2,092 Matching Annotations
  1. Mar 2021
    1. Wang, P., Nair, M. S., Liu, L., Iketani, S., Luo, Y., Guo, Y., Wang, M., Yu, J., Zhang, B., Kwong, P. D., Graham, B. S., Mascola, J. R., Chang, J. Y., Yin, M. T., Sobieszczyk, M., Kyratsous, C. A., Shapiro, L., Sheng, Z., Huang, Y., & Ho, D. D. (2021). Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7. Nature, 1–9. https://doi.org/10.1038/s41586-021-03398-2

    1. Ashish K. Jha, MD, MPH. (2020, December 12). Michigan vs. Ohio State Football today postponed due to COVID But a comparison of MI vs OH on COVID is useful Why? While vaccines are coming, we have 6-8 hard weeks ahead And the big question is—Can we do anything to save lives? Lets look at MI, OH for insights Thread [Tweet]. @ashishkjha. https://twitter.com/ashishkjha/status/1337786831065264128

    1. James Hamblin. (2021, March 17). Whenever you vaccinate millions and millions of people, some will inevitably die shortly after. Others will get blood clots. Others will crash cars, or fall down stairs. None of this is newsworthy until there’s reason to believe these things are connected. [Tweet]. @jameshamblin. https://twitter.com/jameshamblin/status/1371993047261667329

    1. ReconfigBehSci. ‘RT @ashishkjha: Over Past Week We Got 11.4 Million Doses into Arms 5.6 Million Were 1st Doses 5.8 Million Were 2nd Doses That’s a Proble…’. Tweet. @SciBeh (blog), 1 March 2021. https://twitter.com/SciBeh/status/1366421544495382533.

    1. Voysey, M., Costa Clemens, S. A., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B. J., Baillie, V., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Clutterbuck, E., Collins, A. M., Cutland, C., Darton, T., Dheda, K., Douglas, A. D., … Group, O. C. V. T. (2021). Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine (SSRN Scholarly Paper ID 3777268). Social Science Research Network. https://papers.ssrn.com/abstract=3777268

    1. A re-analysis of published data from the Israeli Health Ministry by Dr. Hervé Seligmann, a member of the faculty of Medicine Emerging Infectious and Tropical Diseases at Aix-Marseille University, and engineer Haim Yativ reveal, in short, that the mRNA experimental vaccine from Pfizer killed “about 40 times more (elderly) people than the disease itself would have killed” during a recent five-week vaccination period. Among the younger class, these numbers are compounded to death rates at 260 times what the COVID-19 virus would have claimed in the given time frame.

      Effects of vaccine on elderly and young appear to cause more deaths than Covid19.

    1. “The mRNA molecule is vulnerable to destruction. So, in order to protect the fragile mRNA strands while they are being inserted into our DNA they are coated with PEGylated lipid nanoparticles. This coating hides the mRNA from our immune system which ordinarily would kill any foreign material injected into the body. PEGylated lipid nanoparticles have been used in several different drugs for years. Because of their effect on immune system balance, several studies have shown them to induce allergies and autoimmune diseases. Additionally, PEGylated lipid nanoparticles have been shown to trigger their own immune reactions, and to cause damage to the liver.”

      LNP and PEG can cause autoimmune disease. They also damage the liver.

    1. Eran Segal. (2021, January 22). Israel: 2.4M after 1st dose (27% pop) 78% of all 60+ years old Despite that, we have a problem: Cities of lower socio-economic status and more cases get vaccinated less X: Socioeconomic rank Y: % 60+ years old vaccinated Color: Vaccination need ratio @MDCaspi by covid-19 cases https://t.co/t5vC8hjXA4 [Tweet]. @segal_eran. https://twitter.com/segal_eran/status/1352579515592138753

  2. Feb 2021
    1. Youyang Gu. (2021, February 24). When can we return to normal? Forget about ‘herd immunity’. Below is my estimate for the number of susceptible individuals over time, as a proportion of the US population. Looking at this graph, what is the best point to go back to normal? Christmas? Fall? Or Summer? 🧵 https://t.co/V4uiFk5YcP [Tweet]. @youyanggu. https://twitter.com/youyanggu/status/1364627872233750543

    1. Dr. Tara C. Smith. (2021, January 23). A reminder: Especially among the elderly, some individuals will die shortly after receipt of the vaccine. What we need to understand is the background rate of such deaths. Are they higher then in the vaccinated population? We didn’t see that in the trials. Some data from @RtAVM. https://t.co/LJe9k1WJQC [Tweet]. @aetiology. https://twitter.com/aetiology/status/1352810672359428097

    1. Dr Ellie Murray. (2020, December 3). Some really great resources & discussions in this thread. The tl;dr is (1) yes, the vaccine trials included some people who had previously had COVID; and (2) in general vaccination plans will include those who have previously been sick/infected. Thanks all! [Tweet]. @EpiEllie. https://twitter.com/EpiEllie/status/1334545373126389766

    1. Andrew💙Croxford. (2020, December 3). NEW THREAD: possible development of anti-Syncytin responses after immunization with the SARS-CoV-2 spike protein-coding mRNA vaccines, based on a ‘homologous’ region shared between these proteins. [Tweet]. @andrew_croxford. https://twitter.com/andrew_croxford/status/1334593606196187136

    1. Carl T. Bergstrom. (2021, January 31). A somewhat technical thread about measuring vaccine efficacy. We’re used to the notion that certain properties of tests for disease depend on prevalence: Positive and negative predictive value do, for example, whereas sensitivity and specificity do not. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1355762090078703621

    1. Carl T. Bergstrom. (2020, December 5). I don’t have a background in medical ethics but this makes me uncomfortable unless it was very clearly explained to study participants at enrollment, and to some degree even then. H/t @RMCarpiano https://t.co/WUE1mXgjJG https://t.co/yLXkxIa5O8 [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1335152266840424449

    1. Eric Feigl-Ding. (2020, December 6). HUMAN➡️MINKS➡️HUMAN transmission on mink farms in NL. 68% of the tested farm workers and/or contacts had evidence of #SARSCoV2 infection. The coronavirus mutated & even evolved within minks before transmitted back to humans—& keeps #COVID19 perpetuating. Https://t.co/5ARZ6Pq5mO https://t.co/fhrQC9ZVDo [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1335419078446551041

    1. Stephan Lewandowsky. (2021, February 15). But why stop at German? We also have a Spanish translation: ‘Manual de Comunicación Para la Vacuna Contra el COVID-19’ available at https://t.co/tf2ru9T4tp Yet another @BaerbelW Incorporated accomplishment. And yes, another translation due tomorrow... Stand by to learn more... Https://t.co/h6NR083hoA [Tweet]. @STWorg. https://twitter.com/STWorg/status/1361388366265212934

    1. Yale SOM. (2020, October 27). Herd immunity is the end goal of developing a vaccine, @thehowie explains. But when government officials talk about relying on “herd immunity” as a strategy for slowing or stopping the Covid-19 pandemic without a vaccine, it’s a more dangerous approach. Https://t.co/aJ8VXos7zh [Tweet]. @YaleSOM. https://twitter.com/YaleSOM/status/1321150247503101956

    1. Tim Colbourn. (2021, February 22). It’s good that opening up will be done in stages, though more could be done to ensure we don’t fail after the 1st stage and end up back in lockdown due to hospitals filling up again with unvaccinated people. I hope the government don’t end up regretting not doing the above. END [Tweet]. @timcolbourn. https://twitter.com/timcolbourn/status/1363989485516693508

    1. ReconfigBehSci. (2021, February 19). RT @DrTolullah: Last night @SliderCuts & I discussed qq his 95k+ followers have about #COVID19 vaccines. Went on > 1.5 hrs in the end!! Ppl… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1363423504935366657

    1. Wibmer, C. K., Ayres, F., Hermanus, T., Madzivhandila, M., Kgagudi, P., Lambson, B. E., Vermeulen, M., Berg, K. van den, Rossouw, T., Boswell, M., Ueckermann, V., Meiring, S., Gottberg, A. von, Cohen, C., Morris, L., Bhiman, J. N., & Moore, P. L. (2021). SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. BioRxiv, 2021.01.18.427166. https://doi.org/10.1101/2021.01.18.427166

    1. Shen, X., Tang, H., McDanal, C., Wagh, K., Fischer, W. M., Theiler, J., Yoon, H., Li, D., Haynes, B. F., Saunders, K. O., Gnanakaran, S., Hengartner, N. W., Pajon, R., Smith, G., Dubovsky, F., Glenn, G. M., Korber, B. T., & Montefiori, D. C. (2021). SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike Vaccines (SSRN Scholarly Paper ID 3777473). Social Science Research Network. https://papers.ssrn.com/abstract=3777473

    1. He said the pharmaceutical industry was following the lead of governments, who have sought to strike their own deals for vaccines, technology and treatments rather than prioritise global distribution.“That means inevitably that industry is also having to respond to that,” Gore said. “If countries are saying the most important thing is, ‘I want you to do a deal now with me’, the companies can’t say, ‘We’ll come back to you later, we’re trying to do a deal for global access’.”

      This is an interesting/ new point I haven't seen before. It turns out partially blame is on rich country governments as well.

  3. Jan 2021
    1. Sadoff, J., Le Gars, M., Shukarev, G., Heerwegh, D., Truyers, C., de Groot, A. M., Stoop, J., Tete, S., Van Damme, W., Leroux-Roels, I., Berghmans, P.-J., Kimmel, M., Van Damme, P., de Hoon, J., Smith, W., Stephenson, K. E., De Rosa, S. C., Cohen, K. W., McElrath, M. J., … Schuitemaker, H. (2021). Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMoa2034201

    1. Benjy Renton. (2020, December 5). Launching a new dashboard to track local news reports and state press releases on how many vaccine doses will be allocated to each state, since there seems to be no public federal effort. Browse each state’s allocations and a map of doses per capita. Https://t.co/CUP2W2ph7X [Tweet]. @bhrenton. https://twitter.com/bhrenton/status/1335306082693083137

  4. Dec 2020
    1. mRNA-1273 vaccine candidate, manufactured by Moderna, encodes the S-2P antigen, consisting of the SARS-CoV-2 glycoprotein with a transmembrane anchor and an intact S1–S2 cleavage site. S-2P is stabilized in its prefusion conformation by two consecutive proline substitutions at amino acid positions 986 and 987, at the top of the central helix in the S2 subunit
    1. We report the preclinical development of BNT162b2, a lipid-nanoparticle (LNP) formulated N1-methyl-pseudouridine (m1Ψ) nucleoside-modified mRNA (modRNA) vaccine candidate that encodes P2 S with a native furin cleavage site resulting in the S1 and S2 cleavage fragments
    2. To generate the template for RNA synthesis, a DNA fragment encoding the SARS-CoV-2 P2 279 S protein (based on GenBank: MN908947), including the amino acid exchanges K986P and 280 V987P, was cloned into a starting plasmid vector with backbone sequence elements for 281 improved RNA stability and translational efficiency19,34

      BNT162b2

    1. The MHRA urgently seeks an Artificial Intelligence (AI) software tool to process the expected high volume of Covid-19 vaccine Adverse Drug Reaction (ADRs) and ensure that no details from the ADRs’ reaction text are missed.

      Is this expectation higher than for other coronavirus vaccines? MHRA: Medicines & Healthcare products Regulatory Agency

    1. Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Collins, A. M., Colin-Jones, R., Cutland, C. L., Darton, T. C., Dheda, K., Duncan, C. J. A., … Zuidewind, P. (2020). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)32661-1

  5. Nov 2020
  6. Oct 2020
  7. Sep 2020
    1. Natalie E. Dean en Twitter: “VACCINE EFFICACY 101: A biostatistician's primer. Ten tweets to cover:- How is vaccine efficacy calculated?- Distinguishing between infection, disease, & severe disease.- Measuring reduced infectiousness.- Vaccine efficacy vs. effectiveness!n” / Twitter. (n.d.). Twitter. Retrieved September 30, 2020, from https://twitter.com/nataliexdean/status/1310613702476017666