8,823 Matching Annotations
  1. Jul 2021
    1. Toor, J., Echeverria-Londono, S., Li, X., Abbas, K., Carter, E. D., Clapham, H. E., Clark, A., de Villiers, M. J., Eilertson, K., Ferrari, M., Gamkrelidze, I., Hallett, T. B., Hinsley, W. R., Hogan, D., Huber, J. H., Jackson, M. L., Jean, K., Jit, M., Karachaliou, A., … Gaythorpe, K. A. (2021). Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world. ELife, 10, e67635. https://doi.org/10.7554/eLife.67635

    1. ReconfigBehSci on Twitter: ‘@Professologue @sciam well it also gives references to documented cases. Why do you think uncertainty means we should not clean? And how is this different from debate (until very recently) about “airborne” nature, in your view?’ / Twitter. (n.d.). Retrieved 15 July 2021, from https://twitter.com/SciBeh/status/1415357732446633984

    1. ReconfigBehSci on Twitter: ‘@ToddHorowitz3 I think that attribution is hard to make. I have no doubt they’re systematically promoted by bad faith actors, but I think it’s much harder to feel confident about all those who repeat them. But the rather extensive public discussion of efficacy does make this case seem unlikely’ / Twitter. (n.d.). Retrieved 15 July 2021, from https://twitter.com/SciBeh/status/1415364895046963205

    1. Gargano, J. W., Wallace, M., Hadler, S. C., Langley, G., Su, J. R., Oster, M. E., Broder, K. R., Gee, J., Weintraub, E., Shimabukuro, T., Scobie, H. M., Moulia, D., Markowitz, L. E., Wharton, M., McNally, V. V., Romero, J. R., Talbot, H. K., Lee, G. M., Daley, M. F., & Oliver, S. E. (2021). Use of mRNA COVID-19 Vaccine After Reports of Myocarditis Among Vaccine Recipients: Update from the Advisory Committee on Immunization Practices — United States, June 2021. MMWR. Morbidity and Mortality Weekly Report, 70(27), 977–982. https://doi.org/10.15585/mmwr.mm7027e2

    1. Regev-Yochay, G., Amit, S., Bergwerk, M., Lipsitch, M., Leshem, E., Kahn, R., Lustig, Y., Cohen, C., Doolman, R., Ziv, A., Novikov, I., Rubin, C., Gimpelevich, I., Huppert, A., Rahav, G., Afek, A., & Kreiss, Y. (2021). Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel. The Lancet Regional Health - Europe, 7, 100150. https://doi.org/10.1016/j.lanepe.2021.100150

    1. Dr. Tara C. Smith. (2021, March 26). ‘What motivation could anti-vaxxers possibly have to spread misinformation?’ Story: ‘Organizers of the course attended by CBC journalists said that 400 people had signed up, which at $623 per student, adds up to almost $250,000 in course fees’ + tests & supplements she plugged. [Tweet]. @aetiology. https://twitter.com/aetiology/status/1375468823508348928

    1. Alvin. (2021, July 8). An Estimated 279,000 Deaths & up to 1.25 Million Hospitalizations Averted by U.S. #COVID19 Vaccination Campaign (@commonwealthfnd analysis) 👉 Interpretation: #VaccinesWork Link: Https://t.co/0m8tq3In4f @Alison_Galvani @EricSchneiderMD @Vaccinologist @V2019N #SARSCoV2 https://t.co/SwaWxFnJ2H [Tweet]. @alvie_barr. https://twitter.com/alvie_barr/status/1413150922356654088

    1. David Fisman. (2021, July 8). Fascinating new preprint on delta vs older variants in well-investigated outbreaks in China. Viral load for delta is 3 log higher, and latent period is shorter too (estimate is 4 days vs 6 days). This may explain much higher R estimates which may be due to elevated viral load [Tweet]. @DFisman. https://twitter.com/DFisman/status/1413126886570536963

    1. This Kickstarter was made to be run during WellyCon, New Zealand's board game convention (which carefully and successfully hosted the world's biggest live board game con in 2020!)
    1. David Dowdy on Twitter: “One term I worry that we (as a public health community) have mis-messaged during the pandemic: ‘herd immunity threshold’ A non-technical thread on why this is not ‘% of the population that needs to be vaccinated for us to return to life as normal while eradicating COVID-19’... Https://t.co/5As4N9YV9N” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/davidwdowdy/status/1389791544425828357?s=20

    1. G. Elliott Morris on Twitter: “New weekly The Economist/YouGov national poll shows vaccine reluctance hitting another new low. - 69% of adults say they have been at least partially vaccinated, or plan to get vaccinated soon—17% say they will not get vaccinated—14% say they’re unsure https://t.co/OVLSuHyVrC” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/gelliottmorris/status/1392465678309933057

    1. Jesse O’Shea MD, MSc on Twitter: “Okay Twitter! Here is the new vaccine side effect chart (aka reactogenicity) for FDA submitted COVID19 vaccines vs Shingrix & Flu. J&J’s Ad26.COV2.S has the least side effect profile of the COVID vaccines so far. Https://t.co/MFGzWDqQKZ” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/JesseOSheaMD/status/1364645966826070016?s=20

    1. Sarah Kliff on Twitter: “Coronavirus vaccines are free—But 9 percent of Americans say they’re not getting one because they are worried about cost. I see this a lot in my reporting: Patients who don’t seek care because they’re become so accustomed to surprise bills that follow. Https://t.co/gu6oDnlvhB” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/sarahkliff/status/1395032095819542528?s=20

    1. Dr. Jeff Benyacar on Twitter: “@AlexBerenson ‘Even if a link between myocarditis and the vaccine holds up, the condition is usually mild, requiring treatment only with anti-inflammatory drugs, whereas COVID-19 infection can also cause serious disease and long-term side effects, even in young people.’ https://t.co/3VQprF7bIz” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/jbenyacar/status/1399851524487106562?s=12

    1. UNICEF on Twitter: “This is what it takes to deliver lifesaving vaccines to the world. Thank you for your support. Https://t.co/Y04PhlMSRb” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/UNICEF/status/1400002998198280192

    2. Adam Kucharski on Twitter: “Useful data 👇– quick look suggests odds ratio for detection of B.1.617.2 relative to non-B.1.617.2 in vaccinated group compared to controls is 2.7 (95% CI: 0.7-10) after one dose and 1.2 (0.4-3.6) after two...” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/AdamJKucharski/status/1400443351908892675?s=20

    1. Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R., Lim, E., Touizer, E., Meng, B., Abdullahi, A., Elmer, A., Kingston, N., Graves, B., Gresley, E. L., Caputo, D., Bergamaschi, L., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., … Gupta, R. K. (2021). Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature, 1–9. https://doi.org/10.1038/s41586-021-03739-1

    1. Youyang Gu. (2021, June 30). South Dakota has a vaccination rate of 50% (1+ dose). Maine is at 66%. So is Maine better protected? Not quite. If you factor in immunity from natural infection, SD has a total population immunity of ~70%, while ME is at ~62%. I created a calculator: Https://t.co/j4tMI2zN2K [Tweet]. @youyanggu. https://twitter.com/youyanggu/status/1410264061900726283

    1. Lemey, P., Ruktanonchai, N., Hong, S. L., Colizza, V., Poletto, C., Van den Broeck, F., Gill, M. S., Ji, X., Levasseur, A., Oude Munnink, B. B., Koopmans, M., Sadilek, A., Lai, S., Tatem, A. J., Baele, G., Suchard, M. A., & Dellicour, S. (2021). Untangling introductions and persistence in COVID-19 resurgence in Europe. Nature, 1–8. https://doi.org/10.1038/s41586-021-03754-2

    1. adaptive systems likely activate innate cells through antibodies and cytokines

      Long COVID

      Damaged endothelial cells from initial viral infection circulate the blood a month after symptom onset https://doi.org/10.7554/eLife.64909

      These will activate monocytes and neutrophils, but are also thought to facilitate clotting which will add to symptoms.

      Importantly, this late in the disease recovery it is not surprising to note that IL-2 and other pro-T cell cytokines are elevated which correlates with enhanced effector T-cells https://doi.org/10.7554/eLife.64909

      These adaptive cells along with autoantibodies likely propagate the effects of COVID-19 long term.

  2. Jun 2021
    1. Helen McArdle on Twitter: “The good news: An astonishing 98.2% of over-60s in Scotland are now fully vaccinated. That’s an amazing uptake. It doesn’t mean they are 100% protected of course (and especially not when case rates are high) but their risk of hospitalisation/death is cut by over 90% https://t.co/DzAxkpLvcR” / Twitter. (n.d.). Retrieved June 30, 2021, from https://twitter.com/HMcArdleHT/status/1409821893557768195

    1. Jeremy Faust MD MS (ER physician) on Twitter: “Number of Covid cases among children in US: >4 million. Number of Covid deaths in US children: 300-400. Number of kids vaccinated: 7 million. Number of kids who died from vaccine-related myocarditis: Zero. #vaccinate @bhrenton @RickABright @angie_rasmussen @celinegounder” / Twitter. (n.d.). Retrieved June 28, 2021, from https://twitter.com/jeremyfaust/status/1408880589319647243?s=20

    1. Borobia, A. M., Carcas, A. J., Pérez-Olmeda, M., Castaño, L., Bertran, M. J., García-Pérez, J., Campins, M., Portolés, A., González-Pérez, M., García Morales, M. T., Arana-Arri, E., Aldea, M., Díez-Fuertes, F., Fuentes, I., Ascaso, A., Lora, D., Imaz-Ayo, N., Barón-Mira, L. E., Agustí, A., … Torvisco, J. M. (2021). Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): A multicentre, open-label, randomised, controlled, phase 2 trial. The Lancet, S0140673621014203. https://doi.org/10.1016/S0140-6736(21)01420-3

    1. Christophe Fraser 💙 on Twitter: “Reading Cummings accounts of early creation of Test & Trace, a question I have is when and how it was morphed from aiming to find ~30 contacts per index case, needed to contain spread, into a service that contacts 2-4 contacts per index case, mostly within household.” / Twitter. (n.d.). Retrieved June 28, 2021, from https://twitter.com/ChristoPhraser/status/1408454903249477632

    1. Eric Topol on Twitter: “As the Delta variant (B.1.617.2) becomes dominant throughout the world, there are 2 patterns emerging: —Countries w/ low vaccination rates are seeing both case and fatality rates increase—Countries w/ high vaccination rate: Some case increase and minimal to no fatality increase https://t.co/sSE4RlSeUJ” / Twitter. (n.d.). Retrieved June 28, 2021, from https://twitter.com/EricTopol/status/1408195243279667204

    1. Regev-Yochay, G., Amit, S., Bergwerk, M., Lipsitch, M., Leshem, E., Kahn, R., Lustig, Y., Cohen, C., Doolman, R., Ziv, A., Novikov, I., Rubin, C., Gimpelevich, I., Huppert, A., Rahav, G., Afek, A., & Kreiss, Y. (2021). Decreased Infectivity Following BNT162b2 Vaccination. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3815668

    1. Michael Makris on Twitter: “The cumulative incidence of VITT after AZ first vaccination in the UK is continuing to increase with the latest data being 1 in 81,000. However this is rather misleading because VITT is age related with a higher incidence in the young. Https://t.co/CSjshAoRsN” / Twitter. (n.d.). Retrieved June 27, 2021, from https://twitter.com/ProfMakris/status/1395457748721184777?s=20

    2. Julia Chatterley. (2021, May 21). "I think the #EU needs to be on the right side of history.” @JNkengasong Head of @AfricaCDC welcomes news of $1.2 bn EU investment but says the continent can produce vaccines at scale IF #patents are waived. ‘The time is always right to do the right thing...’ PART I https://t.co/N1Xw9QLFhu [Tweet]. @jchatterleyCNN. https://twitter.com/jchatterleyCNN/status/1395755122320416775

    3. ViralFacts on Twitter: “Your questions answered: Why some COVID-19 vaccines require two doses #ViralFactsAfrica #VFACheck https://t.co/hytCd2pd80” / Twitter. (n.d.). Retrieved June 26, 2021, from https://twitter.com/viralfacts/status/1394213113541574658

    1. Lewis Spurgin on Twitter: “Perhaps an under appreciated point with the B.1.617.2 variant is that regional PHE teams and local authorities across the country are putting in heroic amounts of effort to break chains of transmission. (1/2)” / Twitter. (n.d.). Retrieved June 27, 2021, from https://twitter.com/LewisSpurgin/status/1395827267297759234

    1. Deepti Gurdasani on Twitter: “I’m still utterly stunned by yesterday’s events—Let me go over this in chronological order & why I’m shocked. - First, in the morning yesterday, we saw a ‘leaked’ report to FT which reported on @PHE_uk data that was not public at the time🧵” / Twitter. (n.d.). Retrieved June 27, 2021, from https://twitter.com/dgurdasani1/status/1396373990986375171

    1. UK is with EU. (2021, January 18). ..The reason we are in this third lockdown is because of the anti lockdowners like Lord Sumption ..We are going in circles, countries who have done well controlled the virus and now have an economic recovery ..And every life matters #GMB @devisridhar speaking truth to power https://t.co/U3BBV0uUSb [Tweet]. @ukiswitheu. https://twitter.com/ukiswitheu/status/1351089812799950850

    1. Knock, E. S., Whittles, L. K., Lees, J. A., Perez-Guzman, P. N., Verity, R., FitzJohn, R. G., Gaythorpe, K. A. M., Imai, N., Hinsley, W., Okell, L. C., Rosello, A., Kantas, N., Walters, C. E., Bhatia, S., Watson, O. J., Whittaker, C., Cattarino, L., Boonyasiri, A., Djaafara, B. A., … Baguelin, M. (2021). Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England. Science Translational Medicine, eabg4262. https://doi.org/10.1126/scitranslmed.abg4262

    1. Thompson, M. G., Burgess, J. L., Naleway, A. L., Tyner, H. L., Yoon, S. K., Meece, J., Olsho, L. E. W., Caban-Martinez, A. J., Fowlkes, A., Lutrick, K., Kuntz, J. L., Dunnigan, K., Odean, M. J., Hegmann, K. T., Stefanski, E., Edwards, L. J., Schaefer-Solle, N., Grant, L., Ellingson, K., … Gaglani, M. (2021). Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers—Eight U.S. Locations, December 2020–March 2021. MMWR. Morbidity and Mortality Weekly Report, 70(13), 495–500. https://doi.org/10.15585/mmwr.mm7013e3

    1. Bolze, A., Cirulli, E. T., Luo, S., White, S., Cassens, T., Jacobs, S., Nguyen, J., Ramirez, J. M., Sandoval, E., Wang, X., Wong, D., Becker, D., Laurent, M., Lu, J. T., Isaksson, M., Washington, N. L., & Lee, W. (2021). Rapid displacement of SARS-CoV-2 variant B.1.1.7 by B.1.617.2 and P.1 in the United States [Preprint]. Infectious Diseases (except HIV/AIDS). https://doi.org/10.1101/2021.06.20.21259195

    1. Parry, H. M., Tut, G., Faustini, S., Stephens, C., Saunders, P., Bentley, C., Hilyard, K., Brown, K., Amirthalingam, G., Charlton, S., Leung, S., Chiplin, E., Coombes, N. S., Bewley, K. R., Penn, E. J., Rowe, C., Otter, A., Watts, R., D’Arcangelo, S., … Moss, P. (2021). BNT162b2 Vaccination in People Over 80 Years of Age Induces Strong Humoral Immune Responses with Cross Neutralisation of P.1 Brazilian Variant. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3816840