411 Matching Annotations
  1. May 2021
  2. Apr 2021
    1. Graham, M. S., Sudre, C. H., May, A., Antonelli, M., Murray, B., Varsavsky, T., Kläser, K., Canas, L. S., Molteni, E., Modat, M., Drew, D. A., Nguyen, L. H., Polidori, L., Selvachandran, S., Hu, C., Capdevila, J., Koshy, C., Ash, A., Wise, E., … Ourselin, S. (2021). Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: An ecological study. The Lancet Public Health, 0(0). https://doi.org/10.1016/S2468-2667(21)00055-4

  3. Mar 2021
    1. Griffith, G. J., Morris, T. T., Tudball, M. J., Herbert, A., Mancano, G., Pike, L., Sharp, G. C., Sterne, J., Palmer, T. M., Davey Smith, G., Tilling, K., Zuccolo, L., Davies, N. M., & Hemani, G. (2020). Collider bias undermines our understanding of COVID-19 disease risk and severity. Nature Communications, 11(1), 5749. https://doi.org/10.1038/s41467-020-19478-2

    1. Gupta, R. K., Marks, M., Samuels, T. H. A., Luintel, A., Rampling, T., Chowdhury, H., Quartagno, M., Nair, A., Lipman, M., Abubakar, I., Smeden, M. van, Wong, W. K., Williams, B., & Noursadeghi, M. (2020). Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study. MedRxiv, 2020.07.24.20149815. https://doi.org/10.1101/2020.07.24.20149815

  4. Feb 2021
    1. Ghio, D., Lawes-Wickwar, S., Tang, M. Y., Epton, T., Howlett, N., Jenkinson, E., Stanescu, S., Westbrook, J., Kassianos, A., Watson, D., Sutherland, L., Stanulewicz, N., Guest, E., Scanlan, D., Carr, N., Chater, A., Hotham, S., Thorneloe, R., Armitage, C., … Keyworth, C. (2020). What influences people’s responses to public health messages for managing risks and preventing infectious diseases? A rapid systematic review of the evidence and recommendations [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/nz7tr

    1. Verani, J. R., Baqui, A. H., Broome, C. V., Cherian, T., Cohen, C., Farrar, J. L., Feikin, D. R., Groome, M. J., Hajjeh, R. A., Johnson, H. L., Madhi, S. A., Mulholland, K., O’Brien, K. L., Parashar, U. D., Patel, M. M., Rodrigues, L. C., Santosham, M., Scott, J. A., Smith, P. G., … Zell, E. R. (2017). Case-control vaccine effectiveness studies: Preparation, design, and enrollment of cases and controls. Vaccine, 35(25), 3295–3302. https://doi.org/10.1016/j.vaccine.2017.04.037

  5. Jan 2021
    1. ReconfigBehSci. (2020, November 9). RT @peterbachmd: Relevant today: Ever sharp @nataliexdean on Vaccine Effectiveness vs Efficacy from many moons ago (i.e. About a month). Sh… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1325889181097267200

  6. Dec 2020
  7. Oct 2020
    1. Cholesterol

      This is a fat-like substance found in every single cell in the body. It aides the body to create hormones, vitamin D, and it also helps to digest food. Many dairy products are rich in Cholesterol which can be harmful if intaking high levels of it. This is due to fat deposits in the blood vessels which increases the risks of heart disease.

  8. Sep 2020
  9. Aug 2020
    1. Hogan, A. B., Jewell, B. L., Sherrard-Smith, E., Vesga, J. F., Watson, O. J., Whittaker, C., Hamlet, A., Smith, J. A., Winskill, P., Verity, R., Baguelin, M., Lees, J. A., Whittles, L. K., Ainslie, K. E. C., Bhatt, S., Boonyasiri, A., Brazeau, N. F., Cattarino, L., Cooper, L. V., … Hallett, T. B. (2020). Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: A modelling study. The Lancet Global Health, 0(0). https://doi.org/10.1016/S2214-109X(20)30288-6

    1. Sun, W., McCroskery, S., Liu, W.-C., Leist, S. R., Liu, Y., Albrecht, R. A., Slamanig, S., Oliva, J., Amanat, F., Schäfer, A., Dinnon, K. H., Innis, B. L., García-Sastre, A., Krammer, F., Baric, R. S., & Palese, P. (2020). A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine. BioRxiv, 2020.07.30.229120. https://doi.org/10.1101/2020.07.30.229120

  10. Jul 2020
  11. Jun 2020
    1. Kempfert, K., Martinez, K., Siraj, A., Conrad, J., Fairchild, G., Ziemann, A., Parikh, N., Osthus, D., Generous, N., Del Valle, S., & Manore, C. (2020). Time Series Methods and Ensemble Models to Nowcast Dengue at the State Level in Brazil. ArXiv:2006.02483 [q-Bio, Stat]. http://arxiv.org/abs/2006.02483

  12. May 2020
  13. Apr 2020
    1. Abdulla, A., Wang, B., Qian, F., Kee, T., Blasiak, A., Ong, Y. H., Hooi, L., Parekh, F., Soriano, R., Olinger, G. G., Keppo, J., Hardesty, C. L., Chow, E. K., Ho, D., & Ding, X. (n.d.). Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention. Advanced Therapeutics, n/a(n/a), 2000034. https://doi.org/10.1002/adtp.202000034

    1. ompared with patients without cardiac injury, patients with cardiac injury presented with more severe acute illness, manifested by abnormal laboratory and radiographic findings, such as higher levels of C-reactive protein, NT-proBNP, and creatinine levels; more multiple mottling and ground-glass opacity; and a greater proportion requiring noninvasive or invasive ventilation.
  14. Mar 2020
  15. Jan 2020
    1. CONCLUSION: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD.

      Is there anything it can't do? I have noted, however, that larger doses cause nausea for me. That is, 3 or more grams on an empty stomach. I just vomited after taking 7.5 grams before my meal, but I have not yet established the causal link. It is the largest amount I've ever taken at one time. I suspect that it may have contributed significantly, but that it was also one out of half a dozen factors.

  16. Dec 2019
    1. scarlet fever

      Scarlet fever is a disease caused by a streptococcus infection, most common among children and young adults. Until the discovery of penicillin in the early 20th Century, it was frequently fatal. Also compare the 1831 edition, in which Elizabeth's condition is more "severe."

  17. Jul 2019
  18. Jun 2019
    1. In 99.3% of the time under unstressed conditions,

      Danism: A cell in a diseased state does not respond the same way as a cell in a non-diseased state. This is essential and has many roots. Translation Regulation being the most controversial.

  19. May 2019
    1. in February, 1977, Searle's law firm, Sidley & Austin, offered Skinner a job, which he accepted, recusing himself from the case

      The company being sued for the cover up of the negative side effects of aspartame hires the lawyer that represented the FDA thus resulting in the case never making it to trial.

    2. n January 1977, formally requested that a grand jury be convened to investigate whether indictments should be filed against Searle for knowingly misrepresenting findings and "concealing material facts and making false statements" in aspartame safety tests (the first time in the FDA's history that they request a criminal investigation of a manufacturer)

      Aspartame was so poorly misrepresented in the scientific research provided for its approval that it became the first case in history in which a lawsuit was brought against the manufacturer for concealing of material facts and false statements.

    1. elevated cortisol and gut dysbiosis via interactions with different biogenic amine may also have additional impact to modulate neuronal signaling lead to neurobiological impairments

      In summary aspartame increases the fire of neurotransmitters, increases heart rate and and blood pressure, and imbalances gut bacteria.

    2. aspartame metabolite; mainly Phy and its interaction with neurotransmitter and aspartic acid by acting as excitatory neurotransmitter causes this pattern of impairments

      Aspartame alters the chemical composition of the brain and excites neurotransmitters.

    1. examination showed fetal capillaries with condensed nuclei of endothelial cells, cytotrophoblasts with condensed fragmented nuclei and vacuolated cytoplasm, and syncytiotrophoblasts with irregular condensed fragmented nuclei

      In summary aspartame results in the death of cells that carry nutrients and energy to the growing embryo.

    2. Damage in the placenta was detected in the form of rupture of the interhemal membrane, lysis of glycogen trophoblast cells, spongiotrophoblast cells with vacuolated cytoplasm and darkly stained nuclei.

      Aspartame caused placenta cells to rupture and behave like they had been exposed to a pathogen or virus.

    1. Results reveal that the aspartame molecule is inherently amyloidogenic, and the self-assembly of aspartame becomes a toxic trap for proteins and cells

      Aspartame inhibits the function of organs and tissues via clusters of proteins/“plaque”.

    2. amyloidogenic

      producing or tending to produce amyloid deposits. These are associated with malfunction of organs.

    1. Amyloids are aggregates of proteins that become folded into a shape that allows many copies of that protein to stick together, forming fibrils. In the human body, amyloids have been linked to the development of various diseases.

      Amyloids are clusters of proteins that are associated with development of various diseases in humans.