1,353 Matching Annotations
  1. Jan 2022
    1. In a recent paper, Pierre Azoulay and co-authors concluded that Howard Hughes Medical Institute’s long-term grants to high-potential scientists made those scientists 96 percent more likely to produce breakthrough work. If this finding is borne out, it suggests that present funding mechanisms are likely to be far from optimal, in part because they do not focus enough on research autonomy and risk taking.

      Risk taking and the potential return are key pieces of progress.

      Most of our research funding apparatus isn't set up with a capitalistic structure. Would that be good or bad for accelerating progress?

    1. Prof. Gavin Yamey MD MPH. (2022, January 7). Thank you @j_g_allen for continuing to advocate for childhood vaccination & for sharing evidence on masks Yesterday, the U.S. saw a record number of COVID-19 pediatric hospital admissions, almost 1,000 Unvaxxed kids are 10 X more likely to be hospitalized than vaxxed kids 1/2 [Tweet]. @GYamey. https://twitter.com/GYamey/status/1479265484562386944

    1. Multiple factors appear to increase the risk of PGD, including depression, anxiety disorders, current substance use/abuse, multiple losses, particularly stressful circumstances surrounding the death, lack of social supports, uncertainty about the death, and the unavailability of usual mourning rituals.

      depression, anxiety disorders, current substance use/abuse, multiple losses, particularly stressful circumstances surrounding the death, lack of social supports, uncertainty about the death, the unavailability of usual mourning rituals

    1. Frenzel, S. B., Junker, N. M., Avanzi, L., Bolatov, A., Haslam, S. A., Häusser, J. A., Kark, R., Meyer, I., Mojzisch, A., Monzani, L., Reicher, S., Samekin, A., Schury, V. A., Steffens, N. K., Sultanova, L., Van Dijk, D., van Zyl, L. E., & Van Dick, R. (2022). A trouble shared is a trouble halved: The role of family identification and identification with humankind in well-being during the COVID-19 pandemic. British Journal of Social Psychology, 61(1), 55–82. https://doi.org/10.1111/bjso.12470

    1. ReconfigBehSci. (2022, January 4). “Importantly, higher study quality was associated with lower prevalence of all symptoms, except loss of smell & cognitive symptoms” ....as someone who studies cognition I didn’t find that as reassuring as possibly intended... [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1478341731707981829

    1. Riepenhausen, A., Veer, I., Wackerhagen, C., Reppmann, Z. C., Köber, G., Ayuso-Mateos, J.-L., Bögemann, S., Corrao, G., Felez-Nobrega, M., Abad, J. M. H., Hermans, E., Leeuwen, J. van, Lieb, P. D. K., Lorant, V., Mary-Krause, M., Mediavilla, R., Melchior, M., Mittendorfer-Rutz, E., Compagnoni, M. M., … Walter, H. (2021). Coping with COVID: Risk and Resilience Factors for Mental Health in a German Representative Panel Study. PsyArXiv. https://doi.org/10.31234/osf.io/fjqpb

  2. Dec 2021
    1. Deepti Gurdasani. (2021, December 23). Some brief thoughts on the concerning relativism I’ve seen creeping into media, and scientific rhetoric over the past 20 months or so—The idea that things are ok because they’re better relative to a point where things got really really bad. 🧵 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1474042179110772736

    1. Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A. C., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2021). Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-021-01630-0

  3. Nov 2021
    1. it must be acknowledged that conservatism is never more respectable than in education, for nowhere are the risks of change greater.

      —Charles W. Eliot

      And here I thought I was original in thinking this... :)

    1. Dr Nisreen Alwan 🌻. (2021, October 30). Mass infection of kids with a virus less than 2 years old is not ethical, not moral, not scientifically evidenced, not socially just & medically risky. There’s no good argument for this. And no, boosting population immunity to protect the adults is not a valid argument. #Childism [Tweet]. @Dr2NisreenAlwan. https://twitter.com/Dr2NisreenAlwan/status/1454498829403922440

    1. Benjamin Veness. (2021, November 2). Singapore’s 🇸🇬 Senior Minister of State for Health, Dr Janil Puthucheary, told Parliament on 1 November: “I hope my explanation has helped members understand why although we say we are living with COVID-19, we cannot just open up, and risk having the number of cases shoot up.” [Tweet]. @venessb. https://twitter.com/venessb/status/1455396047765733376

  4. Oct 2021
    1. Magusali, N., Graham, A. C., Piers, T. M., Panichnantakul, P., Yaman, U., Shoai, M., Reynolds, R. H., Botia, J. A., Brookes, K. J., Guetta-Baranes, T., Bellou, E., Bayram, S., Sokolova, D., Ryten, M., Sala Frigerio, C., Escott-Price, V., Morgan, K., Pocock, J. M., Hardy, J., & Salih, D. A. (2021). A genetic link between risk for Alzheimer’s disease and severe COVID-19 outcomes via the OAS1 gene. Brain, awab337. https://doi.org/10.1093/brain/awab337

    1. Liverpool, M. L. P., Clare Wilson, Jessica Hamzelou, Sam Wong, Graham Lawton, Adam Vaughan, Conrad Quilty-Harper, Jason Arunn Murugesu and Layal. (n.d.). Covid-19 news: Study finds vaccines prevent over 84% of severe cases. New Scientist. Retrieved October 12, 2021, from https://www.newscientist.com/article/2237475-covid-19-news-study-finds-vaccines-prevent-over-84-of-severe-cases/

    1. Forbes, H., Morton, C. E., Bacon, S., McDonald, H. I., Minassian, C., Brown, J. P., Rentsch, C. T., Mathur, R., Schultze, A., DeVito, N. J., MacKenna, B., Hulme, W. J., Croker, R., Walker, A. J., Williamson, E. J., Bates, C., Mehrkar, A., Curtis, H. J., Evans, D., … Tomlinson, L. A. (2020). Association between living with children and outcomes from COVID-19: An OpenSAFELY cohort study of 12 million adults in England (p. 2020.11.01.20222315). https://doi.org/10.1101/2020.11.01.20222315

    1. Clift, A. K., von Ende, A., Tan, P. S., Sallis, H. M., Lindson, N., Coupland, C. A. C., Munafò, M. R., Aveyard, P., Hippisley-Cox, J., & Hopewell, J. C. (2021). Smoking and COVID-19 outcomes: An observational and Mendelian randomisation study using the UK Biobank cohort. Thorax, thoraxjnl-2021-217080. https://doi.org/10.1136/thoraxjnl-2021-217080

    1. Hippisley-Cox, J., Patone, M., Mei, X. W., Saatci, D., Dixon, S., Khunti, K., Zaccardi, F., Watkinson, P., Shankar-Hari, M., Doidge, J., Harrison, D. A., Griffin, S. J., Sheikh, A., & Coupland, C. A. C. (2021). Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: Self-controlled case series study. BMJ, n1931. https://doi.org/10.1136/bmj.n1931

  5. Sep 2021
    1. Hippisley-Cox, J., Coupland, C. A., Mehta, N., Keogh, R. H., Diaz-Ordaz, K., Khunti, K., Lyons, R. A., Kee, F., Sheikh, A., Rahman, S., Valabhji, J., Harrison, E. M., Sellen, P., Haq, N., Semple, M. G., Johnson, P. W. M., Hayward, A., & Nguyen-Van-Tam, J. S. (2021). Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: National prospective cohort study. BMJ, 374, n2244. https://doi.org/10.1136/bmj.n2244

    1. Sam Wang on Twitter: “These are risk levels that you pose to other people. They’re compared with you as—A nonsmoker—A sober driver—A vaccinated person. Unvaccinated? 5x as likely to get sick, for 3x as long. Total risk to others? 15x a vaccinated person Details:https://t.co/ckTWaivK8n https://t.co/PhpLvX2dsm” / Twitter. (n.d.). Retrieved September 19, 2021, from https://twitter.com/SamWangPhD/status/1438361144759132167

    1. Twohig, K. A., Nyberg, T., Zaidi, A., Thelwall, S., Sinnathamby, M. A., Aliabadi, S., Seaman, S. R., Harris, R. J., Hope, R., Lopez-Bernal, J., Gallagher, E., Charlett, A., Angelis, D. D., Presanis, A. M., Dabrera, G., Koshy, C., Ash, A., Wise, E., Moore, N., … Gunson, R. (2021). Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: A cohort study. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00475-8

    1. John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936

    1. Mike Baker. (2021, August 28). Today, Mississippi surpassed New York in total coronavirus deaths per capita. For a long time, I didn’t think we’d ever see any state end up worse than New York or New Jersey. One year ago today, Mississippi’s death rate was less than half of New York’s. Https://nytimes.com/interactive/2021/us/covid-cases.html https://t.co/sEgUDFOMWz [Tweet]. @bymikebaker. https://twitter.com/bymikebaker/status/1431460167237783555

    1. Viki Male on Twitter: “Updating my single-slide summary on the safety of #COVID19 #vaccines in #pregnancy to include new data from the V-safe pregnancy registry that came out while I was on holiday.... 1/ https://t.co/ij9qqFob69” / Twitter. (n.d.). Retrieved September 2, 2021, from https://twitter.com/VikiLovesFACS/status/1432978088581861376

    1. 风控系统有规则和模型两种技术路线,规则的优点是简单直观、可解释性强、灵活,所以长期活跃在风控系统之中,但缺点是容易被攻破,一但被黑产猜到里面就会失效,于是在实际的风控系统中,往往再结合上基于模型的风控环节来增加健壮性。但限于篇幅,本文中我们只重点讨论一种基于规则的风控系统架构,当然如果有模型风控的诉求,该架构也完全支持

      基于规则和模型的优缺点

  6. Aug 2021
    1. (2) David Fisman on Twitter: “Here’s some really simple modeling that hopefully will help provide some insight into why having a large, unvaccinated minority in Ontario is a problem for the population as a whole.” / Twitter. (n.d.). Retrieved August 23, 2021, from https://twitter.com/DFisman/status/1427940663925092354

    1. (2) Dr Nicole E Basta on Twitter: “There is SO MUCH misunderstanding about what a #vaccine #mandate IS & what a vaccine mandate DOES. No one is calling for anyone to be banned. No one is calling for anyone to be forcibly vaccinated. Please, gather 'round and listen up, so you know what we’re talking about... 1/n” / Twitter. (n.d.). Retrieved August 23, 2021, from https://twitter.com/IDEpiPhD/status/1428410251884302336?s=20