for - question - earth system boundaries - biodiversity - how do we reconcile these boundaries with climate departure?

question - earth system boundaries - biodiversity - how do we reconcile these boundaries with climate departure? - Does the term "functional integrity" imply autonomy from climate feedbacks? Obviously, climate feedback plays a huge role in determining biodiversity health - In 2013, Mora et al. found that climate departure, the year in which a climate variable moves out of the historical bounds will occur everywhere on the planet, regardless of an aggressive RCP pathway being taken. In this study, climate departure was found to take place (relative to 2013) - 37.5 years in the future under RCP45, or - 22.5 years in the future under RCP85 - It would seem that the biodiversity boundaries should take into consideration climate departure as species extinction and ecological system disruption is projected to occur, regardless of whether RCP45 or RCP85 is adopted. - Currently, we are still on a Business-As-Usual trajectory, but since 2013, scientific research has moved the danger threshold even lower so climate departure dates are likely even sooner than those calculated in the 2013 Mora paper

to - Mora, C., Frazier, A., Longman, R. et al. (2013). The projected timing of climate departure from recent variability. Nature 502, 183–187. https://doi.org/10.1038/nature12540 - https://hyp.is/3wZrokX9Ee-XrSvMGWEN2g/www.nature.com/articles/nature12540 - Researchgate copy - https://hyp.is/go?url=https%3A%2F%2Fwww.researchgate.net%2Fpublication%2F257598710_The_projected_timing_of_climate_departure_from_recent_variability&group=world

for - rapid whole system change - to move humanity to a safe and just corridor

for - The projected timing of climate departure from recent variability - Camilo Mora et al. - 6th mass extinction - biodiversity loss - question - 2024 - Sept 13 - how do we reconcile climate departure with quantification of earth system boundary biodiversity safe and just limit?

paper details - title: The projected timing of climate departure from recent variability - author: - Camilo Mora, - Abby G. Frazier, - Ryan J. Longman, - Rachel S. Dacks, - Maya M. Walton, - Eric J. Tong, - Joseph J. Sanchez, - Lauren R. Kaiser, - Yuko O. Stender, - James M. Anderson, - Christine M. Ambrosino, - Iria Fernandez-Silva, - Louise M. Giuseffi, - Thomas W. Giambelluca - date - 9 October, 2013 - publication Nature 502, 183-187 (2013) - https://doi.org/10.1038/nature12540 - https://www.nature.com/articles/nature12540

to - https://hyp.is/0BdCglsHEe-2CteEQbOBfw/www.researchgate.net/publication/257598710_The_projected_timing_of_climate_departure_from_recent_variability

Summary - This is an extremely important paper with a startling conclusion of the magnitude of the social and economic impacts of the biodiversity disruption coming down the pipeline - It is likely that very few governments are prepared to adapt to these levels of ecosystemic disruption - Climate departure is defined as an index of the year when: - The projected mean climate of a given location moves to a state that is - continuously outside the bounds of historical variability - Climate departure is projected to happen regardless of how aggressive our climate mitigation pathway - The business-as-usual (BAU) scenario in the study is RCP85 and leads to a global climate departure mean of 2047 (+/- 14 years s.d.) while - The more aggressive RCP45 scenario (which we are currently far from) leads to a global climate departure mean of 2069 (+/- 18 years s.d.) - So regardless of how aggressive we mitigate, we cannot avoid climate departure. - What consequences will this have on economies around the world? How will we adapt? - The world is not prepared for the vast ecosystem changes, which will reshape our entire economy all around the globe.

question - 2024 - Sept 13 - how do we reconcile climate departure with quantification of earth system boundary biodiversity safe and just limit? - Annotating the Sept 11, 2024 published Earth Commission paper in Lancet, the question arises: - How do we reconcile climate departure dates with the earth system boundary quantification of safe limits for biodiversity? - There, it is claimed that: - 50 to 60 % of intact nature is required<br /> - https://hyp.is/Mt8ocnIEEe-C0dNSJFTjyQ/www.thelancet.com/journals/lanplh/article/PIIS2542-5196(24)00042-1/fulltext - a minimum of 20 to 25% of human modified ecosystems is required - https://hyp.is/AKwa4nIHEe-U1oNQDdFqlA/www.thelancet.com/journals/lanplh/article/PIIS2542-5196(24)00042-1/fulltext - in order to mitigate major species extinction and social disruption crisis - And yet, Mora et al.'s research and subsequent climate departure map shows climate departure is likely to take place everywhere on the globe, with - aggressive RCP decarbonization pathway only delaying climate departure from - Business-As-Usual RCP pathway - by a few decades at most - And this was a 2011 result. 13 years later in 2024, I expect climate departure dates have likely gotten worse and moved closer to the present

from - Gupta, Joyeeta et al.(2024). A just world on a safe planet: a Lancet Planetary Health–Earth Commission report on Earth-system boundaries, translations, and transformations. The Lancet Planetary Health, Volume 0, Issue 0 - https://hyp.is/go?url=https%3A%2F%2Fwww.thelancet.com%2Fjournals%2Flanplh%2Farticle%2FPIIS2542-5196(24)00042-1%2Ffulltext&group=world

Seit 2023 herrscht im Amazonasgebiet eine extreme Dürre, deren Ursachen die Erhitzung der Ozeane und ein durch die globale Erhitzung verstärkter El Niño sind. Sie begünstigt die extrem zahlreichen Waldbrände, deren Rauch gerade die Luft über 60% des brasilianischen Territoriums verschmutzt. 97% der Brände werden aber von Menschen entzündet, vor allem im Interesse der Agrarindustrie. Auch aufgrund der Entwaldung ist der Kipppunkt, von dem an der Wald Kohlenstoff emittiert statt absorbiert, näher als bisher angenommen. Ausführlicher Bericht anlässlich einer neuen Studie und des Aufrufs zum Boykott von.Agrarprodukten aus dem Gebiet. https://www.liberation.fr/environnement/ravagee-par-les-feux-lamazonie-au-bord-du-basculement-le-climat-est-devenu-un-allie-de-la-destruction-de-la-foret-20240911_HEMGMQI7WZCYHAWC6E24ZJCTIU/

Studie: https://www.nature.com/articles/s41586-023-06970-0

Der neue französische Premierminister Michel Barnier hat in seiner Zeit als Umweltminister wesentlich dazu beigetragen, das Vorsorgeprinzip und die finanzielle Verantwortung der Verschmutzenden für Schäden im Umweltrecht zu verankern. Obwohl er zu Amtsbeginn auch von der „ökologischen Schuld" gesprochen hat, erwarten NGOs und Thinktanks, deren Vertreter:innen die Libération befragt hat, allenfalls vorsichtige umweltpolitische Schritte und eine insgesamt restriktive Ausgabenpolitik von ihm.https://www.liberation.fr/environnement/le-premier-ministre-michel-barnier-est-il-vraiment-decide-a-payer-la-dette-ecologique-de-la-france-20240906_7BYVDVAUSJD2VN6M4V7DAI2N2E/

Prominent HKS Professor Ricardo Hausmann Accused of Plagiarism by Former Co-Author by [[William C. Mao]] and [[Dhruv T. Patel]]

Die Fossilindustrie finanziert seit Jahrzehten Universitäten und fördert damit Publikationen in ihrem Interesse, z.B. zu false solutions wie #CCS. Hintergrundbericht anlässlich einer neuen Studie: https://www.theguardian.com/business/article/2024/sep/05/universities-fossil-fuel-funding-green-energy

Studie: https://doi.org/10.1002/wcc.904

for - nonduality - not acting against violence in such a case (as Ukraine war) is an egoic response - acting out of cowardice - Rupert Spira

comment - One can act egoically both to take action AND to not take action.

for - question - nilhism - nondualism - is fighting evil a contradiction? - Rupert Spira - Bernado Kastrup - question - nilhism - how do we prevent falling into?

question - nondualism - is fighting evil a contradiction? - Pondering this idea raises the question: - Is fighting evil a contradiction? - Do we fall into duality if we fight evil? - Does nonduality imply not creating categories of morality of good and evil? - This question has no answer because - If you understand the question, you are already - a language user - applying some morality - We are already post category and post linguistic - we can never undo this and get back to pre-category and pre-linguistic - Fighting evil cannot conquer it because - in fighting evil, this implies using (deadly) force - deadly force results in death, the most extreme form of suffering - It is tantamount to abuse and justifying death is the greatest act of separation, causing great suffering to the other - In effect, we have the same result as the abuser and this can create a new generation of abused

question - nilhism - how do we prevent falling into? - Rather, what is needed is to PENETRATE moral relativism / dualism altogether to re-discover the common sacred ground both moral categories are based upon - The use of force as a form of vengeance - is the perpetuation of the abused-abuser cycle

for - quote - consciousness - model of - as a quantum field - Federico Faggin - question - about Federico Faggin's quantum field theory of consciousness - Is it neo-dualistic?

quote - consciousness - model of - as a quantum field - Federico Faggin - (see below) - Think of the body as a structure in space and time - It is both - classical - cells are made of particles, atoms and molecules that interact quantumly in space and time - AND fields - The body is a bridge between consciousness and the classical (objective spacetime) world - The body reports to the conscious field - and creates quantum states inside the cell

potential future dialogue - Michael Levin and Federico Faggin - To unpack quantum states at cellular or subcellular level, it would be good to see a dialogue between Michael Levin and Federico Faggin

for - unpack - key insight - with the postulate of consciousness as the foundation, it makes sense that this is - an inner reality made of qualia - and an outer reality made of shareable symbols we call matter - Federico Faggin - question - about Federico Faggin's ideas - in what way is matter a symbol? - adjacency - poverty mentality - I am the universe who wants to know itself question - in what way is matter a symbol? - Matter is a symbol in the sense that it - we describe reality using language, both - ordinary words as well as - mathematics - It is those symbolic descriptions that DIRECT US to jump from one phenomena to another related phenomena. - After all, WHO is the knower of the symbolic descriptions? - WHAT is it that knows? Is it not, as FF points out, the universe itself - as expressed uniquely through all the MEs of the world, that knows? - Hence, the true nature of all authentic spiritual practices is that - the reality outside of us is intrinsically the same as - the reality within us - our lebenswelt of qualia

for - answer - It has to be taken as a postulate - Federico Faggin - to question - how can we test that consciousness is the foundation of reality?

for - STOP - intervention - integration of cognitive science and wisdom traditions to - provide a praxis to address the meaning crisis - John Verveake

for - quote - model of a Self that is flowing and collective - John Vervaeke - similiarity to - Deep Humanity foundations on emptiness

quote - model of a Self that is flowing and collective - John Vervaeke - This is equivalent to Stop Reset Go Deep Humanity foundation on the two pillars of emptiness - change and intertwingledness

https://en.wikipedia.org/wiki/Satisficing

for - adjacency - key insight - quote - localization enables (infinite or universal consciousness) to perceive itself - Rupert Spira - discerning single voice at a busy party metaphor - existential isolation - umwelt

adjacency - between - key insight - quote - localization enables (infinite or universal consciousness) to perceive itself - Rupert Spira - discerning single voice at a busy party metaphor - existential isolation - adjacency relationship - quote - localization enables (infinite or universal consciousness) to perceive itself - Rupert Spira - This localization process enables (infinite) consciousness to perceive itself as the universe because - infinite consciousness cannot perceive its own activity directly - because if infinite consciousness were to perceive the universe directly - it would have to do so from every single point of view in the universe - It would be the deepest, darkest black image you could imagine - So in order to perceive an object - (infinite) consciousness must localize itself as an apparently separate subject so - the apparent localization of our self or - the dissociation of ourselves - as finite minds out of infinite consciousness enables - perception and - thought

• There is a metaphor that applies here:
  • At a busy dinner party, many people are talking at the same time
  • As the number of people approach infinite, the signal becomes more difficult to detect
  • In the same manner, as the activities of the universe are seemingly unbounded, how could infinite consciousness possibly observe its own infinite entirety?
  • Existential isolation is deemed depressing because it makes us feel intrinsically separated and disconnected from others, yet
    • it may be very necessary
  • Can you imagine hearing and understanding the voices of every human being, much less every living being?
  • An individual human does not have the capacity to process all that information
  • In the same manner, the body of every living organism is fine tuned for only one specific set of unwelts
  • How would we process the unbound amounts of information if we had an infinite number of different detectors?

Topology Without Tears by [[Sidney A. Morris]]

The Best Topology Book For Beginners is Free by [[The Math Sorcerer]]

Topology Without Tears by Sidney A. Morris<br /> https://www.topologywithouttears.net/

Topology: A Short Introduction by [[badbettybooks]]

only the most surface level review here from the perspective of a relatively unsophisticated undergraduate

for - adjacency - DNA - as an engram - as a memory - Micheal Levin

adjacency - between - DNA - as an engram - as a memory - adjacency relationship - Very interesting n way to see DNA

Today on AirTalk:<br /> - California announces new deal with tech to fund journalism, AI research - How to help your LGBTQ+ student deal with the anxiety of going back to school - Anthology television and its place in mid century American society - Digital driver's licenses are here. Does that mean convenience, privacy headache or both? - Tribute to jazz legends The Mizell Brothers kicks off ‘Jazz Is Dead’ concert series at The Ford - TV Talk: ‘Homicide’ streaming release, ‘City of God,’ ‘Solar Opposites’ and more

https://laist.com/shows/airtalk/california-announces-new-deal-with-tech-to-fund-journalism-ai-research

Propusimos una herramienta basada en IA que podría motivar a las mujeres de América Latina a participar en proyectos de ciencia ciudadana.

Llamado a la acción

Una revisión a nivel de agencias de la ONU sobre la aplicación de las leyes y estándares internacionales de derechos humanos existentes para la gestión de los datos automatizados, el aprendizaje automático y el género: esto puede guiar y provocar el pensamiento creativo para un enfoque basado en los derechos humanos que sea adecuado para el propósito en la era digital que cambia rápidamente.

Desarrollo de un conjunto de métricas para la inclusión digital: debe acordarse urgentemente, medirse en todo el mundo y detallarse con datos desagregados por sexo en los informes anuales de instituciones como la ONU, el Fondo Monetario Internacional, la Unión Internacional de Telecomunicaciones, el Banco Mundial y otros bancos multilaterales de desarrollo, y la OCDE.

Llamado a la acción

Equilibrio de género en la toma de decisiones de IA: el equilibrio de género en la toma de decisiones debe incluirse en la agenda oficial de todos los involucrados en la financiación, el diseño, la adopción y la evaluación de ADM.

Equilibrio de género en los equipos de diseño: empleo de una gama sólida de feministas interseccionales en el diseño de sistemas ADM que desencadenarán y ayudarán a una mayor innovación y creatividad, así como la detección y mitigación de sesgos y efectos nocivos en mujeres, niñas y personas tradicionalmente excluidas.

Exigir a las empresas que divulguen e informen de manera proactiva sobre el equilibrio de género en los equipos de investigación y diseño, incluso en la fase inicial cuando soliciten subvenciones. Incentivar equipos equilibrados y multidisciplinarios.

Fondo de investigación: crear un fondo de investigación para explorar los impactos del género y la IA, el aprendizaje automático, el sesgo y la equidad, con un enfoque multidisciplinario más allá de la informática y la perspectiva económica para incluir nuevas formas de incorporar la alfabetización digital y estudiar los efectos económicos, políticos y sociales de ADM en las vidas de las mujeres y las personas tradicionalmente excluidas de la elaboración de reglas y la toma de decisiones.

Llamado a la acción

Acciones algorítmicas equitativas para corregir los sesgos y barreras de la vida real que impiden que las mujeres y las niñas logren la participación plena y el disfrute igualitario de los derechos.

Instituciones públicas para pilotar y liderar: Acción afirmativa para algoritmos implementados cuando las instituciones públicas pilotan ADM. Basar los pilotos en investigaciones de ciencias sociales nuevas y de larga data que asignan incentivos sociales, subsidios o becas donde las mujeres tradicionalmente han sido dejadas atrás en sistemas anteriores. Esta es una agenda positiva para promover los valores de igualdad que hemos adoptado durante mucho tiempo, para corregir la visibilidad, la calidad y la influencia de las mujeres proporcionales a la población.

Adopción por parte del sector público y privado de evaluaciones de impacto algorítmico (AIA): un marco de autoevaluación diseñado para respetar el derecho del público a conocer los sistemas de IA que impactan sus vidas en términos de principios de responsabilidad y equidad.

Pruebas rigurosas a lo largo del ciclo de vida de los sistemas de IA: las pruebas deben tener en cuenta los orígenes y el uso de los datos de entrenamiento, los datos de prueba, los modelos, la interfaz de programación de aplicaciones (API) y otros componentes a lo largo del ciclo de vida de un producto. Las pruebas deben cubrir ensayos previos al lanzamiento, auditorías independientes, certificación y monitoreo continuo para detectar sesgos y otros daños. La ADM debe mejorar la calidad de la experiencia humana, no controlarla.

Marcos legales sólidos para promover la rendición de cuentas: incluida la posible expansión de poderes para agencias sectoriales específicas o la creación de nuevos términos de referencia para supervisar, auditar y monitorear los sistemas de ADM para la supervisión regulatoria y la responsabilidad legal en el sector privado y público.

Directrices de adquisiciones con perspectiva de género: las organizaciones y todos los niveles de gobierno deben desarrollar directrices de adquisiciones de igualdad de género de ADM con objetivos estrictos; y describir los roles y responsabilidades de aquellas organizaciones requeridas para aplicar estos principios.

Mejorar los conjuntos de datos: datos abiertos desagregados por género, recopilación de datos y conjuntos de datos de calidad inclusivos: producir activamente conjuntos de datos abiertos desagregados por género; Esto permite comprender mejor las fuentes de sesgo en la IA y, en última instancia, mejorar el rendimiento de los sistemas de aprendizaje automático. Invertir en controles para supervisar los procesos de recopilación de datos y la verificación humana en el circuito, de modo que los datos no se recopilen a expensas de las mujeres y otros grupos tradicionalmente excluidos. Participar en procesos de recopilación de datos más inclusivos que se centren no solo en la cantidad sino también en la calidad de los conjuntos de datos.

for - question - how do you know when you are part of a larger cognitive system? - answer - adjacency - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundation theory of affect

question - how do you know when you are part of a larger cognitive system? - answer - adjacency - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundation theory of affect

adjacency - between - answer - synchronicity - lower level example - two neurons talking to each other - Michael Levin - Mark Solms foundational theory of affect - adjacency relationship - This is a very interesting question and Michael Levin provides a very interesting answer - First, it is very interesting that Mark Solms points out that affect is foundational to cognition - This is evident once we begin to think of the fundamental goals of any individual of any species is to optimize survival - The positive or negative affects that we feel are a feedback signal that measures how successful we are in our efforts to survive - Hence, it is more accurate to ask: - How do you know if and when you are part of a larger affective-cognitive system? - Levin illustrates the multi-level nature of simultaneous consciousness by looking at two neurons "in dialogue" with each other, and potentially speculating about a "higher level of consciousness", which is in fact, the level you and I operate at and take for granted - This speculative question is very important for it also can be generalized to the next layer up, - Do collectives of humans, each one experiencing itself a unified, cohesive inner perspective, constitute a higher level "collective consciousness"? - If we humans experience feelings and thinking whilst we have a well defined physical body, then - what does a society feel and think whilst not having such a well defined physical body?

https://www.theguardian.com/us-news/article/2024/aug/16/biden-inflation-reduction-act-tax-benefit-wealthy

for - Federico Faggin - high priority objective - find and implement ways to catalyze authentic awakening experiences in a short time - ie - one week

for - Dr. Donna Thomas - book - Children's unexplained experiences in a post materialistic world - analytic idealism - children perspective of reality - adjacency - children as natural philosophers - Deep Humanity as reminder of our philosophical nature

adjacency - between - Children as natural philosophers - Deep Humanity - adjacency relationship - At time 59 minute of that interview, Dr Thomas makes a very insightful observation that - children are naturally philosophers - and ask deeply philosophical questions - Another way to look at Deep Humanity is that it is reminding us of these deeply philosophical questions the see all had when we were children - but we stopped asking then as we grew out of childhood because nobody could answer them for us

Off-topic, this guy looks really good for his age.

Patience reaction vid

Fear is the deciding factor on how Elio and Oliver decide who they are in the context of their relationships there and then. Their identity is directly based on the social mirror due to fear.

for - planetary emergency - top priority task - get world leaders to meet and develop a plan to return to the safe operating space

for - planetary emergency - narrative shift required - from lack to building a better world

for - quote - Johan Rockstrom - successful phase of of fossil fuels - is a necessary but not sufficient condition for station under 1.5 degree Celsius

for - question - can cities save the planet? - a critical analysis

for - neuroscience - education of children - recommend no digital devices before puberty - allows learning in a 3 dimensional world

for - neuroscience - importance of maintaining curiosity - 1000 questions a day for children - 20 questions a day for adults

Case: Patient Proband SS, Female, Caucasian

DiseaseAssertion: UCD/OTCD

FamilyInfo: De novo inheritance, no family history of disease

CasePresentingHPOs: Hyperammonemia (HP:0001987), oroticaciduria (HP:0003218), Childhood onset (HP:0011463)

CaseHPOFreeText:

CaseNOTHPOs: Positive allopurinol test

CaseNOTHPOFreeText:

CasePreviousTesting: Genomic DNA isolated from peripheral blood leukocytes or cultured skin fibroblasts. Amplification by PCR used. SSCP analysis performed. Sequencing of both free and immobilized single strands carried out by dideoxy chain termination method.

SupplementalData: Table 1: Mutations in the Ornithine Transcarbamylase Gene of 17 Females

Variant: NM_000531.6:c.77+1G>A

ClinVarID: 97313

CAID: CA224773

gnomAD:

for - time sense - more new events gives a longer sense of time

for - neuroscience - how to - create perception of a long life - increase new activities

https://www.theguardian.com/us-news/article/2024/aug/02/great-salt-lake-shrinking-greenhouse-gas-emissions

Case: Patient #50, Male

DiseaseAssertion: UCD/OTCD

FamilyInfo: N/A

CasePresentingHPOs: Neonatal onset (HP:0003623), Hyperammonemia (HP:0001987)

CaseHPOFreeText:

CaseNOTHPOs:

CaseNOTHPOFreeText:

CasePreviousTesting: N/A

Variant: NM_000531.6: c.174G>A (p.Trp58*)

ClinVarID: 97127

CAID: CA224490

gnomAD:

Case: Patient #15, Female

DiseaseAssertion: UCD/OTCD

FamilyInfo: N/A

CasePresentingHPOs: N/A

CaseHPOFreeText:

CaseNOTHPOs:

CaseNOTHPOFreeText:

CasePreviousTesting:

Variant: NM_000531.6: c.77+1G>A

ClinVarID: 97313

CAID: CA224773

gnomAD:

https://www.theguardian.com/environment/2023/jul/25/gulf-stream-could-collapse-as-early-as-2025-study-suggests

Case: patient #10, Male, Argentine

Disease Assertion: UCD/OTCD

Family Info: family history of the disease,

Case Presenting HPOs: Neonatal onset(HP:0003623), Hyperammonemia HP:0001987

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: The OTC gene mutations were identified using PCR amplification, classical sequencing (Sanger), and multiplex ligation-dependent probe amplification.10,11 Mutations were identified by comparison with the GenBank reference sequence for human OTC (GenBank entries: NG_008471.1, NP 000522.3, NM 000531.5, NC 000023.11) Missense mutations were analyzed using different computational algorithms: CLUSTALW2 (http://www.clustal.org/clustal2/), SIFT (http://blocks.fhcrc.org/sift/SIFT.html),Polyphen2(http://genetics.bwh.harvard.edu/pph/),PoPMuSiC(http://babylone.ulb.ac.be/popmusic/), and SIFT Indel(http://siftdna.org/www/SIFT_indels2.html).

Supplemental Data: Table 1 Notes: died at 6 months and had 2 brothers that died a neonatal stage

Variant: NM_000531.6: c.540+1G>A

ClinVarID: 1458773

CAID: CA412724226

gnomAD: X-38381340-A-T

Gene Name: OTC (ornithine transcarbamylase)

for - search - google - high resolution addressing of disaggregated text corpus mapped to graph - search results of interest - high resolution addressing of disaggregated text corpus mapped to graph

search - google - high resolution addressing of disaggregated text corpus mapped to graph - https://www.google.com/search?q=high+resolution+addressing+of+disaggregated+text+corpus+mapped+to+graph&oq=high+resolution+addressing+of+disaggregated+text+corpus+mapped+to+graph&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigATIHCAIQIRigAdIBCTMzNjEzajBqN6gCALACAA&sourceid=chrome&ie=UTF-8

to - search results of interest - high resolution addressing of disaggregated text corpus mapped to graph - A New Method for Graph-Based Representation of Text in - The use of a new text representation method to predict book categories based on the analysis of its content resulted in accuracy, precision, recall and an F1- ... - https://hyp.is/H9UAbk46Ee-PT_vokcnTqA/www.mdpi.com/2076-3417/10/12/4081 - Encoding Text Information with Graph Convolutional Networks - According to our understanding, this is the first personality recognition study to model the entire user text information corpus as a heterogeneous graph and ... - https://hyp.is/H9UAbk46Ee-PT_vokcnTqA/www.mdpi.com/2076-3417/10/12/4081

Case: patient #11, female, 35yo, slovenian

Disease Assertion: UCD/OTCD

Family Info: family history of the disease,

Case Presenting HPOs: Adult onset(HP:0003581), hyperammonemia(HP:0001987), protein avoidance (HP:0002038)

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: Sequencing was performed at a 3rd-party sequencing center using a standardized seq of procedures following PCR-free WGS library preparation protocol Illumina TrueSeq DNA Nano and sequenced on Illumina NovaSeq 6000 platform with a mean autosomal depth greater than 30×. Variants were interpreted by a medical doctor specialized in the NGS sequencing data analysis and those classified as likely pathogenic or pathogenic according to the ACMG/AMP standards and guidelines were considered for reporting, while variants of uncertain clinical significance, were not considered. Likely pathogenic and pathogenic variants were further evaluated by the referring clinical geneticist and were considered and reported if they were classified as both a likely diagnostic finding and if they were compatible with the clinical presentation of referral.

Supplemental Data: Table 4 and section 3.1(Case description) Notes:

Variant: NM_000531.6: c.540+265G>A

ClinVarID: 449382

CAID: CA658658977

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

Case: patient #113, Male

Disease Assertion: UCD/OTCD

Family Info:

Case Presenting HPOs: Neonatal onset(HP:0003623), Hyperammonemia HP:0001987

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: GDNA from blood, cultured skin fibroblasts, liver from patients suspected for otc deficiency was used to amplify all 10 exons and exon/intron boundaries using primers listed in Table 1. The amplified DNA fragments were then screened by single-strand conformational polymorphism (SSCP) and the abnormally migrating DNA fragments were sequenced directly from PCR products (w/o subcloning) to identify the mutation. The amino acid residue substitution created by the mutation is examined using an alignment of 26 OTCase sequences from 23 species.

Supplemental Data: Table 4 Notes:

Variant: NM_000531.6: c.867+1G>A

ClinVarID: 97342

CAID: CA224813

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

for - complexity - evaluation - from - paper - Building a system-based Theory of Change using Participatory Systems Mapping

for - paper review - building a system-based Theory of Change using Participatory Systems Mapping - participatory systems mapping - SRG / Indyweb dev - system mapping - participatory approach

summary - I'm reviewing this paper because the title seems salient for the development of our own participatory Stop Reset Go system mapping tool within Indyweb ecosystem. - The building of - a systems-based Theory of Change using - Participatory Systems Mapping - is salient to our own project and aligns to it with different language: - Theory of Change with uses theory to perform an evaluation and propose an intervention - The Stop Reset Go framework focuses on the specific type of process called "improvement", or - transforming a process to make it "better" in some way

to - Indyweb project info page - https://hyp.is/RRevQk0UEe-xwP-i8Ywwqg/opencollective.com/open-learning-commons/projects/indy-learning-commons

https://www.theguardian.com/environment/article/2024/jul/26/climate-hero-villain-fossil-fuel-frenzy-challenges-norway-green-image

Choosing the Right Typewriter by [[Joe Van Cleave]]

for - question - what's the meaning of life? - a philosophical perspective - John Vervaeke - The meaning crisis

Case: patient is named case #2, male

Disease Assertion: UCD/OTCD

Family Info:

Case Presenting HPOs: Hyperammonemia (HP:0001987), oriticaciduria (HP:0003218), low plasma citrulline (HP:0003572), neonatal onset(HP:0003623), Hyperglutaminemia (HP:0003217)

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: GDNA was isolated from lymphocytes. To examine the small mutations in the coding region of the OTC gene, all 10 exons and their flanking intron regions were amplified using PCR, and the nucleotide sequences of the amplified products were determined. To determine the intron 5 sequence of case 2, PCR was performed using primers OTCex5F and OTCint5R, and primers OTCint5F and OTCex6R (Table 1, Fig. 3). The amplified products were subcloned into the pT7 vector and the inserted DNA was sequenced using an automated DNA sequencer. Allopurinol test

Supplemental Data: TABLE 1, Notes:

Variant: NM_000531.6: c.540+265G>A

ClinVarID: NA

CAID: CA658658977

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

Case: no patient #ID, male Disease Assertion: UCD/OTCD

Family Info: NA

Case Presenting HPOs: NA

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: NA

Supplemental Data: TABLE 1, Notes: NA

Variant: NM_000531.6: c.663+1G>A

ClinVarID: 97283

CAID: CA224730

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

for - paradigm shift - we need a new story quote - a time between stories

quote - a time between stories - Despite this panoply of stories, we are in fact living in a time between stories, because - the dominant narrative remains the same: - progressing within the modern paradigm is the best way to create and maintain a good quality of life, and the only way societies can do this is through - Western-style industrial development, - corporate capitalism, and - representative democracy. - While many people recognise that this narrative needs to be replaced, - we haven’t yet found a new narrative that’s powerful enough to replace it.

for - paradigm shift - we need a new story

article details - title - Finding our place in the human story - author - Paddy Le Flufy - date - 14 July, 2024 - publication - substack - self link - https://paddyleflufy.substack.com/p/finding-our-place-in-the-human-story

26:30 Brings up progress traps of this new technology

26:48

question How do we shift our (human being's) relationship with the rest of nature

27:00

metaphor - interspecies communications - AI can be compared to a new scientific instrument that extends our ability to see - We may discover that humanity is not the center of the universe

32:54

Question - Dr Doolittle question - Will we be able to talk to the animals? - Wittgenstein said no - Human Umwelt is different from others - but it may very well happen

34:54

species have culture - Marine mammals enact behavior similar to humans

• Unknown unknowns will likely move to known unknowns and to some known knowns

36:29

citizen science bioacoustic projects - audio moth - sound invisible to humans - ultrasonic sound - intrasonic sound - example - Amazonian river turtles have been found to have hundreds of unique vocalizations to call their baby turtles to safety out in the ocean

41:56

ocean habitat for whales - they can communicate across the entire ocean of the earth - They tell of a story of a whale in Bermuda can communicate with a whale in Ireland

43:00

progress trap - AI for interspecies communications - examples - examples - poachers or eco tourism can misuse

44:08

progress trap - AI for interspecies communications - policy

45:16

whale protection technology - Kim Davies - University of New Brunswick - aquatic drones - drones triangulate whales - ships must not get near 1,000 km of whales to avoid collision - Canadian government fines are up to 250,000 dollars for violating

50:35

environmental regulation - overhaul for the next century - instead of - treatment, we now have the data tools for - prevention

56:40 - ecological relationship - pollinators and plants have co-evolved

1:00:26

AI for interspecies communication - example - human cultural evolution controlling evolution of life on earth

DOI: 10.1186/s12974-024-03158-9

Resource: IMSR_ORNL:C57BL-6J-A-A

Curator: @evieth

SciCrunch record: RRID:IMSR_ORNL:C57BL-6J-A-A

What is this?

reply to u/Deep-Seaworthiness48 at https://www.reddit.com/r/typewriters/comments/1e5gh4p/two_5_keys_sc_poweriter/

Things like that happened on alternate language/region typewriters. I've got a Dutch keyboard layout that repeats a % symbol twice.

It's likely that the pound symbol was needed/required so they pulled one from a pre-existing typeslug and key cap on a keyboard where the £/5 key was common and replaced the 1/! which in the era was widely known could be done by alternate means (aka lower case 'l' and '.' backspace '''.

The value of the £ was more important to the typist and because of typeface manufacture was probably easier to do in the £/5 existing combination from something like the English No. 1028, International No. 1060 keyboard, the Brazilian No. 1065, or the Danish No. 1047 all of which paired the £/5. See also: https://munk.org/typecast/2023/02/03/1954-smith-corona-scm-typewriter-type-styles-and-keyboards-catalog/

Off hand, I don't see another S-C keyboard combination from that time period that had a £ paired with any other glyph/character. In the "change-a-type" time period they likely wouldn't have done a custom black key for the £/5 when they were already manufacturing one in a matching white. If they didn't also swap out the key at the far right end of that bank, I would expect it to be a standard black '+/=' key cap and slug.

this is just a precursor to genocide.<br /> first they ban your religion, then they wipe out your families.

go ask the armenians how their genocide went...<br /> go ask some turcs why they killed so many armenians...<br /> (spoiler: turcs absolutely hate that question, they will freak out.)

Case: patient #2, male, Saudi Arabian

Disease Assertion: UCD/OTCD

Family Info: Family history of the disease, Variant found in mother of the patient, Brother died of hyperammonemic crisis

Case Presenting HPOs: intellectual disability (HP:0001249), Neonatal onset (HP:0003623), seizure(HP:0001250), episodic hyperammonemia(HP:0001951), intellectual disability (HP:0001249)

Case HPO FreeText: hyperammonemic encephalopathy

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: Liver tissues were used to extract RNA that was later used to synthesize cDNA. The products were compared to healthy controls in order to detect variants. gDNA, in order to determine the size of deletions in patient 3 and 4 , a set of intronic primers presumably flanking the deletions was used and specific primers allowed sequencing of exactly those critical regions(sequencing on paper). To estimate the relevance of the identified intronic variants in terms of their capability to induce splicing, we used a score developed by Shapiro and Senapathy. This splice score offers information about the usage of a certain splice site

Supplemental Data: TABLE 1, Patient was severely mentally retarded after the age of 2. Low OTC activity

Variant: NM_000531.6: c.540+265G>A(p.Gln180_Glu181insX4)

ClinVarID: 449382

CAID: CA658658977

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

Case: no patient ID#, 36yo donor , female

Disease Assertion: UCD/OTCD

Family Info:

Case Presenting HPOs: adult onset (HP:0003581), oriticaciduria (HP:0003218), irritability (HP:0000737), protein avoidance

Case HPO FreeText: hyperammonemic encephalopathy

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: N/A

Supplemental Data: TABLE 1, She is vegeterian. The symptoms of OTCD started showing after the patient donated 60% of liver to her sibling. the information reported in this is the biochemical results during hyperammonemic episode following the transplantation. the patient became irritable and confused, and her level of consciousness deteriorated markedly. After hemodialysis the patient recovered.

Variant: NM_000531.6: c.429T>A(p.Tyr143*)

ClinVarID: 1072591

CAID: CA412723166

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

for - annotate - a new religion of life

question - Is it like Deep Humanity?

for - steady state economy - when we hit physical constraints - a major percentage of our economy needs to be non-physical

for - question - transition - from capitalism to a form of socialism?

question - capitalism to a form of socialism? - To say it seems ludicrous is an opinion that makes sense from a traditional capitalists perspective - From a socialist perspective, it seems feasible - Nothing is free of charge, however, even in socialism, there is always some price an individual must pay, it's more about the incentive structure that differentiates the two - capitalism - polarized towards self-centric perspective - socialism -balanced self-and-other perspective

adjacency - between - capitalism - socialism - differing perspective on self/other worldview - adjacency relationship - While capitalism relies on a self-centric perspective, socialism relies on a more balanced self/other perspective

for - quote - economic growth - pioneering economists saw growth not as permanent, but as just a temporary phase

quote - economic growth - pioneering economists saw growth not as permanent, but as just a temporary phase - (see below) - Given that - assumptions of quantitative growth are pervasive in our society and - have been present for many generations, - it is perhaps not surprising that growth is not widely understood to be a transient phenomenon. - Early thinkers on the physical economy, such as - Adam Smith, <br /> - Thomas Malthus, - David Ricardo and - John Stuart Mill - saw the growth phase as just that: a phase

for - climate crisis - we are in a pivotal moment

for - Climate change impacts - human extinction - don't think so - paleontological evidence shows that humans are a resilient species

Climate change impacts - human extinction - don't think so - paleontological evidence shows that humans are a resilient species - ice ages are really extreme events that humans have survived - Before entering the holocene interglacial period we have been in for the past 10,000 years, the exit from the previous Ice Age took approximately 10,000 years and - there was 400 feet of sea level rise - North America was covered with an Antarctica's equivalence of ice thickness - there was a quarter less vegetation a on the planet - it was dusty and miserable living conditions - There have been dozens of these natural climate oscillations over the past two and a half million years and humans are about 5 to 6 million years old, so have survived all of these - Sometimes in really particularly harsh climate swings,<br /> - speciations of new hominids will appear along with - new tools in the record or - evidence that there's been better control over fire - Humans are resilient and super adaptable - We've lived and adapted to the conditions on all the continents - We will make it through, but modern, industrialized, global society likely won't

for - quote - exceeding 2 Deg C may result in a billion deaths - Joshua Pearce

quote - exceeding 2 Deg C may result in a billion deaths - Joshua Pearce - (see below) - If warming reaches or exceeds 2 °C this century, - mainly richer humans will be responsible for killing roughly 1 billion mainly poorer humans - through anthropogenic global warming, - which is comparable with involuntary or negligent manslaughter.

for - rapid whole system change - need for a new religion - Ronald Wright reflections

comment - Deep Humanity is not a religion, but a deeper understanding of our own humanity, what is it to be human? - but just as important, to understand the distinction between - human nature and - nature - For if human nature is a subset of nature, - which the adjective-noun "human nature" implies - then there is something within humans that is of nature herself - Is it possible that the many fragmented spiritual paths that have emerged in different parts of the world merely reflect the different environs from which they developed, and that in fact, they all are searching for the same essence? - If so, then in perhaps the times we are in are calling us for a global recognition of our common denominators that make us ALL human, - and then the even deeper common denominator with nature herself - So what are those qualities we all have in common as human beings? - and also, what are the qualities our species has in common with nature herself? - neuroscientist David Eagleman coined the term "possibileanism". Perhaps it is that?

for - rapid whole system change - need for something that will create a new form of altruism - Ronald Wright - transition - requires an experience of re-awakening transition - need for a new religion? Deep Humanity?

comment 10 July 2024 - Deep Humanity is our attempt at this. It is not a religion, however. It is humanity, but in the deepest sense, so it is accessible to anyone in our species. Our tagline has been - Rekindling wonder in an age of crisis - However, this morning an adjacency occurred:

adjacency - between - familiarity - wonder - adjacency relationship - Familiarity hides wonder - Richard Dawkins said: - There is an anaesthetic of familiarity, - a sedative of ordinariness - which dulls the senses and hides the wonder of existence. - For those of us not gifted in poetry, - it is at least worth while from time to time - making an effort to shake off the anaesthetic. - What is the best way of countering the sluggish habitutation brought about by our gradual crawl from babyhood? - We can't actually fly to another planet. - But we can recapture that sense of having just tumbled out to life on a new world - by looking at our own world in unfamiliar ways. - That is, when a type of experience becomes familiar through repeated sensory episodes, - we lose the feeling of wonder we had when we initially experienced it - It's much like visiting a place for the very first time. We are struck with a sense of wonder because everything is unpredictable, in a safe way. We have no idea what's around the next corner. It's a surprise. - However, once we live there, and have traced that route hundreds of times, we have transformed that first magical experience into mundane experience. - So it is with everything that makes us human, with all the foundational things about reality that we learned from the moment we were born. - They have all become jaded. We've forgotten the awe of those first experiences in this reality: - our first experience of our basic senses - our first breath of air, instead of amniotic fluid - our first integration of multiple sensory experiences into a cohesive whole - the birth of objectification - the very first application of objectification to form the object we called mOTHER - the Most significant OTHER - our first encounter with the integration of multiple sensory stimuli associated with each object we construct - our first encounter with auditory human, speech symbols - our first experience with object continuity - how objects still exist even if they disappear from view momentarily - do we remember freaking out when mOTHER disappeared from view momentarily? - our first ability to communicate with mOTHER through speech symbols - our first encounter with ability to control our bodies through our own volition - our first encounter with gravity, the pull towards the ground - our first encounter with a large bright sphere suspended in the sky - our first encounter with perspective, how objects change size in our field of view as they get nearer or farer - etc... - What's missing now, is that we have repeated all these experiences so many times, that the feeling of awe no longer emerges with life - To generate awe, the repertoire of existing experiences is insufficient - now we have to create NEW experiences, we have to create novelty - Mortality Salience can help jolt us out of this fixation on novelty, and remind us of the sacred that is already here all the time - For, what happens at the time of death? All the constructions we have taken for granted in life disappear all at once, or perhaps some before others - Hence, we begin to re-experience them as relative, as constructions, and not absolutes - All living organisms have their own unique umwelt - These umwelts are all expressions of the sacred, sensing itself in different ways

• What is required is a kind of awakening, or re-awakening
• When religions do their job, it gives us a framework to engage in a shared sense of the sacred, of wonder in the mundane
• In a sense, Deep Humanity is identifying that most vital commonality in all religions and seeing all their diverse intersectionalities in simply being deeply human
• We awakened once, when we were born into the world
  • then we fell asleep through the dream of familiarity
• Now, we have to collectively re-awaken to the wonder we all experienced in that initial awakening experience as newborns

for - quote - unfortunately, I think we need a near miss to wake us up - Ronald Wright

comment - But the problem is that we can't count on that because it may very well be too late by then - Is the extreme weather events now happening regularly enough to wake us up?

for - rapid whole system change - a new form of asceticism - Ronald Wright - Give me liberty or give me death - degrowth challenges

rapid whole system change - a new form of asceticism - We need something that can be higher than stripping away many of the liberties we take for granted? - This will be challenging because the American dream is based on the feeling and phrase "Give me liberty or give me death!"

for - progress trap - Agriculture appears to be a progress trap - Ronald Wright

argument - progress trap - Agriculture appears to be a progress trap - Ronald Wright - The early progress traps have been comparatively small in scale - During the stone age, there were no more than a few million people alive (3 to 5 million?) and - they destroyed all the big game where humans lived - The Sumerians, with a population of around one million people salted up and destroyed the fertile land of Southern Iraq - Now we have 8 billion people and a third of them are starving - Our continuous technology development is what enables us to stave off the day of reckoning but - we are losing a Scotland-size worth of topsoil every year to - soil erosion - urban sprawl - We still face the possibility of collapse - Our species has existed for 5 to 6 million years and - civilization is an experiment that has only emerged about 10,000 years ago - It's still very possible for the experiment to fail

for - progress trap - dark futures scenario - like Easter Island but on a global scale

comment - The potential global breakdown of global industrialized society, rupturing supply chains so that our highly interdependent world becomes the very Achilles Heel that hastens its demise is chilling - It could mean a huge disruption to the most important aspect of civilization - the continuing accruing and inter-generational transmission of knowledge - It would be catastrophic to lose that, but it is entirely possible - As Wright himself famously said, to use a computer metaphor, we humans are like 50,000 year old hardware, running modern software - By that, he meant that our cognitive physiology (brain and sensory processing system) has not changed for tens of thousands of years, yet cultural evolution happens at exponentially faster rates, so much so that our biological systems are not adapted to keep up with the pace, and that spells disaster - When we no longer have the sensory or cognitive apparatus to sense danger, and we are offloading that to AI, we are in an extremely vulnerable situation

progress trap - Gedanken - Think of our ancestors from 50,000 years ago. - What Wright is saying with his metaphor is that if that child from 50,000 years ago were transported by a time machine to modernity, (s)he would have little problem integrating into modern society - LIKEWISE, if we lose all the knowledge fruits of accumulated over so many thousands of years, it would be like being born into a human tribe 50,000 years ago. - We would likely still have language, but all our technology may have to start from scratch!

for - key insight - progress trap - A Short History of Progress - we are clever but NOT wise!

key insight - progress trap - A Short History of Progress - we are clever but NOT wise! - In other words - Intelligence is FAR DIFFERENT than wisdom

new memes - We have an abundance of intelligence and a dearth of wisdom - A little knowledge is dangerous, a lot of knowledge is even more dangerous

for - agriculture was invented in at least a dozen places around the world

The only true protest vote.

for - health - insulin resistance - a symptom of mitochondria dysfunction

for - medical deception - communicating relative risk instead of absolute risk is misleading and gives the appearance of a greater effect

Case: patient #154, male

Disease Assertion: UCD/OTCD

Family Info: N/A

Case Presenting HPOs: Neonatal onset (HP:0003623)

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: gDNA testing involves PCR amplification of all 10 exons and exon/intron boundaries followed by screening for mutations or sequencing of all fragments, For these patients, confirmation of the diagnosis requires enzymatic assays. No specifications about the test

Supplemental Data: TABLE 1

Variant: NM_000531.6: c.664-1G>A

ClinVarID: 97288

CAID: CA224811

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

Case: patient #213, male

Disease Assertion: UCD/OTCD

Family Info: N/A

Case Presenting HPOs: Neonatal onset (HP:0003623)

Case HPO FreeText:

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: gDNA testing involves PCR amplification of all 10 exons and exon/intron boundaries followed by screening for mutations or sequencing of all fragments, For these patients, confirmation of the diagnosis requires enzymatic assays. No specifications about the test

Supplemental Data: TABLE 1

Variant: NM_000531.6: c.962C>A(p.Ser321*)

ClinVarID: 97373

CAID: CA224859

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

Case: patient #52, female, Japanese

Disease Assertion: UCD/OTCD

Family Info: N/A

Case Presenting HPOs: ,Hyperammonemia (HP:0001987)

Case HPO FreeText: N/A

Case NOT HPOs:

Case NOT HPO Free Text:

Case Previous Testing: The mRNA ref seq were, wherein the “A” nucleotide of the start codon ATG constituted as +1 numbering of the cDNA sequence. Met encoded by the start codon ATG also represented +1 for the amino acid numbering as set forth by the preprotein seq. PolyPhen-2, SIFT, and I-Mutant 3 tools were used for predicting the potential impact of an amino acid alteration in missense mutations on the function of each enzyme.

Supplemental Data: Table 1

Variant: NM_000531.6:c.894G>A(p.Trp298*)

ClinVarID: N/A

CAID: CA412725724

gnomAD:

Gene Name: OTC (ornithine transcarbamylase)

for - key insight - gainful employment of white working class led to cultural backlash and shift from left to far-right - to - Neoliberalism and the Far-Right: A Contradictory Embrace

key insight - gainful employment of white working class led to cultural backlash and shift from left to far-right - source - Davidson and Saul

to - Neoliberalism and the Far-Right: A Contradictory Embrace - https://hyp.is/8Hf0lDzqEe-KM9dQxJDxsw/core.ac.uk/download/pdf/84148846.pdf

for - stats - whites become minority percentage of US working class by 2032

stats - whites become minority percentage of US working class by 2032 - From Economic Policy Institute

to - People of color will be a majority of the American working class in 2032 -

for - adjacency - neoliberalism - far-right - paper details - from -

paper details - title - Neoliberalism and the Far-Right: A Contradictory Embrace - author - Neil Davidson - Rick Saull - date:- aug 2017 - publication - Critical Sociology, 43(4-5), pp. 707- 724.(doi:10.1177/0896920516671180) - https://core.ac.uk/download/pdf/84148846.pdf

from - Backfire: How the Rise of Neoliberalism Facilitated the Rise of the Far-Right - https://hyp.is/eaKZaDzrEe-NQNPud8wuDQ/scholarworks.arcadia.edu/cgi/viewcontent.cgi?article=1066&context=thecompass

for - key insight - Wage stagnation is a universal problem of the working class and reducing racial and gender inequality goes hand-in-hand with reducing class inequality.

for - NAFTA free trade - complexities

NAFTA free trade deal - complexities - NAFTA was a a very complex trade deal and it's not so easy to calculate its net impacts

from - How neoliberalism played a role in emerging the far-right - https://hyp.is/F6XYujyREe-TaldInE8OGA/scholarworks.arcadia.edu/cgi/viewcontent.cgi?article=1066&context=thecompass

Edmund Gröpl's concept map of Adler & Van Doren's How to Read a Book via https://forum.zettelkasten.de/discussion/comment/20668#Comment_20668:

The authour gave three reason why people be;lieve in these abductions: 1.Media ? Images , troupes the romantasization of the "image of alien" 2. Time period 3.

Case: Patient #20, male, Chinese

DiseaseAssertion: UCD/OTCD

FamilyInfo:

CasePresentingHPOs: HP:0011463, HP:0001987, HP:0003218

CaseHPOFreeText: childhood onset, hyperammonemia, oroticaciduria

CaseNOTHPOs:

CaseNOTHPOFreeText: No neurological damage

CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purified and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplification analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

SupplementalData: Table 3, drug treatment (L-arginine, L-Citrulline, sodium benzoate, and sodium phenylbutyrate), deceased

Variant: NM_000531.6:c.794G>A(p.Trp265*)

ClinVarID: N/A

CAID:CA412722994

gnomAD:

GeneName: OTC (ornithine transcarbamylase)

Case: Patient #60, female, Chinese

DiseaseAssertion: UCD/OTCD

FamilyInfo: family history of the disease

CasePresentingHPOs: HP:0011463, HP:0001987, HP:0003218, HP:0003572

CaseHPOFreeText: childhood onset,, hyperammonemia, oroticaciduria, low plasma citrulline

CaseNOTHPOs:

CaseNOTHPOFreeText: neurological damage

CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purified and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplification analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

SupplementalData: Table 3, inherited mutation, drug treatment(L-arginine, L-Citrulline, sodium benzoate, and sodium phenylbutyrate), low protein diet treatment, and continuous veno venous hemodialfiltration

Variant: NM_000531.6:c.718-1G>A

ClinVarID: N/A

CAID: CA412722112

gnomAD:

GeneName: OTC (ornithine transcarbamylase)

Case: Patient #58, female, Chinese

DiseaseAssertion: UCD/OTCD

FamilyInfo: variant pin proband's mother and father CasePresentingHPOs: HP:0003593, HP:0002038, HP:0001987, HP:0003218, HP:0003572

CaseHPOFreeText: infantile onset , protein avoidance, hyperammonemia, oroticaciduria, low plasma citrulline

CaseNOTHPOs: N/A

CaseNOTHPOFreeText: neurological damage

CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purifed and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplifcation analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

SupplementalData: Table 3, low protein diet treatment and drug treatment(L-arginine, L-Citrulline, sodium benzoate, and sodium phenylbutyrate), neurological damage

Variant: NM_000531.6:c.540+265G>A

ClinVarID: 449382

CAID: CA658658977

gnomAD:

GeneName: OTC (ornithine transcarbamylase)

Case: Patient #3, male, Chinese

DiseaseAssertion: UCD/OTCD

FamilyInfo: Family history of the disease, variant in probands mother and father

CasePresentingHPOs: HP:0003623, HP:0001987, HP:0003218

CaseHPOFreeText: neonatal, hyperammonemia , oroticaciduria

CaseNOTHPOs: N/A

CaseNOTHPOFreeText: No neurological damage

CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purified and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplification analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

SupplementalData: Table 3, no therapy received, mutation inherited, family history, deceased

Variant: NM_000531.6:c.579G>A

ClinVarID: N/A

CAID: CA412725369

gnomAD:

GeneName: OTC (ornithine transcarbamylase)

Case: Patient #59, female, Chinese

DiseaseAssertion: UCD/OTCD

FamilyInfo: variant in proband's mother and father

CasePresentingHPOs: HP:0003621, HP:0001987, HP:0003218, HP:0003217

CaseHPOFreeText:juvenile onset, hyperammonemia , oroticaciduria, hyperglutaminemia

CaseNOTHPOs: N/A

CaseNOTHPOFreeText: No neurological damage

CasePreviousTesting: gDNA extracted from peripheral blood leukocytes. PCR all coding exons and exon–intron boundaries of the OTC gene using 9 pairs of synthetic oligonucleotide primers, and the primer sequences and annealing temperature. PCR products were then purified and bidirectionally sequenced. The library was sequenced using Illumina HiSeq4000 and generated 150 bp paired-end reads. Data analysis was performed as previously described [Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, et al. Further delineation of the phenotype of truncating KMT2A mutations: the extended Wiedemann–Steiner syndrome. Am J Med Genet A. 2017;173:510–4.]. Multiplex ligation-dependent probe amplification analysis was performed for samples in which Sanger sequencing or WES failed to detect any disease-causing mutation.

SupplementalData: Table 3, drug treatment(L-arginine, L-Citrulline, sodium benzoate, and sodium phenylbutyrate)

Variant: NM_000531.6:c.664-1G>A

ClinVarID: 97288

CAID: CA224737

gnomAD:

GeneName: OTC (ornithine transcarbamylase)

Comment by onewheeljoe: This question seems like it should be more specific to disciplines. What is annotation in the legal world? How about for scientists? For beginning readers?

If I'm annotating a text to make meaning, that's different than if I'm a prof annotating a historical text to provide relevant background. The two notes have only their "noteness" in common, I'd say.

Anki