1,163 Matching Annotations
  1. Jan 2021
    1. Data analysis, and the parts of statistics which adhere to it, must…take on the characteristics of science rather than those of mathematics…

      Is data analysis included in data science? If not, what is the relationship between them?

  2. Dec 2020
    1. Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Collins, A. M., Colin-Jones, R., Cutland, C. L., Darton, T. C., Dheda, K., Duncan, C. J. A., … Zuidewind, P. (2020). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)32661-1

  3. Nov 2020
  4. Oct 2020
    1. The purpose of this toolkit is to familiarize the user with intellectual and developmental disabilities (I/DD) and communication techniques to assist in successfully facilitating a healthy living program for individuals with I/DD. These are suggested techniques particularly helpful for those who don’t have any experience working with individuals who have I/DD.

      This toolkit can be used as a starting point for working with or developing programs that people with a developmental or intellectual disability might use. It does not go into detail but offers strategies for communication, behavior and setting learners up for success.

      10/10 It is short and highly informative with free resources within it.

    1. t’s not clear why the sequence of the vaccines only mattered in girls, partly because there has been very little research into how male and female immune systems are different. “Somehow immunology has been blind to sex,” says Aaby. “If you read research about mortality in low income countries, there is no such thing as boys and girls – there are children. So we perceive that they have to be the same, and they are definitely not the same.”

      Take away: "Immune training" or bystander effects from other vaccinations may help to fight off Covid-19 or other infections, in spite of not being specific to that pathogen. Some of these effects are sex-specific.

      Claim: "Somehow immunology has been blind to sex"

      The evidence: This is not entirely true- there is actually a LOT of research into sex differences in the immune response, and it is well-known that women can generally mount stronger Th1-type immune responses against viral infections than men. This is thought to be partially linked to estrogen cycling, and partly due to the fact that women have 2 active copies of genes associated with immunity because those are encoded on the X chromosomes. Men only have 1 copy, and thus they don't generally mount as strong an inflammatory response. However, women are also more prone to autoimmune diseases as a consequence of having stronger inflammatory responses than men, which is seen in diseases such as multiple sclerosis, rheumatoid arthritis, and lupus.

      Sources: (https://www.nature.com/articles/nri.2016.90).

  5. Sep 2020
    1. exposure limits are determined by the following equations (NIOSH, 2016):(4)ÂRAL[°C-WBGT]=59.9-14.1log10M<math><mrow is="true"><mi mathvariant="normal" is="true">R</mi><mi mathvariant="normal" is="true">A</mi><mi mathvariant="normal" is="true">L</mi><mo stretchy="false" is="true">[</mo><mi is="true">Â</mi><mi is="true">°</mi><mi mathvariant="normal" is="true">C</mi><mo is="true">-</mo><mi mathvariant="normal" is="true">W</mi><mi mathvariant="normal" is="true">B</mi><mi mathvariant="normal" is="true">G</mi><mi mathvariant="normal" is="true">T</mi><mo stretchy="false" is="true">]</mo><mo is="true">=</mo><mn is="true">59.9</mn><mo is="true">-</mo><mn is="true">14.1</mn><mi mathvariant="normal" is="true">l</mi><mi mathvariant="normal" is="true">o</mi><mi mathvariant="normal" is="true">g</mi><mn is="true">10</mn><mi mathvariant="normal" is="true">M</mi></mrow></math>(5)Â

      regressional analysis of exposure limits

    1. Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Izcovich, A., Kum, E., Pardo-Hernandez, H., Rochwerg, B., Lamontagne, F., Han, M. A., Liu, Q., Agarwal, A., Agoritsas, T., Chu, D. K., Couban, R., Darzi, A., Devji, T., Fang, B., Fang, C., … Brignardello-Petersen, R. (2020). Drug treatments for covid-19: Living systematic review and network meta-analysis. BMJ, 370. https://doi.org/10.1136/bmj.m2980

    1. Ip, A., Ahn, J., Zhou, Y., Goy, A. H., Hansen, E., Pecora, A. L., Sinclaire, B. A., Bednarz, U., Marafelias, M., Mathura, S., Sawczuk, I. S., Underwood, J. P., Walker, D. M., Prasad, R., Sweeney, R. L., Ponce, M. G., LaCapra, S., Cunningham, F. J., Calise, A. G., … Goldberg, S. L. (2020). Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: A multi-center observational study. MedRxiv, 2020.08.20.20178772. https://doi.org/10.1101/2020.08.20.20178772

  6. Aug 2020
    1. Lozano, R., Fullman, N., Mumford, J. E., Knight, M., Barthelemy, C. M., Abbafati, C., Abbastabar, H., Abd-Allah, F., Abdollahi, M., Abedi, A., Abolhassani, H., Abosetugn, A. E., Abreu, L. G., Abrigo, M. R. M., Haimed, A. K. A., Abushouk, A. I., Adabi, M., Adebayo, O. M., Adekanmbi, V., … Murray, C. J. L. (2020). Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)30750-9

    1. Hogan, A. B., Jewell, B. L., Sherrard-Smith, E., Vesga, J. F., Watson, O. J., Whittaker, C., Hamlet, A., Smith, J. A., Winskill, P., Verity, R., Baguelin, M., Lees, J. A., Whittles, L. K., Ainslie, K. E. C., Bhatt, S., Boonyasiri, A., Brazeau, N. F., Cattarino, L., Cooper, L. V., … Hallett, T. B. (2020). Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: A modelling study. The Lancet Global Health, 0(0). https://doi.org/10.1016/S2214-109X(20)30288-6

    1. Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Zicari, S., Ruggiero, A., Pascucci, G. R., Rodriguez, L., Santilli, V., Tan, Z., Eriksson, D., Wang, J., Lakshmikanth, T., Marchesi, A., Lakshmikanth, T., Campana, A., Villani, A., Rossi, P., … Brodin, P. (2020). The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. MedRxiv, 2020.07.08.20148353. https://doi.org/10.1101/2020.07.08.20148353

    1. Bangaru, S., Ozorowski, G., Turner, H. L., Antanasijevic, A., Huang, D., Wang, X., Torres, J. L., Diedrich, J. K., Tian, J.-H., Portnoff, A. D., Patel, N., Massare, M. J., Yates, J. R., Nemazee, D., Paulson, J. C., Glenn, G., Smith, G., & Ward, A. B. (2020). Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate. BioRxiv, 2020.08.06.234674. https://doi.org/10.1101/2020.08.06.234674

    1. Sherrard-Smith, E., Hogan, A. B., Hamlet, A., Watson, O. J., Whittaker, C., Winskill, P., Ali, F., Mohammad, A. B., Uhomoibhi, P., Maikore, I., Ogbulafor, N., Nikau, J., Kont, M. D., Challenger, J. D., Verity, R., Lambert, B., Cairns, M., Rao, B., Baguelin, M., … Churcher, T. S. (2020). The potential public health consequences of COVID-19 on malaria in Africa. Nature Medicine, 1–6. https://doi.org/10.1038/s41591-020-1025-y

    1. Unterman, A., Sumida, T. S., Nouri, N., Yan, X., Zhao, A. Y., Gasque, V., Schupp, J. C., Asashima, H., Liu, Y., Cosme, C., Deng, W., Chen, M., Raredon, M. S. B., Hoehn, K., Wang, G., Wang, Z., Deiuliis, G., Ravindra, N. G., Li, N., … Cruz, C. S. D. (2020). Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19. MedRxiv, 2020.07.16.20153437. https://doi.org/10.1101/2020.07.16.20153437

  7. Jul 2020
    1. Meyer, B., Torriani, G., Yerly, S., Mazza, L., Calame, A., Arm-Vernez, I., Zimmer, G., Agoritsas, T., Stirnemann, J., Spechbach, H., Guessous, I., Stringhini, S., Pugin, J., Roux-Lombard, P., Fontao, L., Siegrist, C.-A., Eckerle, I., Vuilleumier, N., & Kaiser, L. (2020). Validation of a commercially available SARS-CoV-2 serological immunoassay. Clinical Microbiology and Infection, 0(0). https://doi.org/10.1016/j.cmi.2020.06.024

  8. Jun 2020
    1. Chu, D. K., Akl, E. A., Duda, S., Solo, K., Yaacoub, S., Schünemann, H. J., Chu, D. K., Akl, E. A., El-harakeh, A., Bognanni, A., Lotfi, T., Loeb, M., Hajizadeh, A., Bak, A., Izcovich, A., Cuello-Garcia, C. A., Chen, C., Harris, D. J., Borowiack, E., … Schünemann, H. J. (2020). Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: A systematic review and meta-analysis. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)31142-9

  9. May 2020