the case of pregnancy where you have two immune systems in the same system and not only you have two immune system you have a third immune system which is in the placenta
for - research - pregnancy - 3 immune systems
the case of pregnancy where you have two immune systems in the same system and not only you have two immune system you have a third immune system which is in the placenta
for - research - pregnancy - 3 immune systems
Varela who is very famous in the you know body cog cognition literature he was a biologist and he spent quite some time in into um the immune immune systems
for - adjacency - Verela -immune systems
this system that actually tells you which one is you which one is not you is the self is not the self yeah so the immune system
for - adjacency - brain - identity - immune system - immune system involved with identity at a microscopic level - which molecule is part of "you"? - which moleculev is NOT part of you - immune system preceded neural system
? - maybe there is similarity between neural processing and immune system response?
organisms can actually go and use the chance and they're doing that all the time see the way our immune systems work shows that what happens when a new virus or new bacterium or new 00:02:56 anything else arrives
for - key insight - living systems use chance to adapt
key insight - living systems use chance to adapt - immune system defends against novel viruses - cancers grow - bacteria become resistant to antibiotics
phytoncides, antibacterial and antimicrobial substances that trees and other plants release into the air to help them fight diseases and harmful organisms. When humans breathe in these substances—typically by spending time in nature—their health can improve. Across several studies, phytoncides have been shown to boost immune function, increase anticancer protein production, reduce stress hormones, improve mood, and help people relax.
I always feel better during and after a forest walk.
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ReconfigBehSci. (2021, December 22). RT @chrischirp: Positivity rising steeply too—There are definitely many more people we aren’t catching https://t.co/4xDPwYQtrx [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473695678610214927
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ReconfigBehSci. (2021, November 26). RT @PeterHotez: …this info is more relevant than immune escape. For instance the B.1.351 from ZA last year never really took off. So transm… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464240155070447632
Although if you catch it as an adult it has one major, VERY nasty side effect: something about a measles infection temporarily 'resets' the immune system. Meaning that all your previous immunities, from illness or vaccination, go away. In the western world if you catch measles you will later need to redo your entire childhood vaccination program, just in case.
Ugh. That's so nasty.
Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., Manne, S., Chen, Z., Huang, Y. J., Reilly, J. P., Weisman, A. R., Ittner, C. A. G., Kuthuru, O., Dougherty, J., Nzingha, K., … Wherry, E. J. (2020). Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science, 369(6508), eabc8511. https://doi.org/10.1126/science.abc8511
Edward Nirenberg 🇺🇦 [@ENirenberg]. (2021, November 30). This is also not limited to the vaccine- any infection we encounter will do the same thing. It’s how we evolved to get around a massive genetic and bioenergetic challenge and it’s brilliant and it’s happening all the time regardless of any vaccines we get. [Tweet]. Twitter. https://twitter.com/ENirenberg/status/1465698637434933254
Katherine J. Wu, Ph.D. (2021, December 29). I wrote (last week!) about the future of boosting—How many more shots will we need? Will they all contain the same ingredients? Ultimately, it depends on our immune systems, how the virus looks, and how much of the virus is around. 1/3 https://t.co/bJKYyriE9a [Tweet]. @KatherineJWu. https://twitter.com/KatherineJWu/status/1476249881073303552
ReconfigBehSci. (2022, January 31). RT @fascinatorfun: Interesting as 🇩🇰 Omicron BA2 wave started sooner than 🇬🇧 “We conclude that Omicron BA.2 is inherently substantially m… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1488152457012297736
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Anthony J Leonardi, PhD, MS. (2022, February 28). Damn, nice find https://t.co/cJRhB2k4zH [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1498113886846914567
Meaghan Kall. (2022, February 17). BA.2 risk assessment New this week is upgrading Immune Evasion—Amber 🟨 from low to moderate that BA.2 is antigentically different to BA.1 Unsurprising given the mutation profile, with BA.2 slightly more immune evasive than BA.1 on neuts studies https://t.co/n6DWtiRaNH [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1494100170195312646
Altarawneh, H. N., Chemaitelly, H., Hasan, M. R., Ayoub, H. H., Qassim, S., AlMukdad, S., Coyle, P., Yassine, H. M., Al-Khatib, H. A., Benslimane, F. M., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., … Abu-Raddad, L. J. (2022). Protection against the Omicron Variant from Previous SARS-CoV-2 Infection. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMc2200133
Lyngse, F. P., Mortensen, L. H., Denwood, M. J., Christiansen, L. E., Møller, C. H., Skov, R. L., Spiess, K., Fomsgaard, A., Lassaunière, M. M., Rasmussen, M., Stegger, M., Nielsen, C., Sieber, R. N., Cohen, A. S., Møller, F. T., Overvad, M., Mølbak, K., Krause, T. G., & Kirkeby, C. T. (2021). SARS-CoV-2 Omicron VOC Transmission in Danish Households (p. 2021.12.27.21268278). medRxiv. https://doi.org/10.1101/2021.12.27.21268278
Eric Feigl-Ding. (2022, January 13). WATCH📺—Despite 97.5% of all adults in England🏴 with antibodies to #COVID19 (via vax/infection)–hospitalizations still surging. Why? Because variants like #Omicron are adapting. Need multivalent vax, plus ➡️N95 & ventilation are agnostic to variants—Key! Https://t.co/gDNRJIWojX [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1481732793482813443
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Anthony J Leonardi, PhD, MS. (2022, January 22). Wow. This is concerning. H/t @ForesightWisdom it is learning to become more chronic. Https://t.co/XwFR4D0kiy [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1484996537889476610
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Ulrich Elling. (2022, January 12). While #Omicron BA.1 leads the race, the little sister BA.2 is catching up in numbers. They are rather different with likely functional implications. BA.2 might be more immune evasive in RBD, less in NTD. And due to reduced mutation load in NTD maybe different fusion properties? Https://t.co/kEACjzQDs3 [Tweet]. @EllingUlrich. https://twitter.com/EllingUlrich/status/1481214901997682692
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Eric Topol. (2021, October 19). Just published @ScienceTM With blunting of the immune response, why it is so important for pregnant women to get a Covid vaccine https://science.org/doi/10.1126/scitranslmed.abm2070 w/ @ScienceVisuals https://t.co/aCY6LP4Taa [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1450475410328850435
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Theo Sanderson. (2021, December 8). SGTF Regional data to Dec 6 from https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1039470/Omicron_SGTF_case_update.pdf (Last data point would be expected to be incomplete based on the dates and so to slightly understate growth. And also will already have moved substantially from the midpoint of that last week on 3rd Dec.) https://t.co/1L6tM0sXIZ [Tweet]. @theosanderson. https://twitter.com/theosanderson/status/1468648673668128775
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It remains unclear whether the reduction in the neutralization sensitivity of the N501Y.V2 strain to vaccine-induced antibodies is enough to seriously reduce vaccine efficacy. First, mRNA vaccines also induce virus-specific helper T cells and cytotoxic T cells, both of which might be involved in protection against challenge. Also, the mRNA vaccines, in particular, induce such a strong NAb response that there could be enough “spare capacity” to deal with reductions in the sensitivity of the variant to NAbs. In other words, N501Y.V2 (and the related virus from Brazil) may be less sensitive to NAbs, but not to an extent that will cause widespread vaccine failure.
Variants that show reduced sensitivity to NAbs don't necessarily mean mRNA vaccine failure
New variants may emerge that show reduced sensitivity to NAbs.
This may not result in vaccine failure because:
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By and large, this first defense is effective and may be why many people who contract COVID-19 are asymptomatic.
It may be that some people have the virus enter their nostrils but the mucus captures it and the virus doesn't enter the cells.
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Immune neglect describes another failure of affective fore-casting, specifically around predicting our ability to cope with adverse outcomes.
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attraverso l'inserimento nel corpo umano di un agente patogeno attenuato o di una sua subunità
In pratica, questa considerazione ignora completamente l'esistenza del sistema immune innato, presupponendo che sia una cosa normale aggirarlo..
Systematic discovery of antiphage defense systems in the microbial pangenome
Combination therapy strategies for improving PD-1 blockade efficacy
Methods of augmenting PD-1 blockade against cancer involve concomitant CTLA-4 inhibition among others. Here is a visual representation of common biological pathways and cell types between these genes.
https://www.biovista.com/vizit-research/#!bv_gid=1357fa5ee3b610d1918476e21c7be00c