but that it was also one out of half a dozen factors.
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www.encognitive.com www.encognitive.com
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0.19
This is the only group with a TSH significantly below the reference range. The reason, of course, is that the patients with the most symptoms ended up getting the highest doses of thyroxine (T4) by the end of the study.
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- Nov 2019
- Mar 2019
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hypothes.is hypothes.is
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rth and
I am checking
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- Nov 2018
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Starts with a small amount of history and its use; this article actually discusses an experimental seminar done to test the usefulness of Slack in education. (4/5)
NOTE: MOOC is a Massive Online Open Course)
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- Feb 2018
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info.levelaccess.com info.levelaccess.com
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Gil v. Winn Dixie Stores, Inc.: The First Digital Accessibility Case to Go to Trial
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- Jan 2018
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query.nytimes.com query.nytimes.com
- Jun 2016
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us9.campaign-archive2.com us9.campaign-archive2.com
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fail a little less
Much insight in this phrase.
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- May 2016
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www.brainpickings.org www.brainpickings.org
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Mistakes are not just opportunities for learning; they are, in an important sense, the only opportunity for learning or making something truly new. Before there can be learning, there must be learners. There are only two non-miraculous ways for learners to come into existence: they must either evolve or be designed and built by learners that evolved. Biological evolution proceeds by a grand, inexorable process of trial and error — and without the errors the trials wouldn’t accomplish anything.
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- Jun 2015
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auspost.com.au auspost.com.au
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Get an estimated price for posting a parcel or letter within Australia or overseas. Prefer an easy, fixed cost on sending a parcel in Australia? View our prepaid satchels starting from $8.25
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