- May 2024
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organisms can actually go and use the chance and they're doing that all the time see the way our immune systems work shows that what happens when a new virus or new bacterium or new 00:02:56 anything else arrives
for - key insight - living systems use chance to adapt
key insight - living systems use chance to adapt - immune system defends against novel viruses - cancers grow - bacteria become resistant to antibiotics
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- Nov 2022
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nautil.us nautil.us
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phytoncides, antibacterial and antimicrobial substances that trees and other plants release into the air to help them fight diseases and harmful organisms. When humans breathe in these substances—typically by spending time in nature—their health can improve. Across several studies, phytoncides have been shown to boost immune function, increase anticancer protein production, reduce stress hormones, improve mood, and help people relax.
I always feel better during and after a forest walk.
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- Aug 2022
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www.news-medical.net www.news-medical.net
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Thomas, L. (2021, October 14). SARS-CoV-2 induces tissue immune memory. News-Medical.Net. https://www.news-medical.net/news/20211014/SARS-CoV-2-induces-tissue-immune-memory.aspx
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NDR. (2021, March 19). AstraZeneca: Greifswalder Forscher finden Thrombose-Ursache. /nachrichten/mecklenburg-vorpommern/AstraZeneca-Greifswalder-Forscher-finden-Thrombose-Ursache,coronavirus4660.html
Tags
- vaccine
- lang:de
- immune system
- brain
- AstraZeneca
- thrombosis
- blood clot
- is:news
- Paul-Ehrlich-Institut
- healthcare
- COVID-19
Annotators
URL
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www.theguardian.com www.theguardian.com
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Ball, P. (2022, February 26). Will we get a single, variant-proof vaccine for Covid? The Observer. https://www.theguardian.com/society/2022/feb/26/will-we-get-a-single-variant-proof-vaccine-for-covid
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www.theguardian.com www.theguardian.com
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Beaumont, P. (2021, December 17). T-cells in Pfizer Covid jab recipients stay robust against severe illness. The Guardian. https://www.theguardian.com/world/2021/dec/17/t-cells-pfizer-covid-jab-robust-against-severe-illness-south-africa-research
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www.medrxiv.org www.medrxiv.org
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Sadoff, J., Gars, M. L., Cardenas, V., Shukarev, G., Vaissiere, N., Heerwegh, D., Truyers, C., Groot, A. M. de, Scheper, G., Hendriks, J., Ruiz-Guinazu, J., Struyf, F., Hoof, J. V., Douoguih, M., & Schuitemaker, H. (2021). Durability of antibody responses elicited by a single dose of Ad26.COV2.S and substantial increase following late boosting (p. 2021.08.25.21262569). https://doi.org/10.1101/2021.08.25.21262569
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www.nature.com www.nature.com
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Pozzetto, B., Legros, V., Djebali, S., Barateau, V., Guibert, N., Villard, M., Peyrot, L., Allatif, O., Fassier, J.-B., Massardier-Pilonchéry, A., Brengel-Pesce, K., Yaugel-Novoa, M., Denolly, S., Boson, B., Bourlet, T., Bal, A., Valette, M., Andrieu, T., Lina, B., … Trouillet-Assant, S. (2021). Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination. Nature, 1–9. https://doi.org/10.1038/s41586-021-04120-y
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www.nytimes.com www.nytimes.com
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Zimmer, C. (2021, June 6). We’ll Probably Need Booster Shots for Covid-19. But When? And Which Ones? The New York Times. https://www.nytimes.com/2021/06/06/science/covid-vaccine-boosters.html
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Varmus, H. (2021, August 31). Covid has revealed the need for genomic sequencing around the world. Financial Times. https://www.ft.com/content/342fd3c3-5a22-49a0-9cef-135f2ccd8700
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www.theguardian.com www.theguardian.com
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Davis, N. (2021, October 18). Valneva Covid vaccine could be as effective as Oxford jab, study suggests. The Guardian. https://www.theguardian.com/society/2021/oct/18/valneva-covid-vaccine-could-be-as-effective-as-oxford-jab-study-suggests
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inst-fs-iad-prod.inscloudgate.net inst-fs-iad-prod.inscloudgate.net
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Krause, P. R., Fleming, T. R., Peto, R., Longini, I. M., Figueroa, J. P., Sterne, J. A. C., Cravioto, A., Rees, H., Higgins, J. P. T., Boutron, I., Pan, H., Gruber, M. F., Arora, N., Kazi, F., Gaspar, R., Swaminathan, S., Ryan, M. J., & Henao-Restrepo, A.-M. (2021). Considerations in boosting COVID-19 vaccine immune responses. The Lancet, 4. https://doi.org/10.1016/S0140-6736(21)02046-8
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- is:article
- vaccine
- immunity
- immune response
- lang:en
- Delta variant
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- booster
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- COVID-19
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www.medrxiv.org www.medrxiv.org
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Collier, A. Y., Brown, C. M., Mcmahan, K., Yu, J., Liu, J., Jacob-Dolan, C., Chandrashekar, A., Tierney, D., Ansel, J. L., Rowe, M., Sellers, D., Ahmad, K., Aguayo, R., Anioke, T., Gardner, S., Siamatu, M., Rivera, L. B., Hacker, M. R., Madoff, L. C., & Barouch, D. H. (2021). Immune Responses in Fully Vaccinated Individuals Following Breakthrough Infection with the SARS-CoV-2 Delta Variant in Provincetown, Massachusetts (p. 2021.10.18.21265113). https://doi.org/10.1101/2021.10.18.21265113
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plus.tagesspiegel.de plus.tagesspiegel.de
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Karberg, S., & Friebe, R. (2022, January 18). Virologe Drosten im Interview: „Wie lange geht diese Quälerei noch weiter?“. https://plus.tagesspiegel.de/wissen/virologe-drosten-im-interview-wie-lange-geht-diese-qualerei-noch-weiter-361636.html
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Gallagher, J. (2021, November 14). Covid vaccine ‘waning immunity’: How worried should I be? BBC News. https://www.bbc.com/news/health-59260294
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elifesciences.org elifesciences.org
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Li, Z., Tomlinson, A. C., Wong, A. H., Zhou, D., Desforges, M., Talbot, P. J., Benlekbir, S., Rubinstein, J. L., & Rini, J. M. (2019). The human coronavirus HCoV-229E S-protein structure and receptor binding. ELife, 8, e51230. https://doi.org/10.7554/eLife.51230
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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SARS-CoV-2 variants of concern and variants under investigation. (2021). 45.
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twitter.com twitter.com
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ReconfigBehSci. (2021, December 22). RT @chrischirp: Positivity rising steeply too—There are definitely many more people we aren’t catching https://t.co/4xDPwYQtrx [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473695678610214927
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www.washingtonpost.com www.washingtonpost.com
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Perspective | Even the best-case scenario with omicron will still be bad. (n.d.). Washington Post. Retrieved December 23, 2021, from https://www.washingtonpost.com/outlook/2021/12/21/omicron-mild-cases-numbers/
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twitter.com twitter.com
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ReconfigBehSci. (2021, November 26). RT @PeterHotez: …this info is more relevant than immune escape. For instance the B.1.351 from ZA last year never really took off. So transm… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464240155070447632
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- Jul 2022
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www.schlaugh.com www.schlaugh.com
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Although if you catch it as an adult it has one major, VERY nasty side effect: something about a measles infection temporarily 'resets' the immune system. Meaning that all your previous immunities, from illness or vaccination, go away. In the western world if you catch measles you will later need to redo your entire childhood vaccination program, just in case.
Ugh. That's so nasty.
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Annotators
URL
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- Apr 2022
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www.science.org www.science.org
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Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., Manne, S., Chen, Z., Huang, Y. J., Reilly, J. P., Weisman, A. R., Ittner, C. A. G., Kuthuru, O., Dougherty, J., Nzingha, K., … Wherry, E. J. (2020). Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science, 369(6508), eabc8511. https://doi.org/10.1126/science.abc8511
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twitter.com twitter.com
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Edward Nirenberg 🇺🇦 [@ENirenberg]. (2021, November 30). This is also not limited to the vaccine- any infection we encounter will do the same thing. It’s how we evolved to get around a massive genetic and bioenergetic challenge and it’s brilliant and it’s happening all the time regardless of any vaccines we get. [Tweet]. Twitter. https://twitter.com/ENirenberg/status/1465698637434933254
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twitter.com twitter.com
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Katherine J. Wu, Ph.D. (2021, December 29). I wrote (last week!) about the future of boosting—How many more shots will we need? Will they all contain the same ingredients? Ultimately, it depends on our immune systems, how the virus looks, and how much of the virus is around. 1/3 https://t.co/bJKYyriE9a [Tweet]. @KatherineJWu. https://twitter.com/KatherineJWu/status/1476249881073303552
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 31). RT @fascinatorfun: Interesting as 🇩🇰 Omicron BA2 wave started sooner than 🇬🇧 “We conclude that Omicron BA.2 is inherently substantially m… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1488152457012297736
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www.bmj.com www.bmj.com
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Pavord, S., Hunt, B. J., Horner, D., Bewley, S., & Karpusheff, J. (2021). Vaccine induced immune thrombocytopenia and thrombosis: Summary of NICE guidance. BMJ, 375, n2195. https://doi.org/10.1136/bmj.n2195
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- Mar 2022
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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Bellesi, S., Metafuni, E., Hohaus, S., Maiolo, E., Marchionni, F., D’Innocenzo, S., La Sorda, M., Ferraironi, M., Ramundo, F., Fantoni, M., Murri, R., Cingolani, A., Sica, S., Gasbarrini, A., Sanguinetti, M., Chiusolo, P., & De Stefano, V. (2020). Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients. British Journal of Haematology, 191(2), 207–211. https://doi.org/10.1111/bjh.17034
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theconversation.com theconversation.com
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Lee, A., Cheng, K. K., Cruickshank, S., & Greenhalgh, T. (n.d.). “We suppressed our scientific imagination”: Four experts examine the big successes and failures of the COVID response so far. The Conversation. Retrieved March 31, 2022, from http://theconversation.com/we-suppressed-our-scientific-imagination-four-experts-examine-the-big-successes-and-failures-of-the-covid-response-so-far-178705
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kareem.substack.com kareem.substack.com
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Abdul-Jabbar, K. (2021, November 8). Aaron Rodgers Didn’t Just Lie [Substack newsletter]. Kareem Abdul-Jabbar. https://kareem.substack.com/p/aaron-rodgers-didnt-just-lie
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hackmd.io hackmd.io
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Myths about COVID-19 vaccination. (n.d.). HackMD. Retrieved March 23, 2022, from https://hackmd.io/@scibehC19vax/misinfo_myths
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www.science.org www.science.org
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Altmann, D. M., & Boyton, R. J. (2022). COVID-19 vaccination: The road ahead. Science, 375(6585), 1127–1132. https://doi.org/10.1126/science.abn1755
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www.theguardian.com www.theguardian.com
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Al Newman. (2022, March 8). @danaparish @jennybluebird2U To your point: Https://t.co/CsULpIACoI [Tweet]. @AlNewman_. https://twitter.com/AlNewman_/status/1501056062262333441
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insights.som.yale.edu insights.som.yale.edu
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Health & Veritas: Is Long COVID One Disease or Many? (Ep. 19). (n.d.). Yale Insights. Retrieved 21 March 2022, from https://insights.som.yale.edu/insights/health-veritas-is-long-covid-one-disease-or-many-ep-19
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www.news18.com www.news18.com
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Corbevax: All About India’s First Protein Sub-Unit Covid Vaccine to be Given to 12-14 Age Group From Today. (2022, March 16). News18. https://www.news18.com/news/india/corbevax-all-about-indias-first-protein-sub-unit-covid-vaccine-to-be-given-to-12-14-age-group-from-today-4874345.html
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www.theatlantic.com www.theatlantic.com
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Wu, K. J. (2021, December 29). Our Relationship With COVID Vaccines Is Just Getting Started. The Atlantic. https://www.theatlantic.com/science/archive/2021/12/how-many-covid-19-booster-shots/621132/
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twitter.com twitter.com
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Anthony J Leonardi, PhD, MS. (2022, February 28). Damn, nice find https://t.co/cJRhB2k4zH [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1498113886846914567
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- Feb 2022
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twitter.com twitter.com
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Meaghan Kall. (2022, February 17). BA.2 risk assessment New this week is upgrading Immune Evasion—Amber 🟨 from low to moderate that BA.2 is antigentically different to BA.1 Unsurprising given the mutation profile, with BA.2 slightly more immune evasive than BA.1 on neuts studies https://t.co/n6DWtiRaNH [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1494100170195312646
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www.nejm.org www.nejm.org
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Altarawneh, H. N., Chemaitelly, H., Hasan, M. R., Ayoub, H. H., Qassim, S., AlMukdad, S., Coyle, P., Yassine, H. M., Al-Khatib, H. A., Benslimane, F. M., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., … Abu-Raddad, L. J. (2022). Protection against the Omicron Variant from Previous SARS-CoV-2 Infection. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMc2200133
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www.medrxiv.org www.medrxiv.org
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Lyngse, F. P., Mortensen, L. H., Denwood, M. J., Christiansen, L. E., Møller, C. H., Skov, R. L., Spiess, K., Fomsgaard, A., Lassaunière, M. M., Rasmussen, M., Stegger, M., Nielsen, C., Sieber, R. N., Cohen, A. S., Møller, F. T., Overvad, M., Mølbak, K., Krause, T. G., & Kirkeby, C. T. (2021). SARS-CoV-2 Omicron VOC Transmission in Danish Households (p. 2021.12.27.21268278). medRxiv. https://doi.org/10.1101/2021.12.27.21268278
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twitter.com twitter.com
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Eric Feigl-Ding. (2022, January 13). WATCH📺—Despite 97.5% of all adults in England🏴 with antibodies to #COVID19 (via vax/infection)–hospitalizations still surging. Why? Because variants like #Omicron are adapting. Need multivalent vax, plus ➡️N95 & ventilation are agnostic to variants—Key! Https://t.co/gDNRJIWojX [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1481732793482813443
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www.theatlantic.com www.theatlantic.com
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Yong, E. (2022, February 16). The Millions of People Stuck in Pandemic Limbo. The Atlantic. https://www.theatlantic.com/health/archive/2022/02/covid-pandemic-immunocompromised-risk-vaccines/622094/
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www.mercurynews.com www.mercurynews.com
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Living with COVID-19: How the virus could turn into the common cold, or something far worse. (2022, January 9). The Mercury News. https://www.mercurynews.com/2022/01/09/living-with-covid-19-how-the-virus-could-turn-into-the-common-cold-or-something-far-worse
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
Tags
- testing
- vaccine
- viral evolution
- therapeutic
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- UK
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- COVID-19
Annotators
URL
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twitter.com twitter.com
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Anthony J Leonardi, PhD, MS. (2022, January 22). Wow. This is concerning. H/t @ForesightWisdom it is learning to become more chronic. Https://t.co/XwFR4D0kiy [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1484996537889476610
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www.youtube.com www.youtube.com
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American Medical Association (AMA). (2021, December 6). Peter Hotez, MD, PhD, on the omicron variant and Delta winter surge | COVID-19 Update for Dec. 6, 20. https://www.youtube.com/watch?v=WnfpC1_N2Mg
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twitter.com twitter.com
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Ulrich Elling. (2022, January 12). While #Omicron BA.1 leads the race, the little sister BA.2 is catching up in numbers. They are rather different with likely functional implications. BA.2 might be more immune evasive in RBD, less in NTD. And due to reduced mutation load in NTD maybe different fusion properties? Https://t.co/kEACjzQDs3 [Tweet]. @EllingUlrich. https://twitter.com/EllingUlrich/status/1481214901997682692
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www.medrxiv.org www.medrxiv.org
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Vanshylla, K., Tober-Lau, P., Gruell, H., Muenn, F., Eggeling, R., Pfeifer, N., Le, N. H., Landgraf, I., Kurth, F., Sander, L. E., & Klein, F. (2022). Durability of Omicron-neutralizing serum activity following mRNA booster immunization in elderly individuals (p. 2022.02.02.22270302). medRxiv. https://doi.org/10.1101/2022.02.02.22270302
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www.nature.com www.nature.com
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Adam, D. (2022). Will Omicron end the pandemic? Here’s what experts say. Nature, 602(7895), 20–21. https://doi.org/10.1038/d41586-022-00210-7
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twitter.com twitter.com
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ScienceUpFirst, LaScienced’Abord. (2022, February 1). Got Omicron? You are not alone! See our thread on what we know so far 👇 🧵 [1/11] #ScienceUpFirst https://t.co/7Hi3lHo5LS [Tweet]. @ScienceUpFirst. https://twitter.com/ScienceUpFirst/status/1488601396421316613
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Tayag, Y. (2022, January 31). What causes long Covid? Scientists are zeroing in on the answer. Vox. https://www.vox.com/22906853/omicron-long-covid-vaccinated-symptoms-cause
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- Jan 2022
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www.medrxiv.org www.medrxiv.org
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Gentles, L. E., Kehoe, L., Crawford, K. H. D., Lacombe, K., Dickerson, J., Wolf, C., Yuan, J., Schuler, S., Watson, J. T., Nyanseor, S., Briggs-Hagen, M., Saydah, S., Midgley, C. M., Pringle, K., Chu, H., Bloom, J. D., & Englund, J. A. (2022). Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time (p. 2022.01.14.22269235). medRxiv. https://doi.org/10.1101/2022.01.14.22269235
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www.statnews.com www.statnews.com
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Early data indicate vaccines still protect against Omicron’s sister variant, BA.2. (2022, January 28). STAT. https://www.statnews.com/2022/01/28/early-data-indicate-vaccines-still-protect-against-omicrons-sister-variant-ba-2/
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www.bmj.com www.bmj.com
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Taylor, L. (2022). Covid-19: CoronaVac immunity is strongest after boosting with a different vaccine. BMJ, 376, o210. https://doi.org/10.1136/bmj.o210
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www.nature.com www.nature.com
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Zimmerman, M. I., Porter, J. R., Ward, M. D., Singh, S., Vithani, N., Meller, A., Mallimadugula, U. L., Kuhn, C. E., Borowsky, J. H., Wiewiora, R. P., Hurley, M. F. D., Harbison, A. M., Fogarty, C. A., Coffland, J. E., Fadda, E., Voelz, V. A., Chodera, J. D., & Bowman, G. R. (2021). SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome. Nature Chemistry, 13(7), 651–659. https://doi.org/10.1038/s41557-021-00707-0
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Kozlov, M. (2022). How does Omicron spread so fast? A high viral load isn’t the answer. Nature. https://doi.org/10.1038/d41586-022-00129-z
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healthpolicy-watch.news healthpolicy-watch.news
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Backed By Science: Here’s How We Can Eliminate COVID-19 - Health Policy Watch. (2022, January 23). https://healthpolicy-watch.news/93258-2/
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- airborne transmission
- attitudes
- vaccine
- pandemic management
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www.theguardian.com www.theguardian.com
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Davis, N., & correspondent, N. D. S. (2022, January 21). Covid reinfection: How likely are you to catch virus multiple times? The Guardian. https://www.theguardian.com/world/2022/jan/21/covid-reinfection-how-likely-are-you-to-catch-virus-multiple-times
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www.frontiersin.org www.frontiersin.org
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Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932
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Dolgin, E. (2022). Omicron thwarts some of the world’s most-used COVID vaccines. Nature. https://doi.org/10.1038/d41586-022-00079-6
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www.medrxiv.org www.medrxiv.org
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Home
Zuo, F., Abolhassani, H., Du, L., Piralla, A., Bertoglio, F., Campos-Mata, L. de, Wan, H., Schubert, M., Wang, Y., Sun, R., Cassaniti, I., Vlachiotis, S., Kumagai-Braesch, M., Andréll, J., Zhang, Z., Xue, Y., Wenzel, E. V., Calzolai, L., Varani, L., … Pan-Hammarström, Q. (2022). Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant (p. 2022.01.04.22268755). https://doi.org/10.1101/2022.01.04.22268755
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www.reuters.com www.reuters.com
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Lapid, N. (2022, January 4). Covid Science: Virus leaves antibodies that may attack healthy tissues. Reuters. https://www.reuters.com/business/healthcare-pharmaceuticals/virus-leaves-antibodies-that-may-attack-healthy-tissues-b-cell-antibodies-2022-01-03/
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- is:webpage
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www.imperial.ac.uk www.imperial.ac.uk
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Omicron largely evades immunity from past infection or two vaccine doses | Imperial News | Imperial College London. (n.d.). Imperial News. Retrieved January 12, 2022, from https://www.imperial.ac.uk/news/232698/omicron-largely-evades-immunity-from-past/
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www.medrxiv.org www.medrxiv.org
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Eric Topol. (2021, October 19). Just published @ScienceTM With blunting of the immune response, why it is so important for pregnant women to get a Covid vaccine https://science.org/doi/10.1126/scitranslmed.abm2070 w/ @ScienceVisuals https://t.co/aCY6LP4Taa [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1450475410328850435
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Thiruvengadam, R., Awasthi, A., Medigeshi, G., Bhattacharya, S., Mani, S., Sivasubbu, S., Shrivastava, T., Samal, S., Rathna Murugesan, D., Koundinya Desiraju, B., Kshetrapal, P., Pandey, R., Scaria, V., Kumar Malik, P., Taneja, J., Binayke, A., Vohra, T., Zaheer, A., Rathore, D., … Garg, P. K. (2021). Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases, S1473309921006800. https://doi.org/10.1016/S1473-3099(21)00680-0
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Thiruvengadam, R., Awasthi, A., Medigeshi, G., Bhattacharya, S., Mani, S., Sivasubbu, S., Shrivastava, T., Samal, S., Murugesan, D. R., Desiraju, B. K., Kshetrapal, P., Pandey, R., Scaria, V., Malik, P. K., Taneja, J., Binayke, A., Vohra, T., Zaheer, A., Rathore, D., … Garg, P. K. (2021). Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00680-0
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jamanetwork.com jamanetwork.com
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It remains unclear whether the reduction in the neutralization sensitivity of the N501Y.V2 strain to vaccine-induced antibodies is enough to seriously reduce vaccine efficacy. First, mRNA vaccines also induce virus-specific helper T cells and cytotoxic T cells, both of which might be involved in protection against challenge. Also, the mRNA vaccines, in particular, induce such a strong NAb response that there could be enough “spare capacity” to deal with reductions in the sensitivity of the variant to NAbs. In other words, N501Y.V2 (and the related virus from Brazil) may be less sensitive to NAbs, but not to an extent that will cause widespread vaccine failure.
Variants that show reduced sensitivity to NAbs don't necessarily mean mRNA vaccine failure
New variants may emerge that show reduced sensitivity to NAbs.
This may not result in vaccine failure because:
- The mRNA vaccines induce such a strong NAb response, there will be enough spare capacity to deal with the virus.
- The mRNA vaccines also induce other virus specific protection such as helper T cells and cytotoxic T cells, which may not be affected by the reduction in NAb sensitivity.
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www.nature.com www.nature.com
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Reardon, S. (2021). Cuba’s bet on home-grown COVID vaccines is paying off. Nature. https://doi.org/10.1038/d41586-021-03470-x
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Scott, Jake, Aaron Richterman, and Muge Cevik. ‘Covid-19 Vaccination: Evidence of Waning Immunity Is Overstated’. BMJ 374 (23 September 2021): n2320. https://doi.org/10.1136/bmj.n2320.
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The Lancet Haematology. (2021, November 12). NEW Viewpoint by @Erik_Klok_MD, @MPaiMD, Menno Huisman & @ProfMakris discussing the epidemiology, pathophysiology, and optimal diagnostic and therapeutic management of vaccine-induced immune thrombotic thrombocytopenia #VITT #COVID19Vaccine https://thelancet.com/journals/lanhae/article/PIIS2352-3026(21)00306-9/fulltext https://t.co/9PbjaioA2T [Tweet]. @TheLancetHaem. https://twitter.com/TheLancetHaem/status/1459072729332826123
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www.statnews.com www.statnews.com
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3 takeaways from the emergence of the ‘Delta Plus’ coronavirus variant. (2021, October 27). STAT. https://www.statnews.com/2021/10/27/3-takeaways-from-the-emergence-of-the-delta-plus-coronavirus-variant/
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Sun, W., Liu, Y., Amanat, F., González-Domínguez, I., McCroskery, S., Slamanig, S., Coughlan, L., Rosado, V., Lemus, N., Jangra, S., Rathnasinghe, R., Schotsaert, M., Martinez, J. L., Sano, K., Mena, I., Innis, B. L., Wirachwong, P., Thai, D. H., Oliveira, R. D. N., … Palese, P. (2021). A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses. Nature Communications, 12(1), 6197. https://doi.org/10.1038/s41467-021-26499-y
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ReconfigBehSci. (2021, July 6). RT @mvankerkhove: I’m struggling with how best to stress how fragile the global situation is, so I’ll be blunt: Each week >2.6 million cas… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1412416348676820992
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COVID-19 immunity: Natural infection compared to vaccination | British Society for Immunology. (n.d.). Retrieved October 10, 2021, from https://www.immunology.org/coronavirus/connect-coronavirus-public-engagement-resources/covid-immunity-natural-infection-vaccine
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Karlsson, L. C., Soveri, A., Lewandowsky, S., Karlsson, L., Karlsson, H., Nolvi, S., Karukivi, M., Lindfelt, M., & Antfolk, J. (2022). The behavioral immune system and vaccination intentions during the coronavirus pandemic. Personality and Individual Differences, 185, 111295. https://doi.org/10.1016/j.paid.2021.111295
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www.nature.com www.nature.com
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Lee, J. W., Su, Y., Baloni, P., Chen, D., Pavlovitch-Bedzyk, A. J., Yuan, D., Duvvuri, V. R., Ng, R. H., Choi, J., Xie, J., Zhang, R., Murray, K., Kornilov, S., Smith, B., Magis, A. T., Hoon, D. S. B., Hadlock, J. J., Goldman, J. D., Price, N. D., … Heath, J. R. (2021). Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19. Nature Biotechnology, 1–11. https://doi.org/10.1038/s41587-021-01020-4
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Male, Victoria. ‘Menstrual Changes after Covid-19 Vaccination’. BMJ 374 (16 September 2021): n2211. https://doi.org/10.1136/bmj.n2211.
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twitter.com twitter.com
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Michael Mina on Twitter: “With all the news of vaccines & immunity, did you know measles infections destroy immunity and cause ‘Immune Amnesia’, increasing risk of all other infections Our research in ‘15 & ‘19 discovered this & the abbreviated story is written up nicely here: 1/ https://t.co/t5DKoQljxM” / Twitter. (n.d.). Retrieved September 7, 2021, from https://twitter.com/michaelmina_lab/status/1435037668027641861
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Wu, K. J. (2021, September 3). What We Actually Know About Waning Immunity. The Atlantic. https://www.theatlantic.com/science/archive/2021/09/waning-immunity-not-crisis-right-now/619965/
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Israelow, B., Mao, T., Klein, J., Song, E., Menasche, B., Omer, S. B., & Iwasaki, A. (2021). Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2. Science Immunology. https://doi.org/10.1126/sciimmunol.abl4509
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Liu, Y., Arase, N., Kishikawa, J., Hirose, M., Li, S., Tada, A., Matsuoka, S., Arakawa, A., Akamatsu, K., Ono, C., Jin, H., Kishida, K., Nakai, W., Kohyama, M., Nakagawa, A., Yamagishi, Y., Nakagami, H., Kumanogoh, A., Matsuura, Y., … Arase, H. (2021). The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines (p. 2021.08.22.457114). https://doi.org/10.1101/2021.08.22.457114
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What Is “Natural Immunity”? And Why Should You Get the Vaccine Even if You Already Had COVID? - The Bulwark. (n.d.). Retrieved August 11, 2021, from https://www.thebulwark.com/what-is-natural-immunity-and-why-should-you-get-the-vaccine-even-if-you-already-had-covid/
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www.thelancet.com www.thelancet.com
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Tenbusch, M., Schumacher, S., Vogel, E., Priller, A., Held, J., Steininger, P., Beileke, S., Irrgang, P., Brockhoff, R., Salmanton-García, J., Tinnefeld, K., Mijocevic, H., Schober, K., Bogdan, C., Yazici, S., Knolle, P., Cornely, O. A., Überla, K., Protzer, U., … Wytopil, M. (2021). Heterologous prime–boost vaccination with ChAdOx1 nCoV-19 and BNT162b2. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00420-5
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Barouch, Dan H., Kathryn E. Stephenson, Jerald Sadoff, Jingyou Yu, Aiquan Chang, Makda Gebre, Katherine McMahan, et al. “Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination.” New England Journal of Medicine 0, no. 0 (July 14, 2021): null. https://doi.org/10.1056/NEJMc2108829.
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Bressan, P. (2021). Strangers look sicker (with implications in times of COVID-19). PsyArXiv. https://doi.org/10.31234/osf.io/x4unv
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ReconfigBehSci. (2021, April 8). RT @EricTopol: The variants of concern/interest fall into a spectrum of immune evasiveness, w/ B.1.351 being most; B.1.1.7, B.1.429 least.… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1397697142769152001
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Luoto, Severi, Marjorie L. Prokosch, Marco Antonio Correa Varella, Indrikis Krams, and Corey L. Fincher. “Editorial: Coronavirus Disease (COVID-19) and Its Psychobehavioral Consequences.” Frontiers in Psychology 0 (2021). https://doi.org/10.3389/fpsyg.2021.723282.
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Griffin, S. (2021). Covid-19: China’s CoronaVac vaccine offers 83.5% protection against symptomatic infection, interim analysis finds. BMJ, 374, n1755. https://doi.org/10.1136/bmj.n1755
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The immune system: How to boost your immunity to infection | Science with Sam—YouTube. (n.d.). Retrieved July 2, 2021, from https://www.youtube.com/watch?v=MLw2Y3yF0fE
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Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R., Lim, E., Touizer, E., Meng, B., Abdullahi, A., Elmer, A., Kingston, N., Graves, B., Gresley, E. L., Caputo, D., Bergamaschi, L., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., … Gupta, R. K. (2021). Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature, 1–9. https://doi.org/10.1038/s41586-021-03739-1
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the Guardian. “Vaccines Are Not Magic Bullets – We’ll Still Have to Take Precautions | Zania Stamataki,” June 22, 2021. http://www.theguardian.com/commentisfree/2021/jun/22/viruses-wearing-mask-england-vaccines.
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Pishko, A. M., Bussel, J. B., & Cines, D. B. (2021). COVID-19 vaccination and immune thrombocytopenia. Nature Medicine, 1–2. https://doi.org/10.1038/s41591-021-01419-1
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Callaway, E. (2021). Mix-and-match COVID vaccines trigger potent immune response. Nature, 593(7860), 491–491. https://doi.org/10.1038/d41586-021-01359-3
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Eric Topol on Twitter: “New reports on transmissibility and immune evasiveness for delta (B.1.617.2) lead to an update of this Table of the variants and key properties https://t.co/nGzEa39eF4” / Twitter. (n.d.). Retrieved June 5, 2021, from https://twitter.com/EricTopol/status/1400590583274426370
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Khoury, D. S., Cromer, D., Reynaldi, A., Schlub, T. E., Wheatley, A. K., Juno, J. A., Subbarao, K., Kent, S. J., Triccas, J. A., & Davenport, M. P. (2021). Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection. Nature Medicine, 1–7. https://doi.org/10.1038/s41591-021-01377-8
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Tybur, J. M., Lieberman, D., Fan, L., Kupfer, T. R., & de Vries, R. E. (2020). Behavioral Immune Trade-Offs: Interpersonal Value Relaxes Social Pathogen Avoidance. Psychological Science, 31(10), 1211–1221. https://doi.org/10.1177/0956797620960011
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www.cnn.com www.cnn.com
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CNN, M. F. (n.d.). How coronavirus affects the entire body. CNN. Retrieved July 13, 2020, from https://www.cnn.com/2020/07/10/health/coronavirus-entire-body-effects-columbia/index.html
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twitter.com twitter.com
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Eric Topol. (2021, February 17). New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines https://t.co/2N7eKDllso [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1362160675913568256
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- Apr 2021
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twitter.com twitter.com
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Eric Topol on Twitter: “The variants of concern/interest fall into a spectrum of immune evasiveness, w/ B.1.351 being most; B.1.1.7, B.1.429 least. This property pertains to potential for reinfection & some reduction in vaccine efficacy My prelim estimates based on publications/preprints, subject to Δ https://t.co/fQZwBCUEGS” / Twitter. (n.d.). Retrieved April 28, 2021, from https://twitter.com/EricTopol/status/1380203664317456385
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www.thelancet.com www.thelancet.com
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Tan, Steph H., Orchid Allicock, Mari Armstrong-Hough, and Anne L. Wyllie. ‘Saliva as a Gold-Standard Sample for SARS-CoV-2 Detection’. The Lancet Respiratory Medicine 0, no. 0 (19 April 2021). https://doi.org/10.1016/S2213-2600(21)00178-8.
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blogs.bmj.com blogs.bmj.com
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Nabavi, N., & Dobson, J. (2021, April 21). Covid-19 new variants—known unknowns. The BMJ Opinion. https://blogs.bmj.com/bmj/2021/04/21/covid-19-new-variants-known-unknowns/?utm_campaign=shareaholic&utm_medium=twitter&utm_source=socialnetwork
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- Mar 2021
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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Gray, Kathryn J., Evan A. Bordt, Caroline Atyeo, Elizabeth Deriso, Babatunde Akinwunmi, Nicola Young, Aranxta Medina Baez, et al. ‘COVID-19 Vaccine Response in Pregnant and Lactating Women: A Cohort Study’. MedRxiv: The Preprint Server for Health Sciences, 8 March 2021. https://doi.org/10.1101/2021.03.07.21253094.
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www.newscientist.com www.newscientist.com
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Page, M. L. (n.d.). Should you pay for a coronavirus test? Here’s what you need to know. New Scientist. Retrieved June 20, 2020, from https://www.newscientist.com/article/2246514-should-you-pay-for-a-coronavirus-test-heres-what-you-need-to-know/
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pharmaphorum.com pharmaphorum.com
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EU probes low platelet safety signal with COVID-19 shots -. (n.d.). Retrieved March 17, 2021, from https://pharmaphorum.com/news/eu-experts-call-for-allergic-reaction-safety-update-on-astrazeneca-covid-shot/
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www.health.com www.health.com
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A Few People Developed a Rare Blood Disorder, Immune Thrombocytopenia, After Getting a COVID Vaccine | Health.com. (n.d.). Retrieved March 17, 2021, from https://www.health.com/condition/infectious-diseases/coronavirus/rare-blood-disorder-covid-vaccine-thrombocytopenia
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psyarxiv.com psyarxiv.com
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Henderson, Robert K., and Simone Schnall. ‘Disease and Disapproval: COVID-19 Concern Is Related to Greater Moral Condemnation’. PsyArXiv, 7 December 2020. https://doi.org/10.31234/osf.io/7szaw.
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www.nytimes.com www.nytimes.com
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Mandavilli, A. (2021, January 28). Some Covid Survivors Have Antibodies That Attack the Body, not Virus. The New York Times. https://www.nytimes.com/2020/10/27/health/covid-antibodies-autoimmunity.html
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www-nature-com.ezp.lib.cam.ac.uk www-nature-com.ezp.lib.cam.ac.uk
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Nature Editorial. (2020, October 23). The race to make COVID antibody therapies cheaper and more potent. Nature. https://www.nature.com/articles/d41586-020-02965-3?utm_source=twt_nnc&utm_medium=social&utm_campaign=naturenews&sf239165668=1&error=cookies_not_supported&code=2b2dd7c6-d01f-4057-8389-3be656a7ba58
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psyarxiv.com psyarxiv.com
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Karlsson, L. C., Soveri, A., Lewandowsky, S., Karlsson, L., Karlsson, H., Nolvi, S., … Antfolk, J. (2021, March 4). The Behavioral Immune System and Vaccination Intentions During the Coronavirus Pandemic. https://doi.org/10.31234/osf.io/r8uaz
Tags
- intention
- contaminant aversion
- is:preprint
- lang:en
- evolutionary psychology
- perceived infectability
- social science
- behavioral science
- vaccine hesitancy
- immune response
- health psychology
- evolution
- disgust
- vulnerable
- germ aversion
- behavioural immune system
- individual differences
- vaccination
- COVID-19
Annotators
URL
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- Feb 2021
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www.forbes.com www.forbes.com
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By and large, this first defense is effective and may be why many people who contract COVID-19 are asymptomatic.
It may be that some people have the virus enter their nostrils but the mucus captures it and the virus doesn't enter the cells.
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twitter.com twitter.com
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Andrew💙Croxford. (2020, December 3). NEW THREAD: possible development of anti-Syncytin responses after immunization with the SARS-CoV-2 spike protein-coding mRNA vaccines, based on a ‘homologous’ region shared between these proteins. [Tweet]. @andrew_croxford. https://twitter.com/andrew_croxford/status/1334593606196187136
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chicinacademia.com chicinacademia.com
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Science Says Sunday – 5 reasons I’m still wearing my mask even after getting the COVID-19 vaccine. (2021, February 22). Chic in Academia. https://chicinacademia.com/2021/02/21/science-says-sunday-5-reasons-im-still-wearing-my-mask-even-after-getting-the-covid-19-vaccine/
Tags
- mutation
- vaccine
- pandemic
- lang:en
- is:blog
- mask
- USA
- effectiveness
- immune system
- dose
- strain
- vaccination
- limited
- protection
- social distancing
- COVID-19
Annotators
URL
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www.youtube.com www.youtube.com
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Center for Infectious Disease Dynamics—YouTube. (n.d.). Retrieved 21 February 2021, from https://www.youtube.com/channel/UC1dZp4v6sF2jKjutJguk7ng/videos?view=0&sort=da&flow=grid&view_as=subscriber
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brief19.com brief19.com
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Vaccinations Could Limit Further Mutations. (n.d.). Retrieved 18 February 2021, from https://brief19.com/2021/02/17/brief
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twitter.com twitter.com
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Susan Cole-Haley on Twitter. (n.d.). Twitter. Retrieved 17 February 2021, from https://twitter.com/susancolehaley/status/1340231804431773699
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www.nih.gov www.nih.gov
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Researchers propose that humidity from masks may lessen severity of COVID-19. (2021, February 12). National Institutes of Health (NIH). https://www.nih.gov/news-events/news-releases/researchers-propose-humidity-masks-may-lessen-severity-covid-19
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Mannix, L. (2021, February 8). Where did these COVID-19 variants come from – and what are they? The Sydney Morning Herald. https://www.smh.com.au/national/what-do-new-variants-of-the-coronavirus-mean-for-us-20210126-p56wuo.html
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www.wired.com www.wired.com
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More Covid Vaccine Choices Mean New Equity Challenges. (n.d.). Wired. Retrieved 11 February 2021, from https://www.wired.com/story/more-covid-vaccine-choices-mean-new-equity-challenges/
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psyarxiv.com psyarxiv.com
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Kramer, P., & Bressan, P. (2021). Infection threat shapes our social instincts. PsyArXiv. https://doi.org/10.31234/osf.io/pbf4d
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papers.ssrn.com papers.ssrn.com
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Shen, X., Tang, H., McDanal, C., Wagh, K., Fischer, W. M., Theiler, J., Yoon, H., Li, D., Haynes, B. F., Saunders, K. O., Gnanakaran, S., Hengartner, N. W., Pajon, R., Smith, G., Dubovsky, F., Glenn, G. M., Korber, B. T., & Montefiori, D. C. (2021). SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike Vaccines (SSRN Scholarly Paper ID 3777473). Social Science Research Network. https://papers.ssrn.com/abstract=3777473
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Report of 8% vaccine efficacy for elderly debunked by German government. (14:24:16+00:00). Full Fact. https://fullfact.org/health/german-astrazeneca-8-percent-handelsblatt/
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- Dec 2020
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mailchi.mp mailchi.mp
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🔥 Your COVID Roundup, Week #31. (n.d.). Retrieved December 9, 2020, from https://mailchi.mp/8338eb3924db/your-covid-roundup-7106445?e=feb8bf1ac8
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- Oct 2020
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www.npr.org www.npr.org
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Aubrey, A. (2020). Will Kids Get A COVID-19 Vaccine? Pfizer To Expand Trial To Ages 12 And Up. NPR. https://www.npr.org/sections/health-shots/2020/10/13/923248377/will-kids-get-a-covid-19-vaccine-pfizer-to-expand-trial-to-ages-12-and-up?t=1602805163253
Tags
- vaccine
- immune response
- lang:en
- vaccine safety
- is:news
- USA
- virus immunity
- adolescent
- COVID-19
- vaccine trial
Annotators
URL
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Sia, S. F., Yan, L.-M., Chin, A. W. H., Fung, K., Choy, K.-T., Wong, A. Y. L., Kaewpreedee, P., Perera, R. A. P. M., Poon, L. L. M., Nicholls, J. M., Peiris, M., & Yen, H.-L. (2020). Pathogenesis and transmission of SARS-CoV-2 in golden hamsters. Nature, 583(7818), 834–838. https://doi.org/10.1038/s41586-020-2342-5
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www.pnas.org www.pnas.org
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Bosco-Lauth, A. M., Hartwig, A. E., Porter, S. M., Gordy, P. W., Nehring, M., Byas, A. D., VandeWoude, S., Ragan, I. K., Maison, R. M., & Bowen, R. A. (2020). Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2013102117
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www.theguardian.com www.theguardian.com
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Scientists study whether immune response wards off or worsens Covid. (2020, October 4). The Guardian. http://www.theguardian.com/science/2020/oct/04/scientists-study-whether-immune-response-wards-off-or-worsens-covid
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- Sep 2020
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science.sciencemag.org science.sciencemag.org
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Saad-Roy, C. M., Wagner, C. E., Baker, R. E., Morris, S. E., Farrar, J., Graham, A. L., Levin, S. A., Mina, M. J., Metcalf, C. J. E., & Grenfell, B. T. (2020). Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years. Science. https://doi.org/10.1126/science.abd7343
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www.thelancet.com www.thelancet.com
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Felsenstein, S., & Hedrich, C. M. (2020). COVID-19 in children and young people. The Lancet Rheumatology, 2(9), e514–e516. https://doi.org/10.1016/S2665-9913(20)30212-5
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- Aug 2020
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psyarxiv.com psyarxiv.com
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Tybur, J. M., Lieberman, D., Fan, L., Kupfer, T., & de Vries, R. E. (2020). Behavioral immune tradeoffs: Interpersonal value relaxes social pathogen avoidance [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/ec8uw
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science.sciencemag.org science.sciencemag.org
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Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871
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Felipe, L. S., Vercruysse, T., Sharma, S., Ma, J., Lemmens, V., Looveren, D. van, Javarappa, M. P. A., Boudewijns, R., Malengier-Devlies, B., Kaptein, S. F., Liesenborghs, L., Keyzer, C. D., Bervoets, L., Rasulova, M., Seldeslachts, L., Jansen, S., Yakass, M. B., Quaye, O., Li, L.-H., … Dallmeier, K. (2020). A single-dose live-attenuated YF17D-vectored SARS-CoV2 vaccine candidate. BioRxiv, 2020.07.08.193045. https://doi.org/10.1101/2020.07.08.193045
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Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., Amit, I., Liu, L., Zhang, S., & Zhang, Z. (2020). The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. MedRxiv, 2020.08.15.20175638. https://doi.org/10.1101/2020.08.15.20175638
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www.thelancet.com www.thelancet.com
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Zhu, F.-C., Guan, X.-H., Li, Y.-H., Huang, J.-Y., Jiang, T., Hou, L.-H., Li, J.-X., Yang, B.-F., Wang, L., Wang, W.-J., Wu, S.-P., Wang, Z., Wu, X.-H., Xu, J.-J., Zhang, Z., Jia, S.-Y., Wang, B.-S., Hu, Y., Liu, J.-J., … Chen, W. (2020). Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: A randomised, double-blind, placebo-controlled, phase 2 trial. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31605-6
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www.biorxiv.org www.biorxiv.org
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Qin, M., Cao, Z., Wen, J., Yu, Q., Liu, C., Wang, F., Yang, F., Li, Y., Fishbein, G., Yan, S., Xu, B., Hou, Y., Ning, Z., Nie, K., Jiang, N., Liu, Z., Wu, J., Yu, Y., Li, H., … Lu, Y. (2020). An Antioxidant Enzyme Therapeutic for COVID-19. BioRxiv, 2020.07.15.205211. https://doi.org/10.1101/2020.07.15.205211
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www.sciencedirect.com www.sciencedirect.com
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Xu, G., Qi, F., Li, H., Yang, Q., Wang, H., Wang, X., Liu, X., Zhao, J., Liao, X., Liu, Y., Amit, I., Liu, L., Zhang, S., & Zhang, Z. (2020). The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing. MedRxiv, 2020.08.15.20175638. https://doi.org/10.1101/2020.08.15.20175638
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www.jpeds.com www.jpeds.com
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Yonker, L. M., Neilan, A. M., Bartsch, Y., Patel, A. B., Regan, J., Arya, P., Gootkind, E., Park, G., Hardcastle, M., John, A. S., Appleman, L., Chiu, M. L., Fialkowski, A., Flor, D. D. la, Lima, R., Bordt, E. A., Yockey, L. J., D’Avino, P., Fischinger, S., … Fasano, A. (2020). Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses. The Journal of Pediatrics, 0(0). https://doi.org/10.1016/j.jpeds.2020.08.037
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www.medrxiv.org www.medrxiv.org
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Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. M., Thouvenel, C., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L. P., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. MedRxiv, 2020.08.11.20171843. https://doi.org/10.1101/2020.08.11.20171843
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Bangaru, S., Ozorowski, G., Turner, H. L., Antanasijevic, A., Huang, D., Wang, X., Torres, J. L., Diedrich, J. K., Tian, J.-H., Portnoff, A. D., Patel, N., Massare, M. J., Yates, J. R., Nemazee, D., Paulson, J. C., Glenn, G., Smith, G., & Ward, A. B. (2020). Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate. BioRxiv, 2020.08.06.234674. https://doi.org/10.1101/2020.08.06.234674
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www.nature.com www.nature.com
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Ledford, H. (2020). What the immune response to COVID-19 says about the prospects for a vaccine. Nature. https://doi.org/10.1038/d41586-020-02400-7
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Local file Local file
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Immune neglect describes another failure of affective fore-casting, specifically around predicting our ability to cope with adverse outcomes.
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www.theatlantic.com www.theatlantic.com
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Yong, Ed. ‘Immunology Is Where Intuition Goes to Die’. The Atlantic, 5 August 2020. https://www.theatlantic.com/health/archive/2020/08/covid-19-immunity-is-the-pandemics-central-mystery/614956/.
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www.medrxiv.org www.medrxiv.org
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Unterman, A., Sumida, T. S., Nouri, N., Yan, X., Zhao, A. Y., Gasque, V., Schupp, J. C., Asashima, H., Liu, Y., Cosme, C., Deng, W., Chen, M., Raredon, M. S. B., Hoehn, K., Wang, G., Wang, Z., Deiuliis, G., Ravindra, N. G., Li, N., … Cruz, C. S. D. (2020). Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19. MedRxiv, 2020.07.16.20153437. https://doi.org/10.1101/2020.07.16.20153437
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www.cnn.com www.cnn.com
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CNN, J. G., Naomi Thomas, Dana Vigue and Jacqueline Howard. (n.d.). Oxford’s Covid-19 vaccine appears safe and induces immune response, early results suggest. CNN. Retrieved August 2, 2020, from https://www.cnn.com/2020/07/20/health/oxford-covid-19-vaccine-results-cansino-pfizer-study/index.html
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- Jul 2020
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www.thelancet.com www.thelancet.com
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Peeling, Rosanna W., Catherine J. Wedderburn, Patricia J. Garcia, Debrah Boeras, Noah Fongwen, John Nkengasong, Amadou Sall, Amilcar Tanuri, and David L. Heymann. ‘Serology Testing in the COVID-19 Pandemic Response’. The Lancet Infectious Diseases 0, no. 0 (17 July 2020). https://doi.org/10.1016/S1473-3099(20)30517-X.
Tags
- viral infectivity
- lang:en
- symptomatic patients
- is:report
- public health
- global cooperation
- serology testing
- community
- molecular diagnostics
- surveillance
- situational analysis
- immune response
- serology
- control programmes
- rapid serology tests
- international solidarity
- commercially available
- rapid immunodiagnostic tests
- COVID-19
- host response
Annotators
URL
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psyarxiv.com psyarxiv.com
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Adam-Troian, J., & Bagci, S. (2020). The pathogen paradox: Evidence that perceived COVID-19 threat is associated with both pro- and anti-immigrant attitudes. https://doi.org/10.31234/osf.io/948ch
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- Jun 2020
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www.nature.com www.nature.com
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Long, Q.-X., Tang, X.-J., Shi, Q.-L., Li, Q., Deng, H.-J., Yuan, J., Hu, J.-L., Xu, W., Zhang, Y., Lv, F.-J., Su, K., Zhang, F., Gong, J., Wu, B., Liu, X.-M., Li, J.-J., Qiu, J.-F., Chen, J., & Huang, A.-L. (2020). Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nature Medicine, 1–5. https://doi.org/10.1038/s41591-020-0965-6
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psyarxiv.com psyarxiv.com
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Yamagata, M., Teraguchi, T., & Miura, A. (2020, April 10). The Relationship between Infection-Avoidance Tendency and Exclusionary Attitudes towards Foreigners: A Case Study of the COVID-19 Outbreak in Japan. https://doi.org/10.31234/osf.io/vhrqn
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psyarxiv.com psyarxiv.com
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Yamagata, M., Teraguchi, T., & Miura, A. (2020, May 5). The Relationship between Infection-Avoidance Tendencies and Exclusionary Attitudes toward Foreigners: A Panel Study of the COVID-19 Outbreak in Japan. https://doi.org/10.31234/osf.io/x5emj
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www.theatlantic.com www.theatlantic.com
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Zhang, S. (2020, April 8). The Best Hopes for a Coronavirus Drug. The Atlantic. https://www.theatlantic.com/science/archive/2020/04/what-coronavirus-drug-will-look-like/609661/
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www.theatlantic.com www.theatlantic.com
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Yong, E. (2020, June 4). COVID-19 Can Last for Several Months. The Atlantic. https://www.theatlantic.com/health/archive/2020/06/covid-19-coronavirus-longterm-symptoms-months/612679/
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www.biorxiv.org www.biorxiv.org
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Robbiani, D. F., Gaebler, C., Muecksch, F., Lorenzi, J. C. C., Wang, Z., Cho, A., Agudelo, M., Barnes, C. O., Gazumyan, A., Finkin, S., Hagglof, T., Oliveira, T. Y., Viant, C., Hurley, A., Hoffmann, H.-H., Millard, K. G., Kost, R. G., Cipolla, M., Gordon, K., … Nussenzweig, M. C. (2020). Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals [Preprint]. Immunology. https://doi.org/10.1101/2020.05.13.092619
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twitter.com twitter.com
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Crotty, S. (2020, May 14). "Our new paper rapidly studied T cell + antibody immune responses in average COVID-19 cases. This is good news in multiple ways, including coronavirus vaccines. @ljiresearch cell.com/cell/fulltext/..." Twitter. https://twitter.com/profshanecrotty/status/1261052353773363200
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psyarxiv.com psyarxiv.com
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Adam-Troian, J., Bonetto, E., Varet, F., Arciszewski, T., & Guiller, T. (2020). Pathogen Threat Increases Electoral Success for Conservative Parties: Results from a Natural Experiment with COVID-19 in France. https://doi.org/10.31234/osf.io/aqkpm
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www.theguardian.com www.theguardian.com
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editor, I. S. S. (2020, May 17). Doctors raise hopes of blood test for children with coronavirus-linked syndrome. The Guardian. https://www.theguardian.com/science/2020/may/17/possible-breakthrough-in-coronavirus-related-syndrome-in-children
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- May 2020
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psyarxiv.com psyarxiv.com
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Zmigrod, L., Ebert, T., Götz, F. M., & Rentfrow, J. (2020, April 11). The Psychological and Socio-political Consequences of Infectious Diseases. https://doi.org/10.31234/osf.io/84qcm
Tags
- psychology
- is:preprint
- lang:en
- behavioral immune system
- consequences
- risk perception
- behavior
- BIS
- public health
- socio-political
- USA
- cross-cultural
- authoritarianism
- ideology
- politics
- social psychology
- infection-avoidance
- government
- study
- infectious disease
- attitude
- infection
- research
- disposition
- COVID-19
Annotators
URL
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psyarxiv.com psyarxiv.com
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Michalak, N. M., Sng, O., Wang, I., & Ackerman, J. (2020, May 14). Sounds of sickness: Can people identify infectious disease using sounds of coughs and sneezes?. https://doi.org/10.1098/rspb.2020.0944
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www.theguardian.com www.theguardian.com
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Delvin, H. (2020, May 13). Are children less susceptible to coronavirus? The Guardian. https://www.theguardian.com/world/2020/may/13/are-children-less-susceptible-to-coronavirus
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- Apr 2020
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www.thelancet.com www.thelancet.com
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Mullard, A. (2020). Flooded by the torrent: The COVID-19 drug pipeline. The Lancet, 395(10232), 1245–1246. https://doi.org/10.1016/S0140-6736(20)30894-1
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- Nov 2018
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it.wikipedia.org it.wikipedia.org
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attraverso l'inserimento nel corpo umano di un agente patogeno attenuato o di una sua subunità
In pratica, questa considerazione ignora completamente l'esistenza del sistema immune innato, presupponendo che sia una cosa normale aggirarlo..
Tags
Annotators
URL
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- Feb 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Systematic discovery of antiphage defense systems in the microbial pangenome
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- Jan 2018
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Combination therapy strategies for improving PD-1 blockade efficacy
Methods of augmenting PD-1 blockade against cancer involve concomitant CTLA-4 inhibition among others. Here is a visual representation of common biological pathways and cell types between these genes.
https://www.biovista.com/vizit-research/#!bv_gid=1357fa5ee3b610d1918476e21c7be00c
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