515 Matching Annotations
  1. Jul 2020
    1. Yurkovetskiy, L., Wang, X., Pascal, K. E., Tomkins-Tinch, C., Nyalile, T., Wang, Y., Baum, A., Diehl, W. E., Dauphin, A., Carbone, C., Veinotte, K., Egri, S. B., Schaffner, S. F., Lemieux, J. E., Munro, J., Rafique, A., Barve, A., Sabeti, P. C., Kyratsous, C. A., … Luban, J. (2020). Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant. BioRxiv, 2020.07.04.187757. https://doi.org/10.1101/2020.07.04.187757

    1. Fontanet, A., Grant, R., Tondeur, L., Madec, Y., Grzelak, L., Cailleau, I., Ungeheuer, M.-N., Renaudat, C., Pellerin, S. F., Kuhmel, L., Staropoli, I., Anna, F., Charneau, P., Demeret, C., Bruel, T., Schwartz, O., & Hoen, B. (2020). SARS-CoV-2 infection in primary schools in northern France: A retrospective cohort study in an area of high transmission. MedRxiv, 2020.06.25.20140178. https://doi.org/10.1101/2020.06.25.20140178

  2. Jun 2020
  3. May 2020
    1. Arons, M. M., Hatfield, K. M., Reddy, S. C., Kimball, A., James, A., Jacobs, J. R., Taylor, J., Spicer, K., Bardossy, A. C., Oakley, L. P., Tanwar, S., Dyal, J. W., Harney, J., Chisty, Z., Bell, J. M., Methner, M., Paul, P., Carlson, C. M., McLaughlin, H. P., … Jernigan, J. A. (2020). Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. New England Journal of Medicine, NEJMoa2008457. https://doi.org/10.1056/NEJMoa2008457

    1. Ghinai, I., Woods, S., Ritger, K. A., McPherson, T. D., Black, S. R., Sparrow, L., Fricchione, M. J., Kerins, J. L., Pacilli, M., Ruestow, P. S., Arwady, M. A., Beavers, S. F., Payne, D. C., Kirking, H. L., & Layden, J. E. (2020). Community Transmission of SARS-CoV-2 at Two Family Gatherings—Chicago, Illinois, February–March 2020. MMWR. Morbidity and Mortality Weekly Report, 69(15), 446–450. https://doi.org/10.15585/mmwr.mm6915e1

    1. Yong, S. E. F., Anderson, D. E., Wei, W. E., Pang, J., Chia, W. N., Tan, C. W., Teoh, Y. L., Rajendram, P., Toh, M. P. H. S., Poh, C., Koh, V. T. J., Lum, J., Suhaimi, N.-A. M., Chia, P. Y., Chen, M. I.-C., Vasoo, S., Ong, B., Leo, Y. S., Wang, L., & Lee, V. J. M. (2020). Connecting clusters of COVID-19: An epidemiological and serological investigation. The Lancet Infectious Diseases, S1473309920302735. https://doi.org/10.1016/S1473-3099(20)30273-5

    1. Gudbjartsson, D. F., Helgason, A., Jonsson, H., Magnusson, O. T., Melsted, P., Norddahl, G. L., Saemundsdottir, J., Sigurdsson, A., Sulem, P., Agustsdottir, A. B., Eiriksdottir, B., Fridriksdottir, R., Gardarsdottir, E. E., Georgsson, G., Gretarsdottir, O. S., Gudmundsson, K. R., Gunnarsdottir, T. R., Gylfason, A., Holm, H., … Stefansson, K. (2020). Spread of SARS-CoV-2 in the Icelandic Population. New England Journal of Medicine, NEJMoa2006100. https://doi.org/10.1056/NEJMoa2006100

    1. Zhu, Y., Bloxham, C. J., Hulme, K. D., Sinclair, J. E., Tong, Z. W. M., Steele, L. E., Noye, E. C., Lu, J., Chew, K. Y., Pickering, J., Gilks, C., Bowen, A. C., & Short, K. R. (2020). Children are unlikely to have been the primary source of household SARS-CoV-2 infections [Preprint]. Epidemiology. https://doi.org/10.1101/2020.03.26.20044826

  4. Apr 2020
    1. The rate limit can be just that - a limit rather than also dishing out punishment via the 24 hour block

      Why can't a plain rate limit (without additional blocking) by used even if not authenticated? Seems like it could.

  5. Sep 2019
  6. Jun 2019
    1. To keep recession away, the Federal Reserve lowered the Federal funds rate 11 times - from 6.5% in May 2000 to 1.75% in December 2001 - creating a flood of liquidity in the economy. Cheap money, once out of the bottle, always looks to be taken for a ride. It found easy prey in restless bankers—and even more restless borrowers who had no income, no job and no assets. These subprime borrowers wanted to realize their life's dream of acquiring a home. For them, holding the hands of a willing banker was a new ray of hope. More home loans, more home buyers, more appreciation in home prices. It wasn't long before things started to move just as the cheap money wanted them to.
  7. May 2019
  8. Mar 2019
    1. Una ricerca dell’istituto Ipsos Mori ha scoperto che 6 adulti su 10 in 38 nazioni pensano possa esistere un legame tra l’insorgenza dell’autismo e il vaccino; in Francia sono il 65%, in Gran Bretagna il 55% e in Italia il 52%. Anche per questo, secondo i dati pubblicati dall’Oms tra il 2016 e il 2017 il numero di casi di morbillo è aumentato del 31% in tutto il mondo; nella sola Europa l’incidenza è cresciuta del 400%, con quasi 4mila casi solo nel nostro Paese, dove la copertura vaccinale è scesa sotto il 90% per la prima volta in 10 anni.

      Il grafico qui sotto riportato mostra l'andamento del tasso di crescita dei soggetti autistici nel solo Stato della California nel periodo 2001-2016 ed è stato realizzato secondo le fonti ufficiali del locale Ministero dell'Educazione. Accedendo a questa pagina [https://amp.sacbee.com/site-services/databases/article90300877.html] è possibile vedere il grafico in forma dinamica al fine di avere una percezione del trend esponenziale di crescita. La California è lo Stato dell'Unione in cui il tasso di vaccinazione è altissimo. Troppo evidente per passare inosservato. Osservate bene, nella pagina di cui al link sopra riportato, il grafico dinamico e il tasso di incremento annuale (praticamente esponenziale). Eh, l'"autismo è di natura genetica" continuano a dire... Non si può più ignorare e chi ignora il fatto dovrebbe fare harakiri...Allo stato attuale il Ministero dell'Istruzione italiano non ha mai condotto una statistica seria (anche solo per rendere le strutture e il personale scolastico più adatte e competenti e per fare una seria politica di prevenzione basata sui fatti reali). Eppure è una macchina mangiasoldi che paghiamo tutti non so quante volte e ci viene offerto un servizio di qualità scadente..

  9. Nov 2018
    1. Learning with Random Learning Rates

      作者提出了一种新的Alrao优化算法,让网络中每个 unit 或 feature 都各自从不同级别的随机分布中采样获得其自己的学习率。该算法没有额外计算损耗,可以更快速达到理想 lr 下的SGD性能,用来测试 DL 模型很棒!

  10. Oct 2018
    1. Approximate Fisher Information Matrix to Characterise the Training of Deep Neural Networks

      深度神经网络训练(收敛/泛化性能)的近似Fisher信息矩阵表征,可自动优化mini-batch size/learning rate


      挺有趣的 paper,提出了从 Fisher 矩阵抽象出新的量用来衡量训练过程中的模型表现,来优化mini-batch sizes and learning rates | 另外 paper 中的figure画的很好看 | 作者认为逐步增加batch sizes的传统理解只是partially true,存在逐步递减该 size 来提高 model 收敛和泛化能力的可能。

  11. Oct 2017
    1. Beta blockers have long been associated with sleep disturbances such as difficulty falling asleep, staying asleep, and insomnia. They have been shown to reduce the production of melatonin via specific inhibition of beta-1 adrenergic receptors. Melatonin is a hormone secreted by the pineal gland in the brain, and helps in maintaining normal circadian rhythms.6,20-21 People with hypertension already have a lower melatonin production rate than those with normal blood pressure.22

      The question becomes, then, do beta blockers impair sleep when exogenous melatonin is administered concurrently?

  12. Aug 2017
    1. “throwing seniors under the bus” (to use the words of one senator) by keeping interest rates low.

      Since interest rates are low, seniors who are trying to live off of their savings will be in trouble because their money doesn't earn anything for them.

    2. real interest rates are determined by a wide range of economic factors, including prospects for economic growth—not by the Fed.

      Real interest rate = interest rate - inflation

  13. Apr 2017
    1. Forex Rates website provides accurate and reliable current currency data that helps forex traders to make trading decisions. Forex Rates Today provides a currency conversion tool. This tool displays the currency values of different countries.

  14. Oct 2016
    1. Other smartwatches force you into nightly charging.

      Honestly, this has been a major point for me not to go with Apple Watch (even before knowing about the Pebble 2+ Heart Rate). Such small things but smart alarms and sleep tracking really do help me quite a bit.

    1. How does the heart rate monitor work? The Pebble 2 and Time 2 will use optical heart rate monitors that will monitor heart rate constantly during a workout.  When at rest or sleeping, heart rate will be monitored every 10 minutes, ensuring your resting heart rate is monitored with little to no battery life impact. The monitor will have no problem with sweat, but won’t provide heart rate readings when submerged in water. Please note:  Pebble devices with a heart rate (HR) monitor are intended to be a valuable tool that can provide an accurate estimation of the user’s heart rate. Pebble smartwatches are not medical devices and you should not rely on the accuracy of heart rate data for any purpose, especially for medical or health purposes.

      Straight from the horse’s mouth. We now know that heart rate monitoring on the Pebble smartwatches is as infrequent as the Apple Watch. Ah, well… What remains to be known is what “constantly” means, for workouts. Every second, as with Fitbit?

  15. Sep 2016
    1. The group has reported sustained revenue and operating income growth over the review period, with revenue rising by a five-year CAGR of 14% to reach KES51.6bn in F15 and operating income rising by a CAGR of 26% to KES2.2bn. However, profits have been heavily eroded by rising interest charges, associated with the large quantum of debt that has been used to fund growth. Thus, operating profit of KES2.2bn in F14 and F15 equated to net interest cover of 1.2x in both years, compared to 1.8x in F13. Moreover, NPBT has decreased from KES823m in F13 to KES305m in F15.

      Nakumatt profitability point

  16. Feb 2015