[Paragraph-level] PMCID: PMC7612117 Section: RESULTS PassageIndex: 5

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses a functional analysis of the Brca1 p.L1363P variant, indicating that it alters embryonic development and leads to growth defects in mice, which demonstrates its impact on molecular or biochemical function. Oncogenic: The analysis of the Brca1 p.L1363P variant in the context of embryonic development and its comparison to Brca1-null mice suggests that it may contribute to tumor development or progression, as it is associated with severe phenotypes similar to pathogenic mutations in Brca1.

Gene→Variant (gene-first): 7158:p.L1363P

Genes: 7158

Variants: p.L1363P

[Paragraph-level] PMCID: PMC7612117 Section: RESULTS PassageIndex: 4

Evidence Type(s): Oncogenic

Justification: Oncogenic: The passage indicates that the homozygous variant p.L1363P in Brca1 leads to embryonic lethality in mice, suggesting that it contributes to tumor development or progression.

Gene→Variant (gene-first): 7158:p.L1363P

Genes: 7158

Variants: p.L1363P

[Paragraph-level] PMCID: PMC7612117 Section: RESULTS PassageIndex: 3

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how the variant p.L1407P disrupts the interaction of BRCA1 with PALB2 and predicts that it disables the alpha-helical structure of the coiled-coil domain, indicating an alteration in molecular function. Oncogenic: The use of CRISPR/Cas9 to model the BRCA1 variant in mice suggests that the variant contributes to tumor development or progression, as it is being studied in the context of a gene essential for embryonic development and cancer biology.

Gene→Variant (gene-first): 672:4220T>C 7158:p.L1363P 672:p.L1407P

Genes: 672 7158

Variants: 4220T>C p.L1363P p.L1407P

[Paragraph-level] PMCID: PMC7612117 Section: RESULTS PassageIndex: 2

Evidence Type(s): None

Justification: Not enough information in this passage.

Gene→Variant (gene-first): 7158:p.L1363P

Genes: 7158

Variants: p.L1363P

[Paragraph-level] PMCID: PMC5822176 Section: RESULTS PassageIndex: 6

Evidence Type(s): Diagnostic

Justification: Diagnostic: The passage discusses the correlation of MIB-1 labeling indices with the diagnosis and grade of tumors, indicating that the K27M variant is associated with specific tumor classifications.

Gene→Variant (gene-first): 3417:K27M

Genes: 3417

Variants: K27M

[Paragraph-level] PMCID: PMC5822176 Section: RESULTS PassageIndex: 5

Evidence Type(s): None

Justification: Not enough information in this passage.

Gene→Variant (gene-first): 3417:K27M

Genes: 3417

Variants: K27M

[Paragraph-level] PMCID: PMC5822176 Section: RESULTS PassageIndex: 4

Evidence Type(s): Oncogenic

Justification: Oncogenic: The passage discusses the transformation of tumors associated with the K27M variant, indicating its role in tumor development and progression, particularly in the context of glioblastoma transformation.

Gene→Variant (gene-first): 3417:K27M

Genes: 3417

Variants: K27M

[Paragraph-level] PMCID: PMC5822176 Section: RESULTS PassageIndex: 2

Evidence Type(s): Diagnostic, Oncogenic

Justification: Diagnostic: The passage discusses the identification of H3 K27M-mutant tumors and provides demographic information, indicating that the variant is associated with specific histological diagnoses and patient characteristics. Oncogenic: The mention of H3 K27M in the context of tumors suggests that this somatic variant contributes to tumor development or progression, as it is identified in mutant tumors.

Gene→Variant (gene-first): 3417:K27M

Genes: 3417

Variants: K27M

[Paragraph-level] PMCID: PMC5822176 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Diagnostic, Prognostic, Oncogenic

Justification: Diagnostic: The passage discusses the H3 K27M mutation's association with various tumor types, indicating its role in defining and classifying these tumors, particularly in pediatric and adult cohorts. Prognostic: The passage mentions survival outcomes for patients with H3 K27M-mutant tumors, comparing mean survival times between adults and pediatric patients, which indicates a correlation with disease outcome. Oncogenic: The H3 K27M mutation is described as contributing to tumor development in various glioma types, indicating its role as a somatic variant involved in tumor progression.

Gene→Variant (gene-first): 3417:K27M

Genes: 3417

Variants: K27M

[Paragraph-level] PMCID: PMC3288377 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Diagnostic, Oncogenic

Justification: Diagnostic: The passage discusses the frequency of the p.K27M mutation in DIPGs and its association with this specific subtype of brain tumors, indicating its role in defining or classifying the disease. Oncogenic: The p.K27M and p.G34R mutations are described as somatic mutations found in pediatric gliomas, suggesting their contribution to tumor development or progression.

Gene→Variant (gene-first): 3021:p.G34R 3021:p.K27M

Genes: 3021

Variants: p.G34R p.K27M

[Paragraph-level] PMCID: PMC6368247 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the emergence of the ESR1 Y537S mutation in the context of resistance to CDK4/6 inhibitors, indicating a correlation with treatment response and resistance. Oncogenic: The mention of the ESR1 Y537S mutation as a new driver mutation suggests that it contributes to tumor development or progression, particularly in the context of breast cancer.

Gene→Variant (gene-first): 5728:Y537S

Genes: 5728

Variants: Y537S

[Paragraph-level] PMCID: PMC5122709 Section: RESULTS PassageIndex: 3

Evidence Type(s): Predictive, Diagnostic, Oncogenic

Justification: Predictive: The passage discusses patients treated with BRAF inhibitors, specifically mentioning the BRAF V600E mutation, which correlates with response to these therapies. Diagnostic: The passage states that all patients tested positive for the BRAF V600E mutation, indicating its use in defining or confirming the presence of a specific subtype of melanoma. Oncogenic: The BRAF V600E mutation is implicated in the development of melanoma, suggesting its role as a somatic variant contributing to tumor progression.

Gene→Variant (gene-first): 673:V600E

Genes: 673

Variants: V600E

[Paragraph-level] PMCID: PMC2789045 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how the FGFR3 mutations (S249C, Y375C, and K652E) alter molecular signaling pathways, specifically the phosphorylation of various proteins, indicating a change in biochemical function. Oncogenic: The passage describes how the mutant FGFR3 variants induce morphological transformation, cell proliferation, and anchorage-independent growth, which are indicative of their role in tumor development and progression.

Gene→Variant (gene-first): 2261:K652E 2261:S249C 2261:Y375C

Genes: 2261

Variants: K652E S249C Y375C

[Paragraph-level] PMCID: PMC7099049 Section: ABSTRACT PassageIndex: 4

Evidence Type(s): Prognostic

Justification: Prognostic: The passage indicates that the SNPs are suggested to play a crucial role in the prognosis of HNSCC, which correlates with disease outcome.

Gene→Variant (gene-first): NA:rs16879870 388325:rs2641256 341019:rs2761591 NA:rs854936

Genes: NA 388325 341019

Variants: rs16879870 rs2641256 rs2761591 rs854936

[Paragraph-level] PMCID: PMC7099049 Section: ABSTRACT PassageIndex: 3

Evidence Type(s): Prognostic, Functional

Justification: Prognostic: The passage discusses the association of SNPs with HNSCC survival, indicating that these variants correlate with disease outcome, specifically overall survival, independent of therapy. Functional: The passage mentions that the genotype of rs16879870 and rs854936 is significantly associated with the expression of specific genes in cancer tissues, suggesting that these variants alter molecular function.

Gene→Variant (gene-first): NA:rs16879870 388325:rs2641256 341019:rs2761591 NA:rs854936

Genes: NA 388325 341019

Variants: rs16879870 rs2641256 rs2761591 rs854936

[Paragraph-level] PMCID: PMC7612475 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Predictive, Functional

Justification: Predictive: The K700E mutation in SF3B1 increases cellular sensitivity to ionising radiation and various chemotherapeutic agents, including PARP inhibitors, indicating a correlation with treatment response. Functional: The K700E mutation alters HR efficiency and induces unscheduled R-loop formation, replication fork stalling, and defective replication fork restart, demonstrating an impact on molecular function.

Gene→Variant (gene-first): 23451:K700E

Genes: 23451

Variants: K700E

[Paragraph-level] PMCID: PMC9900321 Section: ABSTRACT PassageIndex: 3

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the efficacy of a small-molecule KRASG12D inhibitor, MRTX1133, in treating pancreatic ductal adenocarcinoma, indicating a correlation between the Gly-to-Asp mutation and response to therapy. Oncogenic: The Gly-to-Asp mutation in the KRAS oncogene is described as contributing to tumor development in pancreatic ductal adenocarcinoma, as it is found in more than 90% of patients with this cancer type.

Gene→Variant (gene-first): 3845:Gly-to-Asp

Genes: 3845

Variants: Gly-to-Asp

[Paragraph-level] PMCID: PMC3542862 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage discusses somatic mutations in PIK3CA (including R115P, E542K, H1047L, and H1047R) that contribute to the pathophysiology of macrodactyly, indicating their role in tumor development or progression through activation of the PI3K/AKT signaling pathway. Functional: The passage mentions that the identified mutations lead to AKT activation, which indicates that these variants alter molecular or biochemical function related to cell signaling pathways.

Gene→Variant (gene-first): 5290:E542K 5290:H1047L 5290:H1047R 5163:R115P

Genes: 5290 5163

Variants: E542K H1047L H1047R R115P

[Paragraph-level] PMCID: PMC4999563 Section: ABSTRACT PassageIndex: 9

Evidence Type(s): Prognostic, Diagnostic

Justification: Prognostic: The passage indicates that KRAS G12C and G13D mutations are associated with inferior progression-free survival (PFS) and overall survival (OS) in mCRC patients, suggesting a correlation with disease outcome independent of therapy. Diagnostic: The mention of KRAS mutations being associated with heterogeneous outcomes compared to unmutated tumors implies that these variants can be used to classify or define a disease subtype in mCRC.

Gene→Variant (gene-first): 3845:G12C 3845:G13D

Genes: 3845

Variants: G12C G13D

[Paragraph-level] PMCID: PMC4999563 Section: ABSTRACT PassageIndex: 7

Evidence Type(s): Prognostic, Diagnostic

Justification: Prognostic: The passage discusses the correlation of KRAS mutations, including specific variants like G12C and G13D, with inferior overall survival (OS) and progression-free survival (PFS), indicating their impact on disease outcome independent of therapy. Diagnostic: The passage mentions that mutations in KRAS were diagnosed in tumors, indicating that these mutations are used to classify or define the disease.

Gene→Variant (gene-first): 3845:G12C 3845:G12D 3845:G12V 3845:G13D

Genes: 3845

Variants: G12C G12D G12V G13D

[Paragraph-level] PMCID: PMC4999563 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Prognostic, Diagnostic

Justification: Prognostic: The passage discusses how KRAS G12C and G13D mutations correlate with inferior progression-free and overall survival in metastatic colorectal cancer patients, indicating their prognostic significance. Diagnostic: The mention of KRAS mutations being associated with tumor characteristics suggests their role in classifying or defining the disease subtype in colorectal cancer.

Gene→Variant (gene-first): 3845:G12C 3845:G13D

Genes: 3845

Variants: G12C G13D

[Paragraph-level] PMCID: PMC9837058 Section: ABSTRACT PassageIndex: 1

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage discusses how mutations in PIK3CA, including G1049R, H1047R, and M1043I/L, contribute to the activation of the PI3K pathway, indicating their role in tumor development or progression. Functional: The passage describes how specific mutations alter the conformation and binding properties of the p110alpha subunit, indicating that these variants affect molecular function related to PI3K activation.

Gene→Variant (gene-first): 5290:G1049R 5290:H1047R 5290:M1043I/L

Genes: 5290

Variants: G1049R H1047R M1043I/L

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 19

Evidence Type(s): Functional

Justification: Functional: The passage discusses how the H1047R variant alters the binding interactions and structural dynamics of the protein in response to pY binding, indicating a change in molecular function.

Gene→Variant (gene-first): 5290:H1047R

Genes: 5290

Variants: H1047R

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 18

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how the H1047R and G1049R variants alter the molecular interactions and conformations within the kinase domain, indicating a change in biochemical function related to the protein's activity. Oncogenic: The evidence suggests that the H1047R and G1049R variants contribute to activation through disruption of the inhibitory conformation, which is indicative of their role in tumor development or progression.

Gene→Variant (gene-first): 5290:G1049R 5290:H1047R 5290:M1043L 5290:N1068fs

Genes: 5290

Variants: G1049R H1047R M1043L N1068fs

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 17

Evidence Type(s): Functional

Justification: Functional: The passage discusses changes observed for the H1047R variant in the context of HDX-MS experiments, indicating that it alters molecular or biochemical function, specifically in terms of perturbations in conformation.

Gene→Variant (gene-first): 5290:H1047R

Genes: 5290

Variants: H1047R

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 16

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how C-terminal mutations, including M1043L, H1047R, G1049R, and N1068fs, affect the inhibitory interaction with the C-terminus, indicating an alteration in molecular function. Oncogenic: The mention of "oncogenic mutation" in relation to M1043L, H1047R, and G1049R suggests that these somatic variants contribute to tumor development or progression.

Gene→Variant (gene-first): 5290:G1049R 5290:H1047R 5290:M1043L 5290:N1068fs

Genes: 5290

Variants: G1049R H1047R M1043L N1068fs

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 14

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how the variants H1047R, G1049R, M1043L, and N1068fs alter membrane binding and ATPase activity, indicating changes in molecular function. Oncogenic: The variants are described in the context of their effects on membrane binding and ATPase activity, which suggests a role in tumor development or progression.

Gene→Variant (gene-first): 5290:G1049R 5290:H1047R 5290:M1043L 5290:N1068fs

Genes: 5290

Variants: G1049R H1047R M1043L N1068fs

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 13

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses the intrinsic ATPase activity of the p110alpha mutants, indicating that the variants G1049R, H1047R, and M1043L alter molecular function by exhibiting significantly increased ATPase activity compared to wild type. Oncogenic: The context of the passage implies that the variants are somatic mutations in a cancer-related gene, contributing to tumor development or progression through their altered biochemical activity.

Gene→Variant (gene-first): 5290:G1049R 5290:H1047R 5290:M1043L 5290:N1068fs

Genes: 5290

Variants: G1049R H1047R M1043L N1068fs

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 12

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage discusses frequent oncogenic mutants and their role in tumor samples, indicating that these variants contribute to tumor development or progression. Functional: The analysis of the mutants and their binding to full-length p85alpha suggests that these variants alter molecular or biochemical function, specifically in the context of their interaction with regulatory complexes.

Gene→Variant (gene-first): 5290:G1049R 5290:H1047R 5290:H1047R/L 5290:M1043L 5290:M1043L/I 5290:N1044K 5290:N1068fs

Genes: 5290

Variants: G1049R H1047R H1047R/L M1043L M1043L/I N1044K N1068fs

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 11

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage discusses the H1047R mutation in the context of its role in activating the kinase domain and increasing membrane binding, indicating its contribution to tumor development or progression. Functional: The passage describes how the H1047R mutation alters the molecular interactions and structural organization of the kinase domain, affecting its binding properties and functionality.

Gene→Variant (gene-first): 5290:H1047R 5290:His1047 5290:Met1043

Genes: 5290

Variants: H1047R His1047 Met1043

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 9

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage discusses the E726K variant in the context of oncogenic mutations and its association with conformational changes that contribute to tumor development, indicating its role in cancer progression. Functional: The passage describes how the E726K variant leads to conformational changes affecting the interaction between the ABD and p85 with the catalytic core, suggesting an alteration in molecular function.

Gene→Variant (gene-first): 5290:E726K

Genes: 5290

Variants: E726K

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 8

Evidence Type(s): Functional

Justification: Functional: The passage discusses how the N345K variant affects the molecular interactions and binding of the p110alpha/p85alpha complex to membranes, indicating an alteration in biochemical function.

Gene→Variant (gene-first): 5290:N345K

Genes: 5290

Variants: N345K

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 4

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage discusses oncogenic mutants (N345K, G106V, and G118D) and their expected role in promoting ABD/iSH2 disengagement, indicating their contribution to tumor development or progression. Functional: The data suggests that the variants alter the dynamics of the ABD-p85 complex and its interaction with the p110alpha catalytic core, indicating a change in molecular function related to binding and mobility.

Gene→Variant (gene-first): 5290:G106V 5290:G118D 5290:N345K

Genes: 5290

Variants: G106V G118D N345K

[Paragraph-level] PMCID: PMC9837058 Section: RESULTS PassageIndex: 2

Evidence Type(s): Functional

Justification: Functional: The passage discusses the D915N mutation in the context of its effect on protein conformation and membrane binding, indicating that it alters molecular function as assessed by HDX-MS experiments.

Gene→Variant (gene-first): 5290:D915N

Genes: 5290

Variants: D915N

[Paragraph-level] PMCID: PMC6280667 Section: RESULTS PassageIndex: 9

Evidence Type(s): Predictive

Justification: Predictive: The passage discusses the correlation of mutations, including those in splicing components like ZRSR2, with sensitivity to various drugs, indicating a relationship between the variant and treatment response.

Gene→Variant (gene-first): 8233:serine/arginine

Genes: 8233

Variants: serine/arginine

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 17

Evidence Type(s): Oncogenic

Justification: Oncogenic: The passage discusses the tumor forming capacity of cells expressing the ERBB2 E401G variant, indicating that this somatic variant contributes to tumor development as evidenced by increased tumor growth in vivo.

Gene→Variant (gene-first): 2176:E401G

Genes: 2176

Variants: E401G

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 16

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses the effects of the ERBB2 E401G and S310F variants on the proliferative and invasive capacities of cancer cells, indicating that these variants alter molecular or biochemical functions related to cell behavior. Oncogenic: The evaluation of the proliferative and invasive capacities of cells expressing the ERBB2 variants suggests that these somatic variants contribute to tumor development or progression.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 15

Evidence Type(s): None

Justification: Not enough information in this passage.

Gene→Variant (gene-first): 2176:E401G

Genes: 2176

Variants: E401G

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 14

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how the variants E401G and S310F alter the phosphorylation of downstream signaling pathway proteins, indicating a change in molecular function related to the MAPK pathway. Oncogenic: The evidence suggests that the variants contribute to tumor development or progression by activating signaling pathways associated with cancer, specifically through the ERBB2 dimerization and its effects on downstream signaling.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 12

Evidence Type(s): Functional

Justification: Functional: The passage discusses how the E401G and S310F mutations affect the dimer interface stability of the EGFR-HER2 complex, indicating that these variants alter molecular interactions and stability.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 11

Evidence Type(s): None

Justification: Not enough information in this passage.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 10

Evidence Type(s): Functional

Justification: Functional: The passage indicates that the variant p.(E401G) alters the stability of the ligand-free EGFR HER2 heterodimer, which suggests a change in molecular function.

Gene→Variant (gene-first): 2176:p.(E401G)

Genes: 2176

Variants: p.(E401G)

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 9

Evidence Type(s): Functional, Oncogenic

Justification: Functional: The passage discusses how the variants E401G and S310F lead to increased phosphorylation levels of HER2 and EGFR, indicating that these variants alter molecular function related to protein activity. Oncogenic: The context of the passage suggests that the variants E401G and S310F contribute to tumor development or progression by enhancing the phosphorylation of key HER family proteins involved in oncogenesis.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 8

Evidence Type(s): Functional

Justification: Functional: The passage discusses the identification of potential dimerization partners of the HER2 E401G protein, indicating that the variant alters molecular interactions.

Gene→Variant (gene-first): 2176:E401G

Genes: 2176

Variants: E401G

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 7

Evidence Type(s): Functional

Justification: Functional: The passage discusses how the variants S310F and E401G alter the C-terminal phosphorylation of HER2, indicating a change in molecular function.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 6

Evidence Type(s): Functional

Justification: Functional: The passage discusses the ability of the variants E321G, E401G, and S310F to form disulfide-linked dimers, indicating that these variants alter molecular function related to protein interactions.

Gene→Variant (gene-first): 7157:E321G 2176:E401G 2064:S310F

Genes: 7157 2176 2064

Variants: E321G E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 5

Evidence Type(s): Functional

Justification: Functional: The passage mentions the evaluation of mechanisms for multiple ERBB2 variants, including E321G, E401G, S310F, and D845A, which suggests that these variants are being assessed for their biochemical functions.

Gene→Variant (gene-first): 2064:D845A 7157:E321G 2176:E401G 2064:S310F

Genes: 2064 7157 2176

Variants: D845A E321G E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 4

Evidence Type(s): Functional

Justification: Functional: The passage indicates that ERBB2 E401G has functional properties similar to S310F, suggesting that these variants alter molecular or biochemical function.

Gene→Variant (gene-first): 2176:E401G 2064:S310F

Genes: 2176 2064

Variants: E401G S310F

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 3

Evidence Type(s): Oncogenic, Functional

Justification: Oncogenic: The passage describes the ERBB2 E401G variant as a somatic mutation that is associated with ERBB2 gene amplification, indicating its contribution to tumor development or progression. Functional: The passage mentions that multiple computational tools supported a deleterious effect of the ERBB2 E401G variant on the encoded gene product, suggesting that it alters molecular or biochemical function.

Gene→Variant (gene-first): 2176:E401G

Genes: 2176

Variants: E401G

[Paragraph-level] PMCID: PMC8881279 Section: RESULTS PassageIndex: 2

Evidence Type(s): Diagnostic

Justification: Diagnostic: The passage mentions the detection of the ERBB2 E401G variant of uncertain significance (VUS) in a patient, indicating its use in defining or classifying a disease context, specifically in a patient with cancer of unknown primary (CUP).

Gene→Variant (gene-first): 2176:E401G

Genes: 2176

Variants: E401G

[Paragraph-level] PMCID: PMC6938308 Section: RESULTS PassageIndex: 2

Evidence Type(s): Diagnostic, Oncogenic

Justification: Diagnostic: The passage indicates that KRAS codon p.12G and BRAF codon p.600V somatic mutations have been linked to brain AVMs, suggesting their role in defining or classifying the disease. Oncogenic: The mention of likely somatic disease-causing mutations, including KRAS mutations (p.G12D and p.G12V) and BRAF mutations (p.V600E and p.Q636X), indicates that these variants contribute to tumor development or progression.

Gene→Variant (gene-first): 3845:p.12G 673:p.600V 3845:p.G12D 3845:p.G12V 673:p.Q636X 673:p.V600E

Genes: 3845 673

Variants: p.12G p.600V p.G12D p.G12V p.Q636X p.V600E

[Paragraph-level] PMCID: PMC8307492 Section: ABSTRACT PassageIndex: 4

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the association of the L858R variant with overall survival (OS) in patients treated with first-line EGFR inhibitors, indicating its relevance to treatment response. Oncogenic: The L858R variant is mentioned in the context of EGFR mutations in non-small-cell lung cancer (NSCLC), suggesting its role in tumor development or progression as part of the broader analysis of clinically actionable EGFR mutations.

Gene→Variant (gene-first): 1956:L858R

Genes: 1956

Variants: L858R

[Paragraph-level] PMCID: PMC10805385 Section: RESULTS PassageIndex: 17

Evidence Type(s): Oncogenic, Predictive

Justification: Oncogenic: The passage discusses the overexpression of HOXC10 in KRAS-mutant tumors, specifically mentioning the genotype KRAS G12C/TP53 G245V, indicating that these somatic variants contribute to tumor development or progression. Predictive: The passage mentions the efficacy of combined MEK/BET inhibitors causing tumor regression in KRAS-mutant patient-derived xenograft models, suggesting a correlation between the variants and response to therapy.

Gene→Variant (gene-first): 3845:G12C 7157:G245V

Genes: 3845 7157

Variants: G12C G245V

[Paragraph-level] PMCID: PMC10690049 Section: RESULTS PassageIndex: 7

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the response of KRASG12D mutant MEFs to a drug combination, indicating that the variant is associated with resistance to growth inhibition by the therapies tested. Oncogenic: The KRASG12D variant is implicated in tumor behavior, as it is described in the context of MEFs (mouse embryonic fibroblasts) and their growth characteristics, suggesting a role in tumor development or progression.

Gene→Variant (gene-first): 3845:G12D

Genes: 3845

Variants: G12D

[Paragraph-level] PMCID: PMC10690049 Section: RESULTS PassageIndex: 6

Evidence Type(s): Predictive, Oncogenic

Justification: Predictive: The passage discusses the response of KRAS G12C-mutant cells to specific therapies, indicating a correlation between the variant and sensitivity to the drugs MRTX849/AMG510 and KPT9274. Oncogenic: The variant KRAS G12C is implicated in tumor development, as the passage describes its presence in cancer cell lines and their proliferation in response to treatment, suggesting a role in cancer progression.

Gene→Variant (gene-first): 3845:G12C

Genes: 3845

Variants: G12C

for - post-growth economy - democratic at every level

• SRG comment - democracy at every level - synchronized multi-scale, multi-dimensional wellbeing

for - quote - millions of Nobel Prize level digital immigrants

for - adjacency - not micromanaging the cell - high level instruction - Michael Levin

for - comparison - multi-level agents - scaffolding

for - definition - level environment - the level environment for each agent at that respective local level of a multi-level, hierarchical intelligent system

for - adjacency - inter level communication - environmental steering - this is very interesting (and obvious) but far from trivial. - adjacency - meditation - interlevel communication - enlightenment? - could we naturalistically frame meditation that leads to non dual awareness, or enlightenment - as being a way for higher level agents - to get in touch with / communicate with - lower level agents - in a multi-agent environment?

question - could we interpret enlightenment as an ecosystem goal of intentional whole system environmental steering? This suggests a new term: - new definition - intentional whole system environmental steering - when environmental steering is intentional done at the highest level for the wellbeing of every level - The author uses the example of hunger as being a high level experience driven by lower level needs - This could qualify as an intentional whole system environmental steering so the term doesn't distinguishing enlightenment drive as anything special. We need some other distinguishing quality

for - definition - multi-level cognition

for - adjacency - group think - cellular level - cultural level - Michael Levin

for - example - cellular level communication - Michael Levin

for - example - higher level collective intelligence overriding lower level intelligence - axelottle

for - quote - consciousness vs cellular level intelligence - Michael Levin - key insight - high level governance (consciousness) vs low level intelligence adjacency hierarchical control - high level consciousness - low level micro intelligence quote - consciousness vs cellular level intelligence - Michael Levin - all intelligence is collective intelligence in the sense that - every agent is made of parts, all of us. - And what you want is for the (high level) agent to have a causal power that is not the same as simply tracking the microstates, the particles.

key insight - high level governance (consciousness) vs low level intelligence - This is a very important observation - It says that a multi-cellular being such as a human being can have consciousness that has agency for the entire organism and governs at that high level, and it must have this beyond just the cognition and intelligence at the lower cellular and subcellular level

Why should the app even know let alone care about which version of the serialization format is in play?

Washington Post-Artikel (mit Links zur Quelle) zu den Forschungen von Ki-Wen Seo und anderen zu den Veränderungen im globalen Wasserkreislauf durch die Erderhitzung. Für den Anstieg des Meeresspiegels war die Austrocknung großer Gebiete auf dem Festland wenigstens in einigen Jahren wichtiger als das Schmelzen des grönländischen Eisschilds. Mit hoher Wahrscheinlichkeit handelt es sich bei dem Wasserverlust um ein irreversibles Phänomen. Es zwingt zu dauerhaften Veränderungen in der Landwirtschaft https://www.washingtonpost.com/climate-environment/2025/03/27/earth-soil-moisture-drying-sea-level-study/

I believe that the more realistic choice of words is equivalent level of educational opportunity. With a classroom as varied as Mrs. Johnson’s, as are most classrooms, how can you really measure the level of education? You can measure what you have exposed to and what they have been successful at regurgitating.

https://taz.de/Bericht-der-Weltwetterorganisation/!6076881/

for - Christine Wamsler - Lund University - homepage - from - youtube - Mindfulness World Community - Awareness, Care and Sustainability for Our Earth - https://hyp.is/GCUJ1APHEfCcr_vvv3lAFw/www.youtube.com/watch?v=CTUc_0GroGM

• to - paper - An Interdisciplinary Model to Foster Existential Resilience and Transformation

  • https://hyp.is/iKxTmgPJEfCkN2PkMDmg1g/www.mdpi.com/2078-1547/16/1/5

• to - paper - Engaging high-income earners in climate action : Policy insights from survey experiments

  • for Deep Humanity Wealth 2 Wellth program
  • https://hyp.is/MIc0DgPKEfC_Z5v_n8P8mA/www.sciencedirect.com/science/article/pii/S0921800924002842

• to - paper - Revolutionising sustainability leadership and education : addressing the human dimension to support flourishing, culture and system transformation

  • for - LCE leadership academy
  • https://hyp.is/nLBHtAPLEfCvUUNZrc_uqw/link.springer.com/article/10.1007/s10584-023-03636-8

• to - The System Within : Addressing the inner dimensions of sustainability and systems change

  • https://hyp.is/VDAcFgPMEfCBPkvnTCjp8w/www.clubofrome.org/wp-content/uploads/2024/05/Earth4All_Deep_Dive_Jamie_Bristow.pdf
• to - paper - Transformative Climate Resilience Education for Children and Youth: From Climate Anxiety to Resilience, Creativity and Regeneration, Literature review conducted for the ERASMUS+ Project 2023-1-SE01-KA220-SCH-000158705

  - for - SRG/TPF/LCE ward-level afterschool outreach program but it's currently a dead link and inaccessible

• to - IMAGINE sustainability : integrated inner-outer transformation in research, education and practice
  • for - Deep Humanity open source praxis
  • Human Interior Transformation (HIT) and
  • Social Exterior Transformation (SET) //
  • https://hyp.is/5_GsSAPNEfC82DMDillDTw/link.springer.com/article/10.1007/s11625-023-01368-3

research areas - sustainable cities - collaborative governance - city-citizen collaboration - citizen participation - sustainability and wellbeing - sustainability transformation - inner development goals - inner transformation - inner transition - existential sustainability

for - futures study - multi-level perspective - MLP

for - multi-scale competency architecture - groups of individuals coalesce into an individual at a higher level - SOURCE - Youtube - Bioelectric fields: A Paradigm Shift in Biology - Michael Levin - 2025, Jan

for - Relevance realization is pre-conceptual - it takes place at a level deeper than the level of beliefs - source - Meaning crisis - episode 33 - The Spirituality of Relevance Realization - Wonder/Awe/Mystery/Sacredness - John Vervaeke - to - YouTube conversation - Micheal Levin, John Vervaeke, Gregg Henrique - 2024 // ,- comment - In light of studying a John's concept of relevance realisation now, - after partially annotating the - Micheal Levin, - John Vervaeke, - Gregg Henrique - YouTube conversation, I should return to that annotation to - finish it and - take a more critical look for comparison between - Micheal Levin's goal oriented behaviour definition of life that drives and expanding cognitive light cone and - John Vervaeke's relevance realisation

to - YouTube conversation - Micheal Levin, John Vervaeke, Gregg Henrique - 2024 - https://hyp.is/go?url=https%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DrAlmzRTbGDE&group=world

for - A Transcender Manifesto - addendum - it is critical to move beneath the story level - Deep Humanity

for - adjacency - regenerative company - need to have voices that represent nature - cross scale translation of earth system boundaries to company level

Adjacency - between - regenerative company - need to have voices that represent nature - cross scale translation of earth system boundaries - adjacency relationship - Regenerative companies need to have voices that represent nature - This means we need to be aware of how the activities of our company is impacting nature - This means we need to have cross scale translation of earth system boundaries to the local community, and finally to our company levels

for - DNA replication accuracy - 1 in 10,000 - too high for successful replication - another higher level mechanism to correct for these errors - need a whole body for that - Denis Noble

TRSP Desirable Characteristics It is recognised that a repository may offer different levels of curation to different digital objects.

TRSP Desirable Characteristics

The life cycle status of the repository: is it still being developed or in production and accepting data submissions? The latter does not exclude that some (re)development, enhancement or maintenance may be ongoing, as happens in any mature system.

TRSP Desirable Characteristics Review and annotation of the data performed by the repository (e.g. via a data submission tool that enforces some curation, or by its curation team): are there a set of minimum curation steps that repository performs on the submitted data? Is there a webpage or document that describes the type of curation done? This criteria is also related to the Data and Metadata Standards criteria.

for - the word "sacred" - sacred 2.0 - low level of the sacred

for - developmental journey - building metaphor - most important problem to fix is foundational - first level problems - John Churchill

for - progress traps - AI - created by mind level that created all our existing problems - AI is not AI but MI - Mineral Intelligence

for - collective intelligence - properties of the higher level whole - that are missing in the lower level individuals that constitute it - example sports team - Jordan Hall

for - topic for further research - higher level of living system - indicator of - Micheal Levin - synchronicity

Adjacency - between - Jordan Hall / Michael Levin conversation - hyperobject - cognitive light cone - lower level indicator of higher level - enlightenment / awakening Frederico Faggin experience - meditation - adjacency statement - Federico Faggin's experience of inter level awareness was - his profound awakening experience transcending even oneness - That was an indicator event that shattered his belief that he was alone, shuttered in existential isolation - and showed him that he was a part of a much larger system - In general, at the level of humans and human consciousness, - awakening and enlightenment experiences described throughout human history in many different - times and - places - could be interpreted as reaching upwards to a higher level in our lower level cognitive light cone

for - inter-level awareness - Micheal Levin - metaphor - 2 neurons conversing with each other

Eine aufwändige Expedition erforscht, ob die Sedimente in den unteren Zonen eines großen grönländischen Gletschers Barrieren gegen warmes Meerwasser bilden, die den Prozess des Abschmelzens verlangsamen und sich vielleicht sogar verstärken lassen. Hauptziel ist, den unaufhaltsamen Anstieg des Meeresspiegels besser modellieren zu können. Ausführliche Reportage im Guardian

for - question - how do you know when you are part of a larger cognitive system? - answer - adjacency - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundation theory of affect

question - how do you know when you are part of a larger cognitive system? - answer - adjacency - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundation theory of affect

adjacency - between - answer - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundational theory of affect - adjacency relationship - This is a very interesting question and Michael Levin provides a very interesting answer - First, it is very interesting that Mark Solms points out that affect is foundational to cognition - This is evident once we begin to think of the fundamental goals of any individual of any species is to optimize survival - The positive or negative affects that we feel are a feedback signal that measures how successful we are in our efforts to survive - Hence, it is more accurate to ask: - How do you know if and when you are part of a larger affective-cognitive system? - Levin illustrates the multi-level nature of simultaneous consciousness by looking at two neurons "in dialogue" with each other, and potentially speculating about a "higher level of consciousness", which is in fact, the level you and I operate at and take for granted - This speculative question is very important for it also can be generalized to the next layer up, - Do collectives of humans, each one experiencing itself a unified, cohesive inner perspective, constitute a higher level "collective consciousness"? - If we humans experience feelings and thinking whilst we have a well defined physical body, then - what does a society feel and think whilst not having such a well defined physical body?

for - question - Is music worse because entry level is lower? - Musicians response - Bernth's response

Erschienen: 2024-05-17 Genre:: Studienbericht Selbst in einem optimistischen Szenario (44 cm Meeresspiegel-Anstieg) werden bis 2100 mehr als ein Drittel der Feuchtgebiete in der Nähe der Mittelmeerküsten überschwemmt sein. In der Camargue ist das Wasser bereits um 15 cm gestiegen. Möglich sind in diesem Jahrhundert bis zu 1,61 Meter Anstieg. Eine neue Studie erfasst systematisch die Folgen der globalen Erhitzung für diese besonders bedrohten und besonders schwer zu schützenden Lebensräume. https://www.liberation.fr/environnement/biodiversite/en-camargue-la-montee-des-eaux-menace-le-paradis-des-flamants-roses-20240517_L6LRO3TY2ZD4FESAHWAWGA32YY/

Die französische Regierung plant die Anpassung an eine Temperatursteigerung um 4° bis zum Ende des Jahrhunderts. Die Libération gibt einen Überblick darüber, wie Frankreich dann aussehen wird.

https://www.derstandard.at/story/3000000215556/franzoesischer-badeort-muss-uebersiedeln-das-meer-ist-immer-staerker

Die weltwetterorganisation WMO fast in ihrem Bericht über 2023 die Daten verschiedener Services zusammen und kommt zu dramatischen Aussagen über die Entwicklung der Temperatur auf der Erdoberfläche insbesondere insgesamt und besonders an der Oberfläche der Meere. Gleichzeitig ergibt eine Studie der BU Wien dass die Prognosen vieler, darunter großer starken über die Entwicklung der Emissionen deutlich zu optimistisch sind. https://www.derstandard.de/story/3000000212370/weltwetterorganisation-zeichnet-duesteres-bild-vom-klima-des-letzten-jahres

https://www.nytimes.com/2024/03/06/climate/sea-level-rise-east-coast-sinking-land-flooding.html

https://www.derstandard.de/story/3000000210168/metropolen-an-der-us-ostkueste-sinken-mit-beunruhigendem-tempo

https://www.nytimes.com/interactive/2024/02/13/climate/flooding-sea-levels-groundwater.html

Der Standard informiert über zwei Studien, die unter anderem den Zusammenhang von Stadtentwicklung und globaler Erhitzung betreffen. Vor allem in den USA wird für die Mehrzahl der großen Städte eine Schrumpfung vorausgesagt, verstärkt durch die Folgen der Erhitzung. Die Studie verwendet ist Szenarien des IPCC. Unter anderem ergibt sich daraus die Forderung, die Stadtplanung nicht mehr vor allem an der Vorstellung von wachsenden Städten auszurichten. https://www.derstandard.de/story/3000000203501/tausende-us-staedte-koennten-bis-2100-zu-geisterorten-werden

In einigen Zonen des Mittelmeers steigt der Meeresspiegel dreimal so schnell wie bisher angenommen. Italien, vor allem das Veneto und die Emilia Romagna. ist davon besonders betroffen. Einer neuen Studie zufolge könnten die Schäden durch Bedrohung von Küstengebieten in Europa bis 2100 827 Milliarden Euro kosten, wenn die globale Temperatur um 4° bzw. der Meeresspiegel um 75 cm steigt. https://www.repubblica.it/green-and-blue/2024/01/19/news/crisi_clima_innalzamento_mari_effetti_pil_costi_regioni-421918563/

Studie: https://iopscience.iop.org/article/10.1088/1748-9326/ad127e

Definition and further explanation of the mean of Web Asssimilation.

for - Rainbow body - Deep Humanity - superorganism - multi-level communication - adjacency between - contemplative practice - direct experience of body's cellular activity

summary - Father Tiso and his catholic lineage combined with scholarship in Tibetan studies places him in a unique position for interfaith dialogue - His research interest in investigating the extraordinary and unexplained Tibetan meditation phenomena of Rainbow Body manifested by the greatest practitioners at the time of death (including contemporary ones) sheds light on the Rainbow Body phenomena in many spiritual traditions and challenges the scientific community to come up with an explanation for it. - If scientifically proven true, it offers an extraordinary possibility of human potential - Contemplation could be the practice technique that could directly bridge normal human consciousness with the microscopic world around us, which to date, is only accessible through scientific instrumentation.

question - Does deep contemplative practice offers a direct access to the microscopic reality? - If so, how does it accomplish this direct communication with human cells, and indeed, even the universe itself? - Father Tiso shares centuries old recorded visual drawings of experiences reported by Rainbow Body practitioners and speculates whether these drawings represent direct experience of the cellular scale of our human form - Indeed, could it even be at the quantum level of experience, since rainbows are an optical phenomenal?

Bangladesch ist dem Climate Risk Index zufolge das am siebtstärksten von den Folgen der globalen Erhitzung betroffene Land. Bis zur Mitte des Jahrhunderts wird dort mit 20 Millionen Binnenflüchtlingen aufgrund der Erhöhung des Meeresspiegels gerechnet. Die Regierung vertritt die Interessen der wirtschaftlichen Elite und reagiert zunehmend mit harter Repression auf Opposition. Reportage über junge AktivistInnen in Bangladesch anlässlich der Wahlen, an denen die wichtigsten Oppositionsparteien nicht teilnehmen. https://www.repubblica.it/green-and-blue/2024/01/05/news/bangladesh_elezioni_cambiamento_climatico-421819356/

Einer neuen Studie zufolge wird der Anstieg des Meeresspiegels bis 2150 in einigen Regionen des Mittelmeer, unter anderem durch geologische Prozesse, dreimal so hoch sein wie bisher angenommen. Damit sind 38.500 Quadratkilometer, davon 10.000 in Italien, von Überschwemmungen bedroht. https://www.greenandblue.it/2023/12/29/news/mediterraneo_coste_rischio_inondazione-421776898/

Studie: https://iopscience.iop.org/article/10.1088/1748-9326/ad127e

https://www.carbonbrief.org/cop28-key-outcomes-agreed-at-the-un-climate-talks-in-dubai/

• for: transition - at local level, community owned production cooperatives

• comment

  • SONECs can provide the vehicle for rapid whole system change and transition at the local level
  • From SONEC neighborhood parliaments, a community can become more independent and production can be relocaized in the form of community owned cooperatives for:
    • energy
    • water
    • food
    • transportation
    • health
    • manufacturing

• for: visualizations - sea level rise at 3 Deg C

• comment

  • Look to canal cities like Venice or Amsterdam for inspiration because if it cities are salvagable, parts of them will become canal cities.

Zwei neue Studien zeigen, dass in Grönland sowohl kleinere Gletscher außerhalb des großen Eisschilds als auch das Schelfeis viel schneller abschmelzen als im vergangenen Jahrhundert. Das Schelfeis s im Norden Grönland hat seit 1978/35% seines Volumens verloren. Wenn Abschnitte des shelf Eis kollabieren, was in diesem Jahrhundert bereits dreimal der Fall war, verdoppelt sich die Abschmelzgeschwindigkeit der Gletscher dahinter.

https://www.nytimes.com/2023/11/09/climate/greenland-glaciers-ice-melt.html

• for: individual / collective gestalt, Deep Humanity, superorganism, multi-level superorganism, major evolutionary transition, MET, cognitive light cone, umwelt

• paraphrase

  • a human being certainly has a light cone that does not belong to any of its pieces (ie cells)
  • at the conscious level of a human being, we have
    • goals
    • preferences
    • hopes
    • dreams
    • narratives
  • humans occupy spaces that do not belong to our individual cells, tissues or organs
    • those smaller parts work in
      • physiological space
      • transcriptional space
      • biomolecular space
  • When we were an embryo we worked in morphogenetic space

• comment

  • Since MET implies that these smaller structures of which we are constituted like
    • cells and
    • sub-cellular structures like mitochondria
  • were descended from individual organisms long ago in deep history, those contemporary proxies are occupying their own umwelt

• for: superorganism, multi-level superorganism, collective intelligence, individual-collective gestalt, Michael Levin,

• title: Cell Intelligence in Physiological and Morphological Spaces

• author: Michael Levin
• date 2022
• comment
  • This is a talk on collective intelligence in unconventional spaces

• for: superorganism, multi-level superorganism, David Chavalarias
• title: From inert matter to the global society life as multi-level networks of processes
• author: David Chavalarias
• date: Feb. 24, 2020
• source
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061952/
• paraphrase: abstract
  • A few billion years have passed since the first life forms appeared.
  • Since then, life has continued to forge complex associations between the different emergent levels of interconnection it forms.
  • The advances of recent decades in molecular chemistry and theoretical biology, which have embraced complex systems approaches, now make it possible to conceptualize the questions of the origins of life and its increasing complexity from three complementary notions of:closure:
    • processes closure,
    • autocatalytic closure and
    • constraints closure.
  • Developed in the wake of the second-order cybernetics, this triple closure approach,
    • that relies on
      • graph theory and
      • complex networks science,
    • sketch a paradigm where it is possible to go up the physical levels of organization of matter,
      • from physics
      • to biology and society,
    • without resorting to strong reductionism. -The phenomenon of life is conceived as the contingent complexification of the organization of matter, until the emergence of life forms, defined as a network of auto-catalytic process networks, organized in a multi-level manner. This approach of living systems, initiated by Maturana & Varela and Kauffman, inevitably leads to a reflection on the nature of cognition; and in the face of the deep changes that affected humanity as a complex systems, on the nature of cultural evolution. Faced with the major challenges that humanity will have to address in the decades to come, this new paradigm invites us to change our conception of causality by shifting our attention from state change to process change and to abandon a widespread notion of 'local' causality in favour of complex systems thinking. It also highlights the importance of a better understanding of the influence of social networks, recommendation systems and artificial intelligence on our future collective dynamics and social cognition processes.

Küsten-Ökosysteme können sich nur eingeschränkt an eine schnelle Erhöhung des Meeresspiegels anpassen. Über 90% der Mangrovenwälder, Korallenriffe und Gezeitensümpfe würden bei einen Temperaturanstieg um 3° nicht mit dem schnellen Anstieg des Meeresspiegels Schritt halten und damit die Fähigkeit verlieren, CO2 zu binden, wie eine neue Studie prognostiziert. https://www.liberation.fr/environnement/biodiversite/rechauffement-climatique-les-ecosystemes-cotiers-risquent-detre-noyes-par-la-montee-des-eaux-20230830_OHOQ4F5XRRA4RCJLRZEWHTJYRE/

• Julian Huxley's biology work was to lay the seed of
  • how one individual organism transforms over many generations
    • into a new higher-level individual organism
  • he called this the "movement of individuality"
  • It has also come to be known as
    • major transitions
    • major evolutionary transition (MET)
    • evolutionary transitions in individuality
  • grandson of Thomas Huxley
  • brother of Aldous Huxley (Brave New World)
  • wrote The Individual in the Animal Kingdom (1912)
  • advocated for closed, independent systems with harmonious parts
  • endorsed gradients of individuality
  • "closure is never complete, the independence never absolute, the harmony never perfect"

Not strictly true. Plenty of happy things happen throughout the lives of the Baudelaire orphans. This series shows us that it's the little things that count. the grim nature of the series is part of the charm of it.

Eine neue Modellierung der Witterung der globalen Erhitzung auf die Gletscher der Arktis i und Antarktis und auf ihreWechselwirkungen mit den Ozeanen ergibt, dass der Meeresspiegel bis Mitte der kommenden Jahrhunderts um anderthalb Meter steigen wird, wenn die Temperatur derbAtmosphäre um mehr als 1,8 Gerade steigt.

FPL is based on year prior to tax year. Ex:- for 2022 tax year FPL table is 2021

federal poverty level (FPL)

Federal Poverty Level (FPL) 2023

Micheal Hudson : tax the rent seeking class or face barbarism like in Rome - The situation today is degrading in the same way Rome degraded into feudalism - rent seeking class today is not the landlord class, but the financial and raw materials class that are making large fortunes from rent seeking - that is the system level reform necessary today

https://www.youtube.com/watch?v=3h0Y6qE4TKg

-I will download this full article through EBSCO

-This article will provide me with teaching strategies that use technology in elementary reading lessons.

-rating 8/10

McDermott, P., & Gormley, K. A. (2016). Teachers’ use of technology in elementary reading lessons. Reading Psychology, 37(1), 121-146.

This article will provide me with insight on the views elementary teachers have on design, engineering and technology.

rating 8/10

Hsu, M. C., Purzer, S., & Cardella, M. E. (2011). Elementary teachers’ views about teaching design, engineering, and technology. Journal of Pre-College Engineering Education Research (J-PEER), 1(2), 5.

This article will provide me insight into teaching with technology at the elementary school level.

rating 6/10

Varol, F. (2013). Elementary School Teachers and Teaching with Technology. Turkish Online Journal of Educational Technology-TOJET, 12(3), 85-90.