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  1. Sep 2021
    1. Pauli and his colleagues captured 10 brown-throated sloths. They are a three-toed species. The scientists also collected 12 Hoffmann’s sloths, which are a two-toed type. All came from a study site in northeastern Costa Rica. Here, the sloths live among a variety of habitats. These range from pristine forest and cacao (Ka-KOW) agroforest to fields of banana and pineapple.“It’s really a quilt of different habitat types,” Pauli says. And it’s one that allowed the researchers not only to study many habitats at once but also to more easily capture and track sloths than if they were in dense jungle.Many elements come in more than one form, or isotope (EYE-so-toap). The researchers injected the sloths with water labeled with specific isotopes of oxygen and hydrogen, then released the animals back to the wild. After 7 to 10 days, the scientists again captured the sloths and sampled their blood. By seeing how much of the isotope labels remained, they could calculate the sloths’ field metabolic rate. This is the energy that an organism uses throughout the day.The field metabolic rate for the three-toed sloths was 31 percent lower than that for two-toed sloths. It also was lower than that found in any mammal that was not hibernating. The researchers reported this May 25 in the American Naturalist.

      Study: 10 3 toed sloths (brown throated) 12 2 toed sloths (Hoffmann)

      where: Costa Rica but variety of habitats

      Researchers injected sloths w/ H20 w/ labeled isotopes of O2 and H before releasing back in wild. 7-10 days later, sloths captured again and measure isotopes by collecting blood --> that how they calculate metabolic rate (by seeing how much is left) (MR_--> energy organism uses throughout the day)

      3 toed sloths--> 31% lower than 2 toed sloths (lower metabolic rate--> less food needed--> less energy wasted)

      Lower than any animals not in hibernating state

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    1. Haber, N. A., Wieten, S. E., Rohrer, J. M., Arah, O. A., Tennant, P. W. G., Stuart, E. A., Murray, E. J., Pilleron, S., Lam, S. T., Riederer, E., Howcutt, S. J., Simmons, A. E., Leyrat, C., Schoenegger, P., Booman, A., Dufour, M.-S. K., O’Donoghue, A. L., Baglini, R., Do, S., … Fox, M. P. (2021). Causal and Associational Linking Language From Observational Research and Health Evaluation Literature in Practice: A systematic language evaluation [Preprint]. Epidemiology. https://doi.org/10.1101/2021.08.25.21262631

    1. We found an association between short-term secondhand exposures to EC emissions, measured by nicotine concentrations, and decreased HRV as well as shortening of the QTc

      It's hard to say what this tells me about my hypothesis that the 7 mg patch increases HRV. It really depends on their blood levels. The second-hand smoke machine is extremely unrealistic. They were exposed to 30 puffs of 1.8% nicotine e-juice in the first measurement interval. Assuming 150 puffs per ml, that's 3.6 mg smoked in a single 15 minute interval! I've not read the full study to confirm this calculation. Nonetheless, it's clear that these insane conditions require scrutiny. That's not even counting the fact that there's no placebo (Or even control). How am I supposed to know if this is not just an effect of being concern about inhaling e-smoke? I'm still searching for studies on low concentration of nicotine and HRV.

  2. Aug 2021
  3. Jul 2021
    1. NIHR HPRU in Behavioural Science and Eval Bristol. (2021, May 27). Event: The CONQUEST study has collected data on the contacts, behaviour & symptoms of staff & students @BristolUni during #COVID19 to inform policy & math modelling. Join us for this webinar on 8 June for an update on the study, its impact & future plans. Https://t.co/DHrmferP0L https://t.co/25cOASdyKJ [Tweet]. @HPRU_BSE. https://twitter.com/HPRU_BSE/status/1397906695775473671

    1. How We Delivered MVP for PlanMyKids - Kids Activities Marketplace (Case Study)Alina NechvolodE-Commerce & SaaS StrategistEugenia ChernukhaProject ManagerInessa IshchenkoUX/UI DesignerMarketplaceCase studyHomeBlogCodica WayHow We Delivered MVP for PlanMyKids - Kids Activities Marketplace (Case Study)Jul 15, 202118 min readIn today’s hectic life keeping children busy after school is a pressing issue for many parents. Not only should they find the most suitable activities for kids, but they also have to monitor the schedule on the go. Such activity booking marketplaces can become a silver bullet for both parents and service providers. Such platforms make it easier for both parties to plan, book, and coordinate these activities for children. Today we would like to share our experience in building a kids activities marketplace. We will lead you through the key stages of custom software product development in our company - from a discovery session to the product launch.

      Today we would like to share our experience in building a kids activities marketplace. We will lead you through the key stages of custom software product development in our company - from a discovery session to the product launch.

    1. Regev-Yochay, G., Amit, S., Bergwerk, M., Lipsitch, M., Leshem, E., Kahn, R., Lustig, Y., Cohen, C., Doolman, R., Ziv, A., Novikov, I., Rubin, C., Gimpelevich, I., Huppert, A., Rahav, G., Afek, A., & Kreiss, Y. (2021). Decreased infectivity following BNT162b2 vaccination: A prospective cohort study in Israel. The Lancet Regional Health - Europe, 7, 100150. https://doi.org/10.1016/j.lanepe.2021.100150

    1. and bullet journal for more modern take on commonplace books

      Bullet Journals certainly are informed by the commonplace tradition, but are an incredibly specialized version of lists for productivity.

      Perhaps there's more influence by Peter Ramus' outlining tradition here as well?

      I've seen a student's written version of the idea of a Bullet Journal technique which came out of a study habits manual in the 1990's. It didn't quite have the simplicity of the modern BuJo idea or the annotations, but in substance it was the same idea. I'll have to dig up a reference for this.

  4. Jun 2021
    1. Li, X., Ostropolets, A., Makadia, R., Shoaibi, A., Rao, G., Sena, A. G., Martinez-Hernandez, E., Delmestri, A., Verhamme, K., Rijnbeek, P. R., Duarte-Salles, T., Suchard, M. A., Ryan, P. B., Hripcsak, G., & Prieto-Alhambra, D. (2021). Characterising the background incidence rates of adverse events of special interest for covid-19 vaccines in eight countries: Multinational network cohort study. BMJ, 373, n1435. https://doi.org/10.1136/bmj.n1435

  5. May 2021
    1. Eric Topol. (2021, May 1). Downgrading the concern on B.1.617, the poorly named ‘double mutant’—98% effectiveness of mRNA vaccine in an Israeli outbreak @CT_Bergstrom https://t.co/tGbuwPUmAL —Lab studies: Minimal immune evasion, expected full protection from vaccine @GuptaR_lab https://t.co/AIp24G0ROK https://t.co/AK20UWlDBD [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1388539223230140422

    1. ReconfigBehSci. (2020, November 18). @danielmabuse yes, we all make mistakes, but a responsible actor also factors the kinds of mistakes she is prone to making into decisions on what actions to take: I’m not that great with my hands, so I never contemplated being a neuro-surgeon. Not everyone should be a public voice on COVID [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1329002783094296577

  6. Apr 2021
    1. Evaluating computerised health information systems: hard lessons still to be learnt

      The article used a Qualitative study design method as it only highlights the problems within the health system in South Africa which is posing threat to the use of health information system in our healthcare centres.

    1. A crucial difference between representations of relative error inthese equations compared withEquations 6and7 for the single-facet designs is that three sources of measurement error varianceare separately represented, withpt2ntequaling specific-factor error,po2noequaling transient error, andpto,e2ntnoequaling random-responseerror. Effects fortasks, occasions, and their interaction are includedin the denominator for the D-coefficient but not the G-coefficientbecause those effects can change the absolutemagnitude of scoresbut not their relative differences.
  7. Mar 2021
  8. Feb 2021
    1. Pastor-Barriuso, R., Pérez-Gómez, B., Hernán, M. A., Pérez-Olmeda, M., Yotti, R., Oteo-Iglesias, J., Sanmartín, J. L., León-Gómez, I., Fernández-García, A., Fernández-Navarro, P., Cruz, I., Martín, M., Delgado-Sanz, C., Larrea, N. F. de, Paniagua, J. L., Muñoz-Montalvo, J. F., Blanco, F., Larrauri, A., & Pollán, M. (2020). Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: Nationwide seroepidemiological study. BMJ, 371, m4509. https://doi.org/10.1136/bmj.m4509

  9. Jan 2021
  10. Dec 2020
  11. Nov 2020
    1. Rosemary enhanced the protective efficacy of AREDS and led to the greatest effect on the retinal genome in animals reared in high environmental light. Chronic administration of rosemary antioxidants may be a useful adjunct to the therapeutic benefit of AREDS in slowing disease progression in AMD.

      This is not in the least surprising. Dietary antioxidants also protect the skin during sunlight exposure.

      Oxidative stress likely also plays a role in diabetic retinopathy. It plays a role in the aging process itself. That said, there is probably a limit to protective powers of antioxidants. Nonetheless, I don't think that that limit has ever been realized in any population. I doubt we've even come close in rats.

    1. Fig 1

      Note that, though folate and B12 were given IV before and after surgery, it did not have an immediate effect. The NO induced rise in homocysteine was not blunted by the end of surgery. However, postoperative homocysteine was lowered to below baseline on all 3 measurement days. The NO induced rise in homocysteine lasted 2 days postoperatively.

      Unsurprisingly, this suggests a lag time between B vitamin administration and homocysteine drop. Thus, what I'd really like to see is a study administering B vitamins 1 day prior to NO use.

    1. Reviewing pre-prints with hypothes.is?

      After conversion using the hypothes.is API tool: https://jonudell.info/h/CopyAnnotations/ , this annotation has been copied to a public annotation (which I subsequently edited).

      Drawback: you can only use it with one user log-in and on a single web domain (so you'd have to run it for every single article someone has reviewed).

      Original annotation (see in group—that one stays there, usefully!)

      This annotation should be private to the group only.

      Tags are permitted, they can be any free text.

  12. Oct 2020
    1. An Evaluation of Problem-based Learning Supported by Information and Communication Technology: A Pilot Study

      (Under "Viewing Options", select PDF.) In this article, Ernawaty and Sujono (2019) summarize results of a study funded by the Research and Higher Education Directorate of Indonesia. The study aimed to evaluate the cogency of information and communication technologies (ICTs) in problem based learning (PBL) and traditional teaching methods (TTM) based upon learner test scores. The concepts of PBL, TTM, and implications of ICTs are briefly reviewed. Results of the study revealed that PBL with the support of an ICT yielded the highest test scores. (6/10)

  13. Sep 2020
    1. Ip, A., Ahn, J., Zhou, Y., Goy, A. H., Hansen, E., Pecora, A. L., Sinclaire, B. A., Bednarz, U., Marafelias, M., Mathura, S., Sawczuk, I. S., Underwood, J. P., Walker, D. M., Prasad, R., Sweeney, R. L., Ponce, M. G., LaCapra, S., Cunningham, F. J., Calise, A. G., … Goldberg, S. L. (2020). Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: A multi-center observational study. MedRxiv, 2020.08.20.20178772. https://doi.org/10.1101/2020.08.20.20178772

  14. Aug 2020
    1. Nguyen, L. H., Drew, D. A., Graham, M. S., Joshi, A. D., Guo, C.-G., Ma, W., Mehta, R. S., Warner, E. T., Sikavi, D. R., Lo, C.-H., Kwon, S., Song, M., Mucci, L. A., Stampfer, M. J., Willett, W. C., Eliassen, A. H., Hart, J. E., Chavarro, J. E., Rich-Edwards, J. W., … Zhang, F. (2020). Risk of COVID-19 among front-line health-care workers and the general community: A prospective cohort study. The Lancet Public Health, 0(0). https://doi.org/10.1016/S2468-2667(20)30164-X

    1. “In 2004, Cleveland Clinic physiologist Guang Yue wanted to know if merely thinking about lifting weights was enough to increase strength. Study subjects were divided into four groups. One group tried to strengthen their finger muscles with physical exercise; one tried to strengthen their finger muscles by only visualizing the exercise; another tried to increase arm strength through visualization; while the last group did nothing at all. The trial lasted twelve weeks.When it was over, those who did nothing saw no gains. The group that relied on physical training saw the greatest increase in strength-at 53 percent. But it’s the mental groups where things got curious. Folks who did no physical training but merely imagined their fingers going through precise exercise motions saw a 35 percent increase in strength, while the ones who visualized arm exercises saw a 13.5 percent increase in strength.”Let’s review — these participants did NOTHING BUT VISUALIZING and saw an increase of up to 35% in strength!But things are all the more convincing when you consider that a few years before Yue’s studies, neuroscientists found no difference between performing an action and merely imagining oneself performing that action-the same neuronal circuits fire in either case.

      Experiments have shown that simply visualizing an can have great impacts.

    1. More information about limitations and exceptions to copyright

      Under more information about limitations and exceptions to copyright add section titled Case Studies: Case studies provide valuable information relating to the state of affairs in various countries, as well as the opposing views when debating copyright issues.

      • South Africa: a case study of politics and the global economics of limitations and exceptions to copyright. The current debate in South Africa regarding proposed amendments to the Copyright Bill allows showcases the different sides of the debate, and how legal frameworks, e.g. the Constitution of the Republic of South Africa also informs decision making.
      1. US Government Threatening To Kill Free Trade With South Africa After Hollywood Complained It Was Adopting American Fair Use Principles, by Mike Masnick, 4 November 2019.
      2. South Africa’s Copyright Amendment Bill – one year on, by Denise Nicholson, 30 March 2020. This work is licensed under a Creative Commons Attribution 4.0 International License.
      3. South Africa’s Copyright Amendment Bill Returned to Parliament for Further Consideration, Mike Palmedo, 22 June 2020. This work is licensed under a Creative Commons Attribution 4.0 International License.
      4. See the light and pass the Copyright Amendment Bill, by Mugwena Maluleke, Tebogo Sithathu, Jack Devnarain, Tusi Fokane, Ben Cashdan and Jace Nair, 24 June 2020. © Mail & Guardian Online.
      5. South African President’s Reservations to Copyright Bill Not Supported by Law, by Sean Flynn, 13 July 2020. This work is licensed under a Creative Commons Attribution 4.0 International License.

      For a comprehensive list of materials relating to the South African Copyright Amendment Bill processes, see Copyright and Related Issues: USTR GSP trade threats re: Bill, list compiled and amended by Denis Nicholson

  15. Jul 2020
    1. Meyer, B., Torriani, G., Yerly, S., Mazza, L., Calame, A., Arm-Vernez, I., Zimmer, G., Agoritsas, T., Stirnemann, J., Spechbach, H., Guessous, I., Stringhini, S., Pugin, J., Roux-Lombard, P., Fontao, L., Siegrist, C.-A., Eckerle, I., Vuilleumier, N., & Kaiser, L. (2020). Validation of a commercially available SARS-CoV-2 serological immunoassay. Clinical Microbiology and Infection, 0(0). https://doi.org/10.1016/j.cmi.2020.06.024

    1. Fontanet, A., Grant, R., Tondeur, L., Madec, Y., Grzelak, L., Cailleau, I., Ungeheuer, M.-N., Renaudat, C., Pellerin, S. F., Kuhmel, L., Staropoli, I., Anna, F., Charneau, P., Demeret, C., Bruel, T., Schwartz, O., & Hoen, B. (2020). SARS-CoV-2 infection in primary schools in northern France: A retrospective cohort study in an area of high transmission. MedRxiv, 2020.06.25.20140178. https://doi.org/10.1101/2020.06.25.20140178

  16. Jun 2020
    1. Gambin, M., Sekowski, M., Woźniak-Prus, M., Wnuk, A., Oleksy, T., Cudo, A., Hansen, K., Huflejt-Łukasik, M., Kubicka, K., Lys, A. E., Gorgol, J., Holas, P., Kmita, G., Łojek, E., & Maison, D. (2020). Generalized anxiety and depressive symptoms in various age groups during the COVID-19 lockdown. Specific predictors and differences in symptoms severity [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/42m87

    1. Kucharski, A. J., Klepac, P., Conlan, A. J. K., Kissler, S. M., Tang, M. L., Fry, H., Gog, J. R., Edmunds, W. J., Emery, J. C., Medley, G., Munday, J. D., Russell, T. W., Leclerc, Q. J., Diamond, C., Procter, S. R., Gimma, A., Sun, F. Y., Gibbs, H. P., Rosello, A., … Simons, D. (2020). Effectiveness of isolation, testing, contact tracing, and physical distancing on reducing transmission of SARS-CoV-2 in different settings: A mathematical modelling study. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(20)30457-6

    1. McBride, O., Murphy, J., Shevlin, M., Gibson Miller, J., Hartman, T. K., Hyland, P., Levita, L., Mason, L., Martinez, A. P., McKay, R., Stocks, T. V. A., bennett, kate m, Vallières, F., Karatzias, T., Valiente, C., Vazquez, C., & Bentall, R. (2020). An overview of the context, design and conduct of the first two waves of the COVID-19 Psychological Research Consortium (C19PRC) Study [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/z3q5p

    1. Siedner, M. J., Kraemer, J. D., Meyer, M. J., Harling, G., Mngomezulu, T., Gabela, P., Dlamini, S., Gareta, D., Majozi, N., Ngwenya, N., Reynolds, Z., Seeley, J., Wong, E., Iwuji, C., Shahmanesh, M., Hanekom, W., & Herbst, K. (2020). Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: A longitudinal cohort study [Preprint]. Health Systems and Quality Improvement. https://doi.org/10.1101/2020.05.15.20103226

  17. May 2020
    1. Gobbi, S., Plomecka, M., Ashraf, Z., Radziński, P., Neckels, R., Lazzeri, S., Dedić, A., Bakalović, A., Hrustić, L., Skórko, B., Es haghi, S., Almazidou, K., Rodríguez-Pino, L., Alp, A. B., Jabeen, H., Waller, V., Shibli, D., AghiliBehnam, M., Strutt, A. M., … Jawaid, A. (2020). Worsening of pre-existing psychiatric conditions during the COVID-19 pandemic [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/x6cyg